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Items: 1 to 50 of 180

1.

Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2.

García-Cano J, Sánchez-Tena S, Sala-Gaston J, Figueras A, Viñals F, Bartrons R, Ventura F, Rosa JL.

Mol Oncol. 2019 Oct 30. doi: 10.1002/1878-0261.12592. [Epub ahead of print]

2.

Editorial: Cancer Ecosystems.

Martinez-Outschoorn UE, Bartrons M, Bartrons R.

Front Oncol. 2019 Aug 20;9:718. doi: 10.3389/fonc.2019.00718. eCollection 2019. No abstract available.

3.

Large HERCs Function as Tumor Suppressors.

Schneider T, Martinez-Martinez A, Cubillos-Rojas M, Bartrons R, Ventura F, Rosa JL.

Front Oncol. 2019 Jun 18;9:524. doi: 10.3389/fonc.2019.00524. eCollection 2019. No abstract available.

4.

Corrigendum to "ERK and p38 pathways regulate amino acid signalling" [BBA-Mol. Cell. Res. Volume 1783/12 (2008) 2241-2254].

Casas-Terradellas E, Tato I, Bartrons R, Ventura F, Rosa JL.

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1687-1688. doi: 10.1016/j.bbamcr.2019.06.008. Epub 2019 Jun 25. No abstract available.

PMID:
31253429
5.

Tris-Acetate Polyacrylamide Gradient Gels for the Simultaneous Electrophoretic Analysis of Proteins of Very High and Low Molecular Mass.

Cubillos-Rojas M, Amair-Pinedo F, Tato I, Bartrons R, Ventura F, Rosa JL.

Methods Mol Biol. 2019;1855:269-277. doi: 10.1007/978-1-4939-8793-1_22.

PMID:
30426423
6.

Fructose 2,6-Bisphosphate in Cancer Cell Metabolism.

Bartrons R, Simon-Molas H, Rodríguez-García A, Castaño E, Navarro-Sabaté À, Manzano A, Martinez-Outschoorn UE.

Front Oncol. 2018 Sep 4;8:331. doi: 10.3389/fonc.2018.00331. eCollection 2018. Review.

7.

The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation.

Schneider T, Martinez-Martinez A, Cubillos-Rojas M, Bartrons R, Ventura F, Rosa JL.

Oncotarget. 2018 Jul 31;9(59):31531-31548. doi: 10.18632/oncotarget.25847. eCollection 2018 Jul 31.

8.

The potential utility of PFKFB3 as a therapeutic target.

Bartrons R, Rodríguez-García A, Simon-Molas H, Castaño E, Manzano A, Navarro-Sabaté À.

Expert Opin Ther Targets. 2018 Aug;22(8):659-674. doi: 10.1080/14728222.2018.1498082. Epub 2018 Jul 16. Review.

PMID:
29985086
9.

PI3K-Akt signaling controls PFKFB3 expression during human T-lymphocyte activation.

Simon-Molas H, Arnedo-Pac C, Fontova P, Vidal-Alabró A, Castaño E, Rodríguez-García A, Navarro-Sabaté À, Lloberas N, Manzano A, Bartrons R.

Mol Cell Biochem. 2018 Nov;448(1-2):187-197. doi: 10.1007/s11010-018-3325-9. Epub 2018 Feb 12.

PMID:
29435871
10.

Leucine reduces the proliferation of MC3T3-E1 cells through DNA damage and cell senescence.

da Luz Dias R, Basso B, Donadio MVF, Pujol FV, Bartrons R, Haute GV, Gassen RB, Bregolin HD, Krause G, Viau C, Saffi J, Nunes FB, Rosa JL, de Oliveira JR.

Toxicol In Vitro. 2018 Apr;48:1-10. doi: 10.1016/j.tiv.2017.12.015. Epub 2017 Dec 24.

11.

NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.

Cubillos-Rojas M, Schneider T, Bartrons R, Ventura F, Rosa JL.

Oncotarget. 2017 Jun 27;8(37):61824-61836. doi: 10.18632/oncotarget.18699. eCollection 2017 Sep 22.

12.

TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells.

Rodríguez-García A, Samsó P, Fontova P, Simon-Molas H, Manzano A, Castaño E, Rosa JL, Martinez-Outshoorn U, Ventura F, Navarro-Sabaté À, Bartrons R.

FEBS J. 2017 Oct;284(20):3437-3454. doi: 10.1111/febs.14201. Epub 2017 Sep 10.

13.

PGC-1α Downregulation in Steatotic Liver Enhances Ischemia-Reperfusion Injury and Impairs Ischemic Preconditioning.

Sánchez-Ramos C, Prieto I, Tierrez A, Laso J, Valdecantos MP, Bartrons R, Roselló-Catafau J, Monsalve M.

Antioxid Redox Signal. 2017 Dec 1;27(16):1332-1346. doi: 10.1089/ars.2016.6836. Epub 2017 Apr 14.

PMID:
28269997
14.

Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes.

Houddane A, Bultot L, Novellasdemunt L, Johanns M, Gueuning MA, Vertommen D, Coulie PG, Bartrons R, Hue L, Rider MH.

Cell Signal. 2017 Jun;34:23-37. doi: 10.1016/j.cellsig.2017.02.019. Epub 2017 Feb 22.

PMID:
28235572
15.

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer.

Ko YH, Domingo-Vidal M, Roche M, Lin Z, Whitaker-Menezes D, Seifert E, Capparelli C, Tuluc M, Birbe RC, Tassone P, Curry JM, Navarro-Sabaté À, Manzano A, Bartrons R, Caro J, Martinez-Outschoorn U.

J Biol Chem. 2016 Dec 16;291(51):26291-26303. Epub 2016 Nov 1.

16.

Analysis of Protein Oligomerization by Electrophoresis.

Cubillos-Rojas M, Schneider T, Sánchez-Tena S, Bartrons R, Ventura F, Rosa JL.

Methods Mol Biol. 2016;1449:341-8. doi: 10.1007/978-1-4939-3756-1_22.

PMID:
27613048
17.

The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination.

Cubillos-Rojas M, Schneider T, Hadjebi O, Pedrazza L, de Oliveira JR, Langa F, Guénet JL, Duran J, de Anta JM, Alcántara S, Ruiz R, Pérez-Villegas EM, Aguilar-Montilla FJ, Carrión ÁM, Armengol JA, Baple E, Crosby AH, Bartrons R, Ventura F, Rosa JL.

Oncotarget. 2016 Aug 30;7(35):56083-56106. doi: 10.18632/oncotarget.11270.

18.

Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition.

Simon-Molas H, Calvo-Vidal MN, Castaño E, Rodríguez-García A, Navarro-Sabaté À, Bartrons R, Manzano A.

FEBS Lett. 2016 Sep;590(17):2915-26. doi: 10.1002/1873-3468.12338. Epub 2016 Aug 24.

19.

Tris-acetate polyacrylamide gradient gel electrophoresis for the analysis of protein oligomerization.

Cubillos-Rojas M, Schneider T, Sánchez-Tena S, Bartrons R, Ventura F, Rosa JL.

Anal Bioanal Chem. 2016 Feb;408(6):1715-9. doi: 10.1007/s00216-015-9283-0. Epub 2016 Jan 11.

PMID:
26753978
20.

Neuregulin improves response to glucose tolerance test in control and diabetic rats.

López-Soldado I, Niisuke K, Veiga C, Adrover A, Manzano A, Martínez-Redondo V, Camps M, Bartrons R, Zorzano A, Gumà A.

Am J Physiol Endocrinol Metab. 2016 Mar 15;310(6):E440-51. doi: 10.1152/ajpendo.00226.2015. Epub 2015 Dec 29.

21.

Therapeutic ultrasound stimulates MC3T3-E1 cell proliferation through the activation of NF-κB1, p38α, and mTOR.

Tassinary JA, Lunardelli A, Basso BS, Stülp S, Pozzobon A, Pedrazza L, Bartrons R, Ventura F, Rosa JL, Melo DA, Nunes FB, Donadio MV, Oliveira JR.

Lasers Surg Med. 2015 Nov;47(9):765-72. doi: 10.1002/lsm.22414. Epub 2015 Sep 28.

PMID:
26414998
22.

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.

Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A, Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD.

Diabetes. 2015 Sep;64(9):3093-103. doi: 10.2337/db15-0370. Epub 2015 May 26.

23.

HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages.

Tawakol A, Singh P, Mojena M, Pimentel-Santillana M, Emami H, MacNabb M, Rudd JH, Narula J, Enriquez JA, Través PG, Fernández-Velasco M, Bartrons R, Martín-Sanz P, Fayad ZA, Tejedor A, Boscá L.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1463-71. doi: 10.1161/ATVBAHA.115.305551. Epub 2015 Apr 16.

24.

p38α function in osteoblasts influences adipose tissue homeostasis.

Rodríguez-Carballo E, Gámez B, Méndez-Lucas A, Sánchez-Freutrie M, Zorzano A, Bartrons R, Alcántara S, Perales JC, Ventura F.

FASEB J. 2015 Apr;29(4):1414-25. doi: 10.1096/fj.14-261891. Epub 2014 Dec 30.

PMID:
25550462
25.

The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization.

Cubillos-Rojas M, Amair-Pinedo F, Peiró-Jordán R, Bartrons R, Ventura F, Rosa JL.

J Biol Chem. 2014 May 23;289(21):14782-95. doi: 10.1074/jbc.M113.527978. Epub 2014 Apr 9.

26.

Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide.

Siebel A, Cubillos-Rojas M, Santos RC, Schneider T, Bonan CD, Bartrons R, Ventura F, Rodrigues de Oliveira J, Rosa JL.

PLoS One. 2013 Sep 18;8(9):e75523. doi: 10.1371/journal.pone.0075523. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi: 10.1371/annotation/0b485bd9-b1b2-4c60-ab22-3ac5d271dc59.

27.

Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells.

Bitencourt S, Mesquita F, Basso B, Schmid J, Ferreira G, Rizzo L, Bauer M, Bartrons R, Ventura F, Rosa JL, Mannaerts I, van Grunsven LA, Oliveira J.

Cell Biochem Biophys. 2014 Mar;68(2):387-96. doi: 10.1007/s12013-013-9719-0.

PMID:
23955514
28.

Role of PFKFB3-driven glycolysis in vessel sprouting.

De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P.

Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037.

29.

MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability.

Gámez B, Rodríguez-Carballo E, Bartrons R, Rosa JL, Ventura F.

J Biol Chem. 2013 May 17;288(20):14264-75. doi: 10.1074/jbc.M112.432104. Epub 2013 Apr 5.

30.

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli.

Novellasdemunt L, Bultot L, Manzano A, Ventura F, Rosa JL, Vertommen D, Rider MH, Navarro-Sabate À, Bartrons R.

Biochem J. 2013 Jun 15;452(3):531-43. doi: 10.1042/BJ20121886.

PMID:
23548149
31.

Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids.

Novellasdemunt L, Tato I, Navarro-Sabate A, Ruiz-Meana M, Méndez-Lucas A, Perales JC, Garcia-Dorado D, Ventura F, Bartrons R, Rosa JL.

J Biol Chem. 2013 Apr 12;288(15):10640-51. doi: 10.1074/jbc.M113.455998. Epub 2013 Mar 2.

32.

Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway.

Gómez M, Manzano A, Figueras A, Viñals F, Ventura F, Rosa JL, Bartrons R, Navarro-Sabaté À.

Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E695-707. doi: 10.1152/ajpendo.00381.2011. Epub 2012 Jul 17.

33.

Tris-acetate polyacrylamide gradient gels for the simultaneous electrophoretic analysis of proteins of very high and low molecular mass.

Cubillos-Rojas M, Amair-Pinedo F, Tato I, Bartrons R, Ventura F, Rosa JL.

Methods Mol Biol. 2012;869:205-13. doi: 10.1007/978-1-61779-821-4_17.

PMID:
22585488
34.

Antiproliferative effect of catechin in GRX cells.

Bragança de Moraes CM, Melo DA, Santos RC, Bitencourt S, Mesquita FC, dos Santos de Oliveira F, Rodriguez-Carballo E, Bartrons R, Rosa JL, Ventura FP, Rodrigues de Oliveira J.

Biochem Cell Biol. 2012 Aug;90(4):575-84. doi: 10.1139/o2012-010. Epub 2012 May 10.

PMID:
22574829
35.

The use of a reversible proteasome inhibitor in a model of Reduced-Size Orthotopic Liver transplantation in rats.

Padrissa-Altés S, Zaouali MA, Boncompagni E, Bonaccorsi-Riani E, Carbonell T, Bardag-Gorce F, Oliva J, French SW, Bartrons R, Roselló-Catafau J.

Exp Mol Pathol. 2012 Aug;93(1):99-110. doi: 10.1016/j.yexmp.2012.03.011. Epub 2012 Mar 25.

PMID:
22475623
36.

Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms.

Padrissa-Altés S, Zaouali MA, Bartrons R, Roselló-Catafau J.

Clin Sci (Lond). 2012 Jul;123(2):93-8. doi: 10.1042/CS20110093.

37.

Fructose-1,6-bisphosphate reduces the mortality in Candida albicans bloodstream infection and prevents the septic-induced platelet decrease.

Santos RC, Moresco RN, Peña Rico MA, Susperregui AR, Rosa JL, Bartrons R, Ventura F, Mário DN, Alves SH, Tatsch E, Kober H, de Mello RO, Scherer P, Dias HB, de Oliveira JR.

Inflammation. 2012 Aug;35(4):1256-61. doi: 10.1007/s10753-012-9436-7.

PMID:
22367598
38.

Fructose-1,6-bisphosphate protects against Zymosan-induced acute lung injury in mice.

Santos RC, Moresco RN, Peña Rico MA, Susperregui AR, Rosa JL, Bartrons R, Ventura F, Mário DN, Alves SH, Tatsch E, Kober H, de Mello RO, Scherer P, de Oliveira JR.

Inflammation. 2012 Jun;35(3):1198-203. doi: 10.1007/s10753-012-9429-6.

PMID:
22327861
39.

Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.

Vidal-Alabró A, Gómez-Valadés AG, Méndez-Lucas A, Llorens J, Bartrons R, Bermúdez J, Perales JC.

Int J Endocrinol. 2011;2011:707928. doi: 10.1155/2011/707928. Epub 2011 Dec 13.

40.

Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells.

Novellasdemunt L, Obach M, Millán-Ariño L, Manzano A, Ventura F, Rosa JL, Jordan A, Navarro-Sabate A, Bartrons R.

Biochem J. 2012 Mar 1;442(2):345-56. doi: 10.1042/BJ20111418.

PMID:
22115192
41.

TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells.

Peña-Rico MA, Calvo-Vidal MN, Villalonga-Planells R, Martínez-Soler F, Giménez-Bonafé P, Navarro-Sabaté À, Tortosa A, Bartrons R, Manzano A.

Radiother Oncol. 2011 Oct;101(1):132-9. doi: 10.1016/j.radonc.2011.07.002. Epub 2011 Aug 22.

PMID:
21864926
42.

Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.

Ruiz-García A, Monsalve E, Novellasdemunt L, Navarro-Sabaté A, Manzano A, Rivero S, Castrillo A, Casado M, Laborda J, Bartrons R, Díaz-Guerra MJ.

J Biol Chem. 2011 Jun 3;286(22):19247-58. doi: 10.1074/jbc.M110.190298. Epub 2011 Apr 4.

43.

Noncanonical BMP signaling regulates cyclooxygenase-2 transcription.

Susperregui AR, Gamell C, Rodríguez-Carballo E, Ortuño MJ, Bartrons R, Rosa JL, Ventura F.

Mol Endocrinol. 2011 Jun;25(6):1006-17. doi: 10.1210/me.2010-0515. Epub 2011 Mar 24.

44.

Modulation of inflammatory response and parasitism by 15-Deoxy-Δ(12,14) prostaglandin J(2) in Trypanosoma cruzi-infected cardiomyocytes.

Hovsepian E, Mirkin GA, Penas F, Manzano A, Bartrons R, Goren NB.

Int J Parasitol. 2011 Apr;41(5):553-62. doi: 10.1016/j.ijpara.2010.12.002. Epub 2011 Jan 6.

PMID:
21215746
45.

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling.

Tato I, Bartrons R, Ventura F, Rosa JL.

J Biol Chem. 2011 Feb 25;286(8):6128-42. doi: 10.1074/jbc.M110.166991. Epub 2010 Dec 3.

46.

The transcriptional activation of the cyclooxygenase-2 gene in zymosan-activated macrophages is dependent on NF-kappa B, C/EBP, AP-1, and CRE sites.

Santos RC, Rico MA, Bartrons R, Pujol FV, Rosa JL, de Oliveira JR.

Inflammation. 2011 Dec;34(6):653-8. doi: 10.1007/s10753-010-9275-3.

PMID:
21104307
47.

Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways.

Rodríguez-Carballo E, Ulsamer A, Susperregui AR, Manzanares-Céspedes C, Sánchez-García E, Bartrons R, Rosa JL, Ventura F.

J Bone Miner Res. 2011 Apr;26(4):718-29. doi: 10.1002/jbmr.260.

48.

p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix.

Ortuño MJ, Ruiz-Gaspà S, Rodríguez-Carballo E, Susperregui AR, Bartrons R, Rosa JL, Ventura F.

J Biol Chem. 2010 Oct 15;285(42):31985-94. doi: 10.1074/jbc.M110.123612. Epub 2010 Aug 3.

49.

Hypoxia inducible factor-1alpha accumulation in steatotic liver preservation: role of nitric oxide.

Zaouali MA, Ben Mosbah I, Boncompagni E, Ben Abdennebi H, Mitjavila MT, Bartrons R, Freitas I, Rimola A, Roselló-Catafau J.

World J Gastroenterol. 2010 Jul 28;16(28):3499-509.

50.

Matrix metalloproteinase 2 in reduced-size liver transplantation: beyond the matrix.

Padrissa-Altés S, Zaouali MA, Franco-Gou R, Bartrons R, Boillot O, Rimola A, Arroyo V, Rodés J, Peralta C, Roselló-Catafau J.

Am J Transplant. 2010 May;10(5):1167-77. doi: 10.1111/j.1600-6143.2010.03092.x. Epub 2010 Mar 26.

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