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[A GERCOR-AERIO national survey of oncology residents in France: Current setting and expectations regarding post-internship and research].

Hilmi M, Rousseau B, Cohen R, Vienot A, Vernerey D, Bartholin L, Blanc-Durand F, Louvet C, Turpin A, Neuzillet C.

Bull Cancer. 2019 May;106(5):407-420. doi: 10.1016/j.bulcan.2019.02.009. Epub 2019 Apr 12. French.


Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells.

Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH.

Immunity. 2019 May 21;50(5):1249-1261.e5. doi: 10.1016/j.immuni.2019.03.002. Epub 2019 Apr 2.


Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment.

Ni N, Gao Y, Fang X, Melgar M, Vincent DF, Lydon JP, Bartholin L, Li Q.

PLoS One. 2018 Dec 14;13(12):e0209417. doi: 10.1371/journal.pone.0209417. eCollection 2018.


Prognostic stratification of resected pancreatic ductal adenocarcinoma: Past, present, and future.

Barhli A, Cros J, Bartholin L, Neuzillet C.

Dig Liver Dis. 2018 Oct;50(10):979-990. doi: 10.1016/j.dld.2018.08.009. Epub 2018 Aug 20. Review.


TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.


Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?

Hilmi M, Bartholin L, Neuzillet C.

World J Gastroenterol. 2018 May 28;24(20):2137-2151. doi: 10.3748/wjg.v24.i20.2137. Review.


A novel mouse model of testicular granulosa cell tumors.

Fang X, Ni N, Gao Y, Vincent DF, Bartholin L, Li Q.

Mol Hum Reprod. 2018 Jul 1;24(7):343-356. doi: 10.1093/molehr/gay023.


Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling.

Gao Y, Fang X, Vincent DF, Threadgill DW, Bartholin L, Li Q.

Reprod Biol Endocrinol. 2017 Dec 8;15(1):94. doi: 10.1186/s12958-017-0312-z.


Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.

Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng SS, Young A, Ngiow SF, Rautela J, Straube J, Waddell N, Blake SJ, Yan J, Bartholin L, Lee JS, Vivier E, Takeda K, Messaoudene M, Zitvogel L, Teng MWL, Belz GT, Engwerda CR, Huntington ND, Nakamura K, Hölzel M, Smyth MJ.

Nat Immunol. 2017 Sep;18(9):1004-1015. doi: 10.1038/ni.3800. Epub 2017 Jul 31.


Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.

Chuvin N, Vincent DF, Pommier RM, Alcaraz LB, Gout J, Caligaris C, Yacoub K, Cardot V, Roger E, Kaniewski B, Martel S, Cintas C, Goddard-Léon S, Colombe A, Valantin J, Gadot N, Servoz E, Morton J, Goddard I, Couvelard A, Rebours V, Guillermet J, Sansom OJ, Treilleux I, Valcourt U, Sentis S, Dubus P, Bartholin L.

Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282. doi: 10.1016/j.jcmgh.2017.05.005. eCollection 2017 Sep.


Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis.

Gao Y, Vincent DF, Davis AJ, Sansom OJ, Bartholin L, Li Q.

Oncotarget. 2016 Jul 5;7(27):40904-40918. doi: 10.18632/oncotarget.10149.


Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells.

Viant C, Rankin LC, Girard-Madoux MJ, Seillet C, Shi W, Smyth MJ, Bartholin L, Walzer T, Huntington ND, Vivier E, Belz GT.

Sci Signal. 2016 May 3;9(426):ra46. doi: 10.1126/scisignal.aaf2176.


Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution.

Le Calvé B, Griveau A, Vindrieux D, Maréchal R, Wiel C, Svrcek M, Gout J, Azzi L, Payen L, Cros J, de la Fouchardière C, Dubus P, Guitton J, Bartholin L, Bachet JB, Bernard D.

Oncotarget. 2016 May 31;7(22):32100-12. doi: 10.18632/oncotarget.8527.


TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma.

Thakur AK, Nigri J, Lac S, Leca J, Bressy C, Berthezene P, Bartholin L, Chan P, Calvo E, Iovanna JL, Vasseur S, Guillaumond F, Tomasini R.

Cell Death Differ. 2016 Aug;23(8):1358-70. doi: 10.1038/cdd.2016.18. Epub 2016 Mar 4.


Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.

Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH.

Nat Immunol. 2016 Apr;17(4):414-21. doi: 10.1038/ni.3396. Epub 2016 Feb 22.


TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway.

Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T.

Sci Signal. 2016 Feb 16;9(415):ra19. doi: 10.1126/scisignal.aad1884.


Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.

Valcourt U, Carthy J, Okita Y, Alcaraz L, Kato M, Thuault S, Bartholin L, Moustakas A.

Methods Mol Biol. 2016;1344:147-81. doi: 10.1007/978-1-4939-2966-5_9.


TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability.

Pommier RM, Gout J, Vincent DF, Alcaraz LB, Chuvin N, Arfi V, Martel S, Kaniewski B, Devailly G, Fourel G, Bernard P, Moyret-Lalle C, Ansieau S, Puisieux A, Valcourt U, Sentis S, Bartholin L.

Cancer Res. 2015 Oct 15;75(20):4335-50. doi: 10.1158/0008-5472.CAN-14-3426. Epub 2015 Aug 17.


Tenascin-X: beyond the architectural function.

Valcourt U, Alcaraz LB, Exposito JY, Lethias C, Bartholin L.

Cell Adh Migr. 2015;9(1-2):154-65. doi: 10.4161/19336918.2014.994893. Review.


Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function.

Gao Y, Duran S, Lydon JP, DeMayo FJ, Burghardt RC, Bayless KJ, Bartholin L, Li Q.

Biol Reprod. 2015 Feb;92(2):34. doi: 10.1095/biolreprod.114.125146. Epub 2014 Dec 10.


Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β.

Alcaraz LB, Exposito JY, Chuvin N, Pommier RM, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U.

J Cell Biol. 2014 May 12;205(3):409-28. doi: 10.1083/jcb.201308031.


TGF-β: duality of function between tumor prevention and carcinogenesis.

Principe DR, Doll JA, Bauer J, Jung B, Munshi HG, Bartholin L, Pasche B, Lee C, Grippo PJ.

J Natl Cancer Inst. 2014 Feb;106(2):djt369. doi: 10.1093/jnci/djt369. Review.


Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.

Wiel C, Augert A, Vincent DF, Gitenay D, Vindrieux D, Le Calvé B, Arfi V, Lallet-Daher H, Reynaud C, Treilleux I, Bartholin L, Lelievre E, Bernard D.

Cell Death Dis. 2013 Oct 10;4:e855. doi: 10.1038/cddis.2013.382.


Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.

Cano CE, Hamidi T, Garcia MN, Grasso D, Loncle C, Garcia S, Calvo E, Lomberk G, Dusetti N, Bartholin L, Urrutia R, Iovanna JL.

Gut. 2014 Jun;63(6):984-95. doi: 10.1136/gutjnl-2013-305221. Epub 2013 Sep 11.


Isolation and culture of mouse primary pancreatic acinar cells.

Gout J, Pommier RM, Vincent DF, Kaniewski B, Martel S, Valcourt U, Bartholin L.

J Vis Exp. 2013 Aug 13;(78). doi: 10.3791/50514.


The conditional expression of KRAS G12D in mouse pancreas induces disorganization of endocrine islets prior the onset of ductal pre-cancerous lesions.

Gout J, Pommier RM, Vincent DF, Ripoche D, Goddard-Léon S, Colombe A, Treilleux I, Valcourt U, Tomasini R, Dufresne M, Bertolino P, Bartholin L.

Pancreatology. 2013 May-Jun;13(3):191-5. doi: 10.1016/j.pan.2013.02.001. Epub 2013 Feb 18.


Generation of a conditional mouse model to target Acvr1b disruption in adult tissues.

Ripoche D, Gout J, Pommier RM, Jaafar R, Zhang CX, Bartholin L, Bertolino P.

Genesis. 2013 Feb;51(2):120-7. doi: 10.1002/dvg.22352. Epub 2012 Nov 7.


Pancreatic cancer and the tumor microenvironment: Mesenchyme’s role in pancreatic carcinogenesis.

Bartholin L.

In: Grippo PJ, Munshi HG, editors. Pancreatic Cancer and Tumor Microenvironment. Trivandrum (India): Transworld Research Network; 2012. Chapter 4.


Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer.

Cano CE, Sandí MJ, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, Kroemer G, Urrutia R, Iovanna JL.

EMBO Mol Med. 2012 Sep;4(9):964-79. doi: 10.1002/emmm.201201255. Epub 2012 Jul 23.


The human NUPR1/P8 gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway.

Pommier RM, Gout J, Vincent DF, Cano CE, Kaniewski B, Martel S, Rodriguez J, Fourel G, Valcourt U, Marie JC, Iovanna JL, Bartholin L.

Biochem J. 2012 Jul 15;445(2):285-93. doi: 10.1042/BJ20120368.


Premature senescence and increased TGFβ signaling in the absence of Tgif1.

Zerlanko BJ, Bartholin L, Melhuish TA, Wotton D.

PLoS One. 2012;7(4):e35460. doi: 10.1371/journal.pone.0035460. Epub 2012 Apr 13.


Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L.

Am J Pathol. 2012 Jun;180(6):2214-21. doi: 10.1016/j.ajpath.2012.02.006. Epub 2012 Mar 31.


New ELISA approach based on coiled-coil interactions.

Liberelle B, Bartholin L, Boucher C, Murschel F, Jolicoeur M, Durocher Y, Merzouki A, De Crescenzo G.

J Immunol Methods. 2010 Oct 31;362(1-2):161-7. doi: 10.1016/j.jim.2010.09.027. Epub 2010 Oct 1.


A rapid strategy to detect the recombined allele in LSL-TβRICA transgenic mice.

Vincent DF, Kaniewski B, Powers SE, Havenar-Daughton C, Marie JC, Wotton D, Bartholin L.

Genesis. 2010 Sep;48(9):559-62. doi: 10.1002/dvg.20653.


Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.

Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, Kaniewski B, Marie JC, Lepinasse F, Martel S, Goddard-Leon S, Iovanna JL, Dubus P, Garcia S, Puisieux A, Rimokh R, Bardeesy N, Scoazec JY, Losson R, Bartholin L.

PLoS Genet. 2009 Jul;5(7):e1000575. doi: 10.1371/journal.pgen.1000575. Epub 2009 Jul 24. Erratum in: PLoS Genet. 2009 Aug;5(8). doi: 10.1371/annotation/7941c465-532f-4b42-b541-72d0810943b9. Kaniewsky, Bastien [corrected to Kaniewski, Bastien].


iNKT cell development is orchestrated by different branches of TGF-beta signaling.

Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC.

J Exp Med. 2009 Jun 8;206(6):1365-78. doi: 10.1084/jem.20090127. Epub 2009 May 18.


Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.

Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC.

Genesis. 2008 Dec;46(12):724-31. doi: 10.1002/dvg.20425.


Maternal Tgif is required for vascularization of the embryonic placenta.

Bartholin L, Melhuish TA, Powers SE, Goddard-Léon S, Treilleux I, Sutherland AE, Wotton D.

Dev Biol. 2008 Jul 15;319(2):285-97. doi: 10.1016/j.ydbio.2008.04.027. Epub 2008 May 2.


AF10-dependent transcription is enhanced by its interaction with FLRG.

Forissier S, Razanajaona D, Ay AS, Martel S, Bartholin L, Rimokh R.

Biol Cell. 2007 Oct;99(10):563-71.


Silencing of FLRG, an antagonist of activin, inhibits human breast tumor cell growth.

Razanajaona D, Joguet S, Ay AS, Treilleux I, Goddard-Léon S, Bartholin L, Rimokh R.

Cancer Res. 2007 Aug 1;67(15):7223-9.


Identification of NF-kappaB responsive elements in follistatin related gene (FLRG) promoter.

Bartholin L, Guindon S, Martel S, Corbo L, Rimokh R.

Gene. 2007 May 15;393(1-2):153-62. Epub 2007 Mar 1.


Functional analysis of mutations in TGIF associated with holoprosencephaly.

El-Jaick KB, Powers SE, Bartholin L, Myers KR, Hahn J, Orioli IM, Ouspenskaia M, Lacbawan F, Roessler E, Wotton D, Muenke M.

Mol Genet Metab. 2007 Jan;90(1):97-111. Epub 2006 Sep 7. Review.


The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells.

Bartholin L, Wessner LL, Chirgwin JM, Guise TA.

Cancer Lett. 2007 Feb 8;246(1-2):230-6. Epub 2006 Apr 17.


TGIF inhibits retinoid signaling.

Bartholin L, Powers SE, Melhuish TA, Lasse S, Weinstein M, Wotton D.

Mol Cell Biol. 2006 Feb;26(3):990-1001.


A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin.

Maguer-Satta V, Forissier S, Bartholin L, Martel S, Jeanpierre S, Bachelard E, Rimokh R.

Exp Cell Res. 2006 Feb 15;312(4):434-42. Epub 2005 Dec 5.


FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation.

Bartholin L, Destaing O, Forissier S, Martel S, Maguer-Satta V, Jurdic P, Rimokh R.

Biol Cell. 2005 Jul;97(7):577-88.


Allele-specific binding to the -308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter.

Baseggio L, Bartholin L, Chantome A, Charlot C, Rimokh R, Salles G.

Eur J Immunogenet. 2004 Feb;31(1):15-9.


Drosophila TGIF proteins are transcriptional activators.

Hyman CA, Bartholin L, Newfeld SJ, Wotton D.

Mol Cell Biol. 2003 Dec;23(24):9262-74.


Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family.

Maguer-Satta V, Bartholin L, Jeanpierre S, Ffrench M, Martel S, Magaud JP, Rimokh R.

Exp Cell Res. 2003 Jan 15;282(2):110-20.


Recurrent involvement of the MLL gene in adult T-lineage acute lymphoblastic leukemia.

Hayette S, Tigaud I, Maguer-Satta V, Bartholin L, Thomas X, Charrin C, Gadoux M, Magaud JP, Rimokh R.

Blood. 2002 Jun 15;99(12):4647-9. No abstract available.

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