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The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma.

Sarić N, Selby M, Ramaswamy V, Kool M, Stockinger B, Hogstrand C, Williamson D, Marino S, Taylor MD, Clifford SC, Basson MA.

Sci Rep. 2020 Jan 10;10(1):148. doi: 10.1038/s41598-019-56876-z.


Infraslow State Fluctuations Govern Spontaneous fMRI Network Dynamics.

Gutierrez-Barragan D, Basson MA, Panzeri S, Gozzi A.

Curr Biol. 2019 Jul 22;29(14):2295-2306.e5. doi: 10.1016/j.cub.2019.06.017. Epub 2019 Jul 11.


Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine.

Vaquero M, Cuesta S, Anerillas C, Altés G, Ribera J, Basson MA, Licht JD, Egea J, Encinas M.

J Am Soc Nephrol. 2019 Aug;30(8):1398-1411. doi: 10.1681/ASN.2018111085. Epub 2019 Jul 12.


Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.

Kasah S, Oddy C, Basson MA.

J Anat. 2018 Dec;233(6):755-769. doi: 10.1111/joa.12889. Epub 2018 Oct 2.


Sex bias in autism: new insights from Chd8 mutant mice?

Andreae LC, Basson MA.

Nat Neurosci. 2018 Sep;21(9):1144-1146. doi: 10.1038/s41593-018-0217-y. No abstract available.


Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice.

Suetterlin P, Hurley S, Mohan C, Riegman KLH, Pagani M, Caruso A, Ellegood J, Galbusera A, Crespo-Enriquez I, Michetti C, Yee Y, Ellingford R, Brock O, Delogu A, Francis-West P, Lerch JP, Scattoni ML, Gozzi A, Fernandes C, Basson MA.

Cereb Cortex. 2018 Jun 1;28(6):2192-2206. doi: 10.1093/cercor/bhy058.


Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.

Badodi S, Dubuc A, Zhang X, Rosser G, Da Cunha Jaeger M, Kameda-Smith MM, Morrissy AS, Guilhamon P, Suetterlin P, Li XN, Guglielmi L, Merve A, Farooq H, Lupien M, Singh SK, Basson MA, Taylor MD, Marino S.

Cell Rep. 2017 Dec 5;21(10):2772-2784. doi: 10.1016/j.celrep.2017.11.021.


Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome.

Whittaker DE, Kasah S, Donovan APA, Ellegood J, Riegman KLH, Volk HA, McGonnell I, Lerch JP, Basson MA.

Am J Med Genet C Semin Med Genet. 2017 Dec;175(4). doi: 10.1002/ajmg.c.31595. Epub 2017 Nov 23.


Cerebellar Vermis and Midbrain Hypoplasia Upon Conditional Deletion of Chd7 from the Embryonic Mid-Hindbrain Region.

Donovan APA, Yu T, Ellegood J, Riegman KLH, de Geus C, van Ravenswaaij-Arts C, Fernandes C, Lerch JP, Basson MA.

Front Neuroanat. 2017 Oct 4;11:86. doi: 10.3389/fnana.2017.00086. eCollection 2017.


Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility.

Ahmed MU, Maurya AK, Cheng L, Jorge EC, Schubert FR, Maire P, Basson MA, Ingham PW, Dietrich S.

Dev Biol. 2017 Oct 1;430(1):90-104. doi: 10.1016/j.ydbio.2017.08.011. Epub 2017 Aug 12.


The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression.

Whittaker DE, Riegman KL, Kasah S, Mohan C, Yu T, Pijuan-Sala B, Hebaishi H, Caruso A, Marques AC, Michetti C, Smachetti ME, Shah A, Sabbioni M, Kulhanci O, Tee WW, Reinberg D, Scattoni ML, Volk H, McGonnell I, Wardle FC, Fernandes C, Basson MA.

J Clin Invest. 2017 Mar 1;127(3):874-887. doi: 10.1172/JCI83408. Epub 2017 Feb 6.


Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.

Janecka M, Mill J, Basson MA, Goriely A, Spiers H, Reichenberg A, Schalkwyk L, Fernandes C.

Transl Psychiatry. 2017 Jan 31;7(1):e1019. doi: 10.1038/tp.2016.294. Review.


The neuroanatomy of autism - a developmental perspective.

Donovan AP, Basson MA.

J Anat. 2017 Jan;230(1):4-15. doi: 10.1111/joa.12542. Epub 2016 Sep 12. Review.


An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.

Balasooriya GI, Johnson JA, Basson MA, Rawlins EL.

Dev Cell. 2016 Apr 4;37(1):85-97. doi: 10.1016/j.devcel.2016.03.001.


Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.

Basson MA, van Ravenswaaij-Arts C.

Trends Genet. 2015 Oct;31(10):600-611. doi: 10.1016/j.tig.2015.05.009. Epub 2015 Sep 24. Review.


CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus.

Jones KM, Sarić N, Russell JP, Andoniadou CL, Scambler PJ, Basson MA.

Stem Cells. 2015 Jan;33(1):196-210. doi: 10.1002/stem.1822.


Epistatic interactions between Chd7 and Fgf8 during cerebellar development: Implications for CHARGE syndrome.

Basson MA.

Rare Dis. 2014 Mar 31;2:e28688. doi: 10.4161/rdis.28688. eCollection 2014.


Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis.

Jackson A, Kasah S, Mansour SL, Morrow B, Basson MA.

Dev Dyn. 2014 Sep;243(9):1143-51. doi: 10.1002/dvdy.24147. Epub 2014 Jun 12.


Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.

Clegg JM, Conway CD, Howe KM, Price DJ, Mason JO, Turnbull JE, Basson MA, Pratt T.

J Neurosci. 2014 Feb 5;34(6):2389-401. doi: 10.1523/JNEUROSCI.3157-13.2014.


Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome.

Yu T, Meiners LC, Danielsen K, Wong MT, Bowler T, Reinberg D, Scambler PJ, van Ravenswaaij-Arts CM, Basson MA.

Elife. 2013 Dec 24;2:e01305. doi: 10.7554/eLife.01305.


Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.

Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD.

Dev Biol. 2014 Feb 1;386(1):1-11. doi: 10.1016/j.ydbio.2013.12.014. Epub 2013 Dec 18.


A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain.

Dyer C, Blanc E, Hanisch A, Roehl H, Otto GW, Yu T, Basson MA, Knight R.

Development. 2014 Jan;141(1):63-72. doi: 10.1242/dev.099507. Epub 2013 Nov 27.


Congenital hypoplasia of the cerebellum: developmental causes and behavioral consequences.

Basson MA, Wingate RJ.

Front Neuroanat. 2013 Sep 3;7:29. doi: 10.3389/fnana.2013.00029. Review.


Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.

Pitera JE, Woolf AS, Basson MA, Scambler PJ.

J Am Soc Nephrol. 2012 Nov;23(11):1790-6. doi: 10.1681/ASN.2012020146. Epub 2012 Oct 11.


Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning.

Magnani D, Hasenpusch-Theil K, Benadiba C, Yu T, Basson MA, Price DJ, Lebrand C, Theil T.

Cereb Cortex. 2014 Jan;24(1):186-98. doi: 10.1093/cercor/bhs303. Epub 2012 Oct 4.


The aged niche disrupts muscle stem cell quiescence.

Chakkalakal JV, Jones KM, Basson MA, Brack AS.

Nature. 2012 Oct 18;490(7420):355-60. doi: 10.1038/nature11438. Epub 2012 Sep 26.


Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis.

Gardiner JR, Jackson AL, Gordon J, Lickert H, Manley NR, Basson MA.

Development. 2012 Sep;139(18):3456-66. doi: 10.1242/dev.079400.


Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling.

Simrick S, Szumska D, Gardiner JR, Jones K, Sagar K, Morrow B, Bhattacharya S, Basson MA.

Dev Dyn. 2012 Aug;241(8):1310-24. doi: 10.1002/dvdy.23812. Epub 2012 Jun 26.


Signaling in cell differentiation and morphogenesis.

Basson MA.

Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6). pii: a008151. doi: 10.1101/cshperspect.a008151. Review.


Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract.

Shin EH, Basson MA, Robinson ML, McAvoy JW, Lovicu FJ.

Mol Med. 2012 Jul 18;18:861-73. doi: 10.2119/molmed.2012.00111.


Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate.

Economou AD, Ohazama A, Porntaveetus T, Sharpe PT, Kondo S, Basson MA, Gritli-Linde A, Cobourne MT, Green JB.

Nat Genet. 2012 Feb 19;44(3):348-51. doi: 10.1038/ng.1090.


Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma.

Macià A, Gallel P, Vaquero M, Gou-Fabregas M, Santacana M, Maliszewska A, Robledo M, Gardiner JR, Basson MA, Matias-Guiu X, Encinas M.

Oncogene. 2012 Aug 30;31(35):3961-72. doi: 10.1038/onc.2011.556. Epub 2011 Dec 12.


Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo.

Simrick S, Lickert H, Basson MA.

Dev Biol. 2011 Oct 1;358(1):147-55. doi: 10.1016/j.ydbio.2011.07.024. Epub 2011 Jul 23.


Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.

Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson MA.

Development. 2011 Jul;138(14):2957-68. doi: 10.1242/dev.063784.


Expression of fibroblast growth factors (Fgfs) in murine tooth development.

Porntaveetus T, Otsuka-Tanaka Y, Basson MA, Moon AM, Sharpe PT, Ohazama A.

J Anat. 2011 May;218(5):534-43. doi: 10.1111/j.1469-7580.2011.01352.x. Epub 2011 Feb 21.


Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.

Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD.

Development. 2011 Mar;138(5):947-57. doi: 10.1242/dev.057166.


FGF ligands emerge as potential specifiers of synaptic identity.

Jones K, Basson MA.

Cellscience. 2010 Jul 27;7(1):33-42.


Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.

Akbulut S, Reddi AL, Aggarwal P, Ambardekar C, Canciani B, Kim MK, Hix L, Vilimas T, Mason J, Basson MA, Lovatt M, Powell J, Collins S, Quatela S, Phillips M, Licht JD.

Mol Biol Cell. 2010 Oct 1;21(19):3487-96. doi: 10.1091/mbc.E10-02-0123. Epub 2010 Aug 18.


Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration.

Shea KL, Xiang W, LaPorta VS, Licht JD, Keller C, Basson MA, Brack AS.

Cell Stem Cell. 2010 Feb 5;6(2):117-29. doi: 10.1016/j.stem.2009.12.015.


Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice.

Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, Bosman E, Steffes G, Steel KP, Simrick S, Basson MA, Illingworth E, Scambler PJ.

J Clin Invest. 2009 Nov;119(11):3301-10. doi: 10.1172/JCI37561. Epub 2009 Oct 12.


Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm.

Calmont A, Ivins S, Van Bueren KL, Papangeli I, Kyriakopoulou V, Andrews WD, Martin JF, Moon AM, Illingworth EA, Basson MA, Scambler PJ.

Development. 2009 Sep;136(18):3173-83. doi: 10.1242/dev.028902.


Loss of Sprouty1 rescues renal agenesis caused by Ret mutation.

Rozen EJ, Schmidt H, Dolcet X, Basson MA, Jain S, Encinas M.

J Am Soc Nephrol. 2009 Feb;20(2):255-9. doi: 10.1681/ASN.2008030267. Epub 2008 Dec 3.


MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S.

Nature. 2008 Dec 18;456(7224):980-4. doi: 10.1038/nature07511. Epub 2008 Nov 30.


Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice.

Parravicini V, Field AC, Tomlinson PD, Basson MA, Zamoyska R.

Blood. 2008 Apr 15;111(8):4273-7282. doi: 10.1182/blood-2007-10-115667. Epub 2008 Feb 6.


Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.

Basson MA, Echevarria D, Ahn CP, Sudarov A, Joyner AL, Mason IJ, Martinez S, Martin GR.

Development. 2008 Mar;135(5):889-98. doi: 10.1242/dev.011569. Epub 2008 Jan 23. Erratum in: Development. 2009 Jun;136(11):1962.


An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.

Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR.

Development. 2008 Jan;135(2):377-85. Epub 2007 Dec 12.


Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.

Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Costantini FD, Wilson PD, Mason IJ, Licht JD.

Dev Biol. 2006 Nov 15;299(2):466-77. Epub 2006 Aug 25.


Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.

Mason JM, Morrison DJ, Basson MA, Licht JD.

Trends Cell Biol. 2006 Jan;16(1):45-54. Epub 2005 Dec 7. Review.


Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region.

Lin W, Jing N, Basson MA, Dierich A, Licht J, Ang SL.

Genesis. 2005 Mar;41(3):110-5.


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