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Items: 1 to 50 of 119

1.

Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells.

Garivet G, Hofer W, Konitsiotis A, Klein C, Kaiser N, Mejuch T, Fansa E, Alsaabi R, Wittinghofer A, Bastiaens PIH, Waldmann H.

Cell Chem Biol. 2019 Jun 20;26(6):842-851.e7. doi: 10.1016/j.chembiol.2019.02.019. Epub 2019 Apr 4.

PMID:
30956149
2.

A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation.

Baumdick M, Gelléri M, Uttamapinant C, Beránek V, Chin JW, Bastiaens PIH.

Nat Commun. 2018 Sep 21;9(1):3847. doi: 10.1038/s41467-018-06299-7.

3.

PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas.

Klein CH, Truxius DC, Vogel HA, Harizanova J, Murarka S, Martín-Gago P, Bastiaens PIH.

Int J Cancer. 2019 Feb 15;144(4):767-776. doi: 10.1002/ijc.31859. Epub 2018 Dec 4.

4.

Co-imaging extrinsic, intrinsic and effector caspase activity by fluorescence anisotropy microscopy.

Corbat AA, Schuermann KC, Liguzinski P, Radon Y, Bastiaens PIH, Verveer PJ, Grecco HE.

Redox Biol. 2018 Oct;19:210-217. doi: 10.1016/j.redox.2018.07.023. Epub 2018 Aug 9.

5.

Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network.

Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Brüggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Roßmannek L, Luig J, Koseska A, Bastiaens PIH.

Cell Syst. 2018 Sep 26;7(3):295-309.e11. doi: 10.1016/j.cels.2018.06.006. Epub 2018 Aug 22.

6.

Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling.

Stallaert W, Brüggemann Y, Sabet O, Baak L, Gattiglio M, Bastiaens PIH.

Sci Signal. 2018 Jul 31;11(541). pii: eaat0114. doi: 10.1126/scisignal.aat0114.

PMID:
30065026
7.

Hypertonicity-induced cation channels in HepG2 cells: architecture and role in proliferation vs. apoptosis.

Koos B, Christmann J, Plettenberg S, Käding D, Becker J, Keteku M, Klein C, Imtiaz S, Janning P, Bastiaens PIH, Wehner F.

J Physiol. 2018 Apr 1;596(7):1227-1241. doi: 10.1113/JP275827. Epub 2018 Feb 25.

8.

Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2.

Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens PIH, Neel BG.

Nat Commun. 2017 Sep 6;8(1):466. doi: 10.1038/s41467-017-00503-w.

9.

Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.

Konitsiotis AD, Roßmannek L, Stanoev A, Schmick M, Bastiaens PIH.

Nat Commun. 2017 Jul 24;8(1):114. doi: 10.1038/s41467-017-00116-3.

10.

Reversible Cryo-arrests of Living Cells to Pause Molecular Movements for High-resolution Imaging.

Huebinger J, Masip ME, Christmann J, Wehner F, Bastiaens PIH.

Bio Protoc. 2017 Apr 20;7(8). pii: e2236. doi: 10.21769/BioProtoc.2236.

11.

Cell signaling as a cognitive process.

Koseska A, Bastiaens PI.

EMBO J. 2017 Mar 1;36(5):568-582. doi: 10.15252/embj.201695383. Epub 2017 Jan 30. Review.

12.

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. doi: 10.1002/anie.201610957. Epub 2017 Jan 20.

PMID:
28106325
13.

Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution.

Masip ME, Huebinger J, Christmann J, Sabet O, Wehner F, Konitsiotis A, Fuhr GR, Bastiaens PIH.

Nat Methods. 2016 Aug;13(8):665-672. doi: 10.1038/nmeth.3921. Epub 2016 Jul 11.

14.

Identification of pyrazolopyridazinones as PDEδ inhibitors.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI.

Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360.

15.

EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling.

Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI.

Elife. 2015 Nov 26;4. pii: e12223. doi: 10.7554/eLife.12223.

16.

Adaptive responses of cell hydration to a low temperature arrest.

Christmann J, Azer L, Dörr D, Fuhr GR, Bastiaens PI, Wehner F.

J Physiol. 2016 Mar 15;594(6):1663-76. doi: 10.1113/JP271245. Epub 2015 Dec 22.

17.

Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits.

Ibach J, Radon Y, Gelléri M, Sonntag MH, Brunsveld L, Bastiaens PI, Verveer PJ.

PLoS One. 2015 Nov 17;10(11):e0143162. doi: 10.1371/journal.pone.0143162. eCollection 2015.

18.

Direct Measurement of Water States in Cryopreserved Cells Reveals Tolerance toward Ice Crystallization.

Huebinger J, Han HM, Hofnagel O, Vetter IR, Bastiaens PI, Grabenbauer M.

Biophys J. 2016 Feb 23;110(4):840-9. doi: 10.1016/j.bpj.2015.09.029. Epub 2015 Nov 2.

19.

Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode.

Sabet O, Stockert R, Xouri G, Brüggemann Y, Stanoev A, Bastiaens PIH.

Nat Commun. 2015 Aug 21;6:8047. doi: 10.1038/ncomms9047.

20.

The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties.

Nakhaei-Rad S, Nakhaeizadeh H, Kordes C, Cirstea IC, Schmick M, Dvorsky R, Bastiaens PI, Häussinger D, Ahmadian MR.

J Biol Chem. 2015 Jun 19;290(25):15892-903. doi: 10.1074/jbc.M115.640607. Epub 2015 May 4.

21.

Ras moves to stay in place.

Schmick M, Kraemer A, Bastiaens PI.

Trends Cell Biol. 2015 Apr;25(4):190-7. doi: 10.1016/j.tcb.2015.02.004. Epub 2015 Mar 8.

PMID:
25759176
22.

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP.

Blood. 2015 May 7;125(19):2948-57. doi: 10.1182/blood-2014-07-586511. Epub 2015 Feb 10.

23.

Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation.

Roda-Navarro P, Bastiaens PI.

PLoS One. 2014 Jul 25;9(7):e103203. doi: 10.1371/journal.pone.0103203. eCollection 2014.

24.

KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport.

Schmick M, Vartak N, Papke B, Kovacevic M, Truxius DC, Rossmannek L, Bastiaens PIH.

Cell. 2014 Apr 10;157(2):459-471. doi: 10.1016/j.cell.2014.02.051.

25.

Configurable low-cost plotter device for fabrication of multi-color sub-cellular scale microarrays.

Arrabito G, Schroeder H, Schröder K, Filips C, Marggraf U, Dopp C, Venkatachalapathy M, Dehmelt L, Bastiaens PI, Neyer A, Niemeyer CM.

Small. 2014 Jul 23;10(14):2870-6. doi: 10.1002/smll.201303390. Epub 2014 Mar 27.

PMID:
24678019
26.

The interdependence of membrane shape and cellular signal processing.

Schmick M, Bastiaens PIH.

Cell. 2014 Mar 13;156(6):1132-1138. doi: 10.1016/j.cell.2014.02.007. Review.

27.

The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins.

Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PI.

Biophys J. 2014 Jan 7;106(1):93-105. doi: 10.1016/j.bpj.2013.11.024.

28.

Biochips for cell biology by combined dip-pen nanolithography and DNA-directed protein immobilization.

Arrabito G, Reisewitz S, Dehmelt L, Bastiaens PI, Pignataro B, Schroeder H, Niemeyer CM.

Small. 2013 Dec 20;9(24):4243-9. doi: 10.1002/smll.201300941. Epub 2013 Jul 24.

PMID:
23881817
29.

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H.

Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22.

PMID:
23698361
30.

Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin.

Bierbaum M, Bastiaens PI.

Biophys J. 2013 Apr 16;104(8):1642-51. doi: 10.1016/j.bpj.2013.03.024.

31.

Quantifying cellular dynamics by fluorescence resonance energy transfer (FRET) microscopy.

Grecco HE, Bastiaens PI.

Curr Protoc Neurosci. 2013 Apr;Chapter 5:Unit5.22. doi: 10.1002/0471142301.ns0522s63.

PMID:
23559306
32.

A protein-interaction array inside a living cell.

Gandor S, Reisewitz S, Venkatachalapathy M, Arrabito G, Reibner M, Schröder H, Ruf K, Niemeyer CM, Bastiaens PI, Dehmelt L.

Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4790-4. doi: 10.1002/anie.201209127. Epub 2013 Mar 4. No abstract available.

33.

Optimizing cell arrays for accurate functional genomics.

Fengler S, Bastiaens PI, Grecco HE, Roda-Navarro P.

BMC Res Notes. 2012 Jul 17;5(1):358. doi: 10.1186/1756-0500-5-358.

34.

Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.

Haj FG, Sabet O, Kinkhabwala A, Wimmer-Kleikamp S, Roukos V, Han HM, Grabenbauer M, Bierbaum M, Antony C, Neel BG, Bastiaens PI.

PLoS One. 2012;7(5):e36633. doi: 10.1371/journal.pone.0036633. Epub 2012 May 24.

35.

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery.

Görmer K, Bürger M, Kruijtzer JA, Vetter I, Vartak N, Brunsveld L, Bastiaens PI, Liskamp RM, Triola G, Waldmann H.

Chembiochem. 2012 May 7;13(7):1017-23. doi: 10.1002/cbic.201200078. Epub 2012 Apr 5.

PMID:
22488913
36.

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins.

Chandra A, Grecco HE, Pisupati V, Perera D, Cassidy L, Skoulidis F, Ismail SA, Hedberg C, Hanzal-Bayer M, Venkitaraman AR, Wittinghofer A, Bastiaens PI.

Nat Cell Biol. 2011 Dec 18;14(2):148-58. doi: 10.1038/ncb2394. Erratum in: Nat Cell Biol. 2012 Mar;14(3):329.

PMID:
22179043
37.

Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors.

Janes PW, Griesshaber B, Atapattu L, Nievergall E, Hii LL, Mensinga A, Chheang C, Day BW, Boyd AW, Bastiaens PI, Jørgensen C, Pawson T, Lackmann M.

J Cell Biol. 2011 Dec 12;195(6):1033-45. doi: 10.1083/jcb.201104037. Epub 2011 Dec 5.

38.

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A.

Nat Chem Biol. 2011 Oct 16;7(12):942-9. doi: 10.1038/nchembio.686.

PMID:
22002721
39.

High-throughput quantification of posttranslational modifications in situ by CA-FLIM.

Grecco HE, Roda-Navarro P, Fengler S, Bastiaens PI.

Methods Enzymol. 2011;500:37-58. doi: 10.1016/B978-0-12-385118-5.00003-7.

PMID:
21943891
40.

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.

Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, Vartak N, Gerding-Reimers C, Bon RS, Bastiaens PI, Waldmann H.

Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9832-7. doi: 10.1002/anie.201102965. Epub 2011 Sep 9.

PMID:
21905185
41.

Signaling from the living plasma membrane.

Grecco HE, Schmick M, Bastiaens PI.

Cell. 2011 Mar 18;144(6):897-909. doi: 10.1016/j.cell.2011.01.029. Review.

42.

PTP1B regulates Eph receptor function and trafficking.

Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M.

J Cell Biol. 2010 Dec 13;191(6):1189-203. doi: 10.1083/jcb.201005035. Epub 2010 Dec 6.

43.

Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.

Lorentzen A, Kinkhabwala A, Rocks O, Vartak N, Bastiaens PI.

Sci Signal. 2010 Sep 21;3(140):ra68. doi: 10.1126/scisignal.20001370.

44.

Spatial organization of intracellular communication: insights from imaging.

Dehmelt L, Bastiaens PI.

Nat Rev Mol Cell Biol. 2010 Jun;11(6):440-52. doi: 10.1038/nrm2903. Epub 2010 May 19. Review.

PMID:
20485292
45.

In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays.

Grecco HE, Roda-Navarro P, Girod A, Hou J, Frahm T, Truxius DC, Pepperkok R, Squire A, Bastiaens PI.

Nat Methods. 2010 Jun;7(6):467-72. doi: 10.1038/nmeth.1458. Epub 2010 May 9.

PMID:
20453867
46.

Small-molecule inhibition of APT1 affects Ras localization and signaling.

Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H.

Nat Chem Biol. 2010 Jun;6(6):449-56. doi: 10.1038/nchembio.362. Epub 2010 Apr 25.

PMID:
20418879
47.

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.

Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI.

Cell. 2010 Apr 30;141(3):458-71. doi: 10.1016/j.cell.2010.04.007. Epub 2010 Apr 22.

48.

Fluorescence fluctuations of quantum-dot sensors capture intracellular protein interaction dynamics.

Zamir E, Lommerse PH, Kinkhabwala A, Grecco HE, Bastiaens PI.

Nat Methods. 2010 Apr;7(4):295-8. doi: 10.1038/nmeth.1441. Epub 2010 Mar 14.

PMID:
20228813
49.

Spatial aspects of intracellular information processing.

Kinkhabwala A, Bastiaens PI.

Curr Opin Genet Dev. 2010 Feb;20(1):31-40. doi: 10.1016/j.gde.2009.12.006. Epub 2010 Jan 22. Review.

PMID:
20096560
50.

Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.

Janes PW, Wimmer-Kleikamp SH, Frangakis AS, Treble K, Griesshaber B, Sabet O, Grabenbauer M, Ting AY, Saftig P, Bastiaens PI, Lackmann M.

PLoS Biol. 2009 Oct;7(10):e1000215. doi: 10.1371/journal.pbio.1000215. Epub 2009 Oct 13.

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