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From RAG2 to T Cell Riches and Future Fortunes.

Glynn RA, Bassing CH.

J Immunol. 2019 Mar 1;202(5):1315-1316. doi: 10.4049/jimmunol.1900010. No abstract available.


Flip the switch: BTG2-PRMT1 protein complexes antagonize pre-B-cell proliferation to promote B-cell development.

Wu GS, Bassing CH.

Cell Mol Immunol. 2018 Sep;15(9):808-811. doi: 10.1038/cmi.2017.156. Epub 2018 Feb 12. No abstract available.


The ESCRT protein CHMP5 escorts αβ T cells through positive selection.

Wu GS, Bassing CH.

Cell Mol Immunol. 2018 Jul;15(7):654-656. doi: 10.1038/cmi.2017.101. Epub 2017 Oct 9. No abstract available.


V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity.

Arya R, Bassing CH.

Trends Genet. 2017 Jul;33(7):479-489. doi: 10.1016/j.tig.2017.04.006. Epub 2017 May 19. Review.


Genomic Alterations of Non-Coding Regions Underlie Human Cancer: Lessons from T-ALL.

Rivera-Reyes A, Hayer KE, Bassing CH.

Trends Mol Med. 2016 Dec;22(12):1035-1046. doi: 10.1016/j.molmed.2016.10.004. Epub 2016 Oct 27. Review.


Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks.

Fisher MR, Rivera-Reyes A, Bloch NB, Schatz DG, Bassing CH.

J Immunol. 2017 Apr 1;198(7):2943-2956. doi: 10.4049/jimmunol.1601639. Epub 2017 Feb 17.


Lymphocyte lineage-specific and developmental stage specific mechanisms suppress cyclin D3 expression in response to DNA double strand breaks.

DeMicco A, Reich T, Arya R, Rivera-Reyes A, Fisher MR, Bassing CH.

Cell Cycle. 2016 Nov;15(21):2882-2894. Epub 2016 Jun 21.


Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses.

Fidanza M, Seif AE, DeMicco A, Rolf N, Jo S, Yin B, Li Y, Barrett DM, Duque-Afonso J, Cleary ML, Bassing CH, Grupp SA, Reid GS.

Leukemia. 2016 Oct;30(10):2116-2119. doi: 10.1038/leu.2016.152. Epub 2016 May 25. No abstract available.


RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.

Bednarski JJ, Pandey R, Schulte E, White LS, Chen BR, Sandoval GJ, Kohyama M, Haldar M, Nickless A, Trott A, Cheng G, Murphy KM, Bassing CH, Payton JE, Sleckman BP.

J Exp Med. 2016 Feb 8;213(2):209-23. doi: 10.1084/jem.20151048. Epub 2016 Feb 1.


Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model.

Balestrini A, Nicolas L, Yang-Lott K, Guryanova OA, Levine RL, Bassing CH, Chaudhuri J, Petrini JH.

Mol Cancer Res. 2016 Feb;14(2):185-95. doi: 10.1158/1541-7786.MCR-15-0281. Epub 2015 Nov 4.


Regulation of Tcrb Gene Assembly by Genetic, Epigenetic, and Topological Mechanisms.

Majumder K, Bassing CH, Oltz EM.

Adv Immunol. 2015;128:273-306. doi: 10.1016/ Epub 2015 Aug 14. Review.


To κ(+) B or not to κ(+) B.

Fisher MR, Bassing CH.

Nat Immunol. 2015 Oct;16(10):1007-9. doi: 10.1038/ni.3277. No abstract available.


B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.

DeMicco A, Naradikian MS, Sindhava VJ, Yoon JH, Gorospe M, Wertheim GB, Cancro MP, Bassing CH.

J Immunol. 2015 Oct 1;195(7):3449-62. doi: 10.4049/jimmunol.1500512. Epub 2015 Aug 28.


Molecular Analysis of Mouse T Cell Receptor α and β Gene Rearrangements.

Rupp LJ, Chen L, Krangel MS, Bassing CH.

Methods Mol Biol. 2016;1323:179-202. doi: 10.1007/978-1-4939-2809-5_16.


Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development.

Majumder K, Rupp LJ, Yang-Iott KS, Koues OI, Kyle KE, Bassing CH, Oltz EM.

J Immunol. 2015 Aug 1;195(3):1262-72. doi: 10.4049/jimmunol.1500692. Epub 2015 Jun 22.


Somatic inactivation of ATM in hematopoietic cells predisposes mice to cyclin D3 dependent T cell acute lymphoblastic leukemia.

Ehrlich LA, Yang-Iott K, DeMicco A, Bassing CH.

Cell Cycle. 2015;14(3):388-98. doi: 10.4161/15384101.2014.988020.


Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.

Majumder K, Koues OI, Chan EA, Kyle KE, Horowitz JE, Yang-Iott K, Bassing CH, Taniuchi I, Krangel MS, Oltz EM.

J Exp Med. 2015 Jan 12;212(1):107-20. doi: 10.1084/jem.20141479. Epub 2014 Dec 15.


Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.

Ehrlich LA, Yang-Iott K, Bassing CH.

Cell Cycle. 2014;13(19):3076-82. doi: 10.4161/15384101.2014.949144.


The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development.

Rupp LJ, Brady BL, Carpenter AC, De Obaldia ME, Bhandoola A, Bosselut R, Muljo SA, Bassing CH.

J Immunol. 2014 Oct 15;193(8):4032-42. doi: 10.4049/jimmunol.1401359. Epub 2014 Sep 12.


The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusion.

Steinel NC, Fisher MR, Yang-Iott KS, Bassing CH.

J Immunol. 2014 Sep 15;193(6):2881-90. doi: 10.4049/jimmunol.1302201. Epub 2014 Aug 15.


Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W.

Cancer Immunol Res. 2013 Dec;1(6):426-37. doi: 10.1158/2326-6066.CIR-13-0065. Epub 2013 Oct 7.


Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.

Horowitz JE, Bassing CH.

J Immunol. 2014 Feb 15;192(4):1609-19. doi: 10.4049/jimmunol.1301599. Epub 2014 Jan 10.


Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.

Chan EA, Teng G, Corbett E, Choudhury KR, Bassing CH, Schatz DG, Krangel MS.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4628-37. doi: 10.1073/pnas.1310846110. Epub 2013 Nov 11.


Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations.

DeMicco A, Yang-Iott K, Bassing CH.

Cell Cycle. 2013 Oct 15;12(20):3307-16. doi: 10.4161/cc.26299. Epub 2013 Sep 9.


Histone H2AX suppresses translocations in lymphomas of Eμ-c-Myc transgenic mice that contain a germline amplicon of tumor-promoting genes.

Fusello A, Horowitz J, Yang-Iott K, Brady BL, Yin B, Rowh MA, Rappaport E, Bassing CH.

Cell Cycle. 2013 Sep 1;12(17):2867-75. doi: 10.4161/cc.25922. Epub 2013 Aug 8.


Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.

Mol Cell Biol. 2013 Sep;33(18):3568-79. doi: 10.1128/MCB.00308-13. Epub 2013 Jul 8.


Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks.

Brady BL, Rupp LJ, Bassing CH.

J Immunol. 2013 Apr 1;190(7):3256-66. doi: 10.4049/jimmunol.1200957. Epub 2013 Feb 20.


The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements.

Steinel NC, Lee BS, Tubbs AT, Bednarski JJ, Schulte E, Yang-Iott KS, Schatz DG, Sleckman BP, Bassing CH.

J Exp Med. 2013 Feb 11;210(2):233-9. doi: 10.1084/jem.20121605. Epub 2013 Feb 4.


Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.

Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC 3rd, Bassing CH, Alt FW.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2934-9. doi: 10.1073/pnas.1222570110. Epub 2013 Feb 4.


ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.

Vaites LP, Lian Z, Lee EK, Yin B, DeMicco A, Bassing CH, Diehl JA.

Oncogene. 2014 Jan 2;33(1):129-33. doi: 10.1038/onc.2012.577. Epub 2013 Jan 14.


Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes.

Yin B, Lee BS, Yang-Iott KS, Sleckman BP, Bassing CH.

J Immunol. 2012 Aug 1;189(3):1372-9. doi: 10.4049/jimmunol.1200829. Epub 2012 Jun 22.


Differential regulation of proximal and distal Vbeta segments upstream of a functional VDJbeta1 rearrangement upon beta-selection.

Brady BL, Bassing CH.

J Immunol. 2011 Sep 15;187(6):3277-85. doi: 10.4049/jimmunol.1101079. Epub 2011 Aug 15.


Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.

Gapud EJ, Lee BS, Mahowald GK, Bassing CH, Sleckman BP.

J Immunol. 2011 Aug 15;187(4):1826-34. doi: 10.4049/jimmunol.1101388. Epub 2011 Jul 8.


Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations.

Rowh MA, DeMicco A, Horowitz JE, Yin B, Yang-Iott KS, Fusello AM, Hobeika E, Reth M, Bassing CH.

Oncogene. 2011 Nov 24;30(47):4757-64. doi: 10.1038/onc.2011.191. Epub 2011 May 30.


Regulation of cell differentiation by the DNA damage response.

Sherman MH, Bassing CH, Teitell MA.

Trends Cell Biol. 2011 May;21(5):312-9. doi: 10.1016/j.tcb.2011.01.004. Epub 2011 Feb 25. Review.


Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.

Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2022-7. doi: 10.1073/pnas.1013295108. Epub 2011 Jan 18.


H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP.

Nature. 2011 Jan 13;469(7329):245-9. doi: 10.1038/nature09585. Epub 2010 Dec 15. Erratum in: Nature. 2011 Apr 14;472(7342):247.


Deciphering the DNA damage histone code.

DeMicco A, Bassing CH.

Cell Cycle. 2010 Oct 1;9(19):3845. doi: 10.4161/cc.9.19.13381. No abstract available.


Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma.

Yin B, Yang-Iott KS, Chao LH, Bassing CH.

Blood. 2011 Jan 6;117(1):175-85. doi: 10.1182/blood-2010-03-273045. Epub 2010 Oct 14.


Antigen receptor allelic exclusion: an update and reappraisal.

Brady BL, Steinel NC, Bassing CH.

J Immunol. 2010 Oct 1;185(7):3801-8. doi: 10.4049/jimmunol.1001158. Review.


Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.

Brady BL, Oropallo MA, Yang-Iott KS, Serwold T, Hochedlinger K, Jaenisch R, Weissman IL, Bassing CH.

J Immunol. 2010 Sep 15;185(6):3564-73. doi: 10.4049/jimmunol.0903098. Epub 2010 Aug 13.


ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.

Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.

J Exp Med. 2010 Jul 5;207(7):1369-80. doi: 10.1084/jem.20100285. Epub 2010 Jun 21.


Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.

Steinel NC, Brady BL, Carpenter AC, Yang-Iott KS, Bassing CH.

J Immunol. 2010 Jul 15;185(2):1055-62. doi: 10.4049/jimmunol.0903099. Epub 2010 Jun 18.


Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.

Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA.

J Clin Invest. 2010 Jul;120(7):2497-507. doi: 10.1172/JCI42382.


TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes.

Yang-Iott KS, Carpenter AC, Rowh MA, Steinel N, Brady BL, Hochedlinger K, Jaenisch R, Bassing CH.

J Immunol. 2010 Feb 1;184(3):1369-78. doi: 10.4049/jimmunol.0900723. Epub 2009 Dec 30.


Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.

Yin B, Savic V, Juntilla MM, Bredemeyer AL, Yang-Iott KS, Helmink BA, Koretzky GA, Sleckman BP, Bassing CH.

J Exp Med. 2009 Nov 23;206(12):2625-39. doi: 10.1084/jem.20091320. Epub 2009 Nov 2.


Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.

Mahowald GK, Baron JM, Mahowald MA, Kulkarni S, Bredemeyer AL, Bassing CH, Sleckman BP.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18339-44. doi: 10.1073/pnas.0902545106. Epub 2009 Oct 9.


Chipping away at gamma-H2AX foci.

Savic V, Sanborn KB, Orange JS, Bassing CH.

Cell Cycle. 2009 Oct 15;8(20):3285-90. Epub 2009 Oct 4.


V(D)J recombination causes dangerous chromosome liaisons in developing thymocytes.

Yin B, Bassing CH.

Cell Cycle. 2009 Aug 15;8(16):2486-7. No abstract available.


Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.

Kadariya Y, Yin B, Tang B, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD.

Cancer Res. 2009 Jul 15;69(14):5961-9. doi: 10.1158/0008-5472.CAN-09-0145. Epub 2009 Jun 30.

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