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Items: 1 to 50 of 441

1.

The consequences of an introgression event.

Barton NH.

Mol Ecol. 2018 Dec;27(24):4973-4975. doi: 10.1111/mec.14950.

PMID:
30599087
2.

Discovery of Potent, Efficient and Selective Inhibitors of Phosphoinositide 3-Kinase δ Through a Deconstruction and Regrowth Approach.

Barton N, Convery MA, Cooper AWJ, Down KD, Hamblin N, Inglis G, Peace S, Rowedder JE, Rowland P, Taylor JA, Wellaway N.

J Med Chem. 2018 Dec 11. doi: 10.1021/acs.jmedchem.8b01556. [Epub ahead of print]

PMID:
30532965
3.

rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial.

Ley D, Hallberg B, Hansen-Pupp I, Dani C, Ramenghi LA, Marlow N, Beardsall K, Bhatti F, Dunger D, Higginson JD, Mahaveer A, Mezu-Ndubuisi OJ, Reynolds P, Giannantonio C, van Weissenbruch M, Barton N, Tocoian A, Hamdani M, Jochim E, Mangili A, Chung JK, Turner MA, Smith LEH, Hellström A; study team.

J Pediatr. 2018 Nov 21. pii: S0022-3476(18)31540-3. doi: 10.1016/j.jpeds.2018.10.033. [Epub ahead of print]

4.

Selection and gene flow shape genomic islands that control floral guides.

Tavares H, Whibley A, Field DL, Bradley D, Couchman M, Copsey L, Elleouet J, Burrus M, Andalo C, Li M, Li Q, Xue Y, Rebocho AB, Barton NH, Coen E.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11006-11011. doi: 10.1073/pnas.1801832115. Epub 2018 Oct 8.

5.

90,000 year-old specialised bone technology in the Aterian Middle Stone Age of North Africa.

Bouzouggar A, Humphrey LT, Barton N, Parfitt SA, Clark Balzan L, Schwenninger JL, El Hajraoui MA, Nespoulet R, Bello SM.

PLoS One. 2018 Oct 3;13(10):e0202021. doi: 10.1371/journal.pone.0202021. eCollection 2018.

6.

Replicability of Introgression Under Linked, Polygenic Selection.

Sachdeva H, Barton NH.

Genetics. 2018 Dec;210(4):1411-1427. doi: 10.1534/genetics.118.301429. Epub 2018 Oct 1.

PMID:
30274989
7.

Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma.

Bu DX, Singh R, Choi EE, Ruella M, Nunez-Cruz S, Mansfield KG, Bennett P, Barton N, Wu Q, Zhang J, Wang Y, Wei L, Cogan S, Ezell T, Joshi S, Latimer KJ, Granda B, Tschantz WR, Young RM, Huet HA, Richardson CJ, Milone MC.

Oncotarget. 2018 May 25;9(40):25764-25780. doi: 10.18632/oncotarget.25359. eCollection 2018 May 25.

8.

Introgression of a Block of Genome Under Infinitesimal Selection.

Sachdeva H, Barton NH.

Genetics. 2018 Aug;209(4):1279-1303. doi: 10.1534/genetics.118.301018. Epub 2018 Jun 12. Erratum in: Genetics. 2018 Dec;210(4):1557.

PMID:
29895560
9.

Evolutionary Pathways for the Generation of New Self-Incompatibility Haplotypes in a Nonself-Recognition System.

Bod'ová K, Priklopil T, Field DL, Barton NH, Pickup M.

Genetics. 2018 Jul;209(3):861-883. doi: 10.1534/genetics.118.300748. Epub 2018 Apr 30.

PMID:
29716955
10.

Efficient inference of paternity and sibship inference given known maternity via hierarchical clustering.

Ellis TJ, Field DL, Barton NH.

Mol Ecol Resour. 2018 Apr 6. doi: 10.1111/1755-0998.12782. [Epub ahead of print]

PMID:
29633531
11.

Tread Lightly Interpreting Polygenic Tests of Selection.

Novembre J, Barton NH.

Genetics. 2018 Apr;208(4):1351-1355. doi: 10.1534/genetics.118.300786. No abstract available. Erratum in: Genetics. 2018 Jun;209(2):627.

12.

From lignin to nylon: Cascaded chemical and biochemical conversion using metabolically engineered Pseudomonas putida.

Kohlstedt M, Starck S, Barton N, Stolzenberger J, Selzer M, Mehlmann K, Schneider R, Pleissner D, Rinkel J, Dickschat JS, Venus J, B J H van Duuren J, Wittmann C.

Metab Eng. 2018 May;47:279-293. doi: 10.1016/j.ymben.2018.03.003. Epub 2018 Mar 14.

PMID:
29548984
13.

Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations.

van de Loosdrecht M, Bouzouggar A, Humphrey L, Posth C, Barton N, Aximu-Petri A, Nickel B, Nagel S, Talbi EH, El Hajraoui MA, Amzazi S, Hublin JJ, Pääbo S, Schiffels S, Meyer M, Haak W, Jeong C, Krause J.

Science. 2018 May 4;360(6388):548-552. doi: 10.1126/science.aar8380. Epub 2018 Mar 15.

PMID:
29545507
14.

CRISPR-based herd immunity can limit phage epidemics in bacterial populations.

Payne P, Geyrhofer L, Barton NH, Bollback JP.

Elife. 2018 Mar 9;7. pii: e32035. doi: 10.7554/eLife.32035.

15.

Estimating Barriers to Gene Flow from Distorted Isolation-by-Distance Patterns.

Ringbauer H, Kolesnikov A, Field DL, Barton NH.

Genetics. 2018 Mar;208(3):1231-1245. doi: 10.1534/genetics.117.300638. Epub 2018 Jan 8.

PMID:
29311149
16.

Cutaneous Hypersensitivity-Like Reactions Associated With Breast Implants: A Review.

Labadie JG, Korta DZ, Barton N, Mesinkovska NA.

Dermatol Surg. 2018 Mar;44(3):323-329. doi: 10.1097/DSS.0000000000001448. Review.

PMID:
29293108
17.

Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116.

Barton N, Horbal L, Starck S, Kohlstedt M, Luzhetskyy A, Wittmann C.

Metab Eng. 2018 Jan;45:200-210. doi: 10.1016/j.ymben.2017.12.001. Epub 2017 Dec 12.

18.

Establishment in a new habitat by polygenic adaptation.

Barton NH, Etheridge AM.

Theor Popul Biol. 2018 Jul;122:110-127. doi: 10.1016/j.tpb.2017.11.007. Epub 2017 Dec 12.

PMID:
29246460
19.

The Spread of an Inversion with Migration and Selection.

Charlesworth B, Barton NH.

Genetics. 2018 Jan;208(1):377-382. doi: 10.1534/genetics.117.300426. Epub 2017 Nov 20.

20.

When Does Frequency-Independent Selection Maintain Genetic Variation?

Novak S, Barton NH.

Genetics. 2017 Oct;207(2):653-668. doi: 10.1534/genetics.117.300129. Epub 2017 Aug 10.

21.

Evolution of new regulatory functions on biophysically realistic fitness landscapes.

Friedlander T, Prizak R, Barton NH, Tkačik G.

Nat Commun. 2017 Aug 9;8(1):216. doi: 10.1038/s41467-017-00238-8.

22.

The infinitesimal model: Definition, derivation, and implications.

Barton NH, Etheridge AM, Véber A.

Theor Popul Biol. 2017 Dec;118:50-73. doi: 10.1016/j.tpb.2017.06.001. Epub 2017 Jul 11. Review.

23.

Identifying Bird Remains Using Ancient DNA Barcoding.

Dalén L, Lagerholm VK, Nylander JAA, Barton N, Bochenski ZM, Tomek T, Rudling D, Ericson PGP, Irestedt M, Stewart JR.

Genes (Basel). 2017 Jun 21;8(6). pii: E169. doi: 10.3390/genes8060169.

24.

The sources of adaptive variation.

Charlesworth D, Barton NH, Charlesworth B.

Proc Biol Sci. 2017 May 31;284(1855). pii: 20162864. doi: 10.1098/rspb.2016.2864. Review.

25.

Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti.

Schmidt TL, Barton NH, Rašić G, Turley AP, Montgomery BL, Iturbe-Ormaetxe I, Cook PE, Ryan PA, Ritchie SA, Hoffmann AA, O'Neill SL, Turelli M.

PLoS Biol. 2017 May 30;15(5):e2001894. doi: 10.1371/journal.pbio.2001894. eCollection 2017 May.

26.

On the mechanistic nature of epistasis in a canonical cis-regulatory element.

Lagator M, Paixão T, Barton NH, Bollback JP, Guet CC.

Elife. 2017 May 18;6. pii: e25192. doi: 10.7554/eLife.25192.

27.

Divergence and evolution of assortative mating in a polygenic trait model of speciation with gene flow.

Sachdeva H, Barton NH.

Evolution. 2017 Jun;71(6):1478-1493. doi: 10.1111/evo.13252. Epub 2017 May 16.

PMID:
28419447
28.

Deploying dengue-suppressing Wolbachia : Robust models predict slow but effective spatial spread in Aedes aegypti.

Turelli M, Barton NH.

Theor Popul Biol. 2017 Jun;115:45-60. doi: 10.1016/j.tpb.2017.03.003. Epub 2017 Apr 12.

29.

Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.

Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J, Phillips T, Swift D, Eaton E.

J Med Chem. 2017 Apr 27;60(8):3405-3421. doi: 10.1021/acs.jmedchem.7b00162. Epub 2017 Apr 17.

PMID:
28368581
30.

Inferring Recent Demography from Isolation by Distance of Long Shared Sequence Blocks.

Ringbauer H, Coop G, Barton NH.

Genetics. 2017 Mar;205(3):1335-1351. doi: 10.1534/genetics.116.196220. Epub 2017 Jan 20.

31.

Gaucher disease: Progress and ongoing challenges.

Mistry PK, Lopez G, Schiffmann R, Barton NW, Weinreb NJ, Sidransky E.

Mol Genet Metab. 2017 Jan - Feb;120(1-2):8-21. doi: 10.1016/j.ymgme.2016.11.006. Epub 2016 Nov 17. Review.

32.

How does epistasis influence the response to selection?

Barton NH.

Heredity (Edinb). 2017 Jan;118(1):96-109. doi: 10.1038/hdy.2016.109. Epub 2016 Nov 30.

33.

Development and verification of a pharmacokinetic model to optimize physiologic replacement of rhIGF-1/rhIGFBP-3 in preterm infants.

Chung JK, Hallberg B, Hansen-Pupp I, Graham MA, Fetterly G, Sharma J, Tocoian A, Kreher NC, Barton N, Hellström A, Ley D.

Pediatr Res. 2017 Mar;81(3):504-510. doi: 10.1038/pr.2016.255. Epub 2016 Nov 21.

PMID:
27870826
34.

Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues.

Desnick RJ, Barton NW, Furbish S, Grabowski GA, Karlsson S, Kolodny EH, Medin JA, Murray GJ, Mistry PK, Patterson MC, Schiffmann R, Weinreb NJ.

Mol Genet Metab. 2017 Jan - Feb;120(1-2):1-7. doi: 10.1016/j.ymgme.2016.10.010. Epub 2016 Nov 12.

PMID:
27866832
35.

Range shifts or extinction? Ancient DNA and distribution modelling reveal past and future responses to climate warming in cold-adapted birds.

Lagerholm VK, Sandoval-Castellanos E, Vaniscotte A, Potapova OR, Tomek T, Bochenski ZM, Shepherd P, Barton N, Van Dyck MC, Miller R, Höglund J, Yoccoz NG, Dalén L, Stewart JR.

Glob Chang Biol. 2017 Apr;23(4):1425-1435. doi: 10.1111/gcb.13522. Epub 2016 Oct 20.

PMID:
27762483
36.

Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.

Amour A, Barton N, Cooper AW, Inglis G, Jamieson C, Luscombe CN, Morrell J, Peace S, Perez D, Rowland P, Tame CJ, Uddin S, Vitulli G, Wellaway N.

J Med Chem. 2016 Oct 27;59(20):9574. Epub 2016 Oct 11. No abstract available.

PMID:
27726364
37.

Reconstruction of Haplotype-Blocks Selected during Experimental Evolution.

Franssen SU, Barton NH, Schlötterer C.

Mol Biol Evol. 2017 Jan;34(1):174-184. doi: 10.1093/molbev/msw210. Epub 2016 Oct 3.

PMID:
27702776
38.

Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.

Amour A, Barton N, Cooper AW, Inglis G, Jamieson C, Luscombe CN, Morrell J, Peace S, Perez D, Rowland P, Tame CJ, Uddin S, Vitulli G, Wellaway N.

J Med Chem. 2016 Sep 8;59(17):8148. doi: 10.1021/acs.jmedchem.6b01157. Epub 2016 Aug 22. No abstract available.

PMID:
27548024
39.

Intrinsic limits to gene regulation by global crosstalk.

Friedlander T, Prizak R, Guet CC, Barton NH, Tkačik G.

Nat Commun. 2016 Aug 4;7:12307. doi: 10.1038/ncomms12307.

40.

Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.

Amour A, Barton N, Cooper AW, Inglis G, Jamieson C, Luscombe CN, Morrell J, Peace S, Perez D, Rowland P, Tame CJ, Uddin S, Vitulli G, Wellaway N.

J Med Chem. 2016 Aug 11;59(15):7239-51. doi: 10.1021/acs.jmedchem.6b00799. Epub 2016 Jul 27. Erratum in: J Med Chem. 2016 Sep 8;59(17 ):8148. J Med Chem. 2016 Oct 27;59(20):9574.

PMID:
27429068
41.

Dynamic Behavior of Engineered Lattice Materials.

Hawreliak JA, Lind J, Maddox B, Barham M, Messner M, Barton N, Jensen BJ, Kumar M.

Sci Rep. 2016 Jun 20;6:28094. doi: 10.1038/srep28094.

42.

Non-progressive Duypytren's disease.

Barton N.

J Hand Surg Eur Vol. 2016 Jun;41(5):564. doi: 10.1177/1753193416632644. No abstract available.

PMID:
27179051
43.

Genomics of hybridization and its evolutionary consequences.

Abbott RJ, Barton NH, Good JM.

Mol Ecol. 2016 Jun;25(11):2325-32. doi: 10.1111/mec.13685. No abstract available.

PMID:
27145128
44.

Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway?

Barton NA, Marsh BJ, Lewis W, Narraidoo N, Seymour GB, Fray R, Hayes CJ.

Chem Sci. 2016 May 1;7(5):3102-3107. doi: 10.1039/c5sc03463a. Epub 2016 Jan 26.

45.

The effect of gene interactions on the long-term response to selection.

Paixão T, Barton NH.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4422-7. doi: 10.1073/pnas.1518830113. Epub 2016 Apr 4.

46.

Richard Hudson and Norman Kaplan on the Coalescent Process.

Barton NH.

Genetics. 2016 Mar;202(3):865-6. doi: 10.1534/genetics.116.187542. No abstract available.

47.

A General Approximation for the Dynamics of Quantitative Traits.

Bod'ová K, Tkačik G, Barton NH.

Genetics. 2016 Apr;202(4):1523-48. doi: 10.1534/genetics.115.184127. Epub 2016 Feb 17.

48.

Sewall Wright on Evolution in Mendelian Populations and the "Shifting Balance".

Barton NH.

Genetics. 2016 Jan;202(1):3-4. doi: 10.1534/genetics.115.184796. No abstract available.

49.

Efficient Strategies for Calculating Blockwise Likelihoods Under the Coalescent.

Lohse K, Chmelik M, Martin SH, Barton NH.

Genetics. 2016 Feb;202(2):775-86. doi: 10.1534/genetics.115.183814. Epub 2015 Dec 29.

50.

Spread of pedigree versus genetic ancestry in spatially distributed populations.

Kelleher J, Etheridge AM, Véber A, Barton NH.

Theor Popul Biol. 2016 Apr;108:1-12. doi: 10.1016/j.tpb.2015.10.008. Epub 2015 Nov 4.

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