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Items: 41

1.

New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors.

Feitosa LM, da Silva ER, Hoelz LVB, Souza DL, Come JAASS, Cardoso-Santos C, Batista MM, Soeiro MNC, Boechat N, Pinheiro LCS.

Bioorg Med Chem. 2019 May 17. pii: S0968-0896(19)30475-4. doi: 10.1016/j.bmc.2019.05.026. [Epub ahead of print]

PMID:
31176565
2.

Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi.

Simões-Silva MR, De Araújo JS, Peres RB, Da Silva PB, Batista MM, De Azevedo LD, Bastos MM, Bahia MT, Boechat N, Soeiro MNC.

Parasitology. 2019 Jul;146(8):1006-1012. doi: 10.1017/S0031182019000234. Epub 2019 Mar 12.

PMID:
30859917
3.

Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.

Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC.

ACS Infect Dis. 2019 Mar 8;5(3):365-371. doi: 10.1021/acsinfecdis.8b00253. Epub 2019 Jan 23.

PMID:
30625275
4.

Repurposing Strategy of Atorvastatin against Trypanosoma cruzi: In Vitro Monotherapy and Combined Therapy with Benznidazole Exhibit Synergistic Trypanocidal Activity.

Araujo-Lima CF, Peres RB, Silva PB, Batista MM, Aiub CAF, Felzenszwalb I, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00979-18. doi: 10.1128/AAC.00979-18. Print 2018 Sep.

5.

Identification and preliminary structure-activity relationship studies of novel pyridyl sulfonamides as potential Chagas disease therapeutic agents.

Peres RB, Ullah AI, de Almeida Fiuza LF, Silva PB, Batista MM, Corcoran O, Reddy TRK, de Nazaré Correia Soeiro M.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2018-2022. doi: 10.1016/j.bmcl.2018.04.064. Epub 2018 Apr 30.

PMID:
29748049
6.

Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines.

Fonseca-Berzal C, Ibáñez-Escribano A, Vela N, Cumella J, Nogal-Ruiz JJ, Escario JA, da Silva PB, Batista MM, Soeiro MNC, Sifontes-Rodríguez S, Meneses-Marcel A, Gómez-Barrio A, Arán VJ.

ChemMedChem. 2018 Jun 20;13(12):1246-1259. doi: 10.1002/cmdc.201800084. Epub 2018 May 22.

PMID:
29624912
7.

In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi.

Santos CC, Lionel JR, Peres RB, Batista MM, da Silva PB, de Oliveira GM, da Silva CF, Batista DGJ, Souza SMO, Andrade CH, Neves BJ, Braga RC, Patrick DA, Bakunova SM, Tidwell RR, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02205-17. doi: 10.1128/AAC.02205-17. Print 2018 Feb.

8.

In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines.

Nefertiti ASG, Batista MM, Da Silva PB, Batista DGJ, Da Silva CF, Peres RB, Torres-Santos EC, Cunha-Junior EF, Holt E, Boykin DW, Brun R, Wenzler T, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01936-17. doi: 10.1128/AAC.01936-17. Print 2018 Feb.

9.

Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy.

Simões-Silva MR, De Araújo JS, Oliveira GM, Demarque KC, Peres RB, D'Almeida-Melo I, Batista DGJ, Da Silva CF, Cardoso-Santos C, Da Silva PB, Batista MM, Bahia MT, Soeiro MNC.

Biochem Pharmacol. 2017 Dec 1;145:46-53. doi: 10.1016/j.bcp.2017.08.025. Epub 2017 Sep 7.

PMID:
28870526
10.

Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.

Guedes-da-Silva FH, Batista DG, Da Silva CF, De Araújo JS, Pavão BP, Simões-Silva MR, Batista MM, Demarque KC, Moreira OC, Britto C, Lepesheva GI, Soeiro MN.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02098-16. doi: 10.1128/AAC.02098-16. Print 2017 Apr.

11.

Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.

Fonseca-Berzal C, DA Silva CF, Menna-Barreto RF, Batista MM, Escario JA, Arán VJ, Gómez-Barrio A, Soeiro Mde N.

Parasitology. 2016 Sep;143(11):1469-78. doi: 10.1017/S0031182016001098. Epub 2016 Jun 17.

PMID:
27312370
12.

Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi.

Simões-Silva MR, Nefertiti AS, De Araújo JS, Batista MM, Da Silva PB, Bahia MT, Menna-Barreto RS, Pavão BP, Green J, Farahat AA, Kumar A, Boykin DW, Soeiro MN.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4701-7. doi: 10.1128/AAC.01788-15. Print 2016 Aug.

13.

Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods.

Mello MSC, Delgado IF, Favareto APA, Lopes CMT, Batista MM, Kempinas WD, Paumgartten FJR.

Toxicol Rep. 2014 Dec 18;2:405-414. doi: 10.1016/j.toxrep.2014.12.006. eCollection 2015.

14.

Nucleoside triphosphate diphosphohydrolase1 (TcNTPDase-1) gene expression is increased due to heat shock and in infective forms of Trypanosoma cruzi.

Silva-Gomes NL, Ennes-Vidal V, Carolo JC, Batista MM, Soeiro MN, Menna-Barreto R, Moreira OC.

Parasit Vectors. 2014 Oct 5;7:463. doi: 10.1186/s13071-014-0463-0.

15.

In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi.

Timm BL, da Silva PB, Batista MM, da Silva FH, da Silva CF, Tidwell RR, Patrick DA, Jones SK, Bakunov SA, Bakunova SM, Soeiro Mde N.

Antimicrob Agents Chemother. 2014 Jul;58(7):3720-6. doi: 10.1128/AAC.02353-14. Epub 2014 Apr 21.

16.

In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.

Timm BL, Da Silva PB, Batista MM, Farahat AA, Kumar A, Boykin DW, Soeiro MN.

Parasitology. 2014 Sep;141(10):1272-6. doi: 10.1017/S0031182014000407. Epub 2014 Apr 15.

PMID:
24735493
17.

In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi.

Silva CF, Batista Dda G, Batista MM, Lionel J, Hammer ER, Brun R, Soeiro Mde N.

Parasitology. 2014 Mar;141(3):367-73. doi: 10.1017/S0031182013001601.

PMID:
24553079
18.

Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo.

da Silva CF, Batista Dda G, De Araújo JS, Batista MM, Lionel J, de Souza EM, Hammer ER, da Silva PB, De Mieri M, Adams M, Zimmermann S, Hamburger M, Brun R, Schühly W, Soeiro Mde N.

Antimicrob Agents Chemother. 2013 Nov;57(11):5307-14. doi: 10.1128/AAC.00595-13. Epub 2013 Aug 12.

19.

In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.

Soeiro Mde N, de Souza EM, da Silva CF, Batista Dda G, Batista MM, Pavão BP, Araújo JS, Aiub CA, da Silva PB, Lionel J, Britto C, Kim K, Sulikowski G, Hargrove TY, Waterman MR, Lepesheva GI.

Antimicrob Agents Chemother. 2013 Sep;57(9):4151-63. doi: 10.1128/AAC.00070-13. Epub 2013 Jun 17.

20.

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds.

Hargrove TY, Kim K, de Nazaré Correia Soeiro M, da Silva CF, Batista DD, Batista MM, Yazlovitskaya EM, Waterman MR, Sulikowski GA, Lepesheva GI.

Int J Parasitol Drugs Drug Resist. 2012 Dec;2:178-186. Epub 2012 Jun 30.

21.

Activation of PPARγ by restores mast cell numbers and reactivity in alloxan-diabetic rats by reducing the systemic glucocorticoid levels.

Torres RC, Batista MM, Pons AH, Silva AR, Cordeiro RS, Martins MA, E Silva PM, Carvalho VF.

Eur J Pharmacol. 2012 Sep 15;691(1-3):261-7. doi: 10.1016/j.ejphar.2012.06.010. Epub 2012 Jun 16.

22.

Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.

de Castro SL, Batista DG, Batista MM, Batista W, Daliry A, de Souza EM, Menna-Barreto RF, Oliveira GM, Salomão K, Silva CF, Silva PB, Soeiro Mde N.

Mol Biol Int. 2011;2011:306928. doi: 10.4061/2011/306928. Epub 2011 Jun 30.

23.

Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats.

Carvalho VF, Florim LT, de O Barreto E, Torres RC, Batista MM, Amendoeira FC, Cordeiro RS, Martins MA, E Silva PM.

Eur J Pharmacol. 2011 Nov 1;669(1-3):143-8. doi: 10.1016/j.ejphar.2011.08.004. Epub 2011 Aug 19.

PMID:
21864526
24.

Mast cell function and death in Trypanosoma cruzi infection.

Meuser-Batista M, Corrêa JR, Carvalho VF, de Carvalho Britto CF, Moreira OC, Batista MM, Soares MJ, Filho FA, E Silva PM, Lannes-Vieira J, Silva RC, Henriques-Pons A.

Am J Pathol. 2011 Oct;179(4):1894-904. doi: 10.1016/j.ajpath.2011.06.014. Epub 2011 Aug 3.

25.

Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.

Batista Dda G, Batista MM, de Oliveira GM, Britto CC, Rodrigues AC, Stephens CE, Boykin DW, Soeiro Mde N.

PLoS One. 2011;6(7):e22155. doi: 10.1371/journal.pone.0022155. Epub 2011 Jul 26.

26.

The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi.

da Silva CF, da Silva PB, Batista MM, Daliry A, Tidwell RR, Soeiro Mde N.

Mem Inst Oswaldo Cruz. 2010 May;105(3):239-45.

27.

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.

Batista Dda G, Batista MM, de Oliveira GM, do Amaral PB, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Boykin DW, Soeiro Mde N.

Antimicrob Agents Chemother. 2010 Jul;54(7):2940-52. doi: 10.1128/AAC.01617-09. Epub 2010 May 10.

28.

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection.

Coutinho L, Ferreira MA, Cosson A, Batista MM, Batista Dda G, Minoprio P, Degrave WM, Berneman A, Soeiro Mde N.

Mem Inst Oswaldo Cruz. 2009 Dec;104(8):1055-62.

29.

Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies.

Soeiro Mde N, Dantas AP, Daliry A, Silva CF, Batista DG, de Souza EM, Oliveira GM, Salomão K, Batista MM, Pacheco MG, Silva PB, Santa-Rita RM, Barreto RF, Boykin DW, Castro SL.

Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1:301-10.

30.

In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi.

Daliry A, Da Silva PB, Da Silva CF, Batista MM, De Castro SL, Tidwell RR, Soeiro Mde N.

J Antimicrob Chemother. 2009 Oct;64(4):747-50. doi: 10.1093/jac/dkp290. Epub 2009 Aug 11.

PMID:
19671588
31.

Trypanosoma cruzi: activity of heterocyclic cationic molecules in vitro.

Pacheco MG, da Silva CF, de Souza EM, Batista MM, da Silva PB, Kumar A, Stephens CE, Boykin DW, Soeiro Mde N.

Exp Parasitol. 2009 Sep;123(1):73-80. doi: 10.1016/j.exppara.2009.06.004. Epub 2009 Jun 9.

PMID:
19520077
32.

In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi.

da Silva CF, Batista MM, Batista Dda G, de Souza EM, da Silva PB, de Oliveira GM, Meuser AS, Shareef AR, Boykin DW, Soeiro Mde N.

Antimicrob Agents Chemother. 2008 Sep;52(9):3307-14. doi: 10.1128/AAC.00038-08. Epub 2008 Jul 14.

33.

Transferrin uptake in Trypanosoma cruzi is impaired by interference on cytostome-associated cytoskeleton elements and stability of membrane cholesterol, but not by obstruction of clathrin-dependent endocytosis.

Corrêa JR, Atella GC, Batista MM, Soares MJ.

Exp Parasitol. 2008 May;119(1):58-66. doi: 10.1016/j.exppara.2007.12.010. Epub 2007 Dec 28.

PMID:
18234197
34.

Fas ligand-dependent inflammatory regulation in acute myocarditis induced by Trypanosoma cruzi infection.

de Oliveira GM, Diniz RL, Batista W, Batista MM, Bani Correa C, de Araújo-Jorge TC, Henriques-Pons A.

Am J Pathol. 2007 Jul;171(1):79-86.

35.

Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro".

Silva CF, Batista MM, Mota RA, de Souza EM, Stephens CE, Som P, Boykin DW, Soeiro Mde N.

Biochem Pharmacol. 2007 Jun 15;73(12):1939-46. Epub 2007 Mar 24.

PMID:
17462605
36.

Molluscicidal activity of some Brazilian Solanum spp. (Solanaceae) against Biomphalaria glabrata.

Silva TM, Batista MM, Camara CA, Agra MF.

Ann Trop Med Parasitol. 2005 Jun;99(4):419-25.

PMID:
15949190
37.

Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis.

De Souza EM, Lansiaux A, Bailly C, Wilson WD, Hu Q, Boykin DW, Batista MM, Araújo-Jorge TC, Soeiro MN.

Biochem Pharmacol. 2004 Aug 15;68(4):593-600.

PMID:
15276066
38.

Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models.

de Souza EM, Araújo-Jorge TC, Bailly C, Lansiaux A, Batista MM, Oliveira GM, Soeiro MN.

Cell Tissue Res. 2003 Nov;314(2):223-35. Epub 2003 Aug 20.

PMID:
12928860
39.

Evidence for a perforin-mediated mechanism controlling cardiac inflammation in Trypanosoma cruzi infection.

Henriques-Pons A, Oliveira GM, Paiva MM, Correa AF, Batista MM, Bisaggio RC, Liu CC, Cotta-De-Almeida V, Coutinho CM, Persechini PM, Araujo-Jorge TC.

Int J Exp Pathol. 2002 Apr;83(2):67-79.

40.

Post-traumatic stress disorder in a patient with an implant cardioverter-defibrillator.

Batista MM.

Int J Psychiatry Clin Pract. 2001;5(4):291-2. doi: 10.1080/13651500152732946.

PMID:
24921699
41.

Antibacterial effects of endodontic irrigants on black-pigmented gram-negative anaerobes and facultative bacteria.

Siqueira JF Jr, Batista MM, Fraga RC, de Uzeda M.

J Endod. 1998 Jun;24(6):414-6.

PMID:
9693585

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