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Inframe deletion of human ESPN is associated with deafness, vestibulopathy and vision impairment.

Ahmed ZM, Jaworek TJ, Sarangdhar GN, Zheng L, Gul K, Khan SN, Friedman TB, Sisk RA, Bartles JR, Riazuddin S, Riazuddin S.

J Med Genet. 2018 Jul;55(7):479-488. doi: 10.1136/jmedgenet-2017-105221. Epub 2018 Mar 23.


Fascin- and α-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting.

Winkelman JD, Suarez C, Hocky GM, Harker AJ, Morganthaler AN, Christensen JR, Voth GA, Bartles JR, Kovar DR.

Curr Biol. 2016 Oct 24;26(20):2697-2706. doi: 10.1016/j.cub.2016.07.080. Epub 2016 Sep 22.


Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espin.

Zheng L, Beeler DM, Bartles JR.

J Cell Sci. 2015 Jun 1;128(11):2208. doi: 10.1242/jcs.174052. No abstract available.


Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espin.

Zheng L, Beeler DM, Bartles JR.

J Cell Sci. 2014 Mar 15;127(Pt 6):1306-17. doi: 10.1242/jcs.143255. Epub 2014 Jan 14. Erratum in: J Cell Sci. 2015 Jun 1;128(11):2208.


Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice.

Sekerková G, Richter CP, Bartles JR.

PLoS Genet. 2011 Mar;7(3):e1002032. doi: 10.1371/journal.pgen.1002032. Epub 2011 Mar 24.


Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing.

Kitajiri S, Sakamoto T, Belyantseva IA, Goodyear RJ, Stepanyan R, Fujiwara I, Bird JE, Riazuddin S, Riazuddin S, Ahmed ZM, Hinshaw JE, Sellers J, Bartles JR, Hammer JA 3rd, Richardson GP, Griffith AJ, Frolenkov GI, Friedman TB.

Cell. 2010 May 28;141(5):786-98. doi: 10.1016/j.cell.2010.03.049.


Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.

Zheng L, Zheng J, Whitlon DS, García-Añoveros J, Bartles JR.

J Neurosci. 2010 May 26;30(21):7187-201. doi: 10.1523/JNEUROSCI.0852-10.2010.


Cooperativity and frustration in protein-mediated parallel actin bundles.

Shin H, Purdy Drew KR, Bartles JR, Wong GC, Grason GM.

Phys Rev Lett. 2009 Dec 4;103(23):238102. Epub 2009 Nov 30.


Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.

Odeh H, Hunker KL, Belyantseva IA, Azaiez H, Avenarius MR, Zheng L, Peters LM, Gagnon LH, Hagiwara N, Skynner MJ, Brilliant MH, Allen ND, Riazuddin S, Johnson KR, Raphael Y, Najmabadi H, Friedman TB, Bartles JR, Smith RJ, Kohrman DC.

Am J Hum Genet. 2010 Feb 12;86(2):148-60. doi: 10.1016/j.ajhg.2010.01.016. Epub 2010 Feb 4.


Structural and viscoelastic properties of actin networks formed by espin or pathologically relevant espin mutants.

Lieleg O, Schmoller KM, Purdy Drew KR, Claessens MM, Semmrich C, Zheng L, Bartles JR, Bausch AR.

Chemphyschem. 2009 Nov 9;10(16):2813-7. doi: 10.1002/cphc.200900604.


Espin actin-cytoskeletal proteins are in rat type I spiral ganglion neurons and include splice-isoforms with a functional nuclear localization signal.

Sekerková G, Zheng L, Mugnaini E, Bartles JR.

J Comp Neurol. 2008 Aug 20;509(6):661-76. doi: 10.1002/cne.21755.


The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.

Nagata K, Zheng L, Madathany T, Castiglioni AJ, Bartles JR, García-Añoveros J.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):353-8. Epub 2007 Dec 27.


Microvillar size and espin expression in principal cells of the adult rat epididymis are regulated by androgens.

Primiani N, Gregory M, Dufresne J, Smith CE, Liu YL, Bartles JR, Cyr DG, Hermo L.

J Androl. 2007 Sep-Oct;28(5):659-69. Epub 2007 Apr 4.


Structural polymorphism of the actin-espin system: a prototypical system of filaments and linkers in stereocilia.

Purdy KR, Bartles JR, Wong GC.

Phys Rev Lett. 2007 Feb 2;98(5):058105. Epub 2007 Feb 1.


Postsynaptic enrichment of Eps8 at dendritic shaft synapses of unipolar brush cells in rat cerebellum.

Sekerková G, Diño MR, Ilijic E, Russo M, Zheng L, Bartles JR, Mugnaini E.

Neuroscience. 2007 Mar 2;145(1):116-29. Epub 2007 Jan 16.


Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli.

Sekerková G, Zheng L, Loomis PA, Mugnaini E, Bartles JR.

Cell Mol Life Sci. 2006 Oct;63(19-20):2329-41. Review.


Espin cytoskeletal proteins in the sensory cells of rodent taste buds.

Sekerková G, Freeman D, Mugnaini E, Bartles JR.

J Neurocytol. 2005 Sep;34(3-5):171-82. Epub 2006 Jul 13.


FSH regulates the formation of adherens junctions and ectoplasmic specialisations between rat Sertoli cells in vitro and in vivo.

Sluka P, O'Donnell L, Bartles JR, Stanton PG.

J Endocrinol. 2006 May;189(2):381-95.


Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells.

Loomis PA, Kelly AE, Zheng L, Changyaleket B, Sekerková G, Mugnaini E, Ferreira A, Mullins RD, Bartles JR.

J Cell Sci. 2006 Apr 15;119(Pt 8):1655-65. Epub 2006 Mar 28.


Balanced levels of Espin are critical for stereociliary growth and length maintenance.

Rzadzinska A, Schneider M, Noben-Trauth K, Bartles JR, Kachar B.

Cell Motil Cytoskeleton. 2005 Nov;62(3):157-65.


Espin gene (ESPN) mutations associated with autosomal dominant hearing loss cause defects in microvillar elongation or organisation.

Donaudy F, Zheng L, Ficarella R, Ballana E, Carella M, Melchionda S, Estivill X, Bartles JR, Gasparini P.

J Med Genet. 2006 Feb;43(2):157-61. Epub 2005 Jun 1.


Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells.

Sekerková G, Zheng L, Loomis PA, Changyaleket B, Whitlon DS, Mugnaini E, Bartles JR.

J Neurosci. 2004 Jun 9;24(23):5445-56.


Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo.

Loomis PA, Zheng L, Sekerková G, Changyaleket B, Mugnaini E, Bartles JR.

J Cell Biol. 2003 Dec 8;163(5):1045-55. Epub 2003 Dec 1.


Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.

Sekerková G, Loomis PA, Changyaleket B, Zheng L, Eytan R, Chen B, Mugnaini E, Bartles JR.

J Neurosci. 2003 Feb 15;23(4):1310-9.


The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.

Zheng L, Sekerková G, Vranich K, Tilney LG, Mugnaini E, Bartles JR.

Cell. 2000 Aug 4;102(3):377-85.


Sertoli cell ectoplasmic specializations in the seminiferous epithelium of the testosterone-suppressed adult rat.

O'Donnell L, Stanton PG, Bartles JR, Robertson DM.

Biol Reprod. 2000 Jul;63(1):99-108.


Parallel actin bundles and their multiple actin-bundling proteins.

Bartles JR.

Curr Opin Cell Biol. 2000 Feb;12(1):72-8. Review.


Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.

Bartles JR, Zheng L, Li A, Wierda A, Chen B.

J Cell Biol. 1998 Oct 5;143(1):107-19.


The spermatid plasma membrane comes of age.

Bartles JR.

Trends Cell Biol. 1995 Oct;5(10):400-4.


Decreases in the relative concentrations of specific hepatocyte plasma membrane proteins during liver regeneration: down-regulation or dilution?

Bartles JR, Zhang LQ, Verheyen EM, Hospodar KS, Nehme CL, Fayos BE.

Dev Biol. 1991 Feb;143(2):258-70.


Expression and compartmentalization of integral plasma membrane proteins by hepatocytes and their progenitors in the rat pancreas.

Bartles JR, Rao MS, Zhang LQ, Fayos BE, Nehme CL, Reddy JK.

J Cell Sci. 1991 Jan;98 ( Pt 1):45-54.


Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.

Bartles JR, Khuon S, Lin XH, Zhang LQ, Reddy JK, Rao MS, Isoye ST, Nehme CL, Fayos BE.

Cancer Res. 1990 Feb 1;50(3):669-76.


Biogenesis of the rat hepatocyte plasma membrane.

Bartles JR, Hubbard AL.

Methods Enzymol. 1990;191:825-41. No abstract available.


Biogenesis of endogenous plasma membrane proteins in epithelial cells.

Hubbard AL, Stieger B, Bartles JR.

Annu Rev Physiol. 1989;51:755-70. Review. No abstract available.


Plasma membrane protein sorting in epithelial cells: do secretory pathways hold the key?

Bartles JR, Hubbard AL.

Trends Biochem Sci. 1988 May;13(5):181-4. No abstract available.


Immuno-isolation of hepatocyte membrane compartments using S. aureus cells.

Hubbard AL, Dunn WA, Mueller SC, Bartles JR.

Prog Clin Biol Res. 1988;270:115-27. No abstract available.


Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane.

Bartles JR, Braiterman LT, Hubbard AL.

J Biol Chem. 1985 Oct 15;260(23):12792-802.


Identification of rat hepatocyte plasma membrane proteins using monoclonal antibodies.

Hubbard AL, Bartles JR, Braiterman LT.

J Cell Biol. 1985 Apr;100(4):1115-25.


Endogenous and exogenous domain markers of the rat hepatocyte plasma membrane.

Bartles JR, Braiterman LT, Hubbard AL.

J Cell Biol. 1985 Apr;100(4):1126-38.

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