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Items: 30


Genome-wide identification of essential genes in Mycobacterium intracellulare by transposon sequencing - Implication for metabolic remodeling.

Tateishi Y, Minato Y, Baughn AD, Ohnishi H, Nishiyama A, Ozeki Y, Matsumoto S.

Sci Rep. 2020 Mar 25;10(1):5449. doi: 10.1038/s41598-020-62287-2.


The Bewildering Antitubercular Action of Pyrazinamide.

Lamont EA, Dillon NA, Baughn AD.

Microbiol Mol Biol Rev. 2020 Mar 4;84(2). pii: e00070-19. doi: 10.1128/MMBR.00070-19. Print 2020 May 20. Review.


Impact of the host environment on the antitubercular action of pyrazinamide.

Lamont EA, Baughn AD.

EBioMedicine. 2019 Nov;49:374-380. doi: 10.1016/j.ebiom.2019.10.014. Epub 2019 Oct 25. Review.


Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance.

Kordus SL, Baughn AD.

Medchemcomm. 2019 May 8;10(6):880-895. doi: 10.1039/c9md00078j. eCollection 2019 Jun 1. Review.


Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways.

Minato Y, Gohl DM, Thiede JM, Chacón JM, Harcombe WR, Maruyama F, Baughn AD.

mSystems. 2019 Jun 25;4(4). pii: e00070-19. doi: 10.1128/mSystems.00070-19.


Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis.

Howe MD, Kordus SL, Cole MS, Bauman AA, Aldrich CC, Baughn AD, Minato Y.

Front Cell Infect Microbiol. 2018 Nov 12;8:399. doi: 10.3389/fcimb.2018.00399. eCollection 2018.


Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole.

Minato Y, Dawadi S, Kordus SL, Sivanandam A, Aldrich CC, Baughn AD.

Nat Commun. 2018 Mar 8;9(1):1003. doi: 10.1038/s41467-018-03447-x.


Subversion of Metabolic Wasting as the Mechanism for folM-Linked Sulfamethoxazole Resistance.

Minato Y, Baughn AD.

mBio. 2017 Nov 28;8(6). pii: e01769-17. doi: 10.1128/mBio.01769-17. No abstract available.


Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates.

Dawadi S, Kordus SL, Baughn AD, Aldrich CC.

Org Lett. 2017 Oct 6;19(19):5220-5223. doi: 10.1021/acs.orglett.7b02487. Epub 2017 Sep 19.


Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells.

Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler KC.

ACS Infect Dis. 2017 Sep 8;3(9):634-644. doi: 10.1021/acsinfecdis.7b00028. Epub 2017 Aug 7.


Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA.

Dillon NA, Peterson ND, Feaga HA, Keiler KC, Baughn AD.

Sci Rep. 2017 Jul 21;7(1):6135. doi: 10.1038/s41598-017-06415-5.


Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates.

Thiede JM, Kordus SL, Turman BJ, Buonomo JA, Aldrich CC, Minato Y, Baughn AD.

Sci Rep. 2016 Dec 1;6:38083. doi: 10.1038/srep38083.


Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.

Rosen BC, Dillon NA, Peterson ND, Minato Y, Baughn AD.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e02130-16. doi: 10.1128/AAC.02130-16. Print 2017 Feb.


Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis.

Peterson ND, Rosen BC, Dillon NA, Baughn AD.

Antimicrob Agents Chemother. 2015 Dec;59(12):7320-6. doi: 10.1128/AAC.00967-15. Epub 2015 Sep 14.


Metabolomics of Central Carbon Metabolism in Mycobacterium tuberculosis.

Baughn AD, Rhee KY.

Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.MGM2-0026-2013. Review.


Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.

Minato Y, Thiede JM, Kordus SL, McKlveen EJ, Turman BJ, Baughn AD.

Antimicrob Agents Chemother. 2015 Sep;59(9):5097-106. doi: 10.1128/AAC.00647-15. Epub 2015 Jun 1. Review.


Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide.

Dillon NA, Peterson ND, Rosen BC, Baughn AD.

Antimicrob Agents Chemother. 2014 Dec;58(12):7258-63. doi: 10.1128/AAC.04028-14. Epub 2014 Sep 22.


Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence.

Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR Jr, Lenaerts AJ, Voskuil MI.

mBio. 2014 Jun 3;5(3):e01106-14. doi: 10.1128/mBio.01106-14.


Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis.

Zhao F, Wang XD, Erber LN, Luo M, Guo AZ, Yang SS, Gu J, Turman BJ, Gao YR, Li DF, Cui ZQ, Zhang ZP, Bi LJ, Baughn AD, Zhang XE, Deng JY.

Antimicrob Agents Chemother. 2014;58(3):1479-87. doi: 10.1128/AAC.01775-13. Epub 2013 Dec 23.


Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis.

Meehan BM, Baughn AD, Gallegos R, Malamy MH.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12153-8. doi: 10.1073/pnas.1203796109. Epub 2012 Jul 9.


Metabolic labeling of fucosylated glycoproteins in Bacteroidales species.

Besanceney-Webler C, Jiang H, Wang W, Baughn AD, Wu P.

Bioorg Med Chem Lett. 2011 Sep 1;21(17):4989-92. doi: 10.1016/j.bmcl.2011.05.038. Epub 2011 May 24.


Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR Jr.

Antimicrob Agents Chemother. 2011 Aug;55(8):3889-98. doi: 10.1128/AAC.00266-11. Epub 2011 May 31.


Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.

Baughn AD, Deng J, Vilchèze C, Riestra A, Welch JT, Jacobs WR Jr, Zimhony O.

Antimicrob Agents Chemother. 2010 Dec;54(12):5323-8. doi: 10.1128/AAC.00529-10. Epub 2010 Sep 27. Erratum in: Antimicrob Agents Chemother. 2011 Apr;55(4):1826.


Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria.

Pruksakorn P, Arai M, Kotoku N, Vilchèze C, Baughn AD, Moodley P, Jacobs WR Jr, Kobayashi M.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3658-63. doi: 10.1016/j.bmcl.2010.04.100. Epub 2010 Apr 26.


An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.

Baughn AD, Garforth SJ, Vilchèze C, Jacobs WR Jr.

PLoS Pathog. 2009 Nov;5(11):e1000662. doi: 10.1371/journal.ppat.1000662. Epub 2009 Nov 20.


Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.

Ojha AK, Baughn AD, Sambandan D, Hsu T, Trivelli X, Guerardel Y, Alahari A, Kremer L, Jacobs WR Jr, Hatfull GF.

Mol Microbiol. 2008 Jul;69(1):164-74. doi: 10.1111/j.1365-2958.2008.06274.x. Epub 2008 May 5.


The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.

Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr.

J Bacteriol. 2007 Aug;189(15):5495-503. Epub 2007 May 25.


The essential role of fumarate reductase in haem-dependent growth stimulation of Bacteroides fragilis.

Baughn AD, Malamy MH.

Microbiology. 2003 Jun;149(Pt 6):1551-1558. doi: 10.1099/mic.0.26247-0.


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