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Items: 1 to 50 of 114

1.

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.

Basler M, Lindstrom MM, LaStant JJ, Bradshaw JM, Owens TD, Schmidt C, Maurits E, Tsu C, Overkleeft HS, Kirk CJ, Langrish CL, Groettrup M.

EMBO Rep. 2018 Oct 2. pii: e46512. doi: 10.15252/embr.201846512. [Epub ahead of print]

PMID:
30279279
2.

Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida.

Brodmann M, Heilig R, Broz P, Basler M.

Front Cell Infect Microbiol. 2018 Aug 31;8:284. doi: 10.3389/fcimb.2018.00284. eCollection 2018.

3.

On the role of the immunoproteasome in transplant rejection.

Basler M, Li J, Groettrup M.

Immunogenetics. 2018 Sep 15. doi: 10.1007/s00251-018-1084-0. [Epub ahead of print] Review.

PMID:
30220008
4.

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Treise I, Huber EM, Klein-Rodewald T, Heinemeyer W, Grassmann SA, Basler M, Adler T, Rathkolb B, Helming L, Andres C, Klaften M, Landbrecht C, Wieland T, Strom TM, McCoy KD, Macpherson AJ, Wolf E, Groettrup M, Ollert M, Neff F, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Groll M, Busch DH.

Sci Rep. 2018 Apr 13;8(1):5975. doi: 10.1038/s41598-018-24199-0.

5.

Bacterial infection and symbiosis.

Basler M, Shao F.

Mol Biol Cell. 2018 Mar 15;29(6):683-684. doi: 10.1091/mbc.E17-11-0668. No abstract available.

6.

The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions.

Schregle R, Mah MM, Mueller S, Aichem A, Basler M, Groettrup M.

Immunogenetics. 2018 Jul;70(7):429-438. doi: 10.1007/s00251-018-1055-5. Epub 2018 Mar 5.

PMID:
29508036
7.

The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer.

Ringel PD, Hu D, Basler M.

Cell Rep. 2017 Dec 26;21(13):3927-3940. doi: 10.1016/j.celrep.2017.12.020.

8.

Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end.

Nazarov S, Schneider JP, Brackmann M, Goldie KN, Stahlberg H, Basler M.

EMBO J. 2018 Feb 15;37(4). pii: e97103. doi: 10.15252/embj.201797103. Epub 2017 Dec 18.

9.

Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation.

Li J, Basler M, Alvarez G, Brunner T, Kirk CJ, Groettrup M.

Kidney Int. 2018 Mar;93(3):670-680. doi: 10.1016/j.kint.2017.09.023. Epub 2017 Dec 8.

PMID:
29229189
10.

Type VI secretion system sheath inter-subunit interactions modulate its contraction.

Brackmann M, Wang J, Basler M.

EMBO Rep. 2018 Feb;19(2):225-233. doi: 10.15252/embr.201744416. Epub 2017 Dec 8.

11.

Resonant reshaping of colloidal clusters on a current carrying wire.

Becu L, Basler M, Kulić ML, Kulić IM.

Eur Phys J E Soft Matter. 2017 Dec 1;40(12):107. doi: 10.1140/epje/i2017-11597-1.

PMID:
29188394
12.

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire.

Basler M, Mundt S, Groettrup M.

Eur J Immunol. 2018 Mar;48(3):419-429. doi: 10.1002/eji.201747282. Epub 2017 Nov 10.

PMID:
29067678
13.

Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.

Basler M, Maurits E, de Bruin G, Koerner J, Overkleeft HS, Groettrup M.

Br J Pharmacol. 2018 Jan;175(1):38-52. doi: 10.1111/bph.14069. Epub 2017 Nov 29.

PMID:
29034459
14.

Cryo-EM structure of the extended type VI secretion system sheath-tube complex.

Wang J, Brackmann M, Castaño-Díez D, Kudryashev M, Goldie KN, Maier T, Stahlberg H, Basler M.

Nat Microbiol. 2017 Nov;2(11):1507-1512. doi: 10.1038/s41564-017-0020-7. Epub 2017 Sep 25.

PMID:
28947741
15.

The type VI secretion system sheath assembles at the end distal from the membrane anchor.

Vettiger A, Winter J, Lin L, Basler M.

Nat Commun. 2017 Jul 13;8:16088. doi: 10.1038/ncomms16088.

16.

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape.

Brodmann M, Dreier RF, Broz P, Basler M.

Nat Commun. 2017 Jun 16;8:15853. doi: 10.1038/ncomms15853.

17.

Using Force to Punch Holes: Mechanics of Contractile Nanomachines.

Brackmann M, Nazarov S, Wang J, Basler M.

Trends Cell Biol. 2017 Sep;27(9):623-632. doi: 10.1016/j.tcb.2017.05.003. Epub 2017 Jun 12. Review.

PMID:
28602424
18.

No prolongation of skin allograft survival by immunoproteasome inhibition in mice.

Mundt S, Basler M, Sawitzki B, Groettrup M.

Mol Immunol. 2017 Aug;88:32-37. doi: 10.1016/j.molimm.2017.05.022. Epub 2017 Jun 2.

PMID:
28582644
19.

Could we see a prescription opioid epidemic in the UK?

Basler MH.

BMJ. 2017 Feb 15;356:j790. doi: 10.1136/bmj.j790. No abstract available.

PMID:
28202445
20.

Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.

Bitzer A, Basler M, Krappmann D, Groettrup M.

Mol Immunol. 2017 Mar;83:147-153. doi: 10.1016/j.molimm.2017.01.019. Epub 2017 Jan 31.

PMID:
28157553
21.

Consent for anaesthesia-sleepwalking into trouble.

Basler MH, Macfarlane AJ, McKinlay S.

BMJ. 2016 Nov 21;355:i6189. doi: 10.1136/bmj.i6189. No abstract available.

PMID:
27872038
22.

Shedding light on biology of bacterial cells.

Schneider JP, Basler M.

Philos Trans R Soc Lond B Biol Sci. 2016 Nov 5;371(1707). pii: 20150499. doi: 10.1098/rstb.2015.0499. Review.

23.

Type VI Secretion System Substrates Are Transferred and Reused among Sister Cells.

Vettiger A, Basler M.

Cell. 2016 Sep 22;167(1):99-110.e12. doi: 10.1016/j.cell.2016.08.023. Epub 2016 Sep 8.

24.

The Microbial Olympics 2016.

Nelson MB, Chase AB, Martiny JB, Stocker R, Nguyen J, Lloyd K, Oshiro RT, Kearns DB, Schneider JP, Ringel PD, Basler M, Olson CA, Vuong HE, Hsiao EY, Roller BR, Ackermann M, Smillie C, Chien D, Alm E, Jermy AJ.

Nat Microbiol. 2016 Jul 26;1(8):16122. doi: 10.1038/nmicrobiol.2016.122. No abstract available.

PMID:
27573121
25.

WHO analgesic ladder gone astray: wider implications.

Basler MH, Keeley PW.

BMJ. 2016 Feb 4;352:i589. doi: 10.1136/bmj.i589. No abstract available.

PMID:
26847579
26.

Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.

Mundt S, Basler M, Buerger S, Engler H, Groettrup M.

Sci Rep. 2016 Jan 18;6:19434. doi: 10.1038/srep19434.

27.

Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation.

Bitzer A, Basler M, Groettrup M.

Mol Immunol. 2016 Jan;69:99-105. doi: 10.1016/j.molimm.2015.11.004. Epub 2015 Nov 17.

PMID:
26598275
28.

Established Microbial Colonies Can Survive Type VI Secretion Assault.

Borenstein DB, Ringel P, Basler M, Wingreen NS.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004520. doi: 10.1371/journal.pcbi.1004520. eCollection 2015 Oct.

29.

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis.

Mundt S, Engelhardt B, Kirk CJ, Groettrup M, Basler M.

Eur J Immunol. 2016 Jan;46(1):104-13. doi: 10.1002/eji.201545578. Epub 2015 Nov 2.

30.

The immunoproteasome: a novel drug target for autoimmune diseases.

Basler M, Mundt S, Bitzer A, Schmidt C, Groettrup M.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S74-9. Epub 2015 Oct 12. Review.

PMID:
26458097
31.

The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection.

Buerger S, Herrmann VL, Mundt S, Trautwein N, Groettrup M, Basler M.

J Immunol. 2015 Nov 1;195(9):4106-16. doi: 10.4049/jimmunol.1500592. Epub 2015 Sep 23.

32.

Type VI secretion system: secretion by a contractile nanomachine.

Basler M.

Philos Trans R Soc Lond B Biol Sci. 2015 Oct 5;370(1679). pii: 20150021. doi: 10.1098/rstb.2015.0021. Review.

33.

The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense.

Basler M, Buerger S, Groettrup M.

Mol Immunol. 2015 Dec;68(2 Pt A):129-32. doi: 10.1016/j.molimm.2015.04.012. Epub 2015 May 14. Review.

PMID:
25983082
34.

Analgesia in mice with experimental meningitis reduces pain without altering immune parameters.

Mundt S, Groettrup M, Basler M.

ALTEX. 2015;32(3):183-9. doi: 10.14573/altex.1502021. Epub 2015 Mar 24.

35.

Structure of the type VI secretion system contractile sheath.

Kudryashev M, Wang RY, Brackmann M, Scherer S, Maier T, Baker D, DiMaio F, Stahlberg H, Egelman EH, Basler M.

Cell. 2015 Feb 26;160(5):952-962. doi: 10.1016/j.cell.2015.01.037.

36.

De novo protein structure determination from near-atomic-resolution cryo-EM maps.

Wang RY, Kudryashev M, Li X, Egelman EH, Basler M, Cheng Y, Baker D, DiMaio F.

Nat Methods. 2015 Apr;12(4):335-8. doi: 10.1038/nmeth.3287. Epub 2015 Feb 23.

37.

The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice.

Spinnenhirn V, Farhan H, Basler M, Aichem A, Canaan A, Groettrup M.

J Cell Sci. 2014 Nov 15;127(Pt 22):4883-93. doi: 10.1242/jcs.152371. Epub 2014 Sep 30.

38.

Urinary excretion of melatonin and association with breast cancer: meta-analysis and review of the literature.

Basler M, Jetter A, Fink D, Seifert B, Kullak-Ublick GA, Trojan A.

Breast Care (Basel). 2014 Jul;9(3):182-7. doi: 10.1159/000363426.

39.

Diagnosis of complex regional pain syndrome needs to be tightened.

Basler MH, Rae CP, Stewart G.

BMJ. 2014 Jun 24;348:g4029. doi: 10.1136/bmj.g4029. No abstract available.

PMID:
24962799
40.

Prolonged postoperative pain is a complex biopsychosocial problem.

Basler MH, Rae CP.

BMJ. 2014 Mar 19;348:g2162. doi: 10.1136/bmj.g2162. No abstract available.

PMID:
24647168
41.

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.

Basler M, Mundt S, Muchamuel T, Moll C, Jiang J, Groettrup M, Kirk CJ.

EMBO Mol Med. 2014 Feb;6(2):226-38. doi: 10.1002/emmm.201303543. Epub 2014 Jan 16.

42.

Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer.

Ho BT, Basler M, Mekalanos JJ.

Science. 2013 Oct 11;342(6155):250-3. doi: 10.1126/science.1243745.

43.

Wanted: national regulatory monitoring system for long term opioid prescription.

Stewart G, Basler MH.

BMJ. 2013 Sep 18;347:f5586. doi: 10.1136/bmj.f5586. No abstract available.

PMID:
24048304
44.

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike.

Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG.

Nature. 2013 Aug 15;500(7462):350-353. doi: 10.1038/nature12453. Epub 2013 Aug 7.

45.

Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins.

Nathan JA, Spinnenhirn V, Schmidtke G, Basler M, Groettrup M, Goldberg AL.

Cell. 2013 Feb 28;152(5):1184-94. doi: 10.1016/j.cell.2013.01.037.

46.

Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions.

Basler M, Ho BT, Mekalanos JJ.

Cell. 2013 Feb 14;152(4):884-94. doi: 10.1016/j.cell.2013.01.042.

47.

Using protease inhibitors in antigen presentation assays.

Basler M, Groettrup M.

Methods Mol Biol. 2013;960:31-39. doi: 10.1007/978-1-62703-218-6_3.

PMID:
23329476
48.

The immunoproteasome in antigen processing and other immunological functions.

Basler M, Kirk CJ, Groettrup M.

Curr Opin Immunol. 2013 Feb;25(1):74-80. doi: 10.1016/j.coi.2012.11.004. Epub 2012 Dec 6. Review.

PMID:
23219269
49.

Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.

Kalim KW, Basler M, Kirk CJ, Groettrup M.

J Immunol. 2012 Oct 15;189(8):4182-93. doi: 10.4049/jimmunol.1201183. Epub 2012 Sep 14.

50.

Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome.

Horváthová L, Šafaríková L, Basler M, Hrdy I, Campo NB, Shin JW, Huang KY, Huang PJ, Lin R, Tang P, Tachezy J.

Genome Biol Evol. 2012;4(10):1017-29. doi: 10.1093/gbe/evs078. Epub 2012 Sep 12.

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