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Increased environmental temperature normalizes energy metabolism outputs between normal and Ames dwarf mice.

Darcy J, McFadden S, Fang Y, Berryman DE, List EO, Milcik N, Bartke A.

Aging (Albany NY). 2018 Oct 18;10(10):2709-2722. doi: 10.18632/aging.101582.


Growth Hormone and Aging: Updated Review.

Bartke A.

World J Mens Health. 2018 May 11. doi: 10.5534/wjmh.180018. [Epub ahead of print] Review.


Ageing and inflammation in the male reproductive tract.

Frungieri MB, Calandra RS, Bartke A, Matzkin ME.

Andrologia. 2018 May 8:e13034. doi: 10.1111/and.13034. [Epub ahead of print] Review.


Dwarf Mice and Aging.

Masternak MM, Darcy J, Victoria B, Bartke A.

Prog Mol Biol Transl Sci. 2018;155:69-83. doi: 10.1016/bs.pmbts.2017.12.002. Epub 2018 Feb 1.


Intestinal immunity in hypopituitary dwarf mice: effects of age.

Wang X, Darcy J, Cai C, Jin J, Bartke A, Cao D.

Aging (Albany NY). 2018 Mar 2;10(3):358-370. doi: 10.18632/aging.101393.


Effects of rapamycin on growth hormone receptor knockout mice.

Fang Y, Hill CM, Darcy J, Reyes-Ordoñez A, Arauz E, McFadden S, Zhang C, Osland J, Gao J, Zhang T, Frank SJ, Javors MA, Yuan R, Kopchick JJ, Sun LY, Chen J, Bartke A.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1495-E1503. doi: 10.1073/pnas.1717065115. Epub 2018 Jan 29.


Somatic growth, aging, and longevity.

Bartke A.

NPJ Aging Mech Dis. 2017 Sep 29;3:14. doi: 10.1038/s41514-017-0014-y. eCollection 2017. Review.


Can FSH influence longevity?

Bartke A.

Aging Cell. 2017 Oct;16(5):916-917. doi: 10.1111/acel.12663. Epub 2017 Aug 30.


Longevity is impacted by growth hormone action during early postnatal period.

Sun LY, Fang Y, Patki A, Koopman JJ, Allison DB, Hill CM, Masternak MM, Darcy J, Wang J, McFadden S, Bartke A.

Elife. 2017 Jul 4;6. pii: e24059. doi: 10.7554/eLife.24059.


Differential Fasting Plasma Glucose and Ketone Body Levels in GHRKO versus 3xTg-AD Mice: A Potential Contributor to Aging-Related Cognitive Status?

Griffith CM, Macklin LN, Bartke A, Patrylo PR.

Int J Endocrinol. 2017;2017:9684061. doi: 10.1155/2017/9684061. Epub 2017 May 30.


Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.


Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice.

Fang Y, McFadden S, Darcy J, Hill CM, Huber JA, Verhulst S, Kopchick JJ, Miller RA, Sun LY, Bartke A.

Geroscience. 2017 Jun;39(3):347-356. doi: 10.1007/s11357-017-9978-6. Epub 2017 May 18.


Analysis of Different Approaches for the Selection of Reference Genes in RT-qPCR Experiments: A Case Study in Skeletal Muscle of Growing Mice.

Piazza VG, Bartke A, Miquet JG, Sotelo AI.

Int J Mol Sci. 2017 May 16;18(5). pii: E1060. doi: 10.3390/ijms18051060.


GH and ageing: Pitfalls and new insights.

Bartke A, Darcy J.

Best Pract Res Clin Endocrinol Metab. 2017 Feb;31(1):113-125. doi: 10.1016/j.beem.2017.02.005. Epub 2017 Feb 24. Review.


Functionally enhanced brown adipose tissue in Ames dwarf mice.

Darcy J, Bartke A.

Adipocyte. 2017 Jan 2;6(1):62-67. doi: 10.1080/21623945.2016.1274470. Epub 2016 Dec 21. Review.


Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.

Darcy J, McFadden S, Bartke A.

Adipocyte. 2017 Apr 3;6(2):69-75. doi: 10.1080/21623945.2017.1308990. Epub 2017 Mar 21. Review.


Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging.

Ratajczak MZ, Bartke A, Darzynkiewicz Z.

Stem Cell Rev. 2017 Aug;13(4):443-453. doi: 10.1007/s12015-017-9728-2. Review.


Attenuation of epidermal growth factor (EGF) signaling by growth hormone (GH).

González L, Miquet JG, Irene PE, Díaz ME, Rossi SP, Sotelo AI, Frungieri MB, Hill CM, Bartke A, Turyn D.

J Endocrinol. 2017 May;233(2):175-186. doi: 10.1530/JOE-16-0606. Epub 2017 Feb 21.


Changes of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging.

Schneider A, Matkovich SJ, Victoria B, Spinel L, Bartke A, Golusinski P, Masternak MM.

PLoS One. 2017 Jan 3;12(1):e0169213. doi: 10.1371/journal.pone.0169213. eCollection 2017.


Ovarian aging and the activation of the primordial follicle reserve in the long-lived Ames dwarf and the short-lived bGH transgenic mice.

Saccon TD, Moreira F, Cruz LA, Mondadori RG, Fang Y, Barros CC, Spinel L, Bartke A, Masternak MM, Schneider A.

Mol Cell Endocrinol. 2017 Nov 5;455:23-32. doi: 10.1016/j.mce.2016.10.015. Epub 2016 Oct 19.


Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice.

Darcy J, McFadden S, Fang Y, Huber JA, Zhang C, Sun LY, Bartke A.

Endocrinology. 2016 Dec;157(12):4744-4753. Epub 2016 Oct 14.


A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.

Gesing A, Wiesenborn D, Do A, Menon V, Schneider A, Victoria B, Stout MB, Kopchick JJ, Bartke A, Masternak MM.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1054-1061. doi: 10.1093/gerona/glw193.


Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.

Schneider A, Matkovich SJ, Saccon T, Victoria B, Spinel L, Lavasani M, Bartke A, Golusinski P, Masternak MM.

Mol Cell Endocrinol. 2017 Jan 5;439:328-336. doi: 10.1016/j.mce.2016.09.019. Epub 2016 Sep 20.


Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.

Hascup KN, Lynn MK, Fitzgerald PJ, Randall S, Kopchick JJ, Boger HA, Bartke A, Hascup ER.

J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):329-337. doi: 10.1093/gerona/glw088.


Original Research: Metabolic alterations from early life thyroxine replacement therapy in male Ames dwarf mice are transient.

Darcy J, Fang Y, Hill CM, McFadden S, Sun LY, Bartke A.

Exp Biol Med (Maywood). 2016 Oct;241(16):1764-71. doi: 10.1177/1535370216650292. Epub 2016 May 13.


Mitogenic signaling pathways in the liver of growth hormone (GH)-overexpressing mice during the growth period.

Martinez CS, Piazza VG, González L, Fang Y, Bartke A, Turyn D, Miquet JG, Sotelo AI.

Cell Cycle. 2016;15(5):748-59. doi: 10.1080/15384101.2016.1148844. Erratum in: Cell Cycle. 2016 May 18;15(10):1386.


Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditure.

Hill CM, Fang Y, Miquet JG, Sun LY, Masternak MM, Bartke A.

Aging Cell. 2016 Jun;15(3):509-21. doi: 10.1111/acel.12467. Epub 2016 Mar 17.


Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling.

Koopman JJ, van Heemst D, van Bodegom D, Bonkowski MS, Sun LY, Bartke A.

Aging (Albany NY). 2016 Mar;8(3):539-46.


The somatotropic axis and aging: Benefits of endocrine defects.

Bartke A, List EO, Kopchick JJ.

Growth Horm IGF Res. 2016 Apr;27:41-45. doi: 10.1016/j.ghir.2016.02.002. Epub 2016 Feb 16. Review.


Healthspan and longevity can be extended by suppression of growth hormone signaling.

Bartke A.

Mamm Genome. 2016 Aug;27(7-8):289-99. doi: 10.1007/s00335-016-9621-3. Epub 2016 Feb 24. Review.


Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.

Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD.

Cell Rep. 2016 Feb 23;14(7):1571-1580. doi: 10.1016/j.celrep.2016.01.044. Epub 2016 Feb 11.


Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes.

Matzkin ME, Miquet JG, Fang Y, Hill CM, Turyn D, Calandra RS, Bartke A, Frungieri MB.

Aging (Albany NY). 2016 Jan;8(1):95-110.


Growth hormone actions during development influence adult phenotype and longevity.

Bartke A, Sun L, Fang Y, Hill C.

Exp Gerontol. 2016 Dec 15;86:22-27. doi: 10.1016/j.exger.2015.12.011. Epub 2016 Jan 2.


Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1.

Piotrowska K, Sluczanowska-Glabowska S, Kucia M, Bartke A, Laszczynska M, Ratajczak MZ.

Folia Histochem Cytobiol. 2015;53(3):249-58. doi: 10.5603/fhc.a2015.0024. Epub 2015 Sep 8.


Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.

Sadagurski M, Landeryou T, Cady G, Kopchick JJ, List EO, Berryman DE, Bartke A, Miller RA.

Aging Cell. 2015 Dec;14(6):1045-54. doi: 10.1111/acel.12382. Epub 2015 Aug 12.


Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.

List EO, Berryman DE, Ikeno Y, Hubbard GB, Funk K, Comisford R, Young JA, Stout MB, Tchkonia T, Masternak MM, Bartke A, Kirkland JL, Miller RA, Kopchick JJ.

Aging (Albany NY). 2015 Jul;7(7):500-12.



Miquet JG, Freund T, Martinez CS, Gonzalez L, Diaz ME, Micucci GP, Zotta E, Boparai RK, Bartke A, Turyn D, Sotelo AI.

Cell Cycle. 2015 Aug 3;14(15):2537. doi: 10.1080/15384101.2015.1066140. No abstract available.


Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice.

Boparai RK, Arum O, Miquet JG, Masternak MM, Bartke A, Khardori RK.

Int J Endocrinol. 2015;2015:282375. doi: 10.1155/2015/282375. Epub 2015 May 18.


Early life events can shape aging and longevity.

Bartke A.

Curr Aging Sci. 2015;8(1):11-3. Review.


Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen.

Capitano ML, Chitteti BR, Cooper S, Srour EF, Bartke A, Broxmeyer HE.

Blood Cells Mol Dis. 2015 Jun;55(1):15-20. doi: 10.1016/j.bcmd.2015.03.004. Epub 2015 Mar 28.


Sex Differences in Longevity and in Responses to Anti-Aging Interventions: A Mini-Review.

Austad SN, Bartke A.

Gerontology. 2015;62(1):40-6. doi: 10.1159/000381472. Epub 2015 May 6. Review.


Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age.

Hill CM, Arum O, Boparai RK, Wang F, Fang Y, Sun LY, Masternak MM, Bartke A.

Age (Dordr). 2015 Jun;37(3):9765. doi: 10.1007/s11357-015-9765-1. Epub 2015 May 8.


Thyroxine modifies the effects of growth hormone in Ames dwarf mice.

Do A, Menon V, Zhi X, Gesing A, Wiesenborn DS, Spong A, Sun L, Bartke A, Masternak MM.

Aging (Albany NY). 2015 Apr;7(4):241-55.


Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice.

Sadagurski M, Landeryou T, Cady G, Bartke A, Bernal-Mizrachi E, Miller RA.

Physiol Rep. 2015 Apr;3(4). pii: e12379. doi: 10.14814/phy2.12379.


Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.


Early Life Events can Shape Aging and Longevity.

Bartke A.

Curr Aging Sci. 2015 Apr 22. [Epub ahead of print]


Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.

Zawada I, Masternak MM, List EO, Stout MB, Berryman DE, Lewinski A, Kopchick JJ, Bartke A, Karbownik-Lewinska M, Gesing A.

Aging (Albany NY). 2015 Mar;7(3):195-204.


The forgotten lactogenic activity of growth hormone: important implications for rodent studies.

Bartke A, Kopchick JJ.

Endocrinology. 2015 May;156(5):1620-2. doi: 10.1210/en.2015-1097. Epub 2015 Mar 2.


Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence?

Arum O, Dawson JA, Smith DL Jr, Kopchick JJ, Allison DB, Bartke A.

Aging Cell. 2015 Jun;14(3):483-90. doi: 10.1111/acel.12318. Epub 2015 Feb 26.


Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging.

Hascup ER, Wang F, Kopchick JJ, Bartke A.

J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):281-9. doi: 10.1093/gerona/glv010. Epub 2015 Feb 22.

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