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Items: 1 to 50 of 172

1.

Thiol regulation by Mn porphyrins, commonly known as SOD mimics.

Batinic-Haberle I, Tome ME.

Redox Biol. 2019 Feb 13:101139. doi: 10.1016/j.redox.2019.101139. [Epub ahead of print]

2.

UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation.

Dhar SK, Batinic-Haberle I, St Clair DK.

J Biol Chem. 2019 Apr 26;294(17):6831-6842. doi: 10.1074/jbc.RA118.006595. Epub 2019 Mar 11.

PMID:
30858178
3.

Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.

MacKinney A, Woska E, Spasojevic I, Batinic-Haberle I, Zennadi R.

Redox Biol. 2019 Jan 11:101097. doi: 10.1016/j.redox.2019.101097. [Epub ahead of print]

4.

Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues.

Mapuskar KA, Anderson CM, Spitz DR, Batinic-Haberle I, Allen BG, E Oberley-Deegan R.

Semin Radiat Oncol. 2019 Jan;29(1):72-80. doi: 10.1016/j.semradonc.2018.10.005. Review.

PMID:
30573187
5.

The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells.

Flórido A, Saraiva N, Cerqueira S, Almeida N, Parsons M, Batinic-Haberle I, Miranda JP, Costa JG, Carrara G, Castro M, Oliveira NG, Fernandes AS.

Redox Biol. 2019 Jan;20:367-378. doi: 10.1016/j.redox.2018.10.016. Epub 2018 Oct 25.

6.

MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.

Bellot GL, Dong X, Lahiri A, Sebastin SJ, Batinic-Haberle I, Pervaiz S, Puhaindran ME.

Redox Biol. 2019 Jan;20:307-320. doi: 10.1016/j.redox.2018.10.014. Epub 2018 Oct 23.

7.

Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis.

Anselmo W, Branchetti E, Grau JB, Li G, Ayoub S, Lai EK, Rioux N, Tovmasyan A, Fortier JH, Sacks MS, Batinic-Haberle I, Hazen SL, Levy RJ, Ferrari G.

J Am Heart Assoc. 2018 Oct 16;7(20):e007861. doi: 10.1161/JAHA.117.007861.

8.

Erratum to "Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite" [Free Radic. Biol. Med. 126 (2018) 379-392].

Carballal S, Valez V, Alvarez-Paggi D, Tovmasyan A, Batinic-Haberle I, Ferrer-Sueta G, Murgida DH, Radi R.

Free Radic Biol Med. 2018 Dec;129:611. doi: 10.1016/j.freeradbiomed.2018.10.001. Epub 2018 Oct 11. No abstract available.

PMID:
30318140
9.

Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite.

Carballal S, Valez V, Alvarez-Paggi D, Tovmasyan A, Batinic-Haberle I, Ferrer-Sueta G, Murgida DH, Radi R.

Free Radic Biol Med. 2018 Oct;126:379-392. doi: 10.1016/j.freeradbiomed.2018.08.023. Epub 2018 Aug 23. Erratum in: Free Radic Biol Med. 2018 Dec;129:611.

PMID:
30144631
10.

Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance.

Al-Mutairi R, Tovmasyan A, Batinic-Haberle I, Benov L.

Front Microbiol. 2018 Jul 31;9:1699. doi: 10.3389/fmicb.2018.01699. eCollection 2018.

11.

Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Antioxid Redox Signal. 2018 Dec 1;29(16):1691-1724. doi: 10.1089/ars.2017.7453. Epub 2018 Aug 28.

PMID:
29926755
12.

INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.

Le O, Palacio L, Bernier G, Batinic-Haberle I, Hickson G, Beauséjour C.

Stem Cell Reports. 2018 Jun 5;10(6):1721-1733. doi: 10.1016/j.stemcr.2018.03.025. Epub 2018 Apr 26.

13.

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning.

Sidlauskaite E, Gibson JW, Megson IL, Whitfield PD, Tovmasyan A, Batinic-Haberle I, Murphy MP, Moult PR, Cobley JN.

Redox Biol. 2018 Jun;16:344-351. doi: 10.1016/j.redox.2018.03.012. Epub 2018 Mar 20.

14.

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z.

Antioxidants (Basel). 2018 Mar 7;7(3). pii: E40. doi: 10.3390/antiox7030040.

15.

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.

Tovmasyan A, Bueno-Janice JC, Jaramillo MC, Sampaio RS, Reboucas JS, Kyui N, Benov L, Deng B, Huang TT, Tome ME, Spasojevic I, Batinic-Haberle I.

Antioxid Redox Signal. 2018 Nov 1;29(13):1196-1214. doi: 10.1089/ars.2017.7218. Epub 2018 Mar 27.

PMID:
29390861
16.

Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.

Ghandhi SA, Turner HC, Shuryak I, Dugan GO, Bourland JD, Olson JD, Tooze JA, Morton SR, Batinic-Haberle I, Cline JM, Amundson SA.

PLoS One. 2018 Jan 19;13(1):e0191402. doi: 10.1371/journal.pone.0191402. eCollection 2018.

17.

Post-illumination cellular effects of photodynamic treatment.

Charara M, Tovmasyan A, Batinic-Haberle I, Craik J, Benov L.

PLoS One. 2017 Dec 4;12(12):e0188535. doi: 10.1371/journal.pone.0188535. eCollection 2017.

18.

Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency.

Moghnie S, Tovmasyan A, Craik J, Batinic-Haberle I, Benov L.

Photochem Photobiol Sci. 2017 Nov 8;16(11):1709-1716. doi: 10.1039/c7pp00143f.

PMID:
29043356
19.

Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.

Boss MK, Dewhirst MW, Sampaio RS, Bennett A, Tovmasyan A, Berman KG, Beaven AW, Rizzieri DA, Batinic-Haberle I, Hauck ML, Spasojevic I.

Cancer Chemother Pharmacol. 2017 Aug;80(2):421-431. doi: 10.1007/s00280-017-3372-z. Epub 2017 Jul 6.

20.

Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.

Birer SR, Lee CT, Choudhury KR, Young KH, Spasojevic I, Batinic-Haberle I, Crapo JD, Dewhirst MW, Ashcraft KA.

Radiat Res. 2017 Jul;188(1):94-104. doi: 10.1667/RR14757.1.S1. Epub 2017 May 18.

21.

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.

Leu D, Spasojevic I, Nguyen H, Deng B, Tovmasyan A, Weitner T, Sampaio RS, Batinic-Haberle I, Huang TT.

Redox Biol. 2017 Aug;12:864-871. doi: 10.1016/j.redox.2017.04.027. Epub 2017 Apr 22.

22.

Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.

Shin SW, Choi C, Lee GH, Son A, Kim SH, Park HC, Batinic-Haberle I, Park W.

Antioxid Redox Signal. 2017 Nov 10;27(14):1067-1082. doi: 10.1089/ars.2016.6889. Epub 2017 Mar 30.

PMID:
28358581
23.

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

Ratcliffe P, Koivunen P, Myllyharju J, Ragoussis J, Bovée JV, Batinic-Haberle I, Vinatier C, Trichet V, Robriquet F, Oliver L, Gardie B.

Hypoxia (Auckl). 2017 Mar 15;5:11-20. doi: 10.2147/HP.S127042. eCollection 2017. Review.

24.

A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.

Zhao Y, Carroll DW, You Y, Chaiswing L, Wen R, Batinic-Haberle I, Bondada S, Liang Y, St Clair DK.

Redox Biol. 2017 Aug;12:129-138. doi: 10.1016/j.redox.2017.02.005. Epub 2017 Feb 10.

25.

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.

Rajic Z, Tovmasyan A, de Santana OL, Peixoto IN, Spasojevic I, do Monte SA, Ventura E, Rebouças JS, Batinic-Haberle I.

J Inorg Biochem. 2017 Apr;169:50-60. doi: 10.1016/j.jinorgbio.2017.01.003. Epub 2017 Jan 5.

26.

Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System.

Yin B, Barrionuevo G, Batinic-Haberle I, Sandberg M, Weber SG.

Antioxid Redox Signal. 2017 Sep 20;27(9):534-549. doi: 10.1089/ars.2016.6706. Epub 2017 Mar 7.

27.

Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy.

Alenezi K, Tovmasyan A, Batinic-Haberle I, Benov LT.

Photodiagnosis Photodyn Ther. 2017 Mar;17:154-159. doi: 10.1016/j.pdpdt.2016.11.009. Epub 2016 Nov 22.

PMID:
27888164
28.

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Weitzel DH, Tovmasyan A, Ashcraft KA, Boico A, Birer SR, Roy Choudhury K, Herndon J 2nd, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Environ Mol Mutagen. 2016 Jun;57(5):372-81. doi: 10.1002/em.22021. Epub 2016 May 25.

PMID:
27224425
29.

Important cellular targets for antimicrobial photodynamic therapy.

Awad MM, Tovmasyan A, Craik JD, Batinic-Haberle I, Benov LT.

Appl Microbiol Biotechnol. 2016 Sep;100(17):7679-88. doi: 10.1007/s00253-016-7632-3. Epub 2016 May 24.

PMID:
27221289
30.

Opinion on Schmidt et al.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Antioxid Redox Signal. 2016 Mar 20;24(9):518-24. doi: 10.1089/ars.2015.6623. No abstract available.

PMID:
26857355
31.

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, Batinic-Haberle I, Vander Kooi CW, Chi W, Latif AA, Panchatcharam M, Prachayasittikul V, Butterfield DA, Vore M, Moscow J, St Clair DK.

Free Radic Biol Med. 2016 Feb;91:68-80. doi: 10.1016/j.freeradbiomed.2015.12.002. Epub 2015 Dec 9.

32.

Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints.

Costa JG, Saraiva N, Guerreiro PS, Louro H, Silva MJ, Miranda JP, Castro M, Batinic-Haberle I, Fernandes AS, Oliveira NG.

Food Chem Toxicol. 2016 Jan;87:65-76. doi: 10.1016/j.fct.2015.11.018. Epub 2015 Dec 2.

PMID:
26627377
33.

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Ashcraft KA, Boss MK, Tovmasyan A, Roy Choudhury K, Fontanella AN, Young KH, Palmer GM, Birer SR, Landon CD, Park W, Das SK, Weitner T, Sheng H, Warner DS, Brizel DM, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):892-900. doi: 10.1016/j.ijrobp.2015.07.2283. Epub 2015 Jul 29.

34.

Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Tovmasyan A, Sampaio RS, Boss MK, Bueno-Janice JC, Bader BH, Thomas M, Reboucas JS, Orr M, Chandler JD, Go YM, Jones DP, Venkatraman TN, Haberle S, Kyui N, Lascola CD, Dewhirst MW, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Dec;89:1231-47. doi: 10.1016/j.freeradbiomed.2015.10.416. Epub 2015 Oct 20.

35.

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.

Yulyana Y, Tovmasyan A, Ho IA, Sia KC, Newman JP, Ng WH, Guo CM, Hui KM, Batinic-Haberle I, Lam PY.

Stem Cell Rev. 2016 Feb;12(1):140-55. doi: 10.1007/s12015-015-9628-2.

36.

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.

Tovmasyan A, Maia CG, Weitner T, Carballal S, Sampaio RS, Lieb D, Ghazaryan R, Ivanovic-Burmazovic I, Ferrer-Sueta G, Radi R, Reboucas JS, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Sep;86:308-21. doi: 10.1016/j.freeradbiomed.2015.05.018. Epub 2015 May 28.

37.

Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity.

Thomas M, Craik JD, Tovmasyan A, Batinic-Haberle I, Benov LT.

Future Microbiol. 2015;10(5):709-24. doi: 10.2217/fmb.14.148.

PMID:
26000647
38.

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Redox Biol. 2015 Aug;5:43-65. doi: 10.1016/j.redox.2015.01.017. Epub 2015 Feb 7. Review. Erratum in: Redox Biol. 2015 Dec;6:656.

39.

Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.

Jaramillo MC, Briehl MM, Batinic-Haberle I, Tome ME.

Free Radic Biol Med. 2015 Jun;83:89-100. doi: 10.1016/j.freeradbiomed.2015.01.031. Epub 2015 Feb 26.

40.

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.

Li AM, Martins J, Tovmasyan A, Valentine JS, Batinic-Haberle I, Spasojevic I, Gralla EB.

Redox Biol. 2014;3:1-6. doi: 10.1016/j.redox.2014.09.003. Epub 2014 Sep 18.

41.

Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.

Tovmasyan A, Carballal S, Ghazaryan R, Melikyan L, Weitner T, Maia CG, Reboucas JS, Radi R, Spasojevic I, Benov L, Batinic-Haberle I.

Inorg Chem. 2014 Nov 3;53(21):11467-83. doi: 10.1021/ic501329p. Epub 2014 Oct 21.

42.

Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

Weitzel DH, Tovmasyan A, Ashcraft KA, Rajic Z, Weitner T, Liu C, Li W, Buckley AF, Prasad MR, Young KH, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Herndon JE 2nd, Batinic-Haberle I, Dewhirst MW.

Mol Cancer Ther. 2015 Jan;14(1):70-9. doi: 10.1158/1535-7163.MCT-14-0343. Epub 2014 Oct 15.

43.

Targeting mitochondria by Zn(II)N-alkylpyridylporphyrins: the impact of compound sub-mitochondrial partition on cell respiration and overall photodynamic efficacy.

Odeh AM, Craik JD, Ezzeddine R, Tovmasyan A, Batinic-Haberle I, Benov LT.

PLoS One. 2014 Sep 24;9(9):e108238. doi: 10.1371/journal.pone.0108238. eCollection 2014.

44.

Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways.

Celic T, Španjol J, Bobinac M, Tovmasyan A, Vukelic I, Reboucas JS, Batinic-Haberle I, Bobinac D.

Free Radic Res. 2014 Dec;48(12):1426-42. doi: 10.3109/10715762.2014.960865. Epub 2014 Oct 10.

45.

Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps.

Alvarez L, Suarez SA, Bikiel DE, Reboucas JS, Batinić-Haberle I, Martí MA, Doctorovich F.

Inorg Chem. 2014 Jul 21;53(14):7351-60. doi: 10.1021/ic5007082. Epub 2014 Jul 8.

PMID:
25001488
46.

Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects.

Batinic-Haberle I, Spasojevic I.

Antioxid Redox Signal. 2014 May 20;20(15):2323-5. doi: 10.1089/ars.2014.5921.

47.

Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.

Holley AK, Xu Y, Noel T, Bakthavatchalu V, Batinic-Haberle I, St Clair DK.

Antioxid Redox Signal. 2014 May 20;20(15):2347-60. doi: 10.1089/ars.2013.5204.

48.

Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment.

Zhao Y, Miriyala S, Miao L, Mitov M, Schnell D, Dhar SK, Cai J, Klein JB, Sultana R, Butterfield DA, Vore M, Batinic-Haberle I, Bondada S, St Clair DK.

Free Radic Biol Med. 2014 Jul;72:55-65. doi: 10.1016/j.freeradbiomed.2014.03.001. Epub 2014 Mar 12.

49.

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).

Gauter-Fleckenstein B, Reboucas JS, Fleckenstein K, Tovmasyan A, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z.

Redox Biol. 2014 Jan 9;2:400-10. doi: 10.1016/j.redox.2013.12.017. eCollection 2014.

50.

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.

Archambeau JO, Tovmasyan A, Pearlstein RD, Crapo JD, Batinic-Haberle I.

Redox Biol. 2013 Oct 25;1:599-607. doi: 10.1016/j.redox.2013.10.002. eCollection 2013.

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