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A simplified approach to predict CYP3A-mediated drug-drug interactions at early drug discovery: validation with clinical data.

Rioux N, Batonga J, Colombo F, Massé J, Zouki C, Ribadeneira MD, Duan J, Bethell RC.

Xenobiotica. 2013 Jul;43(7):592-7. doi: 10.3109/00498254.2012.751141. Epub 2012 Dec 17.


The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.

Duan J, Bolger G, Garneau M, Amad M, Batonga J, Montpetit H, Otis F, Jutras M, Lapeyre N, Rhéaume M, Kukolj G, White PW, Bethell RC, Cordingley MG.

Antimicrob Agents Chemother. 2012 Oct;56(10):5381-6. doi: 10.1128/AAC.01028-12. Epub 2012 Aug 6.


Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver.

Fradette C, Batonga J, Teng S, Piquette-Miller M, du Souich P.

Drug Metab Dispos. 2007 May;35(5):765-71. Epub 2007 Feb 15.

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