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Items: 34

1.

Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.

Fang C, Lee KK, Nietupski R, Bates RH, Fernandez-Menendez R, Lopez-Roman EM, Guijarro-Lopez L, Yin Y, Peng Z, Gomez JE, Fisher S, Barros-Aguirre D, Hubbard BK, Serrano-Wu MH, Hung DT.

Bioorg Med Chem Lett. 2018 Dec 1;28(22):3529-3533. doi: 10.1016/j.bmcl.2018.09.037. Epub 2018 Sep 29.

PMID:
30316633
2.

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

Smith PW, Zuccotto F, Bates RH, Martinez-Martinez MS, Read KD, Peet C, Epemolu O.

ACS Infect Dis. 2018 Oct 12;4(10):1439-1447. doi: 10.1021/acsinfecdis.8b00160. Epub 2018 Sep 10.

3.

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Fern Toh M, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2018 Jul 13;9:16227. doi: 10.1038/ncomms16227.

4.

In vivo potent BM635 analogue with improved drug-like properties.

Poce G, Cocozza M, Alfonso S, Consalvi S, Venditti G, Fernandez-Menendez R, Bates RH, Barros Aguirre D, Ballell L, De Logu A, Vistoli G, Biava M.

Eur J Med Chem. 2018 Feb 10;145:539-550. doi: 10.1016/j.ejmech.2017.12.075. Epub 2017 Dec 27.

PMID:
29335214
5.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Toh MF, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2017 Jul 17;8:16081. doi: 10.1038/ncomms16081. Erratum in: Nat Commun. 2018 Jul 13;9:16227.

6.

Pharmaceutical salt of BM635 with improved bioavailability.

Poce G, Consalvi S, Cocozza M, Fernandez-Menendez R, Bates RH, Ortega Muro F, Barros Aguirre D, Ballell L, Biava M.

Eur J Pharm Sci. 2017 Mar 1;99:17-23. doi: 10.1016/j.ejps.2016.12.003. Epub 2016 Dec 8.

PMID:
27939618
7.

Identification of KasA as the cellular target of an anti-tubercular scaffold.

Abrahams KA, Chung CW, Ghidelli-Disse S, Rullas J, Rebollo-López MJ, Gurcha SS, Cox JA, Mendoza A, Jiménez-Navarro E, Martínez-Martínez MS, Neu M, Shillings A, Homes P, Argyrou A, Casanueva R, Loman NJ, Moynihan PJ, Lelièvre J, Selenski C, Axtman M, Kremer L, Bantscheff M, Angulo-Barturen I, Izquierdo MC, Cammack NC, Drewes G, Ballell L, Barros D, Besra GS, Bates RH.

Nat Commun. 2016 Sep 1;7:12581. doi: 10.1038/ncomms12581.

8.

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.

Pitta E, Rogacki MK, Balabon O, Huss S, Cunningham F, Lopez-Roman EM, Joossens J, Augustyns K, Ballell L, Bates RH, Van der Veken P.

J Med Chem. 2016 Jul 28;59(14):6709-28. doi: 10.1021/acs.jmedchem.6b00245. Epub 2016 Jul 12.

PMID:
27348630
9.

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery.

Rebollo-Lopez MJ, Lelièvre J, Alvarez-Gomez D, Castro-Pichel J, Martínez-Jiménez F, Papadatos G, Kumar V, Colmenarejo G, Mugumbate G, Hurle M, Barroso V, Young RJ, Martinez-Hoyos M, González del Río R, Bates RH, Lopez-Roman EM, Mendoza-Losana A, Brown JR, Alvarez-Ruiz E, Marti-Renom MA, Overington JP, Cammack N, Ballell L, Barros-Aguire D.

PLoS One. 2015 Dec 7;10(12):e0142293. doi: 10.1371/journal.pone.0142293. eCollection 2015.

10.

Synthesis of Enantiopure 3-Hydroxypiperidines from Sulfinyl Dienyl Amines by Diastereoselective Intramolecular Cyclization and [2,3]-Sigmatropic Rearrangement.

Simal C, Bates RH, Ureña M, Giménez I, Koutsou C, Infantes L, Fernández de la Pradilla R, Viso A.

J Org Chem. 2015 Aug 7;80(15):7674-92. doi: 10.1021/acs.joc.5b01307. Epub 2015 Jul 22.

PMID:
26162504
11.

Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.

Ordas A, Raterink RJ, Cunningham F, Jansen HJ, Wiweger MI, Jong-Raadsen S, Bos S, Bates RH, Barros D, Meijer AH, Vreeken RJ, Ballell-Pages L, Dirks RP, Hankemeier T, Spaink HP.

Antimicrob Agents Chemother. 2015 Feb;59(2):753-62. doi: 10.1128/AAC.03588-14. Epub 2014 Nov 10.

12.

Sulfoxide-directed enantioselective synthesis of functionalized tetrahydropyridines.

Fernández de la Pradilla R, Simal C, Bates RH, Viso A, Infantes L.

Org Lett. 2013 Oct 4;15(19):4936-9. doi: 10.1021/ol402141d. Epub 2013 Sep 24.

PMID:
24063643
13.

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.

Poce G, Bates RH, Alfonso S, Cocozza M, Porretta GC, Ballell L, Rullas J, Ortega F, De Logu A, Agus E, La Rosa V, Pasca MR, De Rossi E, Wae B, Franzblau SG, Manetti F, Botta M, Biava M.

PLoS One. 2013;8(2):e56980. doi: 10.1371/journal.pone.0056980. Epub 2013 Feb 21.

14.

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

Ballell L, Bates RH, Young RJ, Alvarez-Gomez D, Alvarez-Ruiz E, Barroso V, Blanco D, Crespo B, Escribano J, González R, Lozano S, Huss S, Santos-Villarejo A, Martín-Plaza JJ, Mendoza A, Rebollo-Lopez MJ, Remuiñan-Blanco M, Lavandera JL, Pérez-Herran E, Gamo-Benito FJ, García-Bustos JF, Barros D, Castro JP, Cammack N.

ChemMedChem. 2013 Feb;8(2):313-21. doi: 10.1002/cmdc.201200428. Epub 2013 Jan 10.

15.

An approach to the stereoselective synthesis of enantiopure dihydropyrroles and aziridines from a common sulfinyl-sulfinamide intermediate.

Viso A, Fernández de la Pradilla R, Ureña M, Bates RH, del Águila MA, Colomer I.

J Org Chem. 2012 Jan 6;77(1):525-42. doi: 10.1021/jo202144k. Epub 2011 Dec 1.

PMID:
22088141
16.

Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocyles.

Bates RH, Chen M, Roush WR.

Curr Opin Drug Discov Devel. 2008 Nov;11(6):778-92. Review.

PMID:
18946843
17.

Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C.

Bates RH, Shotwell JB, Roush WR.

Org Lett. 2008 Oct 2;10(19):4343-6. doi: 10.1021/ol801852j. Epub 2008 Sep 11.

18.

Fourier coefficient description of left ventricular shape.

Round WH, Bates RH, Ikram H.

Australas Phys Eng Sci Med. 1991 Dec;14(4):220-5.

PMID:
1789774
19.

Intrinsic echolocation capability of Hector's dolphin, Cephalorhynchus hectori.

Thorpe CW, Bates RH, Dawson SM.

J Acoust Soc Am. 1991 Dec;90(6):2931-4.

PMID:
1787235
20.

From living being to medical image--bridging the dimensionality gap.

Garden KL, Bones PJ, Bates RH.

Australas Phys Eng Sci Med. 1989 Dec;12(4):186-204. Review.

PMID:
2692546
21.

Assessment of the significance and severity of premenstrual tension--I. A new model.

Livesey JH, Wells JE, Metcalf MG, Hudson SM, Bates RH.

J Psychosom Res. 1989;33(3):269-79.

PMID:
2795503
22.

Illustrating the effectiveness of surface admittances (impedances) for simplifying modelling physiological (ECG/EEG) potential fields.

Bones PJ, Bates RH.

Australas Phys Eng Sci Med. 1988 Jul-Sep;11(3):94-9. No abstract available.

PMID:
3196240
23.

Modification of spectra of pulses from ultrasonic transducers by scatters in non-attenuating and in attenuating media.

Round WH, Bates RH.

Ultrason Imaging. 1987 Jan;9(1):18-28. Erratum in: Ultrason Imaging 1987 Apr;9(2):146.

PMID:
3603895
24.

Digital filtering aids data processing for exercise test protocols for haemodynamically compromised subjects.

Bates GT, Hamilton EJ, Stewart DE, Bates RH.

Australas Phys Eng Sci Med. 1986 Apr-Jun;9(2):67-76. No abstract available.

PMID:
3778364
25.

Towards direct phase retrieval in macromolecular crystallography.

Millane RP, Bates RH, Fright WR, Norton WA.

Biophys J. 1986 Jan;49(1):60-2. No abstract available.

26.

Fourier transform magnitudes are unique pattern recognition templates.

Gardenier PH, McCallum BC, Bates RH.

Biol Cybern. 1986;54(6):385-91.

PMID:
3756243
27.

Computational assessment of electrocardiographic measurement sensitivity.

Bones PJ, Bates RH.

Med Biol Eng Comput. 1981 Nov;19(6):717-24. No abstract available.

PMID:
7329110
28.

Ultrasonic transmission speckle imaging.

Bates RH, Robinson BS.

Ultrason Imaging. 1981 Oct;3(4):378-94. No abstract available.

PMID:
7197830
29.

Towards imaging the beating heart usefully with a conventional CT scanner.

Mc Kinnon GC, Bates RH.

IEEE Trans Biomed Eng. 1981 Feb;28(2):123-7. No abstract available.

PMID:
7287019
30.
31.

A limitation on systems for imaging electrical conductivity distributions.

Bates RH, McKinnon GC, Seagar AD.

IEEE Trans Biomed Eng. 1980 Jul;27(7):418-20. No abstract available.

PMID:
7409809
32.

A limitation on ultrasonic transmission tomography.

McKinnon GC, Bates RH.

Ultrason Imaging. 1980 Jan;2(1):48-54. No abstract available.

PMID:
7189616
33.

A possible conformation for double-stranded polynucleotides.

Rodley GA, Scobie RS, Bates RH, Lewitt RM.

Proc Natl Acad Sci U S A. 1976 Sep;73(9):2959-63.

34.

Computer generated holograms for processing radiographic data.

Gough PT, Bates RH.

Comput Biomed Res. 1972 Dec;5(6):700-8. No abstract available.

PMID:
4566955

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