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Items: 42

1.

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response.

Giaimo BD, Ferrante F, Vallejo DM, Hein K, Gutierrez-Perez I, Nist A, Stiewe T, Mittler G, Herold S, Zimmermann T, Bartkuhn M, Schwarz P, Oswald F, Dominguez M, Borggrefe T.

Nucleic Acids Res. 2018 Jul 9. doi: 10.1093/nar/gky551. [Epub ahead of print]

PMID:
29986055
2.

Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference.

Bergmaier P, Weth O, Dienstbach S, Boettger T, Galjart N, Mernberger M, Bartkuhn M, Renkawitz R.

Nucleic Acids Res. 2018 May 31. doi: 10.1093/nar/gky483. [Epub ahead of print]

PMID:
29860503
3.

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Xu T, Park SS, Giaimo BD, Hall D, Ferrante F, Ho DM, Hori K, Anhezini L, Ertl I, Bartkuhn M, Zhang H, Milon E, Ha K, Conlon KP, Kuick R, Govindarajoo B, Zhang Y, Sun Y, Dou Y, Basrur V, Elenitoba-Johnson KS, Nesvizhskii AI, Ceron J, Lee CY, Borggrefe T, Kovall RA, Rual JF.

EMBO J. 2017 Nov 2;36(21):3232-3249. doi: 10.15252/embj.201796525. Epub 2017 Oct 13.

4.

Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation.

Jox T, Buxa MK, Bohla D, Ullah I, Mačinković I, Brehm A, Bartkuhn M, Renkawitz R.

Epigenetics Chromatin. 2017 Jul 4;10:32. doi: 10.1186/s13072-017-0140-6. eCollection 2017.

5.

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer.

Kiehl S, Zimmermann T, Savai R, Pullamsetti SS, Seeger W, Bartkuhn M, Dammann RH.

Sci Rep. 2017 Jun 20;7(1):3896. doi: 10.1038/s41598-017-04248-w.

6.

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation.

Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F.

Leukemia. 2017 Nov;31(11):2491-2502. doi: 10.1038/leu.2017.105. Epub 2017 Mar 31.

7.

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells.

Poppe M, Wittig S, Jurida L, Bartkuhn M, Wilhelm J, Müller H, Beuerlein K, Karl N, Bhuju S, Ziebuhr J, Schmitz ML, Kracht M.

PLoS Pathog. 2017 Mar 29;13(3):e1006286. doi: 10.1371/journal.ppat.1006286. eCollection 2017 Mar.

8.

H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements.

Zink LM, Delbarre E, Eberl HC, Keilhauer EC, Bönisch C, Pünzeler S, Bartkuhn M, Collas P, Mann M, Hake SB.

Nucleic Acids Res. 2017 Jun 2;45(10):5691-5706. doi: 10.1093/nar/gkx131.

9.

tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation.

Theofel I, Bartkuhn M, Boettger T, Gärtner SMK, Kreher J, Brehm A, Rathke C.

Biol Open. 2017 Apr 15;6(4):439-448. doi: 10.1242/bio.022467.

10.

Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190.

Ali T, Krüger M, Bhuju S, Jarek M, Bartkuhn M, Renkawitz R.

Nucleic Acids Res. 2017 Mar 17;45(5):2384-2395. doi: 10.1093/nar/gkw1178.

11.

Murine and Human Spermatids Are Characterized by Numerous, Newly Synthesized and Differentially Expressed Transcription Factors and Bromodomain-Containing Proteins.

Klaus ES, Gonzalez NH, Bergmann M, Bartkuhn M, Weidner W, Kliesch S, Rathke C.

Biol Reprod. 2016 Jul;95(1):4. doi: 10.1095/biolreprod.115.137620. Epub 2016 May 11.

PMID:
27170439
12.

Insulators and domains of gene expression.

Ali T, Renkawitz R, Bartkuhn M.

Curr Opin Genet Dev. 2016 Apr;37:17-26. doi: 10.1016/j.gde.2015.11.009. Epub 2016 Jan 20. Review.

13.

Sepsis induces specific changes in histone modification patterns in human monocytes.

Weiterer S, Uhle F, Lichtenstern C, Siegler BH, Bhuju S, Jarek M, Bartkuhn M, Weigand MA.

PLoS One. 2015 Mar 20;10(3):e0121748. doi: 10.1371/journal.pone.0121748. eCollection 2015.

14.

The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.

Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M.

Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00002-9. doi: 10.1016/j.celrep.2015.01.001. [Epub ahead of print]

15.

[Epigenetic regulation in sepsis : current state of knowledge].

Weiterer S, Uhle F, Siegler BH, Lichtenstern C, Bartkuhn M, Weigand MA.

Anaesthesist. 2015 Jan;64(1):42-55. doi: 10.1007/s00101-014-2402-z. Review. German.

PMID:
25471356
16.

Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin.

Maksimenko O, Bartkuhn M, Stakhov V, Herold M, Zolotarev N, Jox T, Buxa MK, Kirsch R, Bonchuk A, Fedotova A, Kyrchanova O, Renkawitz R, Georgiev P.

Genome Res. 2015 Jan;25(1):89-99. doi: 10.1101/gr.174169.114. Epub 2014 Oct 23.

17.

tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.

Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner SM, Leser K, Awe S, Schipper M, Renkawitz-Pohl R, Rathke C.

PLoS One. 2014 Sep 24;9(9):e108267. doi: 10.1371/journal.pone.0108267. eCollection 2014.

18.

A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking.

Bohla D, Herold M, Panzer I, Buxa MK, Ali T, Demmers J, Krüger M, Scharfe M, Jarek M, Bartkuhn M, Renkawitz R.

PLoS One. 2014 Sep 23;9(9):e107765. doi: 10.1371/journal.pone.0107765. eCollection 2014.

19.

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M.

Nature. 2014 Jul 24;511(7510):483-7. doi: 10.1038/nature13473. Epub 2014 Jul 9. Erratum in: Nature. 2014 Dec 18;516(7531):440.

PMID:
25043018
20.

H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat.

Dottermusch-Heidel C, Gärtner SM, Tegeder I, Rathke C, Barckmann B, Bartkuhn M, Bhushan S, Steger K, Meinhardt A, Renkawitz-Pohl R.

Biol Open. 2014 May 2;3(6):444-52. doi: 10.1242/bio.20147302.

21.

From human monocytes to genome-wide binding sites--a protocol for small amounts of blood: monocyte isolation/ChIP-protocol/library amplification/genome wide computational data analysis.

Weiterer S, Uhle F, Bhuju S, Jarek M, Weigand MA, Bartkuhn M.

PLoS One. 2014 Apr 14;9(4):e94164. doi: 10.1371/journal.pone.0094164. eCollection 2014.

22.

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V.

Cancer Discov. 2014 Jun;4(6):688-701. doi: 10.1158/2159-8290.CD-13-0593. Epub 2014 Apr 2.

23.

Ectopically tethered CP190 induces large-scale chromatin decondensation.

Ahanger SH, Günther K, Weth O, Bartkuhn M, Bhonde RR, Shouche YS, Renkawitz R.

Sci Rep. 2014 Jan 29;4:3917. doi: 10.1038/srep03917.

24.

Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.

Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M.

Mol Cell. 2014 Jan 23;53(2):193-208. doi: 10.1016/j.molcel.2013.12.002. Epub 2014 Jan 2. Erratum in: Mol Cell. 2014 Feb 20;53(4):682.

25.

Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder.

Teschler S, Bartkuhn M, Künzel N, Schmidt C, Kiehl S, Dammann G, Dammann R.

PLoS One. 2013 Dec 19;8(12):e84180. doi: 10.1371/journal.pone.0084180. eCollection 2013.

26.

Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.

Günther K, Rust M, Leers J, Boettger T, Scharfe M, Jarek M, Bartkuhn M, Renkawitz R.

Nucleic Acids Res. 2013 Mar 1;41(5):3010-21. doi: 10.1093/nar/gkt035. Epub 2013 Jan 29.

27.

The chromatin insulator CTCF and the emergence of metazoan diversity.

Heger P, Marin B, Bartkuhn M, Schierenberg E, Wiehe T.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17507-12. doi: 10.1073/pnas.1111941109. Epub 2012 Oct 8.

28.

Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development.

Paradowska AS, Miller D, Spiess AN, Vieweg M, Cerna M, Dvorakova-Hortova K, Bartkuhn M, Schuppe HC, Weidner W, Steger K.

Epigenetics. 2012 Sep;7(9):1057-70. Epub 2012 Aug 16.

29.

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.

Sleutels F, Soochit W, Bartkuhn M, Heath H, Dienstbach S, Bergmaier P, Franke V, Rosa-Garrido M, van de Nobelen S, Caesar L, van der Reijden M, Bryne JC, van Ijcken W, Grootegoed JA, Delgado MD, Lenhard B, Renkawitz R, Grosveld F, Galjart N.

Epigenetics Chromatin. 2012 Jun 18;5(1):8. doi: 10.1186/1756-8935-5-8.

30.

CTCF: insights into insulator function during development.

Herold M, Bartkuhn M, Renkawitz R.

Development. 2012 Mar;139(6):1045-57. doi: 10.1242/dev.065268. Review.

31.

Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa.

Steilmann C, Paradowska A, Bartkuhn M, Vieweg M, Schuppe HC, Bergmann M, Kliesch S, Weidner W, Steger K.

Reprod Fertil Dev. 2011;23(8):997-1011. doi: 10.1071/RD10197.

PMID:
22127005
32.

The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men.

Steilmann C, Cavalcanti MC, Bartkuhn M, Pons-Kühnemann J, Schuppe HC, Weidner W, Steger K, Paradowska A.

Reproduction. 2010 Sep;140(3):435-43. doi: 10.1530/REP-10-0139. Epub 2010 Jun 10.

33.

Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites.

Weth O, Weth C, Bartkuhn M, Leers J, Uhle F, Renkawitz R.

PLoS One. 2010 Apr 9;5(4):e10119. doi: 10.1371/journal.pone.0010119.

34.

CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin.

Ohlsson R, Bartkuhn M, Renkawitz R.

Chromosoma. 2010 Aug;119(4):351-60. doi: 10.1007/s00412-010-0262-0. Epub 2010 Feb 20. Review.

35.

Active promoters and insulators are marked by the centrosomal protein 190.

Bartkuhn M, Straub T, Herold M, Herrmann M, Rathke C, Saumweber H, Gilfillan GD, Becker PB, Renkawitz R.

EMBO J. 2009 Apr 8;28(7):877-88. doi: 10.1038/emboj.2009.34. Epub 2009 Feb 19.

36.

Long range chromatin interactions involved in gene regulation.

Bartkuhn M, Renkawitz R.

Biochim Biophys Acta. 2008 Nov;1783(11):2161-6. doi: 10.1016/j.bbamcr.2008.07.011. Epub 2008 Jul 28. Review.

37.

The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.

Mohan M, Bartkuhn M, Herold M, Philippen A, Heinl N, Bardenhagen I, Leers J, White RA, Renkawitz-Pohl R, Saumweber H, Renkawitz R.

EMBO J. 2007 Oct 3;26(19):4203-14. Epub 2007 Sep 6.

38.

CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex.

Holohan EE, Kwong C, Adryan B, Bartkuhn M, Herold M, Renkawitz R, Russell S, White R.

PLoS Genet. 2007 Jul;3(7):e112.

39.
40.

Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila.

Rathke C, Baarends WM, Jayaramaiah-Raja S, Bartkuhn M, Renkawitz R, Renkawitz-Pohl R.

J Cell Sci. 2007 May 1;120(Pt 9):1689-700.

41.

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin.

Burke LJ, Zhang R, Bartkuhn M, Tiwari VK, Tavoosidana G, Kurukuti S, Weth C, Leers J, Galjart N, Ohlsson R, Renkawitz R.

EMBO J. 2005 Sep 21;24(18):3291-300. Epub 2005 Aug 18.

42.

CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator.

Moon H, Filippova G, Loukinov D, Pugacheva E, Chen Q, Smith ST, Munhall A, Grewe B, Bartkuhn M, Arnold R, Burke LJ, Renkawitz-Pohl R, Ohlsson R, Zhou J, Renkawitz R, Lobanenkov V.

EMBO Rep. 2005 Feb;6(2):165-70.

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