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Items: 16


SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.

Witty DR, Bateson JH, Hervieu GJ, Jeffrey P, Johnson CN, Muir AI, O'Hanlon PJ, Stemp G, Stevens AJ, Thewlis KM, Wilson S, Winborn KY.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4865-71. Epub 2006 Jul 12.


S-alkyl dithioformates as 1,3-dipolarophiles. Generation of C(2)-unsubstituted penems.

Sanchez S, Bateson JH, O'Hanlon PJ, Gallagher T.

Org Lett. 2004 Aug 5;6(16):2781-3.


Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases.

Payne DJ, Hueso-Rodríguez JA, Boyd H, Concha NO, Janson CA, Gilpin M, Bateson JH, Cheever C, Niconovich NL, Pearson S, Rittenhouse S, Tew D, Díez E, Pérez P, De La Fuente J, Rees M, Rivera-Sagredo A.

Antimicrob Agents Chemother. 2002 Jun;46(6):1880-6.


Characterization of monomeric L1 metallo-beta -lactamase and the role of the N-terminal extension in negative cooperativity and antibiotic hydrolysis.

Simm AM, Higgins CS, Carenbauer AL, Crowder MW, Bateson JH, Bennett PM, Clarke AR, Halford SE, Walsh TR.

J Biol Chem. 2002 Jul 5;277(27):24744-52. Epub 2002 Apr 8.


beta-Lactamase epidemiology and the utility of established and novel beta-lactamase inhibitors.

Payne DJ, Du W, Bateson JH.

Expert Opin Investig Drugs. 2000 Feb;9(2):247-61. Review.


Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.

Concha NO, Janson CA, Rowling P, Pearson S, Cheever CA, Clarke BP, Lewis C, Galleni M, Frère JM, Payne DJ, Bateson JH, Abdel-Meguid SS.

Biochemistry. 2000 Apr 18;39(15):4288-98.


Crystal structure of the zinc-dependent beta-lactamase from Bacillus cereus at 1.9 A resolution: binuclear active site with features of a mononuclear enzyme.

Fabiane SM, Sohi MK, Wan T, Payne DJ, Bateson JH, Mitchell T, Sutton BJ.

Biochemistry. 1998 Sep 8;37(36):12404-11.


Nucleotide and amino acid sequences of the metallo-beta-lactamase, ImiS, from Aeromonas veronii bv. sobria.

Walsh TR, Neville WA, Haran MH, Tolson D, Payne DJ, Bateson JH, MacGowan AP, Bennett PM.

Antimicrob Agents Chemother. 1998 Feb;42(2):436-9.


Inhibition of metallo-beta-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid.

Payne DJ, Bateson JH, Gasson BC, Khushi T, Proctor D, Pearson SC, Reid R.

FEMS Microbiol Lett. 1997 Dec 1;157(1):171-5.


Inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives.

Payne DJ, Bateson JH, Gasson BC, Proctor D, Khushi T, Farmer TH, Tolson DA, Bell D, Skett PW, Marshall AC, Reid R, Ghosez L, Combret Y, Marchand-Brynaert J.

Antimicrob Agents Chemother. 1997 Jan;41(1):135-40.


Rapid identification of metallo- and serine beta-lactamases.

Payne DJ, Cramp R, Bateson JH, Neale J, Knowles D.

Antimicrob Agents Chemother. 1994 May;38(5):991-6.


Novel C-3 cyclic ether cephalosporins and their orally absorbed prodrug esters.

Bateson JH, Burton G, Fell SC, Smulders HC.

J Antibiot (Tokyo). 1994 Feb;47(2):253-6. No abstract available.


Synthesis of 6-unsubstituted olivanic acid analogues and their antibacterial activities.

Basker MJ, Bateson JH, Baxter AJ, Ponsford RJ, Roberts PM, Southgate R, Smale TC, Smith J.

J Antibiot (Tokyo). 1981 Sep;34(9):1224-6. No abstract available.


Experiments on the synthesis of tetracycline. Part XIV. Closure of ring B by base-catalysed photocyclisation.

Barton DH, Bateson JH, Datta SC, Magnus PD.

J Chem Soc Perkin 1. 1976;(5):503-7. No abstract available.


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