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Dynamic reorganisation of intermediate filaments coordinates early B-cell activation.

Tsui C, Maldonado P, Montaner B, Borroto A, Alarcon B, Bruckbauer A, Martinez-Martin N, Batista FD.

Life Sci Alliance. 2018 Aug 20;1(5):e201800060. doi: 10.26508/lsa.201800060. eCollection 2018 Oct.


One-step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock-in mice.

Lin YC, Pecetta S, Steichen JM, Kratochvil S, Melzi E, Arnold J, Dougan SK, Wu L, Kirsch KH, Nair U, Schief WR, Batista FD.

EMBO J. 2018 Sep 14;37(18). pii: e99243. doi: 10.15252/embj.201899243. Epub 2018 Aug 7.


The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses.

Keppler SJ, Burbage M, Gasparrini F, Hartjes L, Aggarwal S, Massaad MJ, Geha RS, Bruckbauer A, Batista FD.

Cell Rep. 2018 Jul 17;24(3):619-629. doi: 10.1016/j.celrep.2018.06.051.


Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis.

Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI, Cameron AJ, Parker PJ, Leitges M, Bruckbauer A, Batista FD.

Immunity. 2018 Jun 19;48(6):1144-1159.e5. doi: 10.1016/j.immuni.2018.04.031. Epub 2018 Jun 5.


Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity.

Burbage M, Gasparrini F, Aggarwal S, Gaya M, Arnold J, Nair U, Way M, Bruckbauer A, Batista FD.

Elife. 2018 Jan 16;7. pii: e26556. doi: 10.7554/eLife.26556.


Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, Aid M, Tsui C, Maldonado P, Nair U, Ghneim K, Fallon PG, Sekaly RP, Barouch DH, Shalek AK, Bruckbauer A, Strid J, Batista FD.

Cell. 2018 Jan 25;172(3):517-533.e20. doi: 10.1016/j.cell.2017.11.036. Epub 2017 Dec 14.


Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

Nandin IS, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD.

J Exp Med. 2017 Sep 4;214(9):2811. doi: 10.1084/jem.2017063307262017c. Epub 2017 Aug 21. No abstract available.


The Small Rho GTPase TC10 Modulates B Cell Immune Responses.

Burbage M, Keppler SJ, Montaner B, Mattila PK, Batista FD.

J Immunol. 2017 Sep 1;199(5):1682-1695. doi: 10.4049/jimmunol.1602167. Epub 2017 Jul 26.


Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

Sanjuan Nandin I, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD.

J Exp Med. 2017 Jul 24. pii: jem.20170633. doi: 10.1084/jem.20170633. [Epub ahead of print] Erratum in: J Exp Med. 2017 Aug 21;:.


A switch from canonical to noncanonical autophagy shapes B cell responses.

Martinez-Martin N, Maldonado P, Gasparrini F, Frederico B, Aggarwal S, Gaya M, Tsui C, Burbage M, Keppler SJ, Montaner B, Jefferies HB, Nair U, Zhao YG, Domart MC, Collinson L, Bruckbauer A, Tooze SA, Batista FD.

Science. 2017 Feb 10;355(6325):641-647. doi: 10.1126/science.aal3908.


The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

Manno B, Oellerich T, Schnyder T, Corso J, Lösing M, Neumann K, Urlaub H, Batista FD, Engelke M, Wienands J.

Eur J Immunol. 2016 Nov;46(11):2520-2530. doi: 10.1002/eji.201646431. Epub 2016 Sep 14.


The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.

Kühn J, Wong LE, Pirkuliyeva S, Schulz K, Schwiegk C, Fünfgeld KG, Keppler S, Batista FD, Urlaub H, Habeck M, Becker S, Griesinger C, Wienands J.

Sci Signal. 2016 Jun 28;9(434):ra66. doi: 10.1126/scisignal.aad6275.


Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.

Mattila PK, Batista FD, Treanor B.

J Cell Biol. 2016 Feb 1;212(3):267-80. doi: 10.1083/jcb.201504137. Review.


Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.

Gasparrini F, Feest C, Bruckbauer A, Mattila PK, Müller J, Nitschke L, Bray D, Batista FD.

EMBO J. 2016 Feb 1;35(3):258-80. doi: 10.15252/embj.201593027. Epub 2015 Dec 15.


Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.

Keppler SJ, Gasparrini F, Burbage M, Aggarwal S, Frederico B, Geha RS, Way M, Bruckbauer A, Batista FD.

Immunity. 2015 Oct 20;43(4):660-73. doi: 10.1016/j.immuni.2015.09.004. Epub 2015 Oct 6.


Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection.

Gaya M, Castello A, Montaner B, Rogers N, Reis e Sousa C, Bruckbauer A, Batista FD.

Science. 2015 Feb 6;347(6222):667-72. doi: 10.1126/science.aaa1300.


Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.

Burbage M, Keppler SJ, Gasparrini F, Martínez-Martín N, Gaya M, Feest C, Domart MC, Brakebusch C, Collinson L, Bruckbauer A, Batista FD.

J Exp Med. 2015 Jan 12;212(1):53-72. doi: 10.1084/jem.20141143. Epub 2014 Dec 29.


Retrospective. Michael Neuberger (1953-2013).

Sale JE, Patel KJ, Batista FD.

Science. 2013 Dec 13;342(6164):1335. doi: 10.1126/science.1248808. No abstract available.


Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.

Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Batista FD.

Nat Immunol. 2013 Sep;14(9):966-75. doi: 10.1038/ni.2685. Epub 2013 Aug 4.


The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.

Mattila PK, Feest C, Depoil D, Treanor B, Montaner B, Otipoby KL, Carter R, Justement LB, Bruckbauer A, Batista FD.

Immunity. 2013 Mar 21;38(3):461-74. doi: 10.1016/j.immuni.2012.11.019. Epub 2013 Mar 14.


RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, Sartori AA, Adams IR, Batista FD, Boulton SJ.

Mol Cell. 2013 Mar 7;49(5):858-71. doi: 10.1016/j.molcel.2013.01.002. Epub 2013 Jan 17.


Cell:cell interactions in the immune system.

Batista FD, Dustin ML.

Immunol Rev. 2013 Jan;251(1):7-12. doi: 10.1111/imr.12025. No abstract available.


The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.

Lösing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J, Engelke M.

J Biol Chem. 2013 Jan 25;288(4):2303-13. doi: 10.1074/jbc.M112.406546. Epub 2012 Dec 5.


Daughter B cells are not created equal: asymmetric segregation of antigen during B cell division.

Thaunat O, Batista FD.

Cell Cycle. 2012 Jun 15;11(12):2219-20. doi: 10.4161/cc.20634. Epub 2012 Jun 15. No abstract available.


The location of splenic NKT cells favours their rapid activation by blood-borne antigen.

Barral P, Sánchez-Niño MD, van Rooijen N, Cerundolo V, Batista FD.

EMBO J. 2012 May 16;31(10):2378-90. doi: 10.1038/emboj.2012.87. Epub 2012 Apr 13.


Asymmetric segregation of polarized antigen on B cell division shapes presentation capacity.

Thaunat O, Granja AG, Barral P, Filby A, Montaner B, Collinson L, Martinez-Martin N, Harwood NE, Bruckbauer A, Batista FD.

Science. 2012 Jan 27;335(6067):475-9. doi: 10.1126/science.1214100.


Neutrophils--the unexpected helpers of B-cell activation.

Harwood NE, Barral P, Batista FD.

EMBO Rep. 2012 Feb 1;13(2):93-4. doi: 10.1038/embor.2011.259. No abstract available.


Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses.

Chang PP, Barral P, Fitch J, Pratama A, Ma CS, Kallies A, Hogan JJ, Cerundolo V, Tangye SG, Bittman R, Nutt SL, Brink R, Godfrey DI, Batista FD, Vinuesa CG.

Nat Immunol. 2011 Nov 27;13(1):35-43. doi: 10.1038/ni.2166.


The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.

Oellerich T, Bremes V, Neumann K, Bohnenberger H, Dittmann K, Hsiao HH, Engelke M, Schnyder T, Batista FD, Urlaub H, Wienands J.

EMBO J. 2011 Aug 5;30(17):3620-34. doi: 10.1038/emboj.2011.251.


B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.

Schnyder T, Castello A, Feest C, Harwood NE, Oellerich T, Urlaub H, Engelke M, Wienands J, Bruckbauer A, Batista FD.

Immunity. 2011 Jun 24;34(6):905-18. doi: 10.1016/j.immuni.2011.06.001.


Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity.

Treanor B, Depoil D, Bruckbauer A, Batista FD.

J Exp Med. 2011 May 9;208(5):1055-68. doi: 10.1084/jem.20101125. Epub 2011 Apr 11.


Antigen presentation to B cells.

Harwood NE, Batista FD.

F1000 Biol Rep. 2010 Dec 17;2:87. doi: 10.3410/B2-87.


The cytoskeleton coordinates the early events of B-cell activation.

Harwood NE, Batista FD.

Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a002360. doi: 10.1101/cshperspect.a002360. Review.


Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation.

Batista FD, Treanor B, Harwood NE.

Immunol Rev. 2010 Sep;237(1):191-204. doi: 10.1111/j.1600-065X.2010.00943.x. Review.


Synthetic iNKT cell-agonists as vaccine adjuvants--finding the balance.

Cerundolo V, Barral P, Batista FD.

Curr Opin Immunol. 2010 Jun;22(3):417-24. doi: 10.1016/j.coi.2010.04.003. Epub 2010 May 12. Review.


Organisation and dynamics of antigen receptors: implications for lymphocyte signalling.

Treanor B, Batista FD.

Curr Opin Immunol. 2010 Jun;22(3):299-307. doi: 10.1016/j.coi.2010.03.009. Epub 2010 Apr 29. Review.


The immunological synapse enter its second decade...

Batista FD, Saito T.

Curr Top Microbiol Immunol. 2010;340:ix-x. No abstract available.


CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.

Barral P, Polzella P, Bruckbauer A, van Rooijen N, Besra GS, Cerundolo V, Batista FD.

Nat Immunol. 2010 Apr;11(4):303-12. doi: 10.1038/ni.1853. Epub 2010 Mar 14.


Early events in B cell activation.

Harwood NE, Batista FD.

Annu Rev Immunol. 2010;28:185-210. doi: 10.1146/annurev-immunol-030409-101216. Review.


The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.

Treanor B, Depoil D, Gonzalez-Granja A, Barral P, Weber M, Dushek O, Bruckbauer A, Batista FD.

Immunity. 2010 Feb 26;32(2):187-99. doi: 10.1016/j.immuni.2009.12.005. Epub 2010 Feb 18.


Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Randall KL, Lambe T, Johnson AL, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC.

Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820. Epub 2009 Nov 8. Erratum in: Nat Immunol. 2010 Jul;11(7):644. Johnson, Andy [corrected to Johnson, Andy L].


Microsignalosomes: spatially resolved receptor signalling.

Treanor B, Harwood NE, Batista FD.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1014-8. doi: 10.1042/BST0371014. Review.


Visualizing the molecular and cellular events underlying the initiation of B-cell activation.

Harwood NE, Batista FD.

Curr Top Microbiol Immunol. 2009;334:153-77. doi: 10.1007/978-3-540-93864-4_7. Review.


Early events of B cell activation by antigen.

Depoil D, Weber M, Treanor B, Fleire SJ, Carrasco YR, Harwood NE, Batista FD.

Sci Signal. 2009 Mar 24;2(63):pt1. doi: 10.1126/scisignal.263pt1.


The antigen expressway: follicular conduits carry antigen to B cells.

Harwood NE, Batista FD.

Immunity. 2009 Feb 20;30(2):177-9. doi: 10.1016/j.immuni.2009.01.004.


Studying cell-to-cell interactions: an easy method of tethering ligands on artificial membranes.

Fleire SJ, Batista FD.

Methods Mol Biol. 2009;462:145-54. doi: 10.1007/978-1-60327-115-8_9.


BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation.

Eckl-Dorna J, Batista FD.

Blood. 2009 Apr 23;113(17):3969-77. doi: 10.1182/blood-2008-10-185421. Epub 2009 Jan 14.


The who, how and where of antigen presentation to B cells.

Batista FD, Harwood NE.

Nat Rev Immunol. 2009 Jan;9(1):15-27. doi: 10.1038/nri2454. Review.


Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.

Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ.

Blood. 2008 Nov 15;112(10):4158-69. doi: 10.1182/blood-2008-02-140814. Epub 2008 Aug 7.


Regulation of integrin activation through the B-cell receptor.

Arana E, Harwood NE, Batista FD.

J Cell Sci. 2008 Jul 15;121(Pt 14):2279-86. doi: 10.1242/jcs.017905.

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