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Items: 1 to 50 of 99

1.

Release from UNC93B1 reinforces the compartmentalized activation of select TLRs.

Majer O, Liu B, Woo BJ, Kreuk LSM, Van Dis E, Barton GM.

Nature. 2019 Sep 23. doi: 10.1038/s41586-019-1611-7. [Epub ahead of print]

PMID:
31546247
2.

UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.

Majer O, Liu B, Kreuk LSM, Krogan N, Barton GM.

Nature. 2019 Sep 23. doi: 10.1038/s41586-019-1612-6. [Epub ahead of print]

PMID:
31546246
3.

B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota.

Kreuk LS, Koch MA, Slayden LC, Lind NA, Chu S, Savage HP, Kantor AB, Baumgarth N, Barton GM.

Elife. 2019 Aug 21;8. pii: e47015. doi: 10.7554/eLife.47015.

4.

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis.

Ansaldo E, Slayden LC, Ching KL, Koch MA, Wolf NK, Plichta DR, Brown EM, Graham DB, Xavier RJ, Moon JJ, Barton GM.

Science. 2019 Jun 21;364(6446):1179-1184. doi: 10.1126/science.aaw7479.

PMID:
31221858
5.

Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond.

Roberts AW, Popov LM, Mitchell G, Ching KL, Licht DJ, Golovkine G, Barton GM, Cox JS.

Elife. 2019 Jun 17;8. pii: e45957. doi: 10.7554/eLife.45957.

6.

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns.

Price AE, Shamardani K, Lugo KA, Deguine J, Roberts AW, Lee BL, Barton GM.

Immunity. 2018 Sep 18;49(3):560-575.e6. doi: 10.1016/j.immuni.2018.07.016. Epub 2018 Aug 28.

7.

Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells.

Roberts AW, Lee BL, Deguine J, John S, Shlomchik MJ, Barton GM.

Immunity. 2017 Nov 21;47(5):913-927.e6. doi: 10.1016/j.immuni.2017.10.006. Epub 2017 Nov 14.

8.

Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production.

Deguine J, Wei J, Barbalat R, Gronert K, Barton GM.

J Immunol. 2017 Apr 1;198(7):2865-2875. doi: 10.4049/jimmunol.1601465. Epub 2017 Feb 20.

9.

Nucleic acid-sensing TLRs: trafficking and regulation.

Majer O, Liu B, Barton GM.

Curr Opin Immunol. 2017 Feb;44:26-33. doi: 10.1016/j.coi.2016.10.003. Epub 2016 Nov 28. Review.

10.

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life.

Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM.

Cell. 2016 May 5;165(4):827-41. doi: 10.1016/j.cell.2016.04.055.

11.

Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9.

Newman ZR, Young JM, Ingolia NT, Barton GM.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1362-71. doi: 10.1073/pnas.1518976113. Epub 2016 Feb 22.

12.

MyD88: a central player in innate immune signaling.

Deguine J, Barton GM.

F1000Prime Rep. 2014 Nov 4;6:97. doi: 10.12703/P6-97. eCollection 2014. Review.

13.

Emerging principles governing signal transduction by pattern-recognition receptors.

Kagan JC, Barton GM.

Cold Spring Harb Perspect Biol. 2014 Nov 13;7(3):a016253. doi: 10.1101/cshperspect.a016253. Review.

14.

Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.

Han SJ, Melichar HJ, Coombes JL, Chan SW, Koshy AA, Boothroyd JC, Barton GM, Robey EA.

Immunol Cell Biol. 2014 Nov;92(10):872-81. doi: 10.1038/icb.2014.70. Epub 2014 Aug 26.

15.

Toll-like receptor-deficient mice reveal how innate immune signaling influences Salmonella virulence strategies.

Sivick KE, Arpaia N, Reiner GL, Lee BL, Russell BR, Barton GM.

Cell Host Microbe. 2014 Feb 12;15(2):203-13. doi: 10.1016/j.chom.2014.01.013.

16.

Trafficking of endosomal Toll-like receptors.

Lee BL, Barton GM.

Trends Cell Biol. 2014 Jun;24(6):360-9. doi: 10.1016/j.tcb.2013.12.002. Epub 2014 Jan 15. Review.

17.

TLR5 stops commensals in their tracks.

Koch MA, Barton GM.

Cell Host Microbe. 2013 Nov 13;14(5):488-90. doi: 10.1016/j.chom.2013.10.015.

18.

No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice.

Deguine J, Lee BL, Newman ZR, Barton GM.

Nat Immunol. 2013 Nov;14(11):1101-2. doi: 10.1038/ni.2733. No abstract available.

19.

UNC93B1 mediates differential trafficking of endosomal TLRs.

Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, Barton GM.

Elife. 2013 Feb 19;2:e00291. doi: 10.7554/eLife.00291.

20.

The impact of Toll-like receptors on bacterial virulence strategies.

Arpaia N, Barton GM.

Curr Opin Microbiol. 2013 Feb;16(1):17-22. doi: 10.1016/j.mib.2012.11.004. Epub 2013 Jan 3. Review.

21.

Toll-like receptors: key players in antiviral immunity.

Arpaia N, Barton GM.

Curr Opin Virol. 2011 Dec;1(6):447-54. doi: 10.1016/j.coviro.2011.10.006. Epub 2011 Oct 28. Review.

22.

Cofactors required for TLR7- and TLR9-dependent innate immune responses.

Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK.

Cell Host Microbe. 2012 Mar 15;11(3):306-18. doi: 10.1016/j.chom.2012.02.002.

23.

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.

Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC.

Cell. 2011 Nov 11;147(4):868-80. doi: 10.1016/j.cell.2011.09.051.

24.

Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.

Mouchess ML, Arpaia N, Souza G, Barbalat R, Ewald SE, Lau L, Barton GM.

Immunity. 2011 Nov 23;35(5):721-32. doi: 10.1016/j.immuni.2011.10.009. Epub 2011 Nov 10.

25.

Suppression of TLR9 immunostimulatory motifs in the genome of a gammaherpesvirus.

Pezda AC, Penn A, Barton GM, Coscoy L.

J Immunol. 2011 Jul 15;187(2):887-96. doi: 10.4049/jimmunol.1003737. Epub 2011 Jun 10.

26.

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM.

J Exp Med. 2011 Apr 11;208(4):643-51. doi: 10.1084/jem.20100682. Epub 2011 Mar 14.

27.

TLR signaling is required for Salmonella typhimurium virulence.

Arpaia N, Godec J, Lau L, Sivick KE, McLaughlin LM, Jones MB, Dracheva T, Peterson SN, Monack DM, Barton GM.

Cell. 2011 Mar 4;144(5):675-88. doi: 10.1016/j.cell.2011.01.031.

28.

Nucleic acid recognition by the innate immune system.

Barbalat R, Ewald SE, Mouchess ML, Barton GM.

Annu Rev Immunol. 2011;29:185-214. doi: 10.1146/annurev-immunol-031210-101340. Review.

PMID:
21219183
29.

Nucleic acid sensing Toll-like receptors in autoimmunity.

Ewald SE, Barton GM.

Curr Opin Immunol. 2011 Feb;23(1):3-9. doi: 10.1016/j.coi.2010.11.006. Epub 2010 Dec 14. Review.

30.

Compartment-specific control of signaling from a DNA-sensing immune receptor.

Engel A, Barton GM.

Sci Signal. 2010 Nov 30;3(150):pe45. doi: 10.1126/scisignal.3150pe45. Review.

PMID:
21119105
31.

MicroRNAs and LPS: developing a relationship in the neonatal gut.

Barbalat R, Barton GM.

Cell Host Microbe. 2010 Oct 21;8(4):303-4. doi: 10.1016/j.chom.2010.10.001.

32.

Unfolding new roles for XBP1 in immunity.

Engel A, Barton GM.

Nat Immunol. 2010 May;11(5):365-7. doi: 10.1038/ni0510-365. No abstract available.

PMID:
20404847
33.

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands.

Barbalat R, Lau L, Locksley RM, Barton GM.

Nat Immunol. 2009 Nov;10(11):1200-7. doi: 10.1038/ni.1792. Epub 2009 Oct 4. Erratum in: Nat Immunol. 2010 Jun;11(6):543.

34.

A cell biological view of Toll-like receptor function: regulation through compartmentalization.

Barton GM, Kagan JC.

Nat Rev Immunol. 2009 Aug;9(8):535-42. doi: 10.1038/nri2587. Epub 2009 Jun 26. Review.

35.

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM.

Nature. 2008 Dec 4;456(7222):658-62. doi: 10.1038/nature07405. Epub 2008 Sep 28.

36.

A mechanism for the initiation of allergen-induced T helper type 2 responses.

Sokol CL, Barton GM, Farr AG, Medzhitov R.

Nat Immunol. 2008 Mar;9(3):310-8. doi: 10.1038/ni1558.

37.

A calculated response: control of inflammation by the innate immune system.

Barton GM.

J Clin Invest. 2008 Feb;118(2):413-20. doi: 10.1172/JCI34431. Review.

38.

Viral recognition by Toll-like receptors.

Barton GM.

Semin Immunol. 2007 Feb;19(1):33-40. Epub 2007 Mar 2. Review.

PMID:
17336545
39.

What happens when the harassment is personal?

Barton GM, Morrison E.

J Med Pract Manage. 2006 Jan-Feb;21(4):211-4.

PMID:
16562522
40.

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

Barton GM, Kagan JC, Medzhitov R.

Nat Immunol. 2006 Jan;7(1):49-56. Epub 2005 Dec 11.

PMID:
16341217
41.

Toll signaling: RIPping off the TNF pathway.

Barton GM, Medzhitov R.

Nat Immunol. 2004 May;5(5):472-4. No abstract available.

PMID:
15116112
42.

Toll-like receptor signaling pathways.

Barton GM, Medzhitov R.

Science. 2003 Jun 6;300(5625):1524-5.

PMID:
12791976
43.

Linking Toll-like receptors to IFN-alpha/beta expression.

Barton GM, Medzhitov R.

Nat Immunol. 2003 May;4(5):432-3. No abstract available.

PMID:
12719735
44.

Toll-like receptors and their ligands.

Barton GM, Medzhitov R.

Curr Top Microbiol Immunol. 2002;270:81-92. Review.

PMID:
12467245
45.

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Horng T, Barton GM, Flavell RA, Medzhitov R.

Nature. 2002 Nov 21;420(6913):329-33.

PMID:
12447442
46.

Retroviral delivery of small interfering RNA into primary cells.

Barton GM, Medzhitov R.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14943-5. Epub 2002 Nov 4.

47.

Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes.

Barton GM, Beers C, deRoos P, Eastman SR, Gomez ME, Forbush KA, Rudensky AY.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6937-42.

48.

Control of adaptive immune responses by Toll-like receptors.

Barton GM, Medzhitov R.

Curr Opin Immunol. 2002 Jun;14(3):380-3. Review.

PMID:
11973138
49.

Toll-like receptors control activation of adaptive immune responses.

Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R.

Nat Immunol. 2001 Oct;2(10):947-50.

PMID:
11547333
50.

TIRAP: an adapter molecule in the Toll signaling pathway.

Horng T, Barton GM, Medzhitov R.

Nat Immunol. 2001 Sep;2(9):835-41.

PMID:
11526399

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