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Items: 1 to 50 of 131

1.

Population pharmacokinetics of pegaptanib sodium (Macugen(®)) in patients with diabetic macular edema.

Basile AS, Hutmacher MM, Kowalski KG, Gandelman KY, Nickens DJ.

Clin Ophthalmol. 2015 Feb 16;9:323-35. doi: 10.2147/OPTH.S74050. eCollection 2015.

2.

Integrating disease progression models, non-clinical pharmacokinetic data and treatment response endpoints to optimize intravitreal dosing regimens.

Basile AS, Johnson TR, Klamerus KJ, Zhou D, Sultan MB, Amantea M, Nickens DJ.

Int J Clin Pharmacol Ther. 2014 Jul;52(7):574-86. doi: 10.5414/CP201998.

PMID:
24755127
3.

RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801.

Rittenhouse KD, Johnson TR, Vicini P, Hirakawa B, Kalabat D, Yang AH, Huang W, Basile AS.

Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1232-40. doi: 10.1167/iovs.13-13449.

PMID:
24458146
4.

Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.

Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM.

Mol Pharm. 2013 Feb 4;10(2):650-63. doi: 10.1021/mp300429e. Epub 2013 Jan 24.

5.

Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study).

Nguyen QD, Schachar RA, Nduaka CI, Sperling M, Basile AS, Klamerus KJ, Chi-Burris K, Yan E, Paggiarino DA, Rosenblatt I, Aitchison R, Erlich SS; DEGAS Clinical Study Group.

Invest Ophthalmol Vis Sci. 2012 Nov 15;53(12):7666-74. doi: 10.1167/iovs.12-9961.

PMID:
23074206
6.

Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology.

Warnock KT, Yang AR, Yi HS, June HL Jr, Kelly T, Basile AS, Skolnick P, June HL.

Pharmacol Biochem Behav. 2012 Nov;103(1):111-8.

7.

Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients.

Nguyen QD, Schachar RA, Nduaka CI, Sperling M, Basile AS, Klamerus KJ, Chi-Burris K, Yan E, Paggiarino DA, Rosenblatt I, Khan A, Aitchison R, Erlich SS; PF-04523655 Study Group.

Eye (Lond). 2012 Aug;26(8):1099-105. doi: 10.1038/eye.2012.106. Epub 2012 May 25.

8.

Effects of the triple monoamine uptake inhibitor DOV 102,677 on alcohol-motivated responding and antidepressant activity in alcohol-preferring (P) rats.

Yang AR, Yi HS, Warnock KT, Mamczarz J, June HL Jr, Mallick N, Krieter PA, Tonelli L, Skolnick P, Basile AS, June HL Sr.

Alcohol Clin Exp Res. 2012 May;36(5):863-73. doi: 10.1111/j.1530-0277.2011.01671.x. Epub 2011 Dec 7.

9.

Population pharmacokinetics of pegaptanib in patients with neovascular, age-related macular degeneration.

Basile AS, Hutmacher M, Nickens D, Nielsen J, Kowalski K, Whitfield L, Masayo O, Nakane M.

J Clin Pharmacol. 2012 Aug;52(8):1186-99. doi: 10.1177/0091270011412961. Epub 2011 Sep 23.

PMID:
21947371
10.

Intravitreal concentrations of a near-infrared fluorescence-labeled biotherapeutic determined in situ using confocal scanning laser ophthalmoscopy.

Basile AS, Glazier G, Lee A, Jiang LY, Johnson TR, Shields MJ, Vezina M, Doppalapudi VR.

Invest Ophthalmol Vis Sci. 2011 Sep 1;52(9):6949-58. doi: 10.1167/iovs.11-7790.

PMID:
21791590
11.

Preclinical evaluation of the abuse potential of the analgesic bicifadine.

Nicholson KL, Balster RL, Golembiowska K, Kowalska M, Tizzano JP, Skolnick P, Basile AS.

J Pharmacol Exp Ther. 2009 Jul;330(1):236-48. doi: 10.1124/jpet.109.150540. Epub 2009 Apr 8.

12.

Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH.

BMC Pharmacol. 2008 Jun 13;8:11. doi: 10.1186/1471-2210-8-11.

13.

A murine model of retroviral encephalopathy.

Sei Y, Basile AS.

Curr Protoc Neurosci. 2002 Feb;Chapter 9:Unit9.8. doi: 10.1002/0471142301.ns0908s17. Review.

PMID:
18428573
14.

Preclinical models of hepatic encephalopathy.

Basile AS, Mullen K.

Curr Protoc Neurosci. 2001 May;Chapter 9:Unit9.3. doi: 10.1002/0471142301.ns0903s08.

PMID:
18428551
15.

The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.

Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS.

J Pharmacol Exp Ther. 2008 Mar;324(3):1111-26. Epub 2007 Dec 18.

PMID:
18089843
16.

Effect of DOV 102,677 on the volitional consumption of ethanol by Myers' high ethanol-preferring rat.

McMillen BA, Shank JE, Jordan KB, Williams HL, Basile AS.

Alcohol Clin Exp Res. 2007 Nov;31(11):1866-71. Epub 2007 Sep 26.

PMID:
17908267
17.
18.

Triple reuptake inhibitors ("broad spectrum" antidepressants).

Skolnick P, Basile AS.

CNS Neurol Disord Drug Targets. 2007 Apr;6(2):141-9. Review.

PMID:
17430151
19.

Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain.

Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E.

J Pharmacol Exp Ther. 2007 Jun;321(3):1208-25. Epub 2007 Feb 26.

PMID:
17325229
20.

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.

J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13.

PMID:
16971504
21.

Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677.

Popik P, Krawczyk M, Golembiowska K, Nowak G, Janowsky A, Skolnick P, Lippa A, Basile AS.

Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):857-73. Epub 2006 Apr 25.

PMID:
16636898
22.

M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity.

Seeger T, Fedorova I, Zheng F, Miyakawa T, Koustova E, Gomeza J, Basile AS, Alzheimer C, Wess J.

J Neurosci. 2004 Nov 10;24(45):10117-27.

23.

Anxioselective anxiolytics: can less be more?

Basile AS, Lippa AS, Skolnick P.

Eur J Pharmacol. 2004 Oct 1;500(1-3):441-51. Review.

PMID:
15464051
24.

Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide.

Wu SZ, Bodles AM, Porter MM, Griffin WS, Basile AS, Barger SW.

J Neuroinflammation. 2004 Apr 20;1(1):2.

25.

Glutamate-induced over-expression of GAD is down-regulated by acetyl-L-carnitine in rat islet cells.

Hao Y, Basile AS, Chen G, Zhang L.

Endocr Res. 2004 Feb;30(1):107-16.

PMID:
15098924
26.

A pulmonary formulation of L-dopa enhances its effectiveness in a rat model of Parkinson's disease.

Bartus RT, Emerich D, Snodgrass-Belt P, Fu K, Salzberg-Brenhouse H, Lafreniere D, Novak L, Lo ES, Cooper T, Basile AS.

J Pharmacol Exp Ther. 2004 Aug;310(2):828-35. Epub 2004 Mar 23.

PMID:
15039453
27.

Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology.

Yamada M, Basile AS, Fedorova I, Zhang W, Duttaroy A, Cui Y, Lamping KG, Faraci FM, Deng CX, Wess J.

Life Sci. 2003 Dec 5;74(2-3):345-53. Review.

PMID:
14607263
28.

Vivitrex, an injectable, extended-release formulation of naltrexone, provides pharmacokinetic and pharmacodynamic evidence of efficacy for 1 month in rats.

Bartus RT, Emerich DF, Hotz J, Blaustein M, Dean RL, Perdomo B, Basile AS.

Neuropsychopharmacology. 2003 Nov;28(11):1973-82.

29.

Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration.

Salzberg-Brenhouse HC, Chen EY, Emerich DF, Baldwin S, Hogeland K, Ranelli S, Lafreniere D, Perdomo B, Novak L, Kladis T, Fu K, Basile AS, Kordower JH, Bartus RT.

J Pharmacol Exp Ther. 2003 Jul;306(1):218-28. Epub 2003 Apr 3.

PMID:
12676885
30.

Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice.

Duttaroy A, Gomeza J, Gan JW, Siddiqui N, Basile AS, Harman WD, Smith PL, Felder CC, Levey AI, Wess J.

Mol Pharmacol. 2002 Nov;62(5):1084-93.

PMID:
12391271
31.

Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia.

Basile AS, Fedorova I, Zapata A, Liu X, Shippenberg T, Duttaroy A, Yamada M, Wess J.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11452-7. Epub 2002 Aug 1.

32.
34.

Increased glutamate in CSF and plasma of patients with HIV dementia.

Espey MG, Basile AS, Heaton RK, Ellis RJ.

Neurology. 2002 May 14;58(9):1439; author reply 1439-40. No abstract available.

PMID:
12011305
35.

Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.

Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J.

J Neurosci. 2002 Mar 1;22(5):1709-17.

36.

Peripheral benzodiazepine receptors and mitochondrial function.

Casellas P, Galiegue S, Basile AS.

Neurochem Int. 2002 May;40(6):475-86. Review.

PMID:
11850104
37.

IgG isolated from LP-BM5 infected mouse brain activates ionotropic glutamate receptors.

Basile AS, Koustova E, Ioan P, Rizzoli S, Rogawski MA, Usherwood PN.

Neurobiol Dis. 2001 Dec;8(6):1069-81.

PMID:
11741402
38.

The hypnotic actions of the fatty acid amide, oleamide.

Mendelson WB, Basile AS.

Neuropsychopharmacology. 2001 Nov;25(5 Suppl):S36-9. Review.

39.

Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems.

Fedorova I, Hashimoto A, Fecik RA, Hedrick MP, Hanus LO, Boger DL, Rice KC, Basile AS.

J Pharmacol Exp Ther. 2001 Oct;299(1):332-42.

PMID:
11561096
40.

LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor.

Koustova E, Sei Y, Fossom L, Wei ML, Usherwood PN, Keele NB, Rogawski MA, Basile AS.

J Clin Invest. 2001 Mar;107(6):737-44.

41.

Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.

Hernández-Sánchez C, Basile AS, Fedorova I, Arima H, Stannard B, Fernandez AM, Ito Y, LeRoith D.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3549-54. Epub 2001 Feb 27.

43.

Accelerated development of neurochemical and behavioral deficits in LP-BM5 infected mice with targeted deletions of the IFN-gamma gene.

Koustova E, Sei Y, McCarty T, Espey MG, Ming R, Morse HC 3rd, Basile AS.

J Neuroimmunol. 2000 Aug 1;108(1-2):112-21.

PMID:
10900344
44.

Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-alpha gene.

Iida R, Saito K, Yamada K, Basile AS, Sekikawa K, Takemura M, Fujii H, Wada H, Seishima M, Nabeshima T.

FASEB J. 2000 May;14(7):1023-31.

PMID:
10783158
45.

The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist.

Mendelson WB, Basile AS.

Neuroreport. 1999 Oct 19;10(15):3237-9.

PMID:
10574567
46.

Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex.

Espey MG, Ellis RJ, Heaton RK, Basile AS.

Neurology. 1999 Sep 22;53(5):1144-5.

PMID:
10496286
47.

Increased blood-brain barrier permeability in LP-BM5 infected mice is mediated by neuroexcitatory mechanisms.

Kustova Y, Grinberg A, Basile AS.

Brain Res. 1999 Aug 21;839(1):153-63.

PMID:
10482808
48.

Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury.

Allen JW, Ivanova SA, Fan L, Espey MG, Basile AS, Faden AI.

J Pharmacol Exp Ther. 1999 Jul;290(1):112-20.

PMID:
10381766
49.

Evidence of neuronal degeneration in C57B1/6 mice infected with the LP-BM5 leukemia retrovirus mixture.

Kustova Y, Espey MG, Sung EG, Morse D, Sei Y, Basile AS.

Mol Chem Neuropathol. 1998 Aug-Dec;35(1-3):39-59.

PMID:
10343970
50.

A gas chromatographic-mass spectral assay for the quantitative determination of oleamide in biological fluids.

Hanus LO, Fales HM, Spande TF, Basile AS.

Anal Biochem. 1999 May 15;270(1):159-66.

PMID:
10328778

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