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Items: 1 to 50 of 151

1.

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.

Smith KM, Tsimbalyuk S, Edwards MR, Cross EM, Batra J, Soares da Costa TP, Aragão D, Basler CF, Forwood JK.

Nat Commun. 2018 Sep 12;9(1):3703. doi: 10.1038/s41467-018-05928-5.

2.

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses.

Luthra P, Naidoo J, Pietzsch CA, De S, Khadka S, Anantpadma M, Williams CG, Edwards MR, Davey RA, Bukreyev A, Ready JM, Basler CF.

Antiviral Res. 2018 Oct;158:288-302. doi: 10.1016/j.antiviral.2018.08.012. Epub 2018 Aug 23.

PMID:
30144461
3.

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes.

Edwards MR, Liu H, Shabman RS, Ginell GM, Luthra P, Ramanan P, Keefe LJ, Köllner B, Amarasinghe GK, Taylor DJ, Leung DW, Basler CF.

Cell Rep. 2018 Jul 24;24(4):861-872.e6. doi: 10.1016/j.celrep.2018.06.045.

4.

The Antiviral Drug Arbidol Inhibits Zika Virus.

Fink SL, Vojtech L, Wagoner J, Slivinski NSJ, Jackson KJ, Wang R, Khadka S, Luthra P, Basler CF, Polyak SJ.

Sci Rep. 2018 Jun 12;8(1):8989. doi: 10.1038/s41598-018-27224-4.

5.

Taxonomy of the order Mononegavirales: update 2018.

Amarasinghe GK, Aréchiga Ceballos NG, Banyard AC, Basler CF, Bavari S, Bennett AJ, Blasdell KR, Briese T, Bukreyev A, Caì Y, Calisher CH, Campos Lawson C, Chandran K, Chapman CA, Chiu CY, Choi KS, Collins PL, Dietzgen RG, Dolja VV, Dolnik O, Domier LL, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Echevarría JE, Fooks AR, Formenty PBH, Fouchier RAM, Freuling CM, Ghedin E, Goldberg TL, Hewson R, Horie M, Hyndman TH, Jiāng D, Kityo R, Kobinger GP, Kondō H, Koonin EV, Krupovic M, Kurath G, Lamb RA, Lee B, Leroy EM, Maes P, Maisner A, Marston DA, Mor SK, Müller T, Mühlberger E, Ramírez VMN, Netesov SV, Ng TFF, Nowotny N, Palacios G, Patterson JL, Pawęska JT, Payne SL, Prieto K, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Siddell S, Smither SJ, Song Q, Song T, Stenglein MD, Stone DM, Takada A, Tesh RB, Thomazelli LM, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Vázquez-Morón S, Verdugo C, Volchkov VE, Wahl V, Walker PJ, Wang D, Wang LF, Wellehan JFX, Wiley MR, Whitfield AE, Wolf YI, Yè G, Zhāng YZ, Kuhn JH.

Arch Virol. 2018 Aug;163(8):2283-2294. doi: 10.1007/s00705-018-3814-x. Epub 2018 Apr 11.

PMID:
29637429
6.

Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.

Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, Gross ML, Leung DW, Chiu W, Amarasinghe GK.

Cell. 2018 Feb 22;172(5):966-978.e12. doi: 10.1016/j.cell.2018.02.009.

7.

A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication.

Luthra P, Liang J, Pietzsch CA, Khadka S, Edwards MR, Wei S, De S, Posner B, Bukreyev A, Ready JM, Basler CF.

Antiviral Res. 2018 Feb;150:193-201. doi: 10.1016/j.antiviral.2017.12.019. Epub 2017 Dec 30.

PMID:
29294299
8.

Cooperation of the Ebola Virus Proteins VP40 and GP1,2 with BST2 To Activate NF-κB Independently of Virus-Like Particle Trapping.

Rizk MG, Basler CF, Guatelli J.

J Virol. 2017 Oct 27;91(22). pii: e01308-17. doi: 10.1128/JVI.01308-17. Print 2017 Nov 15.

9.

Filovirus Strategies to Escape Antiviral Responses.

Olejnik J, Hume AJ, Leung DW, Amarasinghe GK, Basler CF, Mühlberger E.

Curr Top Microbiol Immunol. 2017;411:293-322. doi: 10.1007/82_2017_13.

10.

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.

Bharaj P, Atkins C, Luthra P, Giraldo MI, Dawes BE, Miorin L, Johnson JR, Krogan NJ, Basler CF, Freiberg AN, Rajsbaum R.

J Virol. 2017 Aug 24;91(18). pii: e00833-17. doi: 10.1128/JVI.00833-17. Print 2017 Sep 15.

11.

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW.

Nat Microbiol. 2017 Jun 30;2:17101. doi: 10.1038/nmicrobiol.2017.101.

12.

The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencing.

Dilley KA, Voorhies AA, Luthra P, Puri V, Stockwell TB, Lorenzi H, Basler CF, Shabman RS.

PLoS One. 2017 Jun 21;12(6):e0178717. doi: 10.1371/journal.pone.0178717. eCollection 2017.

13.

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.

Xu W, Luthra P, Wu C, Batra J, Leung DW, Basler CF, Amarasinghe GK.

Nat Commun. 2017 Jun 8;8:15576. doi: 10.1038/ncomms15576.

14.

Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model.

Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F.

J Virol. 2017 Jul 27;91(16). pii: e00652-17. doi: 10.1128/JVI.00652-17. Print 2017 Aug 15.

15.

Assays to Measure Suppression of Type I Interferon Responses by Filovirus VP35 Proteins.

Luthra P, Basler CF.

Methods Mol Biol. 2017;1628:133-142. doi: 10.1007/978-1-4939-7116-9_10.

PMID:
28573616
16.

Molecular pathogenesis of viral hemorrhagic fever.

Basler CF.

Semin Immunopathol. 2017 Jul;39(5):551-561. doi: 10.1007/s00281-017-0637-x. Epub 2017 May 29. Review.

PMID:
28555386
17.

Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses.

Bào Y, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Dolnik O, Dye JM, Ebihara H, Formenty P, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, Netesov SV, Patterson JL, Paweska JT, Smither SJ, Takada A, Towner JS, Volchkov VE, Wahl-Jensen V, Kuhn JH.

Viruses. 2017 May 11;9(5). pii: E106. doi: 10.3390/v9050106.

18.

Taxonomy of the order Mononegavirales: update 2017.

Amarasinghe GK, Bào Y, Basler CF, Bavari S, Beer M, Bejerman N, Blasdell KR, Bochnowski A, Briese T, Bukreyev A, Calisher CH, Chandran K, Collins PL, Dietzgen RG, Dolnik O, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Fang Q, Formenty P, Fouchier RAM, Ghedin E, Harding RM, Hewson R, Higgins CM, Hong J, Horie M, James AP, Jiāng D, Kobinger GP, Kondo H, Kurath G, Lamb RA, Lee B, Leroy EM, Li M, Maisner A, Mühlberger E, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Pearson MN, Randall RE, Revill PA, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Smither SJ, Song Q, Stone DM, Takada A, Terregino C, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang B, Wang D, Wang F, Wang LF, Werren JH, Whitfield AE, Yan Z, Ye G, Kuhn JH.

Arch Virol. 2017 Aug;162(8):2493-2504. doi: 10.1007/s00705-017-3311-7. Epub 2017 Apr 7.

19.

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.

Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF.

MBio. 2017 Apr 4;8(2). pii: e00368-17. doi: 10.1128/mBio.00368-17.

20.

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.

Aguirre S, Luthra P, Sanchez-Aparicio MT, Maestre AM, Patel J, Lamothe F, Fredericks AC, Tripathi S, Zhu T, Pintado-Silva J, Webb LG, Bernal-Rubio D, Solovyov A, Greenbaum B, Simon V, Basler CF, Mulder LC, García-Sastre A, Fernandez-Sesma A.

Nat Microbiol. 2017 Mar 27;2:17037. doi: 10.1038/nmicrobiol.2017.37.

PMID:
28346446
21.

West African Ebola Virus Strains: Unstable and Ready to Invade?

Basler CF.

Cell Host Microbe. 2017 Mar 8;21(3):316-318. doi: 10.1016/j.chom.2017.02.017.

22.

A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.

Liu G, Nash PJ, Johnson B, Pietzsch C, Ilagan MX, Bukreyev A, Basler CF, Bowlin TL, Moir DT, Leung DW, Amarasinghe GK.

ACS Infect Dis. 2017 Mar 10;3(3):190-198. doi: 10.1021/acsinfecdis.6b00209. Epub 2017 Feb 9.

23.

Innate Immune Responses of Bat and Human Cells to Filoviruses: Commonalities and Distinctions.

Kuzmin IV, Schwarz TM, Ilinykh PA, Jordan I, Ksiazek TG, Sachidanandam R, Basler CF, Bukreyev A.

J Virol. 2017 Mar 29;91(8). pii: e02471-16. doi: 10.1128/JVI.02471-16. Print 2017 Apr 15.

24.

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2017 Jan 31;91(4). pii: e01715-16. doi: 10.1128/JVI.01715-16. Print 2017 Feb 15.

25.

Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials.

Postler TS, Clawson AN, Amarasinghe GK, Basler CF, Bavari S, Benko M, Blasdell KR, Briese T, Buchmeier MJ, Bukreyev A, Calisher CH, Chandran K, Charrel R, Clegg CS, Collins PL, Juan Carlos T, Derisi JL, Dietzgen RG, Dolnik O, Dürrwald R, Dye JM, Easton AJ, Emonet S, Formenty P, Fouchier RAM, Ghedin E, Gonzalez JP, Harrach B, Hewson R, Horie M, Jiang D, Kobinger G, Kondo H, Kropinski AM, Krupovic M, Kurath G, Lamb RA, Leroy EM, Lukashevich IS, Maisner A, Mushegian AR, Netesov SV, Nowotny N, Patterson JL, Payne SL, PaWeska JT, Peters CJ, Radoshitzky SR, Rima BK, Romanowski V, Rubbenstroth D, Sabanadzovic S, Sanfaçon H, Salvato MS, Schwemmle M, Smither SJ, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang LF, Varsani A, Whitfield AE, Zerbini FM, Kuhn JH.

Syst Biol. 2017 May 1;66(3):463-473. doi: 10.1093/sysbio/syw096.

26.

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response.

Bharaj P, Wang YE, Dawes BE, Yun TE, Park A, Yen B, Basler CF, Freiberg AN, Lee B, Rajsbaum R.

PLoS Pathog. 2016 Sep 13;12(9):e1005880. doi: 10.1371/journal.ppat.1005880. eCollection 2016 Sep.

27.

Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses.

Johnson B, Li J, Adhikari J, Edwards MR, Zhang H, Schwarz T, Leung DW, Basler CF, Gross ML, Amarasinghe GK.

J Mol Biol. 2016 Aug 28;428(17):3483-94. doi: 10.1016/j.jmb.2016.07.020. Epub 2016 Aug 4.

28.

Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.

Chatterjee S, Basler CF, Amarasinghe GK, Leung DW.

J Mol Biol. 2016 Aug 28;428(17):3467-82. doi: 10.1016/j.jmb.2016.07.017. Epub 2016 Jul 31. Review.

29.

Isolation and Characterization of a Novel Gammaherpesvirus from a Microbat Cell Line.

Shabman RS, Shrivastava S, Tsibane T, Attie O, Jayaprakash A, Mire CE, Dilley KE, Puri V, Stockwell TB, Geisbert TW, Sachidanandam R, Basler CF.

mSphere. 2016 Feb 17;1(1). pii: e00070-15. doi: 10.1128/mSphere.00070-15. eCollection 2016 Jan-Feb.

30.

Taxonomy of the order Mononegavirales: update 2016.

Afonso CL, Amarasinghe GK, Bányai K, Bào Y, Basler CF, Bavari S, Bejerman N, Blasdell KR, Briand FX, Briese T, Bukreyev A, Calisher CH, Chandran K, Chéng J, Clawson AN, Collins PL, Dietzgen RG, Dolnik O, Domier LL, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Farkas SL, Freitas-Astúa J, Formenty P, Fouchier RA, Fù Y, Ghedin E, Goodin MM, Hewson R, Horie M, Hyndman TH, Jiāng D, Kitajima EW, Kobinger GP, Kondo H, Kurath G, Lamb RA, Lenardon S, Leroy EM, Li CX, Lin XD, Liú L, Longdon B, Marton S, Maisner A, Mühlberger E, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Randall RE, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Shi M, Smither SJ, Stenglein MD, Stone DM, Takada A, Terregino C, Tesh RB, Tian JH, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Verbeek M, Volchkov VE, Wahl-Jensen V, Walsh JA, Walker PJ, Wang D, Wang LF, Wetzel T, Whitfield AE, Xiè JT, Yuen KY, Zhang YZ, Kuhn JH.

Arch Virol. 2016 Aug;161(8):2351-60. doi: 10.1007/s00705-016-2880-1. Epub 2016 May 23.

31.

Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets.

Satterfield BA, Cross RW, Fenton KA, Borisevich V, Agans KN, Deer DJ, Graber J, Basler CF, Geisbert TW, Mire CE.

J Virol. 2016 Jun 24;90(14):6326-6343. doi: 10.1128/JVI.00215-16. Print 2016 Jul 15.

32.

Effects of Filovirus Interferon Antagonists on Responses of Human Monocyte-Derived Dendritic Cells to RNA Virus Infection.

Yen BC, Basler CF.

J Virol. 2016 Apr 29;90(10):5108-5118. doi: 10.1128/JVI.00191-16. Print 2016 May 15.

33.

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.

Edwards MR, Liu G, Mire CE, Sureshchandra S, Luthra P, Yen B, Shabman RS, Leung DW, Messaoudi I, Geisbert TW, Amarasinghe GK, Basler CF.

Cell Rep. 2016 Feb 23;14(7):1632-1640. doi: 10.1016/j.celrep.2016.01.049. Epub 2016 Feb 11.

34.

A high throughput Cre-lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry.

Esposito AM, Cheung P, Swartz TH, Li H, Tsibane T, Durham ND, Basler CF, Felsenfeld DP, Chen BK.

Virology. 2016 Mar;490:6-16. doi: 10.1016/j.virol.2015.10.013. Epub 2016 Jan 21.

35.

Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.

Messaoudi I, Amarasinghe GK, Basler CF.

Nat Rev Microbiol. 2015 Nov;13(11):663-76. doi: 10.1038/nrmicro3524. Epub 2015 Oct 6. Review.

36.

High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication.

Edwards MR, Pietzsch C, Vausselin T, Shaw ML, Bukreyev A, Basler CF.

ACS Infect Dis. 2015 Aug 14;1(8):380-7. doi: 10.1021/acsinfecdis.5b00053. Epub 2015 Jun 24.

37.

Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells.

Feagins AR, Basler CF.

Virology. 2015 Nov;485:145-52. doi: 10.1016/j.virol.2015.07.010. Epub 2015 Aug 6.

38.

Immunological features underlying viral hemorrhagic fevers.

Messaoudi I, Basler CF.

Curr Opin Immunol. 2015 Oct;36:38-46. doi: 10.1016/j.coi.2015.06.003. Epub 2015 Jul 7. Review.

39.

The immunomodulating V and W proteins of Nipah virus determine disease course.

Satterfield BA, Cross RW, Fenton KA, Agans KN, Basler CF, Geisbert TW, Mire CE.

Nat Commun. 2015 Jun 24;6:7483. doi: 10.1038/ncomms8483.

40.

Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.

Edwards MR, Basler CF.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S154-9. doi: 10.1093/infdis/jiv050. Epub 2015 Apr 29.

41.

Amino Acid Residue at Position 79 of Marburg Virus VP40 Confers Interferon Antagonism in Mouse Cells.

Feagins AR, Basler CF.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S219-25. doi: 10.1093/infdis/jiv010. Epub 2015 Apr 29.

42.

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.

Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, Amarasinghe GK.

Cell Rep. 2015 Apr 21;11(3):376-89. doi: 10.1016/j.celrep.2015.03.034. Epub 2015 Apr 9.

43.

Innate immune evasion by filoviruses.

Basler CF.

Virology. 2015 May;479-480:122-30. doi: 10.1016/j.virol.2015.03.030. Epub 2015 Apr 3. Review.

44.

Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.

Miller MS, Rialdi A, Ho JS, Tilove M, Martinez-Gil L, Moshkina NP, Peralta Z, Noel J, Melegari C, Maestre AM, Mitsopoulos P, Madrenas J, Heinz S, Benner C, Young JA, Feagins AR, Basler CF, Fernandez-Sesma A, Becherel OJ, Lavin MF, van Bakel H, Marazzi I.

Nat Immunol. 2015 May;16(5):485-94. doi: 10.1038/ni.3132. Epub 2015 Mar 30.

45.

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.

Ciancanelli MJ, Huang SX, Luthra P, Garner H, Itan Y, Volpi S, Lafaille FG, Trouillet C, Schmolke M, Albrecht RA, Israelsson E, Lim HK, Casadio M, Hermesh T, Lorenzo L, Leung LW, Pedergnana V, Boisson B, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, García-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, Casanova JL.

Science. 2015 Apr 24;348(6233):448-53. doi: 10.1126/science.aaa1578. Epub 2015 Mar 26.

46.

Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.

Luthra P, Jordan DS, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2015 May;89(9):5148-53. doi: 10.1128/JVI.03652-14. Epub 2015 Mar 4.

47.

Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction.

Teixeira A, Yen B, Gusella GL, Thomas AG, Mullen MP, Aberg J, Chen X, Hoshida Y, van Bakel H, Schadt E, Basler CF, García-Sastre A, Mosoian A.

J Infect Dis. 2015 May 1;211(9):1467-75. doi: 10.1093/infdis/jiu643. Epub 2014 Nov 17.

48.

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAs in infected cells.

Shabman RS, Jabado OJ, Mire CE, Stockwell TB, Edwards M, Mahajan M, Geisbert TW, Basler CF.

MBio. 2014 Nov 4;5(6):e02011. doi: 10.1128/mBio.02011-14.

49.

New hope in the search for Ebola virus treatments.

Basler CF.

Immunity. 2014 Oct 16;41(4):515-7. doi: 10.1016/j.immuni.2014.10.001.

50.

Portrait of a killer: genome of the 2014 EBOV outbreak strain.

Basler CF.

Cell Host Microbe. 2014 Oct 8;16(4):419-21. doi: 10.1016/j.chom.2014.09.012.

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