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Steroids and Brain, a Rising Bio-Medical Domain: a Perspective.

Baulieu EE.

Front Endocrinol (Lausanne). 2018 Jun 15;9:316. doi: 10.3389/fendo.2018.00316. eCollection 2018.


Neurosteroids: non-genomic pathways in neuroplasticity and involvement in neurological diseases.

Schverer M, Lanfumey L, Baulieu EE, Froger N, Villey I.

Pharmacol Ther. 2018 Nov;191:190-206. doi: 10.1016/j.pharmthera.2018.06.011. Epub 2018 Jun 25. Review.


Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis.

Shackleford G, Sampathkumar NK, Hichor M, Weill L, Meffre D, Juricek L, Laurendeau I, Chevallier A, Ortonne N, Larousserie F, Herbin M, Bièche I, Coumoul X, Beraneck M, Baulieu EE, Charbonnier F, Pasmant E, Massaad C.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1319-E1328. doi: 10.1073/pnas.1715999115. Epub 2018 Jan 19.


Identification of the Tau phosphorylation pattern that drives its aggregation.

Despres C, Byrne C, Qi H, Cantrelle FX, Huvent I, Chambraud B, Baulieu EE, Jacquot Y, Landrieu I, Lippens G, Smet-Nocca C.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9080-9085. doi: 10.1073/pnas.1708448114. Epub 2017 Aug 7.


Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation.

Akwa Y, Gondard E, Mann A, Capetillo-Zarate E, Alberdi E, Matute C, Marty S, Vaccari T, Lozano AM, Baulieu EE, Tampellini D.

Mol Psychiatry. 2018 Jun;23(6):1530-1540. doi: 10.1038/mp.2017.142. Epub 2017 Jul 11.


The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease.

Farina F, Lambert E, Commeau L, Lejeune FX, Roudier N, Fonte C, Parker JA, Boddaert J, Verny M, Baulieu EE, Neri C.

Sci Rep. 2017 Jun 21;7(1):4014. doi: 10.1038/s41598-017-04256-w.


Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin.

Bielecki B, Mattern C, Ghoumari AM, Javaid S, Smietanka K, Abi Ghanem C, Mhaouty-Kodja S, Ghandour MS, Baulieu EE, Franklin RJ, Schumacher M, Traiffort E.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14829-14834. doi: 10.1073/pnas.1614826113. Epub 2016 Dec 7.


A β-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52.

Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y.

Biochemistry. 2016 Sep 27;55(38):5366-76. doi: 10.1021/acs.biochem.6b00506. Epub 2016 Sep 19.


Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons.

Meduri G, Guillemeau K, Dounane O, Sazdovitch V, Duyckaerts C, Chambraud B, Baulieu EE, Giustiniani J.

Neurobiol Aging. 2016 Oct;46:124-37. doi: 10.1016/j.neurobiolaging.2016.06.017. Epub 2016 Jul 5.


Isomerization and Oligomerization of Truncated and Mutated Tau Forms by FKBP52 are Independent Processes.

Kamah A, Cantrelle FX, Huvent I, Giustiniani J, Guillemeau K, Byrne C, Jacquot Y, Landrieu I, Baulieu EE, Smet C, Chambraud B, Lippens G.

J Mol Biol. 2016 Mar 27;428(6):1080-1090. doi: 10.1016/j.jmb.2016.02.015. Epub 2016 Feb 20.


Effects of the Synthetic Neurosteroid: 3β-Methoxypregnenolone (MAP4343) on Behavioral and Physiological Alterations Provoked by Chronic Psychosocial Stress in Tree Shrews.

Parésys L, Hoffmann K, Froger N, Bianchi M, Villey I, Baulieu EE, Fuchs E.

Int J Neuropsychopharmacol. 2016 Apr 20;19(4). pii: pyv119. doi: 10.1093/ijnp/pyv119. Print 2016 Apr.


From steroid hormones to depressive states and senile dementias: New mechanistic, therapeutical and predictive approaches.

Baulieu ÉÉ.

C R Biol. 2015 Aug-Sep;338(8-9):613-6. doi: 10.1016/j.crvi.2015.06.003. Epub 2015 Aug 3.


Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.

Meffre D, Shackleford G, Hichor M, Gorgievski V, Tzavara ET, Trousson A, Ghoumari AM, Deboux C, Nait Oumesmar B, Liere P, Schumacher M, Baulieu EE, Charbonnier F, Grenier J, Massaad C.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7587-92. doi: 10.1073/pnas.1424951112. Epub 2015 May 28.


The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior.

Giustiniani J, Guillemeau K, Dounane O, Sardin E, Huvent I, Schmitt A, Hamdane M, Buée L, Landrieu I, Lippens G, Baulieu EE, Chambraud B.

FASEB J. 2015 Aug;29(8):3171-81. doi: 10.1096/fj.14-268243. Epub 2015 Apr 17.


Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.

Giustiniani J, Chambraud B, Sardin E, Dounane O, Guillemeau K, Nakatani H, Paquet D, Kamah A, Landrieu I, Lippens G, Baulieu EE, Tawk M.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4584-9. doi: 10.1073/pnas.1402645111. Epub 2014 Mar 12.


Seymour Lieberman: in vivo endocrine chemist.

Baulieu ÉÉ.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6246-7. doi: 10.1073/pnas.1302153110. Epub 2013 Apr 8. No abstract available.


Lithium enhances remyelination of peripheral nerves.

Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3973-8. doi: 10.1073/pnas.1121367109. Epub 2012 Feb 21.


3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders.

Bianchi M, Baulieu EE.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1713-8. doi: 10.1073/pnas.1121485109. Epub 2012 Jan 19. Erratum in: Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4708.


Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): a pilot study.

Dumas de La Roque E, Savineau JP, Metivier AC, Billes MA, Kraemer JP, Doutreleau S, Jougon J, Marthan R, Moore N, Fayon M, Baulieu EÉ, Dromer C.

Ann Endocrinol (Paris). 2012 Feb;73(1):20-5. doi: 10.1016/j.ando.2011.12.005. Epub 2012 Jan 26.


Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.

Giustiniani J, Sineus M, Sardin E, Dounane O, Panchal M, Sazdovitch V, Duyckaerts C, Chambraud B, Baulieu EE.

J Alzheimers Dis. 2012;29(2):471-83. doi: 10.3233/JAD-2011-111895.


Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC.

Ladurelle N, Gabriel C, Viggiano A, Mocaër E, Baulieu EE, Bianchi M.

Psychopharmacology (Berl). 2012 Jun;221(3):493-509. doi: 10.1007/s00213-011-2597-5. Epub 2011 Dec 8.


Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons.

Rakotomamonjy J, Levenes C, Baulieu EE, Schumacher M, Ghoumari AM.

FASEB J. 2011 Nov;25(11):3999-4010. doi: 10.1096/fj.11-183384. Epub 2011 Jul 27.


Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone.

Duchossoy Y, David S, Baulieu EE, Robel P.

Brain Res. 2011 Jul 27;1403:57-66. doi: 10.1016/j.brainres.2011.05.065. Epub 2011 Jun 12.


Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.

Janmaat S, Akwa Y, Doulazmi M, Bakouche J, Gautheron V, Liere P, Eychenne B, Pianos A, Luiten P, Groothuis T, Baulieu EE, Mariani J, Sherrard RM, Frédéric F.

Age (Dordr). 2011 Dec;33(4):565-78. doi: 10.1007/s11357-010-9203-3. Epub 2011 Jan 11.


A role for FKBP52 in Tau protein function.

Chambraud B, Sardin E, Giustiniani J, Dounane O, Schumacher M, Goedert M, Baulieu EE.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2658-63. doi: 10.1073/pnas.0914957107. Epub 2010 Jan 25.


The Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis (POPART'MUS) trial: rationale, objectives and state of advancement.

Vukusic S, Ionescu I, El-Etr M, Schumacher M, Baulieu EE, Cornu C, Confavreux C; Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis Study Group.

J Neurol Sci. 2009 Nov 15;286(1-2):114-8. doi: 10.1016/j.jns.2009.08.056. Epub 2009 Sep 15.


Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key.

Liere P, Pianos A, Eychenne B, Cambourg A, Bodin K, Griffiths W, Schumacher M, Baulieu EE, Sjövall J.

J Lipid Res. 2009 Dec;50(12):2430-44. doi: 10.1194/jlr.M900162-JLR200. Epub 2009 Jun 8.


Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons.

Sanchez PE, Fares RP, Risso JJ, Bonnet C, Bouvard S, Le-Cavorsin M, Georges B, Moulin C, Belmeguenai A, Bodennec J, Morales A, Pequignot JM, Baulieu EE, Levine RA, Bezin L.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9848-53. doi: 10.1073/pnas.0901840106. Epub 2009 Jun 3.


Etifoxine improves peripheral nerve regeneration and functional recovery.

Girard C, Liu S, Cadepond F, Adams D, Lacroix C, Verleye M, Gillardin JM, Baulieu EE, Schumacher M, Schweizer-Groyer G.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20505-10. doi: 10.1073/pnas.0811201106. Epub 2008 Dec 15.


DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension.

Dessouroux A, Akwa Y, Baulieu EE.

J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):81-9. doi: 10.1016/j.jsbmb.2007.12.001. Epub 2007 Dec 7.


Pregnenolone sulfate in the brain: a controversial neurosteroid.

Schumacher M, Liere P, Akwa Y, Rajkowski K, Griffiths W, Bodin K, Sjövall J, Baulieu EE.

Neurochem Int. 2008 Mar-Apr;52(4-5):522-40. Epub 2007 Oct 9. Review.


The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation.

Chambraud B, Belabes H, Fontaine-Lenoir V, Fellous A, Baulieu EE.

FASEB J. 2007 Sep;21(11):2787-97. Epub 2007 Apr 13.


Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.

Schumacher M, Guennoun R, Ghoumari A, Massaad C, Robert F, El-Etr M, Akwa Y, Rajkowski K, Baulieu EE.

Endocr Rev. 2007 Jun;28(4):387-439. Epub 2007 Apr 12. Review.


A steroid hormone that extends the lifespan of Caenorhabditis elegans.

Broué F, Liere P, Kenyon C, Baulieu EE.

Aging Cell. 2007 Feb;6(1):87-94. Erratum in: Aging Cell. 2011 Jun;10(3):555.


Hypoxia and dehydroepiandrosterone in old age: a mouse survival study.

Debonneuil EH, Quillard J, Baulieu EE.

Respir Res. 2006 Dec 18;7:144.


Neuroprotective effect of mifepristone involves neuron depolarization.

Ghoumari AM, Piochon C, Tomkiewicz C, Eychenne B, Levenes C, Dusart I, Schumacher M, Baulieu EE.

FASEB J. 2006 Jul;20(9):1377-86.


Deaths from Clostridium sordellii after medical abortion.

Baulieu EE.

N Engl J Med. 2006 Apr 13;354(15):1645-7; author reply 1645-7. No abstract available.


Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor.

Fontaine-Lenoir V, Chambraud B, Fellous A, David S, Duchossoy Y, Baulieu EE, Robel P.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4711-6. Epub 2006 Mar 14.


[The Institute of longevity and ageing].

Mariani J, Hanseler MF, Baulieu EE.

Med Sci (Paris). 2006 Mar;22(3):321-2. French. No abstract available.


Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells.

Fonte C, Grenier J, Trousson A, Chauchereau A, Lahuna O, Baulieu EE, Schumacher M, Massaad C.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14260-5. Epub 2005 Sep 26.


Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures.

Ghoumari AM, Baulieu EE, Schumacher M.

Neuroscience. 2005;135(1):47-58.


Steroid hormones in multiple sclerosis.

El-Etr M, Vukusic S, Gignoux L, Durand-Dubief F, Achiti I, Baulieu EE, Confavreux C.

J Neurol Sci. 2005 Jun 15;233(1-2):49-54. Review.


7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.

Matsunaga M, Ukena K, Baulieu EE, Tsutsui K.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17282-7. Epub 2004 Nov 29.


Dose-dependent effect of dehydroepiandrosterone, but not of its sulphate ester, on angiogenesis.

Varet J, Vincent L, Akwa Y, Mirshahi P, Lahary A, Legrand E, Opolon P, Mishal Z, Baulieu EE, Soria J, Soria C, Li H.

Eur J Pharmacol. 2004 Oct 11;502(1-2):21-30.


Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain.

Liere P, Pianos A, Eychenne B, Cambourg A, Liu S, Griffiths W, Schumacher M, Sjövall J, Baulieu EE.

J Lipid Res. 2004 Dec;45(12):2287-302. Epub 2004 Sep 1.


MAPREG: toward a novel approach of neuroprotection and treatment of Alzheimer's disease.

Baulieu EE, Robel P, Fellous A, Duchossoy Y, Fontaine-Lenoir V, David S.

J Mol Neurosci. 2004;24(1):63-5. Review.


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