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Items: 30


UTS2B defines a novel enteroendocrine cell population and regulates GLP-1 secretion through SSTR5 in male mice.

Tang C, Ksiazek I, Siccardi N, Gapp B, Weber D, Wirsching J, Beck V, Reist M, Gaudet L, Stuber N, Surber SS, Mao X, Nicholson TB, Carbone W, Beibel M, Roma G, Keller CG, Bassilana F.

Endocrinology. 2019 Sep 26. pii: en.2019-00549. doi: 10.1210/en.2019-00549. [Epub ahead of print]


Adhesion G protein-coupled receptors: opportunities for drug discovery.

Bassilana F, Nash M, Ludwig MG.

Nat Rev Drug Discov. 2019 Aug 28. doi: 10.1038/s41573-019-0039-y. [Epub ahead of print] Review.


A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.

Suply T, Hannedouche S, Carte N, Li J, Grosshans B, Schaefer M, Raad L, Beck V, Vidal S, Hiou-Feige A, Beluch N, Barbieri S, Wirsching J, Lageyre N, Hillger F, Debon C, Dawson J, Smith P, Lannoy V, Detheux M, Bitsch F, Falchetto R, Bouwmeester T, Porter J, Baumgarten B, Mansfield K, Carballido JM, Seuwen K, Bassilana F.

Sci Signal. 2017 Sep 12;10(496). pii: eaal0180. doi: 10.1126/scisignal.aal0180.


DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect.

Kim M, Minoux M, Piaia A, Kueng B, Gapp B, Weber D, Haller C, Barbieri S, Namoto K, Lorenz T, Wirsching J, Bassilana F, Dietrich W, Rijli FM, Ksiazek I.

Dev Biol. 2017 Nov 15;431(2):297-308. doi: 10.1016/j.ydbio.2017.09.001. Epub 2017 Sep 6.


The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.

Küffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakirci P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilana F, Monk KR, Aguzzi A.

Nature. 2016 Aug 25;536(7617):464-8. Epub 2016 Aug 8.


Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

Bassilana F, Carlson A, DaSilva JA, Grosshans B, Vidal S, Beck V, Wilmeringwetter B, Llamas LA, Showalter TB, Rigollier P, Bourret A, Ramamurthy A, Wu X, Harbinski F, Plonsky S, Lee L, Ruffner H, Grandi P, Schirle M, Jenkins J, Sailer AW, Bouwmeester T, Porter JA, Myer V, Finan PM, Tallarico JA, Kelleher JF 3rd, Seuwen K, Jain RK, Luchansky SJ.

Nat Chem Biol. 2014 May;10(5):343-9. doi: 10.1038/nchembio.1481. Epub 2014 Mar 16.


Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages.

Preuss I, Ludwig MG, Baumgarten B, Bassilana F, Gessier F, Seuwen K, Sailer AW.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):663-8. doi: 10.1016/j.bbrc.2014.01.069. Epub 2014 Jan 27.


Second generation S1P pathway modulators: research strategies and clinical developments.

Bigaud M, Guerini D, Billich A, Bassilana F, Brinkmann V.

Biochim Biophys Acta. 2014 May;1841(5):745-58. doi: 10.1016/j.bbalip.2013.11.001. Epub 2013 Nov 12. Review.


Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.

Hannedouche S, Beck V, Leighton-Davies J, Beibel M, Roma G, Oakeley EJ, Lannoy V, Bernard J, Hamon J, Barbieri S, Preuss I, Lasbennes MC, Sailer AW, Suply T, Seuwen K, Parker CN, Bassilana F.

J Biol Chem. 2013 Sep 20;288(38):27434-43. doi: 10.1074/jbc.M113.497214. Epub 2013 Aug 12.


An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.

Angst D, Janser P, Quancard J, Buehlmayer P, Berst F, Oberer L, Beerli C, Streiff M, Pally C, Hersperger R, Bruns C, Bassilana F, Bollbuck B.

J Med Chem. 2012 Nov 26;55(22):9722-34. doi: 10.1021/jm3009508. Epub 2012 Oct 26.


A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.

Quancard J, Bollbuck B, Janser P, Angst D, Berst F, Buehlmayer P, Streiff M, Beerli C, Brinkmann V, Guerini D, Smith PA, Seabrook TJ, Traebert M, Seuwen K, Hersperger R, Bruns C, Bassilana F, Bigaud M.

Chem Biol. 2012 Sep 21;19(9):1142-51. doi: 10.1016/j.chembiol.2012.07.016.


R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.

Ruffner H, Sprunger J, Charlat O, Leighton-Davies J, Grosshans B, Salathe A, Zietzling S, Beck V, Therier M, Isken A, Xie Y, Zhang Y, Hao H, Shi X, Liu D, Song Q, Clay I, Hintzen G, Tchorz J, Bouchez LC, Michaud G, Finan P, Myer VE, Bouwmeester T, Porter J, Hild M, Bassilana F, Parker CN, Cong F.

PLoS One. 2012;7(7):e40976. doi: 10.1371/journal.pone.0040976. Epub 2012 Jul 16.


Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration.

Minetti GC, Feige JN, Rosenstiel A, Bombard F, Meier V, Werner A, Bassilana F, Sailer AW, Kahle P, Lambert C, Glass DJ, Fornaro M.

Sci Signal. 2011 Nov 29;4(201):ra80. doi: 10.1126/scisignal.2002038.


Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.

Mullershausen F, Craveiro LM, Shin Y, Cortes-Cros M, Bassilana F, Osinde M, Wishart WL, Guerini D, Thallmair M, Schwab ME, Sivasankaran R, Seuwen K, Dev KK.

J Neurochem. 2007 Aug;102(4):1151-61.


Unraveling substantia nigra sequential gene expression in a progressive MPTP-lesioned macaque model of Parkinson's disease.

Bassilana F, Mace N, Li Q, Stutzmann JM, Gross CE, Pradier L, Benavides J, Ménager J, Bezard E.

Neurobiol Dis. 2005 Oct;20(1):93-103.


Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells.

Marrony S, Bassilana F, Seuwen K, Keller H.

Bone. 2003 Sep;33(3):426-33.


Stem cell characteristics of human trabecular bone-derived cells.

Sottile V, Halleux C, Bassilana F, Keller H, Seuwen K.

Bone. 2002 May;30(5):699-704.


Dependence of the acid-sensitive ion channel, ASIC1a, on extracellular Ca(2+) ions.

de Weille J, Bassilana F.

Brain Res. 2001 May 11;900(2):277-81.


Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel.

de Weille JR, Bassilana F, Lazdunski M, Waldmann R.

FEBS Lett. 1998 Aug 21;433(3):257-60.


Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension.

Persu A, Barbry P, Bassilana F, Houot AM, Mengual R, Lazdunski M, Corvol P, Jeunemaitre X.

Hypertension. 1998 Jul;32(1):129-37.


A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells.

Lingueglia E, de Weille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M.

J Biol Chem. 1997 Nov 21;272(47):29778-83.


The amiloride-sensitive Na+ channel: from primary structure to function.

Voilley N, Galibert A, Bassilana F, Renard S, Lingueglia E, Coscoy S, Champigny G, Hofman P, Lazdunski M, Barbry P.

Comp Biochem Physiol A Physiol. 1997 Oct;118(2):193-200. Review.


The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.

Bassilana F, Champigny G, Waldmann R, de Weille JR, Heurteaux C, Lazdunski M.

J Biol Chem. 1997 Nov 14;272(46):28819-22.


Genotype-phenotype analysis of a newly discovered family with Liddle's syndrome.

Jeunemaitre X, Bassilana F, Persu A, Dumont C, Champigny G, Lazdunski M, Corvol P, Barbry P.

J Hypertens. 1997 Oct;15(10):1091-100.


Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.

Waldmann R, Bassilana F, de Weille J, Champigny G, Heurteaux C, Lazdunski M.

J Biol Chem. 1997 Aug 22;272(34):20975-8.


A proton-gated cation channel involved in acid-sensing.

Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M.

Nature. 1997 Mar 13;386(6621):173-7.


Assignment of the human amiloride-sensitive Na+ channel delta isoform to chromosome 1p36.3-p36.2.

Waldmann R, Bassilana F, Voilley N, Lazdunski M, Mattéi M.

Genomics. 1996 Jun 1;34(2):262-3. No abstract available.


Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.

Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M.

J Biol Chem. 1995 Nov 17;270(46):27411-4.


Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel.

Voilley N, Bassilana F, Mignon C, Merscher S, Mattéi MG, Carle GF, Lazdunski M, Barbry P.

Genomics. 1995 Aug 10;28(3):560-5.


Localization and regulation by steroids of the alpha, beta and gamma subunits of the amiloride-sensitive Na+ channel in colon, lung and kidney.

Renard S, Voilley N, Bassilana F, Lazdunski M, Barbry P.

Pflugers Arch. 1995 Jul;430(3):299-307.


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