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Comorbidity associated to Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but not affect the parasite cycle in mice.

Oliveira FMS, da Paixão Matias PH, Kraemer L, Gazzinelli-Guimarães AC, Santos FV, Amorim CCO, Nogueira DS, Freitas CS, Caliari MV, Bartholomeu DC, Bueno LL, Russo RC, Fujiwara RT.

PLoS Negl Trop Dis. 2019 Nov 25;13(11):e0007896. doi: 10.1371/journal.pntd.0007896. eCollection 2019 Nov.


Identification of B-Cell Epitopes with Potential to Serologicaly Discrimnate Dengue from Zika Infections.

Versiani AF, Rocha RP, Mendes TAO, Pereira GC, Coelho Dos Reis JGA, Bartholomeu DC, da Fonseca FG.

Viruses. 2019 Nov 19;11(11). pii: E1079. doi: 10.3390/v11111079.


The Use of Specific Serological Biomarkers to Detect CaniLeish Vaccination in Dogs.

Lima C, Santarém N, Nieto J, Moreno J, Carrillo E, Bartholomeu DC, Bueno LL, Fujiwara R, Amorim C, Cordeiro-da-Silva A.

Front Vet Sci. 2019 Oct 24;6:373. doi: 10.3389/fvets.2019.00373. eCollection 2019.


ProphET, prophage estimation tool: A stand-alone prophage sequence prediction tool with self-updating reference database.

Reis-Cunha JL, Bartholomeu DC, Manson AL, Earl AM, Cerqueira GC.

PLoS One. 2019 Oct 2;14(10):e0223364. doi: 10.1371/journal.pone.0223364. eCollection 2019.


Mapping benznidazole resistance in trypanosomatids and exploring evolutionary histories of nitroreductases and ABCG transporter protein sequences.

Petravicius PO, Costa-Martins AG, Silva MN, Reis-Cunha JL, Bartholomeu DC, Teixeira MMG, Zingales B.

Acta Trop. 2019 Dec;200:105161. doi: 10.1016/j.actatropica.2019.105161. Epub 2019 Sep 5.


Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil.

Silva LA, Fernandes MD, Machado AS, Reis-Cunha JL, Bartholomeu DC, Almeida Vitor RW.

Exp Parasitol. 2019 Jul;202:7-14. doi: 10.1016/j.exppara.2019.05.001. Epub 2019 May 8.


Trypanosoma cruzi Genome Assemblies: Challenges and Milestones of Assembling a Highly Repetitive and Complex Genome.

Reis-Cunha JL, Bartholomeu DC.

Methods Mol Biol. 2019;1955:1-22. doi: 10.1007/978-1-4939-9148-8_1. Review.


Detection of multiple circulating Leishmania species in Lutzomyia longipalpis in the city of Governador Valadares, southeastern Brazil.

Cardoso MS, Bento GA, de Almeida LV, de Castro JC, Reis-Cunha JL, Barbosa VA, de Souza CF, Brazil RP, Valdivia HO, Bartholomeu DC.

PLoS One. 2019 Feb 5;14(2):e0211831. doi: 10.1371/journal.pone.0211831. eCollection 2019.


Leishmania infantum recombinant kinesin degenerated derived repeat (rKDDR): A novel potential antigen for serodiagnosis of visceral leishmaniasis.

Dhom-Lemos L, Viana AG, Cunha JLR, Cardoso MS, Mendes TAO, Pinheiro GRG, Siqueira WF, Lobo FP, Teles LF, Bueno LL, Guimarães-Carvalho SF, Bartholomeu DC, Fujiwara RT.

PLoS One. 2019 Jan 31;14(1):e0211719. doi: 10.1371/journal.pone.0211719. eCollection 2019.


IgG Induced by Vaccination With Ascaris suum Extracts Is Protective Against Infection.

Gazzinelli-Guimarães AC, Gazzinelli-Guimarães PH, Nogueira DS, Oliveira FMS, Barbosa FS, Amorim CCO, Cardoso MS, Kraemer L, Caliari MV, Akamatsu MA, Ho PL, Jones KM, Weatherhead J, Bottazzi ME, Hotez PJ, Zhan B, Bartholomeu DC, Russo RC, Bueno LL, Fujiwara RT.

Front Immunol. 2018 Nov 9;9:2535. doi: 10.3389/fimmu.2018.02535. eCollection 2018.


Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU.

Reis-Cunha JL, Baptista RP, Rodrigues-Luiz GF, Coqueiro-Dos-Santos A, Valdivia HO, de Almeida LV, Cardoso MS, D'Ávila DA, Dias FHC, Fujiwara RT, Galvão LMC, Chiari E, Cerqueira GC, Bartholomeu DC.

BMC Genomics. 2018 Nov 13;19(1):816. doi: 10.1186/s12864-018-5198-4.


Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania.

Damasceno JD, Obonaga R, Silva GLA, Reis-Cunha JL, Duncan SM, Bartholomeu DC, Mottram JC, McCulloch R, Tosi LRO.

Nucleic Acids Res. 2018 Dec 14;46(22):11835-11846. doi: 10.1093/nar/gky1017.


Chromosomal copy number variation analysis by next generation sequencing confirms ploidy stability in Trypanosoma brucei subspecies.

Almeida LV, Coqueiro-Dos-Santos A, Rodriguez-Luiz GF, McCulloch R, Bartholomeu DC, Reis-Cunha JL.

Microb Genom. 2018 Oct;4(10). doi: 10.1099/mgen.0.000223. Epub 2018 Sep 27.


Development of the PraziCalc mobile device-app to calculate praziquantel dosage in the treatment of schistosomiasis.

Viana AG, Coelho ALG, Gazzinelli-Guimarães PH, Phillips AE, Bartholomeu DC, Bueno LL, Fujiwara RT.

Rev Inst Med Trop Sao Paulo. 2018 Aug 20;60:e42. doi: 10.1590/S1678-9946201860042. No abstract available.


Gene and Chromosomal Copy Number Variations as an Adaptive Mechanism Towards a Parasitic Lifestyle in Trypanosomatids.

Reis-Cunha JL, Valdivia HO, Bartholomeu DC.

Curr Genomics. 2018 Feb;19(2):87-97. doi: 10.2174/1389202918666170911161311. Review.


Assembly of highly repetitive genomes using short reads: the genome of discrete typing unit III Trypanosoma cruzi strain 231.

Baptista RP, Reis-Cunha JL, DeBarry JD, Chiari E, Kissinger JC, Bartholomeu DC, Macedo AM.

Microb Genom. 2018 Apr;4(4). doi: 10.1099/mgen.0.000156. Epub 2018 Feb 14.


Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection.

Belew AT, Junqueira C, Rodrigues-Luiz GF, Valente BM, Oliveira AER, Polidoro RB, Zuccherato LW, Bartholomeu DC, Schenkman S, Gazzinelli RT, Burleigh BA, El-Sayed NM, Teixeira SMR.

PLoS Pathog. 2017 Dec 14;13(12):e1006767. doi: 10.1371/journal.ppat.1006767. eCollection 2017 Dec.


Virus-like Particle Display of the α-Gal Carbohydrate for Vaccination against Leishmania Infection.

Moura APV, Santos LCB, Brito CRN, Valencia E, Junqueira C, Filho AAP, Sant'Anna MRV, Gontijo NF, Bartholomeu DC, Fujiwara RT, Gazzinelli RT, McKay CS, Sanhueza CA, Finn MG, Marques AF.

ACS Cent Sci. 2017 Sep 27;3(9):1026-1031. doi: 10.1021/acscentsci.7b00311. Epub 2017 Sep 13.


Epitope mapping of recombinant Leishmania donovani virulence factor A2 (recLdVFA2) and canine leishmaniasis diagnosis using a derived synthetic bi-epitope.

Mendes TM, Roma EH, Costal-Oliveira F, Dhom-Lemos LC, Toledo-Machado CM, Bruna-Romero O, Bartholomeu DC, Fujiwara RT, Chávez-Olórtegui C.

PLoS Negl Trop Dis. 2017 May 30;11(5):e0005562. doi: 10.1371/journal.pntd.0005562. eCollection 2017 May.


Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection.

Passos LS, Gazzinelli-Guimarães PH, Oliveira Mendes TA, Guimarães AC, Silveira Lemos DD, Ricci ND, Gonçalves R, Bartholomeu DC, Fujiwara RT, Bueno LL.

BMC Infect Dis. 2017 Apr 8;17(1):253. doi: 10.1186/s12879-017-2366-0.


Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis.

Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bartholomeu DC, Fujiwara RT, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG.

PLoS Negl Trop Dis. 2017 Mar 9;11(3):e0005374. doi: 10.1371/journal.pntd.0005374. eCollection 2017 Mar.


TipMT: Identification of PCR-based taxon-specific markers.

Rodrigues-Luiz GF, Cardoso MS, Valdivia HO, Ayala EV, Gontijo CM, Rodrigues TS, Fujiwara RT, Lopes RS, Bartholomeu DC.

BMC Bioinformatics. 2017 Feb 11;18(1):104. doi: 10.1186/s12859-017-1485-3.


On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease.

Hojo-Souza NS, Pereira DB, de Souza FS, de Oliveira Mendes TA, Cardoso MS, Tada MS, Zanini GM, Bartholomeu DC, Fujiwara RT, Bueno LL.

Malar J. 2017 Jan 24;16(1):42. doi: 10.1186/s12936-017-1683-5.


Genetic Polymorphisms and Phenotypic Profiles of Sulfadiazine-Resistant and Sensitive Toxoplasma gondii Isolates Obtained from Newborns with Congenital Toxoplasmosis in Minas Gerais, Brazil.

Silva LA, Reis-Cunha JL, Bartholomeu DC, Vítor RW.

PLoS One. 2017 Jan 24;12(1):e0170689. doi: 10.1371/journal.pone.0170689. eCollection 2017.


Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil.

Valdivia HO, Almeida LV, Roatt BM, Reis-Cunha JL, Pereira AA, Gontijo C, Fujiwara RT, Reis AB, Sanders MJ, Cotton JA, Bartholomeu DC.

Sci Rep. 2017 Jan 16;7:40804. doi: 10.1038/srep40804.


Application of rapid in vitro co-culture system of macrophages and T-cell subsets to assess the immunogenicity of dogs vaccinated with live attenuated Leishmania donovani centrin deleted parasites (LdCen-/-).

Viana KF, Fiuza JA, Gannavaram S, Dey R, Selvapandiyan A, Bartholomeu DC, da Silveira-Lemos D, Bueno LL, Dutra WO, Fujiwara RT, Nakhasi HL, Giunchetti RC.

Parasit Vectors. 2016 Apr 30;9:250. doi: 10.1186/s13071-016-1528-z.


Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection.

Cardoso MS, Reis-Cunha JL, Bartholomeu DC.

Front Immunol. 2016 Jan 18;6:659. doi: 10.3389/fimmu.2015.00659. eCollection 2015. Review.


TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus.

Gomes MT, Campos PC, Pereira Gde S, Bartholomeu DC, Splitter G, Oliveira SC.

J Leukoc Biol. 2016 May;99(5):771-80. doi: 10.1189/jlb.4A0815-346R. Epub 2015 Nov 17.


The Leishmania metaphylome: a comprehensive survey of Leishmania protein phylogenetic relationships.

Valdivia HO, Scholte LL, Oliveira G, Gabaldón T, Bartholomeu DC.

BMC Genomics. 2015 Oct 30;16:887. doi: 10.1186/s12864-015-2091-2.


Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis.

Valdivia HO, Reis-Cunha JL, Rodrigues-Luiz GF, Baptista RP, Baldeviano GC, Gerbasi RV, Dobson DE, Pratlong F, Bastien P, Lescano AG, Beverley SM, Bartholomeu DC.

BMC Genomics. 2015 Sep 18;16:715. doi: 10.1186/s12864-015-1928-z.


Proteins Selected in Leishmania (Viannia) braziliensis by an Immunoproteomic Approach with Potential Serodiagnosis Applications for Tegumentary Leishmaniasis.

Duarte MC, Pimenta DC, Menezes-Souza D, Magalhães RD, Diniz JL, Costa LE, Chávez-Fumagalli MA, Lage PS, Bartholomeu DC, Alves MJ, Fernandes AP, Soto M, Tavares CA, Gonçalves DU, Rocha MO, Coelho EA.

Clin Vaccine Immunol. 2015 Nov;22(11):1187-96. doi: 10.1128/CVI.00465-15. Epub 2015 Sep 16.


Chromosomal copy number variation reveals differential levels of genomic plasticity in distinct Trypanosoma cruzi strains.

Reis-Cunha JL, Rodrigues-Luiz GF, Valdivia HO, Baptista RP, Mendes TA, de Morais GL, Guedes R, Macedo AM, Bern C, Gilman RH, Lopez CT, Andersson B, Vasconcelos AT, Bartholomeu DC.

BMC Genomics. 2015 Jul 4;16:499. doi: 10.1186/s12864-015-1680-4.


Use of Phage Display technology in development of canine visceral leishmaniasis vaccine using synthetic peptide trapped in sphingomyelin/cholesterol liposomes.

Toledo-Machado CM, Bueno LL, Menezes-Souza D, Machado-de-Avila RA, Nguyen C, Granier C, Bartholomeu DC, Chávez-Olórtegui C, Fujiwara RT.

Parasit Vectors. 2015 Feb 28;8:133. doi: 10.1186/s13071-015-0747-z.


A new methodology for evaluation of nematode viability.

Ferreira SR, Mendes TA, Bueno LL, de Araújo JV, Bartholomeu DC, Fujiwara RT.

Biomed Res Int. 2015;2015:879263. doi: 10.1155/2015/879263. Epub 2015 Mar 19.


ProGeRF: proteome and genome repeat finder utilizing a fast parallel hash function.

Lopes Rda S, Moraes WJ, Rodrigues Tde S, Bartholomeu DC.

Biomed Res Int. 2015;2015:394157. doi: 10.1155/2015/394157. Epub 2015 Feb 25.


Phenotypic profiling of CD8(+) T cells during Plasmodium vivax blood-stage infection.

Hojo-Souza NS, Pereira DB, Passos LS, Gazzinelli-Guimarães PH, Cardoso MS, Tada MS, Zanini GM, Bartholomeu DC, Fujiwara RT, Bueno LL.

BMC Infect Dis. 2015 Jan 31;15:35. doi: 10.1186/s12879-015-0762-x.


Improving serodiagnosis of human and canine leishmaniasis with recombinant Leishmania braziliensis cathepsin l-like protein and a synthetic peptide containing its linear B-cell epitope.

Menezes-Souza D, Mendes TA, Gomes Mde S, Bartholomeu DC, Fujiwara RT.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3426. doi: 10.1371/journal.pntd.0003426. eCollection 2015 Jan.


CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways.

Hojo-Souza NS, Pereira DB, Mendes TA, Passos LS, Gazzinelli-Guimarães AC, Gazzinelli-Guimarães PH, Tada MS, Zanini GM, Bartholomeu DC, Fujiwara RT, Bueno LL.

Malar J. 2015 Jan 5;14:5. doi: 10.1186/1475-2875-14-5.


Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum.

Fiuza JA, Gannavaram S, Santiago Hda C, Selvapandiyan A, Souza DM, Passos LS, de Mendonça LZ, Lemos-Giunchetti Dda S, Ricci ND, Bartholomeu DC, Giunchetti RC, Bueno LL, Correa-Oliveira R, Nakhasi HL, Fujiwara RT.

Vaccine. 2015 Jan 3;33(2):280-8. doi: 10.1016/j.vaccine.2014.11.039. Epub 2014 Dec 1.


Unveiling the intracellular survival gene kit of trypanosomatid parasites.

Bartholomeu DC, de Paiva RM, Mendes TA, DaRocha WD, Teixeira SM.

PLoS Pathog. 2014 Dec 4;10(12):e1004399. doi: 10.1371/journal.ppat.1004399. eCollection 2014 Dec. Review.


Linear B-cell epitope mapping of MAPK3 and MAPK4 from Leishmania braziliensis: implications for the serodiagnosis of human and canine leishmaniasis.

Menezes-Souza D, de Oliveira Mendes TA, de Araújo Leão AC, de Souza Gomes M, Fujiwara RT, Bartholomeu DC.

Appl Microbiol Biotechnol. 2015 Feb;99(3):1323-36. doi: 10.1007/s00253-014-6168-7. Epub 2014 Oct 31.


Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli.

Stoco PH, Wagner G, Talavera-Lopez C, Gerber A, Zaha A, Thompson CE, Bartholomeu DC, Lückemeyer DD, Bahia D, Loreto E, Prestes EB, Lima FM, Rodrigues-Luiz G, Vallejo GA, Filho JF, Schenkman S, Monteiro KM, Tyler KM, de Almeida LG, Ortiz MF, Chiurillo MA, de Moraes MH, Cunha Ode L, Mendonça-Neto R, Silva R, Teixeira SM, Murta SM, Sincero TC, Mendes TA, Urmenyi TP, Silva VG, DaRocha WD, Andersson B, Romanha AJ, Steindel M, de Vasconcelos AT, Grisard EC.

PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3176. doi: 10.1371/journal.pntd.0003176. eCollection 2014 Sep.


Genome-wide screening and identification of new Trypanosoma cruzi antigens with potential application for chronic Chagas disease diagnosis.

Reis-Cunha JL, Mendes TA, de Almeida Lourdes R, Ribeiro DR, Machado-de-Avila RA, de Oliveira Tavares M, Lemos DS, Câmara AC, Olórtegui CC, de Lana M, da Cunha Galvão LM, Fujiwara RT, Bartholomeu DC.

PLoS One. 2014 Sep 16;9(9):e106304. doi: 10.1371/journal.pone.0106304. eCollection 2014.


Mapping B-cell epitopes for the peroxidoxin of Leishmania (Viannia) braziliensis and its potential for the clinical diagnosis of tegumentary and visceral leishmaniasis.

Menezes-Souza D, Mendes TA, Nagem RA, Santos TT, Silva AL, Santoro MM, de Carvalho SF, Coelho EA, Bartholomeu DC, Fujiwara RT.

PLoS One. 2014 Jun 12;9(6):e99216. doi: 10.1371/journal.pone.0099216. eCollection 2014.


Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses novel targets for immunodiagnosis of tegumentary and visceral clinical forms of leishmaniasis.

Menezes-Souza D, Mendes TA, Gomes Mde S, Reis-Cunha JL, Nagem RA, Carneiro CM, Coelho EA, Galvão LM, Fujiwara RT, Bartholomeu DC.

Clin Vaccine Immunol. 2014 Jul;21(7):949-59. doi: 10.1128/CVI.00151-14. Epub 2014 May 7.


Evaluation of three recombinant Leishmania infantum antigens in human and canine visceral leishmaniasis diagnosis.

Fonseca AM, Faria AR, Rodrigues FT, Nagem RA, Magalhães RD, Cunha JL, Bartholomeu DC, de Andrade HM.

Acta Trop. 2014 Sep;137:25-30. doi: 10.1016/j.actatropica.2014.04.028. Epub 2014 May 4.


Identification of strain-specific B-cell epitopes in Trypanosoma cruzi using genome-scale epitope prediction and high-throughput immunoscreening with peptide arrays.

Mendes TA, Reis Cunha JL, de Almeida Lourdes R, Rodrigues Luiz GF, Lemos LD, dos Santos AR, da Câmara AC, Galvão LM, Bern C, Gilman RH, Fujiwara RT, Gazzinelli RT, Bartholomeu DC.

PLoS Negl Trop Dis. 2013 Oct 31;7(10):e2524. doi: 10.1371/journal.pntd.0002524. eCollection 2013.


Parasitological and immunological aspects of early Ascaris spp. infection in mice.

Gazzinelli-Guimarães PH, Gazzinelli-Guimarães AC, Silva FN, Mati VL, Dhom-Lemos Lde C, Barbosa FS, Passos LS, Gaze S, Carneiro CM, Bartholomeu DC, Bueno LL, Fujiwara RT.

Int J Parasitol. 2013 Aug;43(9):697-706. doi: 10.1016/j.ijpara.2013.02.009. Epub 2013 May 9.


Expression of IL-4, IL-10 and IFN-γ in the liver tissue of cattle that are naturally infected with Fasciola hepatica.

Mendes EA, Mendes TA, dos Santos SL, Menezes-Souza D, Bartholomeu DC, Martins IV, Silva LM, Lima Wdos S.

Vet Parasitol. 2013 Jul 1;195(1-2):177-82. doi: 10.1016/j.vetpar.2013.03.035. Epub 2013 Apr 15.


Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family.

Motta MC, Martins AC, de Souza SS, Catta-Preta CM, Silva R, Klein CC, de Almeida LG, de Lima Cunha O, Ciapina LP, Brocchi M, Colabardini AC, de Araujo Lima B, Machado CR, de Almeida Soares CM, Probst CM, de Menezes CB, Thompson CE, Bartholomeu DC, Gradia DF, Pavoni DP, Grisard EC, Fantinatti-Garboggini F, Marchini FK, Rodrigues-Luiz GF, Wagner G, Goldman GH, Fietto JL, Elias MC, Goldman MH, Sagot MF, Pereira M, Stoco PH, de Mendonça-Neto RP, Teixeira SM, Maciel TE, de Oliveira Mendes TA, Ürményi TP, de Souza W, Schenkman S, de Vasconcelos AT.

PLoS One. 2013;8(4):e60209. doi: 10.1371/journal.pone.0060209. Epub 2013 Apr 3.

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