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Items: 1 to 50 of 150

1.

Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents.

Nakagawa-Goto K, Bastow KF, Ohkoshi E, Morris-Natschke SL, Lee KH.

Med Chem (Los Angeles). 2011 Dec 1;1(101). pii: 1000101.

2.

Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.

Wang XF, Ohkoshi E, Wang SB, Hamel E, Bastow KF, Morris-Natschke SL, Lee KH, Xie L.

Bioorg Med Chem. 2013 Feb 1;21(3):632-42. doi: 10.1016/j.bmc.2012.11.047. Epub 2012 Dec 6.

3.

Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica.

Wang Q, Chen TH, Bastow KF, Morris-Natschke SL, Lee KH, Chen DF.

J Nat Prod. 2013 Mar 22;76(3):305-10. doi: 10.1021/np300532p. Epub 2012 Oct 8.

4.

Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.

Wang XF, Tian XT, Ohkoshi E, Qin B, Liu YN, Wu PC, Hour MJ, Hung HY, Qian K, Huang R, Bastow KF, Janzen WP, Jin J, Morris-Natschke SL, Lee KH, Xie L.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6224-8. doi: 10.1016/j.bmcl.2012.08.014. Epub 2012 Aug 9.

PMID:
22932313
5.

Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.

Yang X, Shi Q, Lai CY, Chen CY, Ohkoshi E, Yang SC, Wang CY, Bastow KF, Wu TS, Pan SL, Teng CM, Yang PC, Lee KH.

J Med Chem. 2012 Aug 9;55(15):6751-61. doi: 10.1021/jm3001218. Epub 2012 Jul 23.

6.

Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.

Hung HY, Ohkoshi E, Goto M, Bastow KF, Nakagawa-Goto K, Lee KH.

J Med Chem. 2012 Jun 14;55(11):5413-24. doi: 10.1021/jm300378k. Epub 2012 May 21.

7.

Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents.

Yen CT, Nakagawa-Goto K, Hwang TL, Morris-Natschke SL, Bastow KF, Wu YC, Lee KH.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4018-22. doi: 10.1016/j.bmcl.2012.04.084. Epub 2012 Apr 25.

8.

Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.

Zhou T, Ohkoshi E, Shi Q, Bastow KF, Lee KH.

Bioorg Med Chem Lett. 2012 May 1;22(9):3219-22. doi: 10.1016/j.bmcl.2012.03.037. Epub 2012 Mar 13.

9.

Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility.

Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Kim Y, Lee EY, Lee KH.

J Nat Prod. 2012 Mar 23;75(3):370-7. doi: 10.1021/np2007878. Epub 2012 Feb 3.

10.

Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line.

Wada K, Ohkoshi E, Morris-Natschke SL, Bastow KF, Lee KH.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):249-52. doi: 10.1016/j.bmcl.2011.11.026. Epub 2011 Nov 11.

11.

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.

Vijaya Bhaskar Reddy M, Shen YC, Ohkoshi E, Bastow KF, Qian K, Lee KH, Wu TS.

Eur J Med Chem. 2012 Jan;47(1):97-103. doi: 10.1016/j.ejmech.2011.10.026. Epub 2011 Oct 20.

PMID:
22115618
12.

Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.

Yang X, Shi Q, Yang SC, Chen CY, Yu SL, Bastow KF, Morris-Natschke SL, Wu PC, Lai CY, Wu TS, Pan SL, Teng CM, Lin JC, Yang PC, Lee KH.

J Med Chem. 2011 Jul 28;54(14):5097-107. doi: 10.1021/jm200330s. Epub 2011 Jun 28.

13.

Cytotoxic geranylflavonoids from Bonannia graeca.

Rosselli S, Bruno M, Maggio A, Raccuglia RA, Safder M, Lai CY, Bastow KF, Lee KH.

Phytochemistry. 2011 Jun;72(9):942-5. doi: 10.1016/j.phytochem.2011.03.005. Epub 2011 Apr 1.

14.

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.

Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2341-4. doi: 10.1016/j.bmcl.2011.02.084. Epub 2011 Mar 21.

15.

Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.

Chan HH, Hwang TL, Reddy MV, Li DT, Qian K, Bastow KF, Lee KH, Wu TS.

J Nat Prod. 2011 Apr 25;74(4):796-802. doi: 10.1021/np100851s. Epub 2011 Mar 18.

16.

New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.

Reddy MV, Shen YC, Yang JS, Hwang TL, Bastow KF, Qian K, Lee KH, Wu TS.

Bioorg Med Chem. 2011 Mar 15;19(6):1895-906. doi: 10.1016/j.bmc.2011.02.004. Epub 2011 Mar 4.

17.

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.

Kuo TC, Chiang PC, Yu CC, Nakagawa-Goto K, Bastow KF, Lee KH, Guh JH.

Biochem Pharmacol. 2011 May 1;81(9):1136-44. doi: 10.1016/j.bcp.2011.02.013. Epub 2011 Mar 1.

PMID:
21371443
18.

Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action.

Nakagawa-Goto K, Wu PC, Bastow KF, Yang SC, Yu SL, Chen HY, Lin JC, Goto M, Morris-Natschke SL, Yang PC, Lee KH.

Bioorg Med Chem. 2011 Mar 1;19(5):1816-22. doi: 10.1016/j.bmc.2011.01.001. Epub 2011 Jan 15.

19.

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Nakagawa-Goto K, Wu PC, Lai CY, Hamel E, Zhu H, Zhang L, Kozaka T, Ohkoshi E, Goto M, Bastow KF, Lee KH.

J Med Chem. 2011 Mar 10;54(5):1244-55. doi: 10.1021/jm1011947. Epub 2011 Feb 1.

20.

Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.

Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EY, Bastow KF, Lee KH.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):52-7. doi: 10.1016/j.bmcl.2010.11.077. Epub 2010 Nov 21.

21.

Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.

Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):546-9. doi: 10.1016/j.bmcl.2010.10.074. Epub 2010 Nov 17.

23.

Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.

Wu SJ, Leu YL, Chen CH, Chao CH, Shen DY, Chan HH, Lee EJ, Wu TS, Wang YH, Shen YC, Qian K, Bastow KF, Lee KH.

J Nat Prod. 2010 Nov 29;73(11):1756-62. doi: 10.1021/np1002143. Epub 2010 Oct 28.

24.

Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.

Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natschke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K, Hung MC, Lee EY, Lee KH.

J Nat Prod. 2010 Sep 24;73(9):1553-8. doi: 10.1021/np100406d.

25.

Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues.

Nakagawa-Goto K, Chang PC, Lai CY, Hung HY, Chen TH, Wu PC, Zhu H, Sedykh A, Bastow KF, Lee KH.

J Med Chem. 2010 Sep 23;53(18):6699-705. doi: 10.1021/jm100846r.

26.

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.

Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4085-7. doi: 10.1016/j.bmcl.2010.05.079. Epub 2010 May 24.

27.

Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.

Kozaka T, Nakagawa-Goto K, Shi Q, Lai CY, Hamel E, Bastow KF, Brossi A, Lee KH.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4091-4. doi: 10.1016/j.bmcl.2010.05.081. Epub 2010 May 24.

28.

Acid rearrangment of epoxy-germacranolides and absolute configuration of 1beta,10alpha-epoxy-salonitenolide.

Rosselli S, Maggio AM, Raccuglia RA, Morris-Natschke SL, Bastow KF, Lee KH, Bruno M.

Nat Prod Commun. 2010 May;5(5):675-80.

PMID:
20521529
29.

Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica.

Zhang LJ, Chiou CT, Cheng JJ, Huang HC, Kuo LM, Liao CC, Bastow KF, Lee KH, Kuo YH.

J Nat Prod. 2010 Apr 23;73(4):557-62. doi: 10.1021/np900620y.

30.

Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues.

Yang X, Shi Q, Bastow KF, Lee KH.

Org Lett. 2010 Apr 2;12(7):1416-9. doi: 10.1021/ol902819j.

31.

Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.

Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, Hung MC, Lee EY, Lee KH.

J Med Chem. 2010 Mar 11;53(5):2299-308. doi: 10.1021/jm1000858.

32.

The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.

Rosselli S, Maggio AM, Faraone N, Spadaro V, Morris-Natschke SL, Bastow KF, Lee KH, Bruno M.

Nat Prod Commun. 2009 Dec;4(12):1701-6.

PMID:
20120111
33.

Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica.

Wang Q, Chen TH, Bastow KF, Lee KH, Chen DF.

J Nat Prod. 2010 Feb 26;73(2):139-42. doi: 10.1021/np900489h.

34.

Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents.

Yen CT, Nakagawa-Goto K, Hwang TL, Wu PC, Morris-Natschke SL, Lai WC, Bastow KF, Chang FR, Wu YC, Lee KH.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1037-9. doi: 10.1016/j.bmcl.2009.12.041. Epub 2009 Dec 16.

35.

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.

Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH.

Bioorg Med Chem. 2010 Jan 15;18(2):803-8. doi: 10.1016/j.bmc.2009.11.049. Epub 2009 Dec 2.

36.

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Bastow KF, Morris-Natschke SL, Lee KH.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6289-92. doi: 10.1016/j.bmcl.2009.09.092. Epub 2009 Sep 29.

37.

Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.

Yang X, Shi Q, Liu YN, Zhao G, Bastow KF, Lin JC, Yang SC, Yang PC, Lee KH.

J Med Chem. 2009 Aug 27;52(16):5262-8. doi: 10.1021/jm9009263.

38.

Anti-HBV and cytotoxic activities of pyranocoumarin derivatives.

Su CR, Yeh SF, Liu CM, Damu AG, Kuo TH, Chiang PC, Bastow KF, Lee KH, Wu TS.

Bioorg Med Chem. 2009 Aug 15;17(16):6137-43. doi: 10.1016/j.bmc.2008.12.007. Epub 2008 Dec 13.

PMID:
19635670
39.
40.

Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.

Lee CL, Chang FR, Yen MH, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Wu YC, Lee KH.

J Nat Prod. 2009 Feb 27;72(2):210-3. doi: 10.1021/np800622a.

41.

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.

Wu G, Guo HF, Gao K, Liu YN, Bastow KF, Morris-Natschke SL, Lee KH, Xie L.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5272-6. doi: 10.1016/j.bmcl.2008.08.050. Epub 2008 Aug 22.

42.

Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis.

Lee CL, Nakagawa-Goto K, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Chang FR, Wu YC, Lee KH.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4275-7. doi: 10.1016/j.bmcl.2008.06.099. Epub 2008 Jul 3.

43.

Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.

Reddy MV, Su CR, Chiou WF, Liu YN, Chen RY, Bastow KF, Lee KH, Wu TS.

Bioorg Med Chem. 2008 Aug 1;16(15):7358-70. doi: 10.1016/j.bmc.2008.06.018. Epub 2008 Jun 14.

PMID:
18602831
44.

Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity.

Nakagawa-Goto K, Bastow KF, Chen TH, Morris-Natschke SL, Lee KH.

J Med Chem. 2008 Jun 12;51(11):3297-303. doi: 10.1021/jm701208v. Epub 2008 May 13.

PMID:
18473435
45.

Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.

Su CR, Damu AG, Chiang PC, Bastow KF, Morris-Natschke SL, Lee KH, Wu TS.

Bioorg Med Chem. 2008 Jun 1;16(11):6233-41. doi: 10.1016/j.bmc.2008.04.032. Epub 2008 Apr 18.

46.

Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.

Peng CY, Pan SL, Lee KH, Bastow KF, Teng CM.

Cancer Lett. 2008 May 8;263(1):114-21. doi: 10.1016/j.canlet.2007.12.028. Epub 2008 Feb 20.

PMID:
18243528
47.

Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.

Nakagawa-Goto K, Yamada K, Nakamura S, Chen TH, Chiang PC, Bastow KF, Wang SC, Spohn B, Hung MC, Lee FY, Lee FC, Lee KH.

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5204-9. Epub 2007 Jul 4.

48.

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.

Zhou LB, Chen TH, Bastow KF, Shibano M, Lee KH, Chen DF.

J Nat Prod. 2007 Aug;70(8):1263-7. Epub 2007 Jul 13.

PMID:
17629328
49.

Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.

Tatsuzaki J, Taniguchi M, Bastow KF, Nakagawa-Goto K, Morris-Natschke SL, Itokawa H, Baba K, Lee KH.

Bioorg Med Chem. 2007 Sep 15;15(18):6193-9. Epub 2007 Jun 14.

50.

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

Wei L, Shi Q, Bastow KF, Brossi A, Morris-Natschke SL, Nakagawa-Goto K, Wu TS, Pan SL, Teng CM, Lee KH.

J Med Chem. 2007 Jul 26;50(15):3674-80. Epub 2007 Jun 22.

PMID:
17585747

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