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Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis.

Drent M, Proesmans VLJ, Elfferich MDP, Jessurun NT, de Jong SMG, Ebner NM, Lewis EDO, Bast A.

Lung. 2020 Jan 20. doi: 10.1007/s00408-020-00323-8. [Epub ahead of print]


Haemodynamic effects of the flavonoid quercetin in rats revisited.

Vrolijk MF, van Essen H, Opperhuizen A, Bast A, Janssen BJ.

Br J Pharmacol. 2019 Dec 26. doi: 10.1111/bph.14955. [Epub ahead of print]


Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers.

Egger R, Narayanan RT, Guest JM, Bast A, Udvary D, Messore LF, Das S, de Kock CPJ, Oberlaender M.

Neuron. 2020 Jan 8;105(1):122-137.e8. doi: 10.1016/j.neuron.2019.10.011. Epub 2019 Nov 26.


(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation.

Milenkovic D, Declerck K, Guttman Y, Kerem Z, Claude S, Weseler AR, Bast A, Schroeter H, Morand C, Vanden Berghe W.

Biochem Pharmacol. 2019 Nov 20:113699. doi: 10.1016/j.bcp.2019.113699. [Epub ahead of print]


Self-reported Gastrointestinal Side Effects of Antifibrotic Drugs in Dutch Idiopathic Pulmonary Fibrosis patients.

Proesmans VLJ, Drent M, Elfferich MDP, Wijnen PAHM, Jessurun NT, Bast A.

Lung. 2019 Oct;197(5):551-558. doi: 10.1007/s00408-019-00260-1. Epub 2019 Aug 22.


Drug-induced interstitial lung disease: role of pharmacogenetics in predicting cytotoxic mechanisms and risks of side effects.

Jessurun NT, Drent M, van Puijenbroek EP, Bekers O, Wijnen PA, Bast A.

Curr Opin Pulm Med. 2019 Sep;25(5):468-477. doi: 10.1097/MCP.0000000000000590.


Drug-induced interstitial lung disease: role of pharmacogenetics in predicting cytotoxic mechanisms and risks of side effects.

Jessurun NT, Drent M, van Puijenbroek EP, Bekers O, Wijnen PA, Bast A.

Curr Opin Pulm Med. 2019 May 6. doi: 10.1097/MCP.0000000000000590. [Epub ahead of print]


Towards improved pharmacotherapy in pulmonary arterial hypertension. Can diet play a role?

Semen KO, Bast A.

Clin Nutr ESPEN. 2019 Apr;30:159-169. doi: 10.1016/j.clnesp.2018.12.087. Epub 2019 Jan 14.


VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis.

Wijnen P, Drent M, Bekers O, Verschakelen J, Bast A.

Int J Mol Sci. 2019 Mar 7;20(5). pii: E1160. doi: 10.3390/ijms20051160.


Dietary Advanced Glycation Endproducts Induce an Inflammatory Response in Human Macrophages in Vitro.

van der Lugt T, Weseler AR, Gebbink WA, Vrolijk MF, Opperhuizen A, Bast A.

Nutrients. 2018 Dec 2;10(12). pii: E1868. doi: 10.3390/nu10121868.


Rapid Microbiological Diagnostics from Explanted Heart Valves by a Multiplex PCR Assay.

Bast A, Dohmen PM, Podbielski A, Warnke P.

J Clin Microbiol. 2019 Jan 30;57(2). pii: e01575-18. doi: 10.1128/JCM.01575-18. Print 2019 Feb. No abstract available.


Protective role of c-Jun N-terminal kinase-2 (JNK2) in ibuprofen-induced acute liver injury.

Zoubek ME, Woitok MM, Sydor S, Nelson LJ, Bechmann LP, Lucena MI, Andrade RJ, Bast A, Koek GH, Trautwein C, Cubero FJ.

J Pathol. 2019 Jan;247(1):110-122. doi: 10.1002/path.5174. Epub 2018 Dec 11.


The direct and sustained consequences of severe placental hypoxia on vascular contractility.

Vangrieken P, Al-Nasiry S, Janssen GMJ, Weseler AR, Spaanderman ME, Bast A, Schiffers PMH.

PLoS One. 2018 Aug 24;13(8):e0202648. doi: 10.1371/journal.pone.0202648. eCollection 2018.


Enhancing and Extending Biological Performance and Resilience.

Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, Bøtker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME.

Dose Response. 2018 Aug 15;16(3):1559325818784501. doi: 10.1177/1559325818784501. eCollection 2018 Jul-Sep. Review.


BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells.

Hajek E, Krebs F, Bent R, Haas K, Bast A, Steinmetz I, Tuettenberg A, Grabbe S, Bros M.

Oncotarget. 2018 Jun 19;9(47):28294-28308. doi: 10.18632/oncotarget.25511. eCollection 2018 Jun 19.


Nutrition and corticosteroids in the treatment of sarcoidosis.

Bast A, Semen KO, Drent M.

Curr Opin Pulm Med. 2018 Sep;24(5):479-486. doi: 10.1097/MCP.0000000000000501. Review.


Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro.

Veríssimo G, Bast A, Weseler AR.

Chem Biol Interact. 2018 Aug 1;291:237-244. doi: 10.1016/j.cbi.2018.06.024. Epub 2018 Jun 21.


Dietary supplement intake during pregnancy; better safe than sorry?

de Boer A, Bast A, Godschalk R.

Regul Toxicol Pharmacol. 2018 Jun;95:442-447. doi: 10.1016/j.yrtph.2018.03.014. Epub 2018 Mar 20.


One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia.

Decroix L, Tonoli C, Lespagnol E, Balestra C, Descat A, Drittij-Reijnders MJ, Blackwell JR, Stahl W, Jones AM, Weseler AR, Bast A, Meeusen R, Heyman E.

J Appl Physiol (1985). 2018 Jul 1;125(1):8-18. doi: 10.1152/japplphysiol.00055.2018. Epub 2018 Mar 15. Erratum in: J Appl Physiol (1985). 2018 Aug 1;125(2):685.


Pharmacogenetic variants and vitamin K deficiency: a risk factor or trigger for fibrosing interstitial pneumonias?

Drent M, Wijnen P, Bast A.

Curr Opin Pulm Med. 2018 May;24(3):287-295. doi: 10.1097/MCP.0000000000000467. Review.


Burkholderia pseudomallei modulates host iron homeostasis to facilitate iron availability and intracellular survival.

Schmidt IHE, Gildhorn C, Böning MAL, Kulow VA, Steinmetz I, Bast A.

PLoS Negl Trop Dis. 2018 Jan 12;12(1):e0006096. doi: 10.1371/journal.pntd.0006096. eCollection 2018 Jan.


Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model.

Zanoni TB, Pedrosa TN, Catarino CM, Spiekstra SW, de Oliveira DP, Den Hartog G, Bast A, Hagemann G, Gibbs S, de Moraes Barros SB, Maria-Engler SS.

Food Chem Toxicol. 2018 Feb;112:265-272. doi: 10.1016/j.fct.2017.12.033. Epub 2017 Dec 19.


The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial.

Baumgartner S, Mensink RP, Haenen GR, Bast A, Binder CJ, Bekers O, Husche C, Lütjohann D, Plat J.

Sci Rep. 2017 Nov 10;7(1):15288. doi: 10.1038/s41598-017-15615-y.


The disturbed redox-balance in pulmonary fibrosis is modulated by the plant flavonoid quercetin.

Veith C, Drent M, Bast A, van Schooten FJ, Boots AW.

Toxicol Appl Pharmacol. 2017 Dec 1;336:40-48. doi: 10.1016/j.taap.2017.10.001. Epub 2017 Oct 4.


Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial.

Decroix L, Tonoli C, Soares DD, Descat A, Drittij-Reijnders MJ, Weseler AR, Bast A, Stahl W, Heyman E, Meeusen R.

J Int Soc Sports Nutr. 2017 Aug 10;14:28. doi: 10.1186/s12970-017-0186-7. eCollection 2017.


Activation versus inhibition of microsomal glutathione S-transferase activity by acrolein. Dependence on the concentration and time of acrolein exposure.

Sthijns MMJPE, den Hartog GJM, Scasso C, Haenen JP, Bast A, Haenen GRMM.

Chem Biol Interact. 2017 Sep 25;275:116-120. doi: 10.1016/j.cbi.2017.08.001. Epub 2017 Aug 2.


The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function.

Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM.

Toxicol In Vitro. 2017 Oct;44:206-212. doi: 10.1016/j.tiv.2017.07.009. Epub 2017 Jul 14.


Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress.

Sthijns MMJPE, Schiffers PM, Janssen GM, Lemmens KJA, Ides B, Vangrieken P, Bouwman FG, Mariman EC, Pader I, Arnér ESJ, Johansson K, Bast A, Haenen GRMM.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1177-1189. doi: 10.1016/j.bbagen.2017.03.004. Epub 2017 Mar 7.


The effect of dietary components on inflammatory lung diseases - a literature review.

de Boer A, van de Worp WRPH, Hageman GJ, Bast A.

Int J Food Sci Nutr. 2017 Nov;68(7):771-787. doi: 10.1080/09637486.2017.1288199. Epub 2017 Feb 14. Review.


Paraquat disrupts the anti-inflammatory action of cortisol in human macrophages in vitro: therapeutic implications for paraquat intoxications.

Veríssimo G, Bast A, Weseler AR.

Toxicol Res (Camb). 2017 Feb 2;6(2):232-241. doi: 10.1039/c6tx00406g. eCollection 2017 Mar 1.


Silver nanoparticles induce hormesis in A549 human epithelial cells.

Sthijns MM, Thongkam W, Albrecht C, Hellack B, Bast A, Haenen GR, Schins RP.

Toxicol In Vitro. 2017 Apr;40:223-233. doi: 10.1016/j.tiv.2017.01.010. Epub 2017 Jan 18.


NADPH Oxidase Contributes to Resistance against Aggregatibacter actinomycetemcomitans-Induced Periodontitis in Mice.

Bast A, Kubis H, Holtfreter B, Ribback S, Martin H, Schreiner HC, Dominik MJ, Breitbach K, Dombrowski F, Kocher T, Steinmetz I.

Infect Immun. 2017 Jan 26;85(2). pii: e00849-16. doi: 10.1128/IAI.00849-16. Print 2017 Feb.


Time in Redox Adaptation Processes: From Evolution to Hormesis.

Sthijns MM, Weseler AR, Bast A, Haenen GR.

Int J Mol Sci. 2016 Sep 29;17(10). pii: E1649. Review.


Repositioning 'old' drugs to treat rare diseases: arguing from the mechanism of action.

Drent M, Bast A, Bootsma HP, Deneer V.

Sarcoidosis Vasc Diffuse Lung Dis. 2016 Aug 1;33(2):191-4. No abstract available.


Structure engineering of filled protein microbeads to tailor release of oil droplets in gastric digestion.

van Leusden P, den Hartog GJ, Bast A, Postema M, van der Linden E, Sagis LM.

Food Funct. 2016 Aug 10;7(8):3539-47. doi: 10.1039/c6fo00405a. Epub 2016 Jul 26.


Heme Oxygenase-1 and Carbon Monoxide Promote Burkholderia pseudomallei Infection.

Stolt C, Schmidt IH, Sayfart Y, Steinmetz I, Bast A.

J Immunol. 2016 Aug 1;197(3):834-46. doi: 10.4049/jimmunol.1403104. Epub 2016 Jun 17.


Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation.

Bolze F, Bast A, Mocek S, Morath V, Yuan D, Rink N, Schlapschy M, Zimmermann A, Heikenwalder M, Skerra A, Klingenspor M.

Diabetologia. 2016 Sep;59(9):2005-12. doi: 10.1007/s00125-016-4004-6. Epub 2016 Jun 7.


Iron Supplements and Magnesium Peroxide: An Example of a Hazardous Combination in Self-Medication.

Vrolijk MF, Opperhuizen A, Jansen EH, Bast A, Haenen GR.

Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):412-7. doi: 10.1111/bcpt.12603. Epub 2016 May 4.


Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?

Pijls KE, Jonkers DM, Elizalde M, Drittij-Reijnders MJ, Haenen GR, Bast A, Masclee AA, Koek GH.

Ann Hepatol. 2016 May-Jun;15(3):402-9. doi: 10.5604/16652681.1198816.


Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.

Heyninck K, Sabbe L, Chirumamilla CS, Szarc Vel Szic K, Vander Veken P, Lemmens KJA, Lahtela-Kakkonen M, Naulaerts S, Op de Beeck K, Laukens K, Van Camp G, Weseler AR, Bast A, Haenen GRMM, Haegeman G, Vanden Berghe W.

Biochem Pharmacol. 2016 Jun 1;109:48-61. doi: 10.1016/j.bcp.2016.03.026. Epub 2016 Apr 1.


Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones.

Kaminskyy D, den Hartog GJM, Wojtyra M, Lelyukh M, Gzella A, Bast A, Lesyk R.

Eur J Med Chem. 2016 Apr 13;112:180-195. doi: 10.1016/j.ejmech.2016.02.011. Epub 2016 Feb 9.


Food-Derived Bioactives Can Protect the Anti-Inflammatory Activity of Cortisol with Antioxidant-Dependent and -Independent Mechanisms.

Ruijters EJ, Haenen GR, Willemsen M, Weseler AR, Bast A.

Int J Mol Sci. 2016 Feb 15;17(2):239. doi: 10.3390/ijms17020239.


Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lep(ob/ob) Mice.

Bolze F, Morath V, Bast A, Rink N, Schlapschy M, Mocek S, Skerra A, Klingenspor M.

Endocrinology. 2016 Jan;157(1):233-44. doi: 10.1210/en.2015-1519. Epub 2015 Oct 22.


Adverse food-drug interactions.

de Boer A, van Hunsel F, Bast A.

Regul Toxicol Pharmacol. 2015 Dec;73(3):859-65. doi: 10.1016/j.yrtph.2015.10.009. Epub 2015 Oct 19. Review.


The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase.

Randall MJ, Haenen GR, Bouwman FG, van der Vliet A, Bast A.

Toxicol Lett. 2016 Jan 5;240(1):43-9. doi: 10.1016/j.toxlet.2015.10.009. Epub 2015 Oct 19.


The oxidation of p-phenylenediamine, an ingredient used for permanent hair dyeing purposes, leads to the formation of hydroxyl radicals: Oxidative stress and DNA damage in human immortalized keratinocytes.

Zanoni TB, Hudari F, Munnia A, Peluso M, Godschalk RW, Zanoni MV, den Hartog GJ, Bast A, Barros SB, Maria-Engler SS, Hageman GJ, de Oliveira DP.

Toxicol Lett. 2015 Dec 15;239(3):194-204. doi: 10.1016/j.toxlet.2015.09.026. Epub 2015 Oct 9.


Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial.

Balk JM, Haenen GR, Koc ÖM, Peters R, Bast A, van der Vijgh WJ, Koek GH.

Pharmgenomics Pers Med. 2015 Aug 12;8:137-44. doi: 10.2147/PGPM.S82782. eCollection 2015.


Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?

Brouwers MCGJ, Jacobs C, Bast A, Stehouwer CDA, Schaper NC.

Trends Mol Med. 2015 Oct;21(10):583-594. doi: 10.1016/j.molmed.2015.08.004. Review.


Chemical characteristics for optimizing CYP2E1 inhibition.

van de Wier B, Balk JM, Bast A, Koek GH, Haenen GR.

Chem Biol Interact. 2015 Dec 5;242:139-44. doi: 10.1016/j.cbi.2015.09.024. Epub 2015 Sep 30.


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