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Items: 1 to 50 of 78

1.

Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin.

Fudim R, Szczepek M, Vierock J, Vogt A, Schmidt A, Kleinau G, Fischer P, Bartl F, Scheerer P, Hegemann P.

Sci Signal. 2019 Mar 19;12(573). pii: eaav4203. doi: 10.1126/scisignal.aav4203.

PMID:
30890657
2.

Synthesis, docking and antibacterial studies of more potent amine and hydrazone rifamycin congeners than rifampicin.

Pyta K, Janas A, Szukowska M, Pecyna P, Jaworska M, Gajecka M, Bartl F, Przybylski P.

Eur J Med Chem. 2019 Apr 1;167:96-104. doi: 10.1016/j.ejmech.2019.02.009. Epub 2019 Feb 4.

PMID:
30769243
3.

Tracking Pore Hydration in Channelrhodopsin by Site-Directed Infrared-Active Azido Probes.

Krause BS, Kaufmann JCD, Kuhne J, Vierock J, Huber T, Sakmar TP, Gerwert K, Bartl FJ, Hegemann P.

Biochemistry. 2019 Mar 5;58(9):1275-1286. doi: 10.1021/acs.biochem.8b01211. Epub 2019 Feb 19.

PMID:
30702875
4.

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

Majcher U, Klejborowska G, Moshari M, Maj E, Wietrzyk J, Bartl F, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 1;7(11). pii: E192. doi: 10.3390/cells7110192.

5.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.

Bioorg Chem. 2018 Dec;81:553-566. doi: 10.1016/j.bioorg.2018.09.004. Epub 2018 Sep 12.

PMID:
30248507
6.

The arrestin-1 finger loop interacts with two distinct conformations of active rhodopsin.

Elgeti M, Kazmin R, Rose AS, Szczepek M, Hildebrand PW, Bartl FJ, Scheerer P, Hofmann KP.

J Biol Chem. 2018 Mar 23;293(12):4403-4410. doi: 10.1074/jbc.M117.817890. Epub 2018 Jan 23.

7.

Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function.

Kaufmann JCD, Krause BS, Grimm C, Ritter E, Hegemann P, Bartl FJ.

J Biol Chem. 2017 Aug 25;292(34):14205-14216. doi: 10.1074/jbc.M117.779629. Epub 2017 Jun 28.

8.

Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR.

Krause BS, Grimm C, Kaufmann JCD, Schneider F, Sakmar TP, Bartl FJ, Hegemann P.

Biophys J. 2017 Mar 28;112(6):1166-1175. doi: 10.1016/j.bpj.2017.02.001.

9.

16-Membered Macrolide Lactone Derivatives Bearing a Triazole-Functionalized Arm at the Aglycone C13 Position as Antibacterial and Anticancer Agents.

Domagalska J, Janas A, Pyta K, Pecyna P, Ruszkowski P, Celewicz L, Gajecka M, Bartl F, Przybylski P.

ChemMedChem. 2016 Sep 6;11(17):1886-91. doi: 10.1002/cmdc.201600250. Epub 2016 Jul 14.

PMID:
27411730
10.

Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives.

Huczyński A, Majcher U, Maj E, Wietrzyk J, Janczak J, Moshari M, Tuszynski JA, Bartl F.

Bioorg Chem. 2016 Feb;64:103-12. doi: 10.1016/j.bioorg.2016.01.002. Epub 2016 Jan 12.

PMID:
26794327
11.

Time-resolved infrared spectroscopic techniques as applied to channelrhodopsin.

Ritter E, Puskar L, Bartl FJ, Aziz EF, Hegemann P, Schade U.

Front Mol Biosci. 2015 Jul 7;2:38. doi: 10.3389/fmolb.2015.00038. eCollection 2015. Review.

12.

The Activation Pathway of Human Rhodopsin in Comparison to Bovine Rhodopsin.

Kazmin R, Rose A, Szczepek M, Elgeti M, Ritter E, Piechnick R, Hofmann KP, Scheerer P, Hildebrand PW, Bartl FJ.

J Biol Chem. 2015 Aug 14;290(33):20117-27. doi: 10.1074/jbc.M115.652172. Epub 2015 Jun 23.

13.

Spectroscopic studies of the equilibrium between complexes of lasalocid acid with propargylamine and metal cations.

Rutkowski J, Huczyński A, Ratajczak-Sitarz M, Katrusiak A, Brzezinski B, Bartl F.

Spectrochim Acta A Mol Biomol Spectrosc. 2015;150:704-11. doi: 10.1016/j.saa.2015.05.099. Epub 2015 Jun 9.

PMID:
26093967
14.

A protonation-coupled feedback mechanism controls the signalling process in bathy phytochromes.

Velazquez Escobar F, Piwowarski P, Salewski J, Michael N, Fernandez Lopez M, Rupp A, Qureshi BM, Scheerer P, Bartl F, Frankenberg-Dinkel N, Siebert F, Andrea Mroginski M, Hildebrandt P.

Nat Chem. 2015 May;7(5):423-30. doi: 10.1038/nchem.2225. Epub 2015 Apr 13.

PMID:
25901821
15.

Formation and decay of the arrestin·rhodopsin complex in native disc membranes.

Beyrière F, Sommer ME, Szczepek M, Bartl FJ, Hofmann KP, Heck M, Ritter E.

J Biol Chem. 2015 May 15;290(20):12919-28. doi: 10.1074/jbc.M114.620898. Epub 2015 Apr 6.

16.

Regioselective long-range proton transfer in new rifamycin antibiotics: a process in which crown ethers act as stronger Brønsted bases than amines.

Pyta K, Przybylski P, Bartl F.

Chemphyschem. 2015 Apr 7;16(5):938-42. doi: 10.1002/cphc.201402892. Epub 2015 Jan 29.

PMID:
25639734
17.

Early formation of the ion-conducting pore in channelrhodopsin-2.

Kuhne J, Eisenhauer K, Ritter E, Hegemann P, Gerwert K, Bartl F.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4953-7. doi: 10.1002/anie.201410180. Epub 2014 Dec 23.

PMID:
25537168
18.

Synthesis, antiproliferative and antibacterial evaluation of C-ring modified colchicine analogues.

Huczyński A, Rutkowski J, Popiel K, Maj E, Wietrzyk J, Stefańska J, Majcher U, Bartl F.

Eur J Med Chem. 2015 Jan 27;90:296-301. doi: 10.1016/j.ejmech.2014.11.037. Epub 2014 Nov 22.

PMID:
25437616
19.

Crystal structure of a common GPCR-binding interface for G protein and arrestin.

Szczepek M, Beyrière F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P.

Nat Commun. 2014 Sep 10;5:4801. doi: 10.1038/ncomms5801.

20.

Precision vs flexibility in GPCR signaling.

Elgeti M, Rose AS, Bartl FJ, Hildebrand PW, Hofmann KP, Heck M.

J Am Chem Soc. 2013 Aug 21;135(33):12305-12. doi: 10.1021/ja405133k. Epub 2013 Aug 9.

PMID:
23883288
21.

Structure of the biliverdin cofactor in the Pfr state of bathy and prototypical phytochromes.

Salewski J, Escobar FV, Kaminski S, von Stetten D, Keidel A, Rippers Y, Michael N, Scheerer P, Piwowarski P, Bartl F, Frankenberg-Dinkel N, Ringsdorf S, Gärtner W, Lamparter T, Mroginski MA, Hildebrandt P.

J Biol Chem. 2013 Jun 7;288(23):16800-14. doi: 10.1074/jbc.M113.457531. Epub 2013 Apr 19.

22.

Light-dark adaptation of channelrhodopsin C128T mutant.

Ritter E, Piwowarski P, Hegemann P, Bartl FJ.

J Biol Chem. 2013 Apr 12;288(15):10451-8. doi: 10.1074/jbc.M112.446427. Epub 2013 Feb 25.

23.

Synthesis, FT-IR, ¹H, ¹³CNMR, ESI MS and PM5 studies of a new Mannich base of polyether antibiotic - Lasalocid acid and its complexes with Li⁺, Na⁺ and K⁺ cations.

Huczyński A, Rutkowski J, Brzezinski B, Bartl F.

Spectrochim Acta A Mol Biomol Spectrosc. 2013 Mar;104:497-504. doi: 10.1016/j.saa.2012.11.106. Epub 2012 Dec 8.

PMID:
23287734
24.

In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle.

Eisenhauer K, Kuhne J, Ritter E, Berndt A, Wolf S, Freier E, Bartl F, Hegemann P, Gerwert K.

J Biol Chem. 2012 Feb 24;287(9):6904-11. doi: 10.1074/jbc.M111.327700. Epub 2012 Jan 4.

25.

Conserved Tyr223(5.58) plays different roles in the activation and G-protein interaction of rhodopsin.

Elgeti M, Kazmin R, Heck M, Morizumi T, Ritter E, Scheerer P, Ernst OP, Siebert F, Hofmann KP, Bartl FJ.

J Am Chem Soc. 2011 May 11;133(18):7159-65. doi: 10.1021/ja200545n. Epub 2011 Apr 20.

PMID:
21506561
26.

Reinvestigation of the structure of monensin A phenylurethane sodium salt based on X-ray crystallographic and spectroscopic studies, and its activity against hospital strains of methicillin-resistant S. epidermidis and S. aureus.

Huczyński A, Ratajczak-Sitarz M, Stefańska J, Katrusiak A, Brzezinski B, Bartl F.

J Antibiot (Tokyo). 2011 Mar;64(3):249-56. doi: 10.1038/ja.2010.167. Epub 2011 Jan 12.

PMID:
21224863
27.

The branched photocycle of the slow-cycling channelrhodopsin-2 mutant C128T.

Stehfest K, Ritter E, Berndt A, Bartl F, Hegemann P.

J Mol Biol. 2010 May 21;398(5):690-702. doi: 10.1016/j.jmb.2010.03.031. Epub 2010 Mar 25.

PMID:
20346954
28.

Light-induced activation of bacterial phytochrome Agp1 monitored by static and time-resolved FTIR spectroscopy.

Piwowarski P, Ritter E, Hofmann KP, Hildebrandt P, von Stetten D, Scheerer P, Michael N, Lamparter T, Bartl F.

Chemphyschem. 2010 Apr 26;11(6):1207-14. doi: 10.1002/cphc.200901008.

PMID:
20333618
29.

Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin.

Przybylski P, Pyta K, Stefańska J, Brzezinski B, Bartl F.

Magn Reson Chem. 2010 Apr;48(4):286-96. doi: 10.1002/mrc.2574.

PMID:
20186698
30.

Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini.

Przybylski P, Pyta K, Remlein-Starosta D, Schroeder G, Brzezinski B, Bartl F.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1996-2000. doi: 10.1016/j.bmcl.2009.02.051. Epub 2009 Feb 20.

PMID:
19264482
31.
32.

Monitoring light-induced structural changes of Channelrhodopsin-2 by UV-visible and Fourier transform infrared spectroscopy.

Ritter E, Stehfest K, Berndt A, Hegemann P, Bartl FJ.

J Biol Chem. 2008 Dec 12;283(50):35033-41. doi: 10.1074/jbc.M806353200. Epub 2008 Oct 16.

33.

Molecular structures and stability constants of gossypol and its aza-derivative complexes with silver(I) cations studied by potentiometric, ESI MS, NMR, and AM1d semiempirical methods.

Przybylski P, Kira J, Schroeder G, Brzezinski B, Bartl F.

J Phys Chem A. 2008 Sep 4;112(35):8061-9. doi: 10.1021/jp8043434. Epub 2008 Aug 13.

PMID:
18698745
34.

Activity switches of rhodopsin.

Ritter E, Elgeti M, Bartl FJ.

Photochem Photobiol. 2008 Jul-Aug;84(4):911-20. doi: 10.1111/j.1751-1097.2008.00324.x. Epub 2008 Apr 18. Review.

PMID:
18422873
35.

Synthesis and antimicrobial properties of monensin A esters.

Huczyński A, Stefańska J, Przybylski P, Brzezinski B, Bartl F.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2585-9. doi: 10.1016/j.bmcl.2008.03.038. Epub 2008 Mar 16.

PMID:
18375122
36.

CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state.

Przybylski P, Schilf W, Kamienski B, Brzezinski B, Bartl F.

Magn Reson Chem. 2008 Jun;46(6):534-44. doi: 10.1002/mrc.2210.

PMID:
18338327
37.

Structural and functional properties of metarhodopsin III: recent spectroscopic studies on deactivation pathways of rhodopsin.

Bartl FJ, Vogel R.

Phys Chem Chem Phys. 2007 Apr 14;9(14):1648-58. Epub 2007 Jan 10. Review.

PMID:
17396175
38.
39.

Spectroscopic and semiempirical studies of a proton channel formed by the methyl ester of monensin A.

Huczyñski A, Przybylski P, Brzezinski B, Bartl F.

J Phys Chem B. 2006 Aug 10;110(31):15615-23.

PMID:
16884286
40.
41.
42.
43.

Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation.

Bartl FJ, Fritze O, Ritter E, Herrmann R, Kuksa V, Palczewski K, Hofmann KP, Ernst OP.

J Biol Chem. 2005 Oct 7;280(40):34259-67. Epub 2005 Jul 18.

44.

Hassallidin A, a glycosylated lipopeptide with antifungal activity from the cyanobacterium Hassallia sp.

Neuhof T, Schmieder P, Preussel K, Dieckmann R, Pham H, Bartl F, von Döhren H.

J Nat Prod. 2005 May;68(5):695-700.

PMID:
15921412
45.

Interaction with transducin depletes metarhodopsin III: a regulated retinal storage in visual signal transduction?

Zimmermann K, Ritter E, Bartl FJ, Hofmann KP, Heck M.

J Biol Chem. 2004 Nov 12;279(46):48112-9. Epub 2004 Aug 20.

46.

Transition of rhodopsin into the active metarhodopsin II state opens a new light-induced pathway linked to Schiff base isomerization.

Ritter E, Zimmermann K, Heck M, Hofmann KP, Bartl FJ.

J Biol Chem. 2004 Nov 12;279(46):48102-11. Epub 2004 Aug 20.

48.

Rapid purification and crystal structure analysis of a small protein carrying two terminal affinity tags.

Mueller U, Büssow K, Diehl A, Bartl FJ, Niesen FH, Nyarsik L, Heinemann U.

J Struct Funct Genomics. 2003;4(4):217-25.

PMID:
15185962
49.
50.

Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II.

Heck M, Schädel SA, Maretzki D, Bartl FJ, Ritter E, Palczewski K, Hofmann KP.

J Biol Chem. 2003 Jan 31;278(5):3162-9. Epub 2002 Nov 9.

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