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Items: 9

1.

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.

Zhou W, Nielsen JB, Fritsche LG, Dey R, Gabrielsen ME, Wolford BN, LeFaive J, VandeHaar P, Gagliano SA, Gifford A, Bastarache LA, Wei WQ, Denny JC, Lin M, Hveem K, Kang HM, Abecasis GR, Willer CJ, Lee S.

Nat Genet. 2018 Sep;50(9):1335-1341. doi: 10.1038/s41588-018-0184-y. Epub 2018 Aug 13.

2.

Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors".

Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, Bernard G, Ekstrom L, Lancaster WJ, Denny JC.

Drug Saf. 2018 Nov;41(11):1101. doi: 10.1007/s40264-018-0701-z. No abstract available.

PMID:
30066313
3.

PregOMICS-Leveraging systems biology and bioinformatics for drug repurposing in maternal-child health.

Goldstein JA, Bastarache LA, Denny JC, Pulley JM, Aronoff DM.

Am J Reprod Immunol. 2018 Aug;80(2):e12971. doi: 10.1111/aji.12971. Epub 2018 May 4.

PMID:
29726581
4.

Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications.

Goldstein JA, Bastarache LA, Denny JC, Roden DM, Pulley JM, Aronoff DM.

Pharmacol Res. 2018 Apr;130:44-51. doi: 10.1016/j.phrs.2018.02.013. Epub 2018 Feb 12.

PMID:
29448118
5.

Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors.

Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, R Bernard G, B Ekstrom L, Lancaster WJ, Denny JC.

Drug Saf. 2018 Mar;41(3):303-311. doi: 10.1007/s40264-017-0616-0.

6.

Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record.

Wei WQ, Bastarache LA, Carroll RJ, Marlo JE, Osterman TJ, Gamazon ER, Cox NJ, Roden DM, Denny JC.

PLoS One. 2017 Jul 7;12(7):e0175508. doi: 10.1371/journal.pone.0175508. eCollection 2017.

7.

A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women.

Zheng NS, Bastarache LA, Bastarache JA, Lu Y, Ware LB, Shu XO, Denny JC, Long J.

J Hum Genet. 2017 Oct;62(10):911-914. doi: 10.1038/jhg.2017.66. Epub 2017 Jun 29.

8.

Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals.

Teixeira PL, Wei WQ, Cronin RM, Mo H, VanHouten JP, Carroll RJ, LaRose E, Bastarache LA, Rosenbloom ST, Edwards TL, Roden DM, Lasko TA, Dart RA, Nikolai AM, Peissig PL, Denny JC.

J Am Med Inform Assoc. 2017 Jan;24(1):162-171. doi: 10.1093/jamia/ocw071. Epub 2016 Aug 7.

9.

Inactivating mutations in NPC1L1 and protection from coronary heart disease.

Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, K├Ânig I, Asselta R, Merlini PA, Marziliano N, Notarangelo MF, Schick U, Auer P, Assimes TL, Reilly M, Wilensky R, Rader DJ, Hovingh GK, Meitinger T, Kessler T, Kastrati A, Laugwitz KL, Siscovick D, Rotter JI, Hazen SL, Tracy R, Cresci S, Spertus J, Jackson R, Schwartz SM, Natarajan P, Crosby J, Muzny D, Ballantyne C, Rich SS, O'Donnell CJ, Abecasis G, Sunaev S, Nickerson DA, Buring JE, Ridker PM, Chasman DI, Austin E, Kullo IJ, Weeke PE, Shaffer CM, Bastarache LA, Denny JC, Roden DM, Palmer C, Deloukas P, Lin DY, Tang ZZ, Erdmann J, Schunkert H, Danesh J, Marrugat J, Elosua R, Ardissino D, McPherson R, Watkins H, Reiner AP, Wilson JG, Altshuler D, Gibbs RA, Lander ES, Boerwinkle E, Gabriel S, Kathiresan S.

N Engl J Med. 2014 Nov 27;371(22):2072-82. doi: 10.1056/NEJMoa1405386. Epub 2014 Nov 12.

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