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Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis.

Kung LHW, Mullan L, Soul J, Wang P, Mori K, Bateman JF, Briggs MD, Boot-Handford RP.

Arthritis Res Ther. 2019 Sep 11;21(1):206. doi: 10.1186/s13075-019-1988-6.


XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease.

Piróg KA, Dennis EP, Hartley CL, Jackson RM, Soul J, Schwartz JM, Bateman JF, Boot-Handford RP, Briggs MD.

PLoS Genet. 2019 Jul 1;15(7):e1008215. doi: 10.1371/journal.pgen.1008215. eCollection 2019 Jul.


Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications.

Maurizi A, Capulli M, Curle A, Patel R, Ucci A, Côrtes JA, Oxford H, Lamandé SR, Bateman JF, Rucci N, Teti A.

Bone Res. 2019 Jun 11;7:17. doi: 10.1038/s41413-019-0055-x. eCollection 2019.


The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line.

Howden S, Hosseini Far H, Motazedian A, Elefanty AG, Stanley EG, Lamandé SR, Bateman JF.

Stem Cell Res. 2019 Jul;38:101453. doi: 10.1016/j.scr.2019.101453. Epub 2019 May 4.


Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing.

Hosseini Far H, Patria YN, Motazedian A, Elefanty AG, Stanley EG, Lamandé SR, Bateman JF.

Stem Cell Res. 2019 May;37:101449. doi: 10.1016/j.scr.2019.101449. Epub 2019 Apr 23.


Genetic Disorders of the Extracellular Matrix.

Lamandé SR, Bateman JF.

Anat Rec (Hoboken). 2019 Feb 15. doi: 10.1002/ar.24086. [Epub ahead of print]


Effect of rapamycin on bone mass and strength in the α2(I)-G610C mouse model of osteogenesis imperfecta.

Bateman JF, Sampurno L, Maurizi A, Lamandé SR, Sims NA, Cheng TL, Schindeler A, Little DG.

J Cell Mol Med. 2019 Mar;23(3):1735-1745. doi: 10.1111/jcmm.14072. Epub 2018 Dec 30.


Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets.

de Kroon LMG, van den Akker GGH, Brachvogel B, Narcisi R, Belluoccio D, Jenner F, Bateman JF, Little CB, Brama PAJ, Blaney Davidson EN, van der Kraan PM, van Osch GJVM.

Bone. 2018 Nov;116:67-77. doi: 10.1016/j.bone.2018.07.008. Epub 2018 Jul 21.


Collagen VI disorders: Insights on form and function in the extracellular matrix and beyond.

Lamandé SR, Bateman JF.

Matrix Biol. 2018 Oct;71-72:348-367. doi: 10.1016/j.matbio.2017.12.008. Epub 2017 Dec 22. Review.


Comprehensive Expression Analysis of microRNAs and mRNAs in Synovial Tissue from a Mouse Model of Early Post-Traumatic Osteoarthritis.

Kung LHW, Ravi V, Rowley L, Bell KM, Little CB, Bateman JF.

Sci Rep. 2017 Dec 18;7(1):17701. doi: 10.1038/s41598-017-17545-1.


Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End-Stage Human Disease.

Kung LHW, Ravi V, Rowley L, Angelucci C, Fosang AJ, Bell KM, Little CB, Bateman JF.

Arthritis Rheumatol. 2018 Mar;70(3):383-395. doi: 10.1002/art.40378. Epub 2018 Feb 6.


Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.

Mullan LA, Mularczyk EJ, Kung LH, Forouhan M, Wragg JM, Goodacre R, Bateman JF, Swanton E, Briggs MD, Boot-Handford RP.

J Clin Invest. 2017 Oct 2;127(10):3861-3865. doi: 10.1172/JCI93094. Epub 2017 Sep 18.


Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis.

Kung LH, Zaki S, Ravi V, Rowley L, Smith MM, Bell KM, Bateman JF, Little CB.

Osteoarthritis Cartilage. 2017 Mar;25(3):426-434. doi: 10.1016/j.joca.2016.09.002. Epub 2016 Sep 9.


The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration.

Dudek M, Yang N, Ruckshanthi JP, Williams J, Borysiewicz E, Wang P, Adamson A, Li J, Bateman JF, White MR, Boot-Handford RP, Hoyland JA, Meng QJ.

Ann Rheum Dis. 2017 Mar;76(3):576-584. doi: 10.1136/annrheumdis-2016-209428. Epub 2016 Aug 3.


A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.

Gandolfi B, Alamri S, Darby WG, Adhikari B, Lattimer JC, Malik R, Wade CM, Lyons LA, Cheng J, Bateman JF, McIntyre P, Lamandé SR, Haase B.

Osteoarthritis Cartilage. 2016 Aug;24(8):1441-50. doi: 10.1016/j.joca.2016.03.019. Epub 2016 Apr 6.


Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation.

Wilson R, Golub SB, Rowley L, Angelucci C, Karpievitch YV, Bateman JF, Fosang AJ.

J Proteome Res. 2016 Mar 4;15(3):1033-50. doi: 10.1021/acs.jproteome.5b01115. Epub 2016 Feb 12.


Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway.

Guo B, Yang N, Borysiewicz E, Dudek M, Williams JL, Li J, Maywood ES, Adamson A, Hastings MH, Bateman JF, White MR, Boot-Handford RP, Meng QJ.

Osteoarthritis Cartilage. 2015 Nov;23(11):1981-8. doi: 10.1016/j.joca.2015.02.020.


XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease.

Cameron TL, Bell KM, Gresshoff IL, Sampurno L, Mullan L, Ermann J, Glimcher LH, Boot-Handford RP, Bateman JF.

PLoS Genet. 2015 Sep 15;11(9):e1005505. doi: 10.1371/journal.pgen.1005505. eCollection 2015 Sep.


Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.

Cameron TL, Gresshoff IL, Bell KM, Piróg KA, Sampurno L, Hartley CL, Sanford EM, Wilson R, Ermann J, Boot-Handford RP, Glimcher LH, Briggs MD, Bateman JF.

Osteoarthritis Cartilage. 2015 Apr;23(4):661-70. doi: 10.1016/j.joca.2015.01.001. Epub 2015 Jan 17.


A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.

Miller KA, Tan TY, Welfare MF, White SM, Stark Z, Savarirayan R, Burgess T, Heggie AA, Caruana G, Bertram JF, Bateman JF, Farlie PG.

Mol Syndromol. 2014 Dec;5(6):276-86. doi: 10.1159/000368865. Epub 2014 Nov 8.


bfb, a novel ENU-induced blebs mutant resulting from a missense mutation in Fras1.

Miller KA, Gordon CT, Welfare MF, Caruana G, Bertram JF, Bateman JF, Farlie PG.

PLoS One. 2013 Oct 15;8(10):e76342. doi: 10.1371/journal.pone.0076342. eCollection 2013.


Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome.

Miller KA, Ah-Cann CJ, Welfare MF, Tan TY, Pope K, Caruana G, Freckmann ML, Savarirayan R, Bertram JF, Dobbie MS, Bateman JF, Farlie PG.

PLoS Genet. 2013 Aug;9(8):e1003746. doi: 10.1371/journal.pgen.1003746. Epub 2013 Aug 29.


The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis.

Gossan N, Zeef L, Hensman J, Hughes A, Bateman JF, Rowley L, Little CB, Piggins HD, Rattray M, Boot-Handford RP, Meng QJ.

Arthritis Rheum. 2013 Sep;65(9):2334-45. doi: 10.1002/art.38035.


Nonsense-mediated mRNA decay of collagen -emerging complexity in RNA surveillance mechanisms.

Fang Y, Bateman JF, Mercer JF, Lamandé SR.

J Cell Sci. 2013 Jun 15;126(Pt 12):2551-60. doi: 10.1242/jcs.120220. Epub 2013 May 31. Review.


Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome.

Brachvogel B, Zaucke F, Dave K, Norris EL, Stermann J, Dayakli M, Koch M, Gorman JJ, Bateman JF, Wilson R.

J Biol Chem. 2013 May 10;288(19):13481-92. doi: 10.1074/jbc.M112.444810. Epub 2013 Mar 24.


Maintaining mRNA integrity during decalcification of mineralized tissues.

Belluoccio D, Rowley L, Little CB, Bateman JF.

PLoS One. 2013;8(3):e58154. doi: 10.1371/journal.pone.0058154. Epub 2013 Mar 7.


Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.

Bateman JF, Rowley L, Belluoccio D, Chan B, Bell K, Fosang AJ, Little CB.

Arthritis Rheum. 2013 Jun;65(6):1547-60. doi: 10.1002/art.37900.


WARP interacts with collagen VI-containing microfibrils in the pericellular matrix of human chondrocytes.

Hansen U, Allen JM, White R, Moscibrocki C, Bruckner P, Bateman JF, Fitzgerald J.

PLoS One. 2012;7(12):e52793. doi: 10.1371/journal.pone.0052793. Epub 2012 Dec 26.


1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep.

Maher AD, Coles C, White J, Bateman JF, Fuller ES, Burkhardt D, Little CB, Cake M, Read R, McDonagh MB, Rochfort SJ.

J Proteome Res. 2012 Aug 3;11(8):4261-8. doi: 10.1021/pr300368h. Epub 2012 Jul 25.


Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.

Grskovic I, Kutsch A, Frie C, Groma G, Stermann J, Schlötzer-Schrehardt U, Niehoff A, Moss SE, Rosenbaum S, Pöschl E, Chmielewski M, Rappl G, Abken H, Bateman JF, Cheah KS, Paulsson M, Brachvogel B.

J Bone Miner Res. 2012 Nov;27(11):2399-412. doi: 10.1002/jbmr.1682.


Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.

Boyden ED, Campos-Xavier AB, Kalamajski S, Cameron TL, Suarez P, Tanackovic G, Andria G, Ballhausen D, Briggs MD, Hartley C, Cohn DH, Davidson HR, Hall C, Ikegawa S, Jouk PS, König R, Megarbané A, Nishimura G, Lachman RS, Mortier G, Rimoin DL, Rogers RC, Rossi M, Sawada H, Scott R, Unger S, Valadares ER, Bateman JF, Warman ML, Superti-Furga A, Bonafé L.

Am J Hum Genet. 2011 Dec 9;89(6):767-72. doi: 10.1016/j.ajhg.2011.10.016. Erratum in: Am J Hum Genet. 2012 Jan 13;90(1):170. Tanackovich, Goranka [corrected to Tanackovic, Goranka].


Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development.

Wilson R, Norris EL, Brachvogel B, Angelucci C, Zivkovic S, Gordon L, Bernardo BC, Stermann J, Sekiguchi K, Gorman JJ, Bateman JF.

Mol Cell Proteomics. 2012 Jan;11(1):M111.014159. doi: 10.1074/mcp.M111.014159. Epub 2011 Oct 11.


Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

Lamandé SR, Yuan Y, Gresshoff IL, Rowley L, Belluoccio D, Kaluarachchi K, Little CB, Botzenhart E, Zerres K, Amor DJ, Cole WG, Savarirayan R, McIntyre P, Bateman JF.

Nat Genet. 2011 Oct 2;43(11):1142-6. doi: 10.1038/ng.945.


Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy.

Cameron TL, Bell KM, Tatarczuch L, Mackie EJ, Rajpar MH, McDermott BT, Boot-Handford RP, Bateman JF.

PLoS One. 2011;6(9):e24600. doi: 10.1371/journal.pone.0024600. Epub 2011 Sep 15.


Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.

Bernardo BC, Belluoccio D, Rowley L, Little CB, Hansen U, Bateman JF.

J Biol Chem. 2011 Oct 28;286(43):37758-67. doi: 10.1074/jbc.M111.248039. Epub 2011 Aug 31.


Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis.

Chan BY, Fuller ES, Russell AK, Smith SM, Smith MM, Jackson MT, Cake MA, Read RA, Bateman JF, Sambrook PN, Little CB.

Osteoarthritis Cartilage. 2011 Jul;19(7):874-85. doi: 10.1016/j.joca.2011.04.014. Epub 2011 May 12.


Collagen VI microfibril formation is abolished by an {alpha}2(VI) von Willebrand factor type A domain mutation in a patient with Ullrich congenital muscular dystrophy.

Tooley LD, Zamurs LK, Beecher N, Baker NL, Peat RA, Adams NE, Bateman JF, North KN, Baldock C, Lamandé SR.

J Biol Chem. 2010 Oct 22;285(43):33567-76. doi: 10.1074/jbc.M110.152520. Epub 2010 Aug 21.


In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences.

Tsang KY, Chan D, Bateman JF, Cheah KS.

J Cell Sci. 2010 Jul 1;123(Pt 13):2145-54. doi: 10.1242/jcs.068833.


Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status.

Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, Ehlen H, Vogel S, Zaucke F, von der Mark K, Bateman JF, Brachvogel B.

J Bone Miner Res. 2010 Jun;25(6):1267-81. doi: 10.1002/jbmr.30.


Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics.

Wilson R, Diseberg AF, Gordon L, Zivkovic S, Tatarczuch L, Mackie EJ, Gorman JJ, Bateman JF.

Mol Cell Proteomics. 2010 Jun;9(6):1296-313. doi: 10.1074/mcp.M000014-MCP201. Epub 2010 Feb 26.


Premature arthritis is a distinct type II collagen phenotype.

Kannu P, Bateman JF, Randle S, Cowie S, du Sart D, McGrath S, Edwards M, Savarirayan R.

Arthritis Rheum. 2010 May;62(5):1421-30. doi: 10.1002/art.27354.


S100A8 and S100A9 in experimental osteoarthritis.

Zreiqat H, Belluoccio D, Smith MM, Wilson R, Rowley LA, Jones K, Ramaswamy Y, Vogl T, Roth J, Bateman JF, Little CB.

Arthritis Res Ther. 2010;12(1):R16. doi: 10.1186/ar2917. Epub 2010 Jan 27.


Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP.

PLoS Genet. 2009 Oct;5(10):e1000691. doi: 10.1371/journal.pgen.1000691. Epub 2009 Oct 16.


Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization.

Belluoccio D, Grskovic I, Niehoff A, Schlötzer-Schrehardt U, Rosenbaum S, Etich J, Frie C, Pausch F, Moss SE, Pöschl E, Bateman JF, Brachvogel B.

J Bone Miner Res. 2010 Jan;25(1):141-53. doi: 10.1359/jbmr.090710.


Proteomics makes progress in cartilage and arthritis research.

Wilson R, Whitelock JM, Bateman JF.

Matrix Biol. 2009 Apr;28(3):121-8. doi: 10.1016/j.matbio.2009.01.004. Epub 2009 Feb 7. Review.


Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection.

Ishida Y, Yamamoto A, Kitamura A, Lamandé SR, Yoshimori T, Bateman JF, Kubota H, Nagata K.

Mol Biol Cell. 2009 Jun;20(11):2744-54. doi: 10.1091/mbc.E08-11-1092. Epub 2009 Apr 8.


Mice lacking the extracellular matrix protein WARP develop normally but have compromised peripheral nerve structure and function.

Allen JM, Zamurs L, Brachvogel B, Schlötzer-Schrehardt U, Hansen U, Lamandé SR, Rowley L, Fitzgerald J, Bateman JF.

J Biol Chem. 2009 May 1;284(18):12020-30. doi: 10.1074/jbc.M806968200. Epub 2009 Mar 11.


Global comparative transcriptome analysis of cartilage formation in vivo.

Cameron TL, Belluoccio D, Farlie PG, Brachvogel B, Bateman JF.

BMC Dev Biol. 2009 Mar 10;9:20. doi: 10.1186/1471-213X-9-20.


Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations.

Bateman JF, Boot-Handford RP, Lamandé SR.

Nat Rev Genet. 2009 Mar;10(3):173-83. doi: 10.1038/nrg2520. Review.


Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis.

Kannu P, Bateman JF, Belluoccio D, Fosang AJ, Savarirayan R.

Arthritis Rheum. 2009 Feb;60(2):325-34. doi: 10.1002/art.24251. Review. No abstract available.

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