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ENACT: a protocol for a randomised placebo-controlled trial investigating the efficacy and mechanisms of action of adjunctive N-acetylcysteine for first-episode psychosis.

Cotton SM, Berk M, Watson A, Wood S, Allott K, Bartholomeusz CF, Bortolasci CC, Walder K, O'Donoghue B, Dean OM, Chanen A, Amminger GP, McGorry PD, Burnside A, Uren J, Ratheesh A, Dodd S.

Trials. 2019 Nov 28;20(1):658. doi: 10.1186/s13063-019-3786-5.


Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia.

Wannan CMJ, Cropley VL, Chakravarty MM, Bousman C, Ganella EP, Bruggemann JM, Weickert TW, Weickert CS, Everall I, McGorry P, Velakoulis D, Wood SJ, Bartholomeusz CF, Pantelis C, Zalesky A.

Am J Psychiatry. 2019 Jul 1;176(7):552-563. doi: 10.1176/appi.ajp.2019.18040380. Epub 2019 Jun 5.


A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.

Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN.

ACS Chem Biol. 2019 Jun 21;14(6):1183-1194. doi: 10.1021/acschembio.9b00093. Epub 2019 May 13.


Harmonised collection of data in youth mental health: Towards large datasets.

Lavoie S, Allott K, Amminger P, Bartholomeusz C, Berger M, Breakspear M, Henders AK, Lee R, Lin A, McGorry P, Rice S, Schmaal L, Wood SJ.

Aust N Z J Psychiatry. 2019 Apr 17:4867419844322. doi: 10.1177/0004867419844322. [Epub ahead of print]


Correction to: Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer.

Lee J, Lim B, Pearson T, Choi K, Fuson JA, Bartholomeusz C, Paradiso LJ, Myers T, Tripathy D, Ueno NT.

Breast Cancer Res Treat. 2019 Jul;176(1):251. doi: 10.1007/s10549-019-05218-8.


An examination of orbitofrontal sulcogyral morphology in obsessive-compulsive disorder.

Delahoy R, Bartholomeusz CF, Pemberton H, Alonso P, Pujol J, Cardoner N, Menchon JM, Soriano-Mas C, Harrison BJ.

Psychiatry Res Neuroimaging. 2019 Apr 30;286:18-23. doi: 10.1016/j.pscychresns.2019.02.004. Epub 2019 Feb 22.


Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer.

Lee J, Lim B, Pearson T, Choi K, Fuson JA, Bartholomeusz C, Paradiso LJ, Myers T, Tripathy D, Ueno NT.

Breast Cancer Res Treat. 2019 Jun;175(2):339-351. doi: 10.1007/s10549-019-05166-3. Epub 2019 Mar 2. Erratum in: Breast Cancer Res Treat. 2019 Apr 15;:.


Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial.

Chanen AM, Betts J, Jackson H, McGorry P, Nelson B, Cotton SM, Bartholomeusz C, Jovev M, Ratheesh A, Davey C, Pantelis C, McCutcheon L, Francey S, Bhaduri A, Lowe D, Rayner V, Thompson K.

Early Interv Psychiatry. 2019 Dec;13(6):1373-1381. doi: 10.1111/eip.12774. Epub 2019 Jan 28.


Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder.

Wannan CMJ, Cropley VL, Chakravarty MM, Van Rheenen TE, Mancuso S, Bousman C, Everall I, McGorry PD, Pantelis C, Bartholomeusz CF.

Psychol Med. 2019 Oct;49(14):2452-2462. doi: 10.1017/S0033291718003458. Epub 2018 Dec 4.


Can antipsychotic dose reduction lead to better functional recovery in first-episode psychosis? A randomized controlled-trial of antipsychotic dose reduction. The reduce trial: Study protocol.

Weller A, Gleeson J, Alvarez-Jimenez M, McGorry P, Nelson B, Allott K, Bendall S, Bartholomeusz C, Koval P, Harrigan S, O'Donoghue B, Fornito A, Pantelis C, Paul Amminger G, Ratheesh A, Polari A, Wood SJ, van der El K, Ellinghaus C, Gates J, O'Connell J, Mueller M, Wunderink L, Killackey E.

Early Interv Psychiatry. 2019 Dec;13(6):1345-1356. doi: 10.1111/eip.12769. Epub 2018 Nov 29.


An fMRI study of theory of mind in individuals with first episode psychosis.

Bartholomeusz CF, Ganella EP, Whittle S, Allott K, Thompson A, Abu-Akel A, Walter H, McGorry P, Killackey E, Pantelis C, Wood SJ.

Psychiatry Res Neuroimaging. 2018 Nov 30;281:1-11. doi: 10.1016/j.pscychresns.2018.08.011. Epub 2018 Aug 23.


Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study.

Ganella EP, Seguin C, Pantelis C, Whittle S, Baune BT, Olver J, Amminger GP, McGorry PD, Cropley V, Zalesky A, Bartholomeusz CF.

Aust N Z J Psychiatry. 2018 Sep;52(9):864-875. doi: 10.1177/0004867418775833. Epub 2018 May 27.


Stress hormones and verbal memory in young people over the first 12 weeks of treatment for psychosis.

Allott KA, Yuen HP, Bartholomeusz CF, Rapado-Castro M, Phassouliotis C, Butselaar F, Wood SJ, Proffitt TM, Savage G, Phillips LJ, Bendall S, Markulev C, Reniers RLEP, Pantelis C, Baldwin L, McGorry PD, Garner B.

Psychiatry Res. 2018 Feb;260:60-66. doi: 10.1016/j.psychres.2017.11.044. Epub 2017 Nov 21.


Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis.

Allott K, Fraguas D, Bartholomeusz CF, Díaz-Caneja CM, Wannan C, Parrish EM, Amminger GP, Pantelis C, Arango C, McGorry PD, Rapado-Castro M.

Psychol Med. 2018 Jul;48(10):1592-1607. doi: 10.1017/S0033291717003002. Epub 2017 Nov 27.


Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth.

Jose J, Tavares CDJ, Ebelt ND, Lodi A, Edupuganti R, Xie X, Devkota AK, Kaoud TS, Van Den Berg CL, Anslyn EV, Tiziani S, Bartholomeusz C, Dalby KN.

ACS Med Chem Lett. 2017 Sep 14;8(10):1072-1076. doi: 10.1021/acsmedchemlett.7b00282. eCollection 2017 Oct 12.


EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer.

Wang X, Reyes ME, Zhang D, Funakoshi Y, Trape AP, Gong Y, Kogawa T, Eckhardt BL, Masuda H, Pirman DA Jr, Yang P, Reuben JM, Woodward WA, Bartholomeusz C, Hortobagyi GN, Tripathy D, Ueno NT.

Oncotarget. 2017 Jul 4;8(40):67904-67917. doi: 10.18632/oncotarget.18958. eCollection 2017 Sep 15.


MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.

Pitner MK, Taliaferro JM, Dalby KN, Bartholomeusz C.

Expert Opin Ther Targets. 2017 Sep;21(9):849-859. doi: 10.1080/14728222.2017.1363183. Epub 2017 Aug 16. Review.


Risk and resilience brain networks in treatment-resistant schizophrenia.

Ganella EP, Seguin C, Bartholomeusz CF, Whittle S, Bousman C, Wannan CMJ, Di Biase MA, Phassouliotis C, Everall I, Pantelis C, Zalesky A.

Schizophr Res. 2018 Mar;193:284-292. doi: 10.1016/j.schres.2017.07.014. Epub 2017 Jul 21.


Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms.

Chye Y, Solowij N, Ganella EP, Suo C, Yücel M, Batalla A, Cousijn J, Goudriaan AE, Martin-Santos R, Whittle S, Bartholomeusz CF, Lorenzetti V.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):392-400. doi: 10.1016/j.pnpbp.2017.07.017. Epub 2017 Jul 20.


Ventricular volumes across stages of schizophrenia and other psychoses.

Berger GE, Bartholomeusz CF, Wood SJ, Ang A, Phillips LJ, Proffitt T, Brewer WJ, Smith DJ, Nelson B, Lin A, Borgwardt S, Velakoulis D, Yung AR, McGorry PD, Pantelis C.

Aust N Z J Psychiatry. 2017 Oct;51(10):1041-1051. doi: 10.1177/0004867417715914. Epub 2017 Jul 1.


Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study.

Wannan CMJ, Bartholomeusz CF, Cropley VL, Van Rheenen TE, Panayiotou A, Brewer WJ, Proffitt TM, Henry L, Harris MG, Velakoulis D, McGorry P, Pantelis C, Wood SJ.

Psychol Med. 2018 Jan;48(1):132-141. doi: 10.1017/S003329171700157X. Epub 2017 Jun 19.


IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.

Battula VL, Nguyen K, Sun J, Pitner MK, Yuan B, Bartholomeusz C, Hail N, Andreeff M.

Oncotarget. 2017 Jun 6;8(23):36936-36949. doi: 10.18632/oncotarget.16294.


Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth.

Edupuganti R, Taliaferro JM, Wang Q, Xie X, Cho EJ, Vidhu F, Ren P, Anslyn EV, Bartholomeusz C, Dalby KN.

Bioorg Med Chem. 2017 May 1;25(9):2609-2616. doi: 10.1016/j.bmc.2017.03.018. Epub 2017 Mar 10.


Functional brain networks in treatment-resistant schizophrenia.

Ganella EP, Bartholomeusz CF, Seguin C, Whittle S, Bousman C, Phassouliotis C, Everall I, Pantelis C, Zalesky A.

Schizophr Res. 2017 Jun;184:73-81. doi: 10.1016/j.schres.2016.12.008. Epub 2016 Dec 20.


c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun.

Xie X, Kaoud TS, Edupuganti R, Zhang T, Kogawa T, Zhao Y, Chauhan GB, Giannoukos DN, Qi Y, Tripathy D, Wang J, Gray NS, Dalby KN, Bartholomeusz C, Ueno NT.

Oncogene. 2017 May 4;36(18):2599-2608. doi: 10.1038/onc.2016.417. Epub 2016 Dec 12.


Deficits in social cognition in first episode psychosis: A review of the literature.

Healey KM, Bartholomeusz CF, Penn DL.

Clin Psychol Rev. 2016 Dec;50:108-137. doi: 10.1016/j.cpr.2016.10.001. Epub 2016 Oct 11. Review.


Structural neuroimaging across early-stage psychosis: Aberrations in neurobiological trajectories and implications for the staging model.

Bartholomeusz CF, Cropley VL, Wannan C, Di Biase M, McGorry PD, Pantelis C.

Aust N Z J Psychiatry. 2017 May;51(5):455-476. doi: 10.1177/0004867416670522. Epub 2016 Oct 12. Review.


White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids.

Vijayakumar N, Bartholomeusz C, Whitford T, Hermens DF, Nelson B, Rice S, Whittle S, Pantelis C, McGorry P, Schäfer MR, Amminger GP.

BMC Psychiatry. 2016 Aug 11;16(1):287. doi: 10.1186/s12888-016-0932-4. Review.


Emotion recognition and theory of mind are related to gray matter volume of the prefrontal cortex in schizophrenia.

Maat A, van Haren NEM, Bartholomeusz CF, Kahn RS, Cahn W.

Eur Neuropsychopharmacol. 2016 Feb;26(2):255-264. doi: 10.1016/j.euroneuro.2015.12.013. Epub 2015 Dec 11.


Examining the association between social cognition and functioning in individuals at ultra-high risk for psychosis.

Cotter J, Bartholomeusz C, Papas A, Allott K, Nelson B, Yung AR, Thompson A.

Aust N Z J Psychiatry. 2017 Jan;51(1):83-92. doi: 10.1177/0004867415622691. Epub 2016 Jul 19.


Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer.

Lee J, Galloway R, Grandjean G, Jacob J, Humphries J, Bartholomeusz C, Goodstal S, Lim B, Bartholomeusz G, Ueno NT, Rao A.

J Cancer. 2015 Oct 28;6(12):1306-19. doi: 10.7150/jca.13266. eCollection 2015.


Meta-analysis of Theory of Mind (ToM) impairment in bipolar disorder.

Bora E, Bartholomeusz C, Pantelis C.

Psychol Med. 2016 Jan;46(2):253-64. doi: 10.1017/S0033291715001993. Epub 2015 Oct 12. Review.


Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.

Kai K, Kondo K, Wang X, Xie X, Pitner MK, Reyes ME, Torres-Adorno AM, Masuda H, Hortobagyi GN, Bartholomeusz C, Saya H, Tripathy D, Sen S, Ueno NT.

Mol Cancer Ther. 2015 Dec;14(12):2687-99. doi: 10.1158/1535-7163.MCT-15-0096. Epub 2015 Oct 6.


Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia.

Cropley VL, Bartholomeusz CF, Wu P, Wood SJ, Proffitt T, Brewer WJ, Desmond PM, Velakoulis D, Pantelis C.

Psychiatry Res. 2015 Nov 30;234(2):280-3. doi: 10.1016/j.pscychresns.2015.09.001. Epub 2015 Sep 5.


MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model.

Bartholomeusz C, Xie X, Pitner MK, Kondo K, Dadbin A, Lee J, Saso H, Smith PD, Dalby KN, Ueno NT.

Mol Cancer Ther. 2015 Dec;14(12):2773-81. doi: 10.1158/1535-7163.MCT-15-0243. Epub 2015 Sep 17.


Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia.

Bartholomeusz CF, Ganella EP, Labuschagne I, Bousman C, Pantelis C.

Schizophr Res. 2015 Nov;168(3):614-27. doi: 10.1016/j.schres.2015.06.007. Epub 2015 Jun 26. Review.


Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up.

Cropley VL, Lin A, Nelson B, Reniers RLEP, Yung AR, Bartholomeusz CF, Klauser P, Velakoulis D, McGorry P, Wood SJ, Pantelis C.

Schizophr Res. 2016 Jun;173(3):152-158. doi: 10.1016/j.schres.2015.05.014. Epub 2015 May 29.


CD44 expression contributes to trastuzumab resistance in HER2-positive breast cancer cells.

Boulbes DR, Chauhan GB, Jin Q, Bartholomeusz C, Esteva FJ.

Breast Cancer Res Treat. 2015 Jun;151(3):501-13. doi: 10.1007/s10549-015-3414-3. Epub 2015 May 14.


Gender effects on brain changes in early-onset psychosis.

Rapado-Castro M, Bartholomeusz CF, Castro-Fornieles J, González-Pinto A, Otero S, Baeza I, Moreno C, Graell M, Janssen J, Bargalló N, Pantelis C, Desco M, Arango C.

Eur Child Adolesc Psychiatry. 2015 Oct;24(10):1193-205. doi: 10.1007/s00787-014-0669-x. Epub 2015 Jan 15.


Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia.

Allott KA, Rice S, Bartholomeusz CF, Klier C, Schlögelhofer M, Schäfer MR, Amminger GP.

Schizophr Res. 2015 Feb;161(2-3):322-8. doi: 10.1016/j.schres.2014.12.010. Epub 2014 Dec 19.


Relationship between amygdala volume and emotion recognition in adolescents at ultra-high risk for psychosis.

Bartholomeusz CF, Whittle SL, Pilioussis E, Allott K, Rice S, Schäfer MR, Pantelis C, Amminger GP.

Psychiatry Res. 2014 Dec 30;224(3):159-67. doi: 10.1016/j.pscychresns.2014.10.005. Epub 2014 Oct 27.


HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.

Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ.

Mol Oncol. 2015 Mar;9(3):586-600. doi: 10.1016/j.molonc.2014.10.011. Epub 2014 Nov 11.


Abnormalities in orbitofrontal cortex gyrification and mental health outcomes in adolescents born extremely preterm and/or at an extremely low birth weight.

Ganella EP, Burnett A, Cheong J, Thompson D, Roberts G, Wood S, Lee K, Duff J, Anderson PJ, Pantelis C, Doyle LW, Bartholomeusz C; Victorian Infant Collaborative Study Group.

Hum Brain Mapp. 2015 Mar;36(3):1138-50. doi: 10.1002/hbm.22692. Epub 2014 Nov 19.


Development of PEA-15 using a potent non-viral vector for therapeutic application in breast cancer.

Xie X, Tang H, Pengliu, Kong Y, Wu M, Xiao X, Yang L, Gao J, Wei W, Lee J, Bartholomeusz C, Ueno NT, Xie X.

Cancer Lett. 2015 Jan 28;356(2 Pt B):374-381. doi: 10.1016/j.canlet.2014.09.033. Epub 2014 Oct 7.


Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis.

Kim SW, Schäfer MR, Klier CM, Berk M, Rice S, Allott K, Bartholomeusz CF, Whittle SL, Pilioussis E, Pantelis C, McGorry PD, Amminger GP.

Schizophr Res. 2014 Sep;158(1-3):39-44. doi: 10.1016/j.schres.2014.06.032. Epub 2014 Jul 25.


A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in HER2-overexpressing breast cancer cells through FOXO3-mediated Bim1 expression.

Lee J, Bartholomeusz C, Mansour O, Humphries J, Hortobagyi GN, Ordentlich P, Ueno NT.

Breast Cancer Res Treat. 2014 Jul;146(2):259-72. doi: 10.1007/s10549-014-3014-7. Epub 2014 Jun 12.


Social neuroscience in psychiatry: pathways to discovering neurobiological risk and resilience.

Pantelis C, Bartholomeusz CF.

World Psychiatry. 2014 Jun;13(2):146-7. doi: 10.1002/wps.20123. No abstract available.


Antagonism of tumoral prolactin receptor promotes autophagy-related cell death.

Wen Y, Zand B, Ozpolat B, Szczepanski MJ, Lu C, Yuca E, Carroll AR, Alpay N, Bartholomeusz C, Tekedereli I, Kang Y, Rupaimoole R, Pecot CV, Dalton HJ, Hernandez A, Lokshin A, Lutgendorf SK, Liu J, Hittelman WN, Chen WY, Lopez-Berestein G, Szajnik M, Ueno NT, Coleman RL, Sood AK.

Cell Rep. 2014 Apr 24;7(2):488-500. doi: 10.1016/j.celrep.2014.03.009. Epub 2014 Apr 3.


Emotion recognition as a predictor of transition to a psychotic disorder in ultra-high risk participants.

Allott KA, Schäfer MR, Thompson A, Nelson B, Bendall S, Bartholomeusz CF, Yuen HP, McGorry PD, Schlögelhofer M, Bechdolf A, Amminger GP.

Schizophr Res. 2014 Mar;153(1-3):25-31. doi: 10.1016/j.schres.2014.01.037. Epub 2014 Feb 16.


Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.

Xie X, Bartholomeusz C, Ahmed AA, Kazansky A, Diao L, Baggerly KA, Hortobagyi GN, Ueno NT.

Mol Cancer Ther. 2013 Jun;12(6):1099-111. doi: 10.1158/1535-7163.MCT-12-0737. Epub 2013 Mar 29.

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