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Items: 1 to 50 of 532

1.

A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy.

Horvat C, Johnson R, Lam L, Munro J, Mazzarotto F, Roberts AM, Herman DS, Parfenov M, Haghighi A, McDonough B, DePalma SR, Keogh AM, Macdonald PS, Hayward CS, Roberts A, Barton PJR, Felkin LE, Giannoulatou E, Cook SA, Seidman JG, Seidman CE, Fatkin D.

Genet Med. 2018 Jun 11. doi: 10.1038/s41436-018-0036-2. [Epub ahead of print]

PMID:
29892087
2.

Development and Characterisation of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery.

Lancett P, Williamson B, Barton P, Riley RJ.

Drug Metab Dispos. 2018 Jun 7. pii: dmd.118.081596. doi: 10.1124/dmd.118.081596. [Epub ahead of print]

PMID:
29880630
3.

Disentangling the effects of farmland use, habitat edges, and vegetation structure on ground beetle morphological traits.

Ng K, Barton PS, Blanchard W, Evans MJ, Lindenmayer DB, Macfadyen S, McIntyre S, Driscoll DA.

Oecologia. 2018 Jun 6. doi: 10.1007/s00442-018-4180-9. [Epub ahead of print]

PMID:
29872917
4.

Genetic Etiology for Alcohol-Induced Cardiac Toxicity.

Ware JS, Amor-Salamanca A, Tayal U, Govind R, Serrano I, Salazar-Mendiguchía J, García-Pinilla JM, Pascual-Figal DA, Nuñez J, Guzzo-Merello G, Gonzalez-Vioque E, Bardaji A, Manito N, López-Garrido MA, Padron-Barthe L, Edwards E, Whiffin N, Walsh R, Buchan RJ, Midwinter W, Wilk A, Prasad S, Pantazis A, Baski J, O'Regan DP, Alonso-Pulpon L, Cook SA, Lara-Pezzi E, Barton PJ, Garcia-Pavia P.

J Am Coll Cardiol. 2018 May 22;71(20):2293-2302. doi: 10.1016/j.jacc.2018.03.462.

5.

Search for Neutrinoless Double-β Decay in ^{76}Ge with the Majorana Demonstrator.

Aalseth CE, Abgrall N, Aguayo E, Alvis SI, Amman M, Arnquist IJ, Avignone FT, Back HO, Barabash AS, Barbeau PS, Barton CJ, Barton PJ, Bertrand FE, Bode T, Bos B, Boswell M, Bradley AW, Brodzinski RL, Brudanin V, Busch M, Buuck M, Caldwell AS, Caldwell TS, Chan YD, Christofferson CD, Chu PH, Collar JI, Combs DC, Cooper RJ, Cuesta C, Detwiler JA, Doe PJ, Dunmore JA, Efremenko Y, Ejiri H, Elliott SR, Fast JE, Finnerty P, Fraenkle FM, Fu Z, Fujikawa BK, Fuller E, Galindo-Uribarri A, Gehman VM, Gilliss T, Giovanetti GK, Goett J, Green MP, Gruszko J, Guinn IS, Guiseppe VE, Hallin AL, Haufe CR, Hehn L, Henning R, Hoppe EW, Hossbach TW, Howe MA, Jasinski BR, Johnson RA, Keeter KJ, Kephart JD, Kidd MF, Knecht A, Konovalov SI, Kouzes RT, LaFerriere BD, Leon J, Lesko KT, Leviner LE, Loach JC, Lopez AM, Luke PN, MacMullin J, MacMullin S, Marino MG, Martin RD, Massarczyk R, McDonald AB, Mei DM, Meijer SJ, Merriman JH, Mertens S, Miley HS, Miller ML, Myslik J, Orrell JL, O'Shaughnessy C, Othman G, Overman NR, Perumpilly G, Pettus W, Phillips DG, Poon AWP, Pushkin K, Radford DC, Rager J, Reeves JH, Reine AL, Rielage K, Robertson RGH, Ronquest MC, Ruof NW, Schubert AG, Shanks B, Shirchenko M, Snavely KJ, Snyder N, Steele D, Suriano AM, Tedeschi D, Tornow W, Trimble JE, Varner RL, Vasilyev S, Vetter K, Vorren K, White BR, Wilkerson JF, Wiseman C, Xu W, Yakushev E, Yaver H, Young AR, Yu CH, Yumatov V, Zhitnikov I, Zhu BX, Zimmermann S; Majorana Collaboration.

Phys Rev Lett. 2018 Mar 30;120(13):132502. doi: 10.1103/PhysRevLett.120.132502.

6.

The Importance of Model Structure in the Cost-Effectiveness Analysis of Primary Care Interventions for the Management of Hypertension.

Peñaloza-Ramos MC, Jowett S, Sutton AJ, McManus RJ, Barton P.

Value Health. 2018 Mar;21(3):351-363. doi: 10.1016/j.jval.2017.03.003. Epub 2017 Oct 19.

PMID:
29566843
7.

Bounds on stochastic chemical kinetic systems at steady state.

Dowdy GR, Barton PI.

J Chem Phys. 2018 Feb 28;148(8):084106. doi: 10.1063/1.5009950.

PMID:
29495780
8.

CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation.

Whiffin N, Walsh R, Govind R, Edwards M, Ahmad M, Zhang X, Tayal U, Buchan R, Midwinter W, Wilk AE, Najgebauer H, Francis C, Wilkinson S, Monk T, Brett L, O'Regan DP, Prasad SK, Morris-Rosendahl DJ, Barton PJR, Edwards E, Ware JS, Cook SA.

Genet Med. 2018 Jan 25. doi: 10.1038/gim.2017.258. [Epub ahead of print]

9.

Dynamic Flux Balance Analysis Using DFBAlab.

Gomez JA, Barton PI.

Methods Mol Biol. 2018;1716:353-370. doi: 10.1007/978-1-4939-7528-0_16.

PMID:
29222762
10.

Economic evaluation of medical tests at the early phases of development: a systematic review of empirical studies.

Frempong SN, Sutton AJ, Davenport C, Barton P.

Expert Rev Pharmacoecon Outcomes Res. 2018 Feb;18(1):13-23. doi: 10.1080/14737167.2018.1411194. Epub 2017 Dec 2. Review.

PMID:
29183175
11.

When has service provision for transient ischaemic attack improved enough? A discrete event simulation economic modelling study.

Barton P, Sheppard JP, Penaloza-Ramos CM, Jowett S, Ford GA, Lasserson D, Mant J, Mellor RM, Quinn T, Rothwell PM, Sandler D, Sims D, McManus RJ; BBC CLAHRC investigators.

BMJ Open. 2017 Nov 25;7(11):e018189. doi: 10.1136/bmjopen-2017-018189.

12.

Fabrication of silver nanostructures using femtosecond laser-induced photoreduction.

Barton P, Mukherjee S, Prabha J, Boudouris BW, Pan L, Xu X.

Nanotechnology. 2017 Dec 15;28(50):505302. doi: 10.1088/1361-6528/aa977b.

PMID:
29091584
13.

Phenotype and Clinical Outcomes of Titin Cardiomyopathy.

Tayal U, Newsome S, Buchan R, Whiffin N, Halliday B, Lota A, Roberts A, Baksi AJ, Voges I, Midwinter W, Wilk A, Govind R, Walsh R, Daubeney P, Jarman JWE, Baruah R, Frenneaux M, Barton PJ, Pennell D, Ware JS, Prasad SK, Cook SA.

J Am Coll Cardiol. 2017 Oct 31;70(18):2264-2274. doi: 10.1016/j.jacc.2017.08.063.

14.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N.

Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z.

15.

Cost-effectiveness analysis of use of a polypill versus usual care or best practice for primary prevention in people at high risk of cardiovascular disease.

Jowett S, Barton P, Roalfe A, Fletcher K, Hobbs FDR, McManus RJ, Mant J.

PLoS One. 2017 Sep 5;12(9):e0182625. doi: 10.1371/journal.pone.0182625. eCollection 2017.

16.

Effects of a large wildfire on vegetation structure in a variable fire mosaic.

Foster CN, Barton PS, Robinson NM, MacGregor CI, Lindenmayer DB.

Ecol Appl. 2017 Dec;27(8):2369-2381. doi: 10.1002/eap.1614. Epub 2017 Oct 26.

PMID:
28851094
17.

Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation.

Rogozińska E, Marlin N, Jackson L, Rayanagoudar G, Ruifrok AE, Dodds J, Molyneaux E, van Poppel MN, Poston L, Vinter CA, McAuliffe F, Dodd JM, Owens J, Barakat R, Perales M, Cecatti JG, Surita F, Yeo S, Bogaerts A, Devlieger R, Teede H, Harrison C, Haakstad L, Shen GX, Shub A, Beltagy NE, Motahari N, Khoury J, Tonstad S, Luoto R, Kinnunen TI, Guelfi K, Facchinetti F, Petrella E, Phelan S, Scudeller TT, Rauh K, Hauner H, Renault K, de Groot CJ, Sagedal LR, Vistad I, Stafne SN, Mørkved S, Salvesen KÅ, Jensen DM, Vitolo M, Astrup A, Geiker NR, Kerry S, Barton P, Roberts T, Riley RD, Coomarasamy A, Mol BW, Khan KS, Thangaratinam S.

Health Technol Assess. 2017 Aug;21(41):1-158. doi: 10.3310/hta21410. Review.

18.

NBEAL2 is required for neutrophil and NK cell function and pathogen defense.

Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA, Hoenderdos K, Harcourt K, Marsden M, Abdul-Karim J, Clement M, Antrobus R, Umrania Y, Barton PR, Flint SM, Juss JK, Condliffe AM, Lyons PA, Humphreys IR, Chilvers ER, Ouwehand WH, Dougan G, Smith KG.

J Clin Invest. 2017 Sep 1;127(9):3521-3526. doi: 10.1172/JCI91684. Epub 2017 Aug 7.

19.

Applications of the Capability Approach in the Health Field: A Literature Review.

Mitchell PM, Roberts TE, Barton PM, Coast J.

Soc Indic Res. 2017;133(1):345-371. doi: 10.1007/s11205-016-1356-8. Epub 2016 May 10.

20.

The Binding Effect of Proteins on Medications and Its Impact on Electrochemical Sensing: Antipsychotic Clozapine as a Case Study.

Banis GE, Winkler T, Barton P, Chocron SE, Kim E, Kelly DL, Payne GF, Ben-Yoav H, Ghodssi R.

Pharmaceuticals (Basel). 2017 Aug 1;10(3). pii: E69. doi: 10.3390/ph10030069.

21.

Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

McCoull W, Abrams RD, Anderson E, Blades K, Barton P, Box M, Burgess J, Byth K, Cao Q, Chuaqui C, Carbajo RJ, Cheung T, Code E, Ferguson AD, Fillery S, Fuller NO, Gangl E, Gao N, Grist M, Hargreaves D, Howard MR, Hu J, Kemmitt PD, Nelson JE, O'Connell N, Prince DB, Raubo P, Rawlins PB, Robb GR, Shi J, Waring MJ, Whittaker D, Wylot M, Zhu X.

J Med Chem. 2017 Jul 27;60(14):6459. doi: 10.1021/acs.jmedchem.7b00962. Epub 2017 Jul 17. No abstract available.

PMID:
28714680
22.

Using high-resolution variant frequencies to empower clinical genome interpretation.

Whiffin N, Minikel E, Walsh R, O'Donnell-Luria AH, Karczewski K, Ing AY, Barton PJR, Funke B, Cook SA, MacArthur D, Ware JS.

Genet Med. 2017 Oct;19(10):1151-1158. doi: 10.1038/gim.2017.26. Epub 2017 May 18.

23.

Truncating Variants in Titin Independently Predict Early Arrhythmias in Patients With Dilated Cardiomyopathy.

Tayal U, Newsome S, Buchan R, Whiffin N, Walsh R, Barton PJ, Ware JS, Cook SA, Prasad SK.

J Am Coll Cardiol. 2017 May 16;69(19):2466-2468. doi: 10.1016/j.jacc.2017.03.530. No abstract available.

24.

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

McCoull W, Abrams RD, Anderson E, Blades K, Barton P, Box M, Burgess J, Byth K, Cao Q, Chuaqui C, Carbajo RJ, Cheung T, Code E, Ferguson AD, Fillery S, Fuller NO, Gangl E, Gao N, Grist M, Hargreaves D, Howard MR, Hu J, Kemmitt PD, Nelson JE, O'Connell N, Prince DB, Raubo P, Rawlins PB, Robb GR, Shi J, Waring MJ, Whittaker D, Wylot M, Zhu X.

J Med Chem. 2017 May 25;60(10):4386-4402. doi: 10.1021/acs.jmedchem.7b00359. Epub 2017 May 9.

PMID:
28485934
25.

Valuing productivity costs using the friction-cost approach: Estimating friction-period estimates by occupational classifications for the UK.

Kigozi J, Jowett S, Lewis M, Barton P, Coast J.

Health Econ. 2017 Dec;26(12):1862-1868. doi: 10.1002/hec.3513. Epub 2017 Apr 27.

PMID:
28449329
27.

Necrophilous Insect Dynamics at Small Vertebrate Carrion in a Temperate Eucalypt Woodland.

Barton PS, Evans MJ, Pechal JL, Benbow ME.

J Med Entomol. 2017 Jul 1;54(4):964-973. doi: 10.1093/jme/tjw242.

PMID:
28399296
28.

Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.

McCoull W, Bailey A, Barton P, Birch AM, Brown AJ, Butler HS, Boyd S, Butlin RJ, Chappell B, Clarkson P, Collins S, Davies RM, Ertan A, Hammond CD, Holmes JL, Lenaghan C, Midha A, Morentin-Gutierrez P, Moore JE, Raubo P, Robb G.

J Med Chem. 2017 Apr 13;60(7):3187-3197. doi: 10.1021/acs.jmedchem.7b00210. Epub 2017 Apr 4.

PMID:
28374589
29.

MICE or NICE? An economic evaluation of clinical decision rules in the diagnosis of heart failure in primary care.

Monahan M, Barton P, Taylor CJ, Roalfe AK, Hobbs FDR; REFER investigators, Cowie M, Davis R, Deeks J, Mant J, McCahon D, McDonagh T, Sutton G, Tait L.

Int J Cardiol. 2017 Aug 15;241:255-261. doi: 10.1016/j.ijcard.2017.02.149. Epub 2017 Mar 2.

30.

How Qualitative Methods Can be Used to Inform Model Development.

Husbands S, Jowett S, Barton P, Coast J.

Pharmacoeconomics. 2017 Jun;35(6):607-612. doi: 10.1007/s40273-017-0499-z.

PMID:
28321640
31.

The Estimation and Inclusion of Presenteeism Costs in Applied Economic Evaluation: A Systematic Review.

Kigozi J, Jowett S, Lewis M, Barton P, Coast J.

Value Health. 2017 Mar;20(3):496-506. doi: 10.1016/j.jval.2016.12.006. Epub 2017 Jan 30. Review.

32.

Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC-MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition.

Turnpenny P, Padfield A, Barton P, Teague J, Rahme LG, Pucci MJ, Zahler R, Rubio A.

J Pharm Biomed Anal. 2017 May 30;139:44-53. doi: 10.1016/j.jpba.2017.02.034. Epub 2017 Feb 28.

PMID:
28273650
33.

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.

Walsh R, Buchan R, Wilk A, John S, Felkin LE, Thomson KL, Chiaw TH, Loong CCW, Pua CJ, Raphael C, Prasad S, Barton PJ, Funke B, Watkins H, Ware JS, Cook SA.

Eur Heart J. 2017 Dec 7;38(46):3461-3468. doi: 10.1093/eurheartj/ehw603.

34.

Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11.

Rea G, Homfray T, Till J, Roses-Noguer F, Buchan RJ, Wilkinson S, Wilk A, Walsh R, John S, McKee S, Stewart FJ, Murday V, Taylor RW, Ashworth M, Baksi AJ, Daubeney P, Prasad S, Barton PJR, Cook SA, Ware JS.

Cold Spring Harb Mol Case Stud. 2017 Jan;3(1):a001271. doi: 10.1101/mcs.a001271.

35.

A Randomised Controlled Trial of Treatment for Post-Stroke Homonymous Hemianopia: Screening and Recruitment.

Rowe FJ, Conroy EJ, Barton PG, Bedson E, Cwiklinski E, Dodridge C, Drummond A, Garcia-Finana M, Howard C, Johnson S, MacIntosh C, Noonan CP, Pollock A, Rockliffe J, Sackley CM, Shipman T.

Neuroophthalmology. 2016 Jan 19;40(1):1-7. eCollection 2016 Feb.

36.

Primary care REFerral for EchocaRdiogram (REFER) in heart failure: a diagnostic accuracy study.

Taylor CJ, Roalfe AK, Iles R, Hobbs FR; REFER investigators, Barton P, Deeks J, McCahon D, Cowie MR, Sutton G, Davis RC, Mant J, McDonagh T, Tait L.

Br J Gen Pract. 2017 Feb;67(655):e94-e102. doi: 10.3399/bjgp16X688393. Epub 2016 Dec 5.

37.

Titin-truncating variants affect heart function in disease cohorts and the general population.

Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik JP, O'Regan D, Ware JS, Hubner N, Cook SA.

Nat Genet. 2017 Jan;49(1):46-53. doi: 10.1038/ng.3719. Epub 2016 Nov 21.

38.

Revealing the dynamics of a large impact.

Barton P.

Science. 2016 Nov 18;354(6314):836-837. No abstract available.

PMID:
27856869
39.

Do temporal changes in vegetation structure additional to time since fire predict changes in bird occurrence?

Lindenmayer DB, Candy SG, MacGregor CI, Banks SC, Westgate M, Ikin K, Pierson J, Tulloch A, Barton P.

Ecol Appl. 2016 Oct;26(7):2267-2279. doi: 10.1002/eap.1367. Epub 2016 Sep 23.

PMID:
27755726
40.

Consensus Decision Models for Biologics in Rheumatoid and Psoriatic Arthritis: Recommendations of a Multidisciplinary Working Party.

Madan J, Ades T, Barton P, Bojke L, Choy E, Helliwell P, Jobanputra P, Stein K, Stevens A, Tosh J, Verstappen S, Wailoo A.

Rheumatol Ther. 2015 Dec;2(2):113-125. Epub 2015 Nov 25.

41.

The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.

Gómez-Salinero JM, López-Olañeta MM, Ortiz-Sánchez P, Larrasa-Alonso J, Gatto A, Felkin LE, Barton PJR, Navarro-Lérida I, Ángel Del Pozo M, García-Pavía P, Sundararaman B, Giovinazo G, Yeo GW, Lara-Pezzi E.

Cell Chem Biol. 2016 Nov 17;23(11):1372-1382. doi: 10.1016/j.chembiol.2016.09.010. Epub 2016 Oct 13.

42.

Testing and Treating Women after Unsuccessful Conservative Treatments for Overactive Bladder or Mixed Urinary Incontinence: A Model-Based Economic Evaluation Based on the BUS Study.

Goranitis I, Barton P, Middleton LJ, Deeks JJ, Daniels JP, Latthe P, Coomarasamy A, Rachaneni S, McCooty S, Verghese TS, Roberts TE.

PLoS One. 2016 Aug 11;11(8):e0160351. doi: 10.1371/journal.pone.0160351. eCollection 2016.

43.

Dynamic flux balance modeling to increase the production of high-value compounds in green microalgae.

Flassig RJ, Fachet M, Höffner K, Barton PI, Sundmacher K.

Biotechnol Biofuels. 2016 Aug 4;9:165. doi: 10.1186/s13068-016-0556-4. eCollection 2016.

44.

Recovery of Cardiac Function in Cardiomyopathy Caused by Titin Truncation.

Felkin LE, Walsh R, Ware JS, Yacoub MH, Birks EJ, Barton PJ, Cook SA.

JAMA Cardiol. 2016 May 1;1(2):234-5. doi: 10.1001/jamacardio.2016.0208. No abstract available.

45.

Effects of past and present livestock grazing on herpetofauna in a landscape-scale experiment.

Kay GM, Mortelliti A, Tulloch A, Barton P, Florance D, Cunningham SA, Lindenmayer DB.

Conserv Biol. 2017 Apr;31(2):446-458. doi: 10.1111/cobi.12779. Epub 2016 Oct 4.

PMID:
27314208
46.

Cost-effectiveness analysis of different systolic blood pressure targets for people with a history of stroke or transient ischaemic attack: Economic analysis of the PAST-BP study.

Penaloza-Ramos MC, Jowett S, Barton P, Roalfe A, Fletcher K, Taylor CJ, Hobbs FR, McManus RJ, Mant J.

Eur J Prev Cardiol. 2016 Oct;23(15):1590-8. doi: 10.1177/2047487316651982. Epub 2016 May 25.

47.

Temporal trends in mammal responses to fire reveals the complex effects of fire regime attributes.

Lindenmayer DB, Blanchard W, MacGregor C, Barton P, Banks SC, Crane M, Michael D, Okada S, Berry L, Florance D, Gill M.

Ecol Appl. 2016 Mar;26(2):557-73.

PMID:
27209795
48.

Pharmaceutical treatments to prevent recurrence of endometriosis following surgery: a model-based economic evaluation.

Sanghera S, Barton P, Bhattacharya S, Horne AW, Roberts TE; PRE-EMPT research group.

BMJ Open. 2016 Apr 15;6(4):e010580. doi: 10.1136/bmjopen-2015-010580.

49.

Spatiotemporal modeling of microbial metabolism.

Chen J, Gomez JA, Höffner K, Phalak P, Barton PI, Henson MA.

BMC Syst Biol. 2016 Mar 1;10:21. doi: 10.1186/s12918-016-0259-2.

50.

Adjusting Expected Value of Sample Information Using Realistic Expectations around Implementation.

Andronis L, Barton PM.

Med Decis Making. 2016 Apr;36(3):284. doi: 10.1177/0272989X16635131. No abstract available.

PMID:
26929165

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