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Items: 28

1.

Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation.

Bartholdy B, Lajugie J, Yan Z, Zhang S, Mukhopadhyay R, Greally JM, Suzuki M, Bouhassira EE.

Blood Adv. 2018 Aug 14;2(15):1833-1852. doi: 10.1182/bloodadvances.2018015651.

2.

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia.

Carvajal LA, Neriah DB, Senecal A, Benard L, Thiruthuvanathan V, Yatsenko T, Narayanagari SR, Wheat JC, Todorova TI, Mitchell K, Kenworthy C, Guerlavais V, Annis DA, Bartholdy B, Will B, Anampa JD, Mantzaris I, Aivado M, Singer RH, Coleman RA, Verma A, Steidl U.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaao3003. doi: 10.1126/scitranslmed.aao3003.

3.

European Society for the Study of Human Evolution 2017: old sites, new methods.

Henry AG, Devereux E, Bartholdy BP.

Evol Anthropol. 2018 Jan;27(1):5-6. doi: 10.1002/evan.21571. No abstract available.

PMID:
29446557
4.

Pharmacological inhibition of the transcription factor PU.1 in leukemia.

Antony-Debré I, Paul A, Leite J, Mitchell K, Kim HM, Carvajal LA, Todorova TI, Huang K, Kumar A, Farahat AA, Bartholdy B, Narayanagari SR, Chen J, Ambesi-Impiombato A, Ferrando AA, Mantzaris I, Gavathiotis E, Verma A, Will B, Boykin DW, Wilson WD, Poon GM, Steidl U.

J Clin Invest. 2017 Dec 1;127(12):4297-4313. doi: 10.1172/JCI92504. Epub 2017 Oct 30.

5.

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E.

Cancer Cell. 2017 Oct 9;32(4):490-505.e10. doi: 10.1016/j.ccell.2017.09.001.

PMID:
29017059
6.

ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.

Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG.

J Biol Chem. 2017 Nov 17;292(46):18924-18936. doi: 10.1074/jbc.M117.811109. Epub 2017 Sep 12.

PMID:
28900037
7.

Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila.

Andreyeva EN, Bernardo TJ, Kolesnikova TD, Lu X, Yarinich LA, Bartholdy BA, Guo X, Posukh OV, Healton S, Willcockson MA, Pindyurin AV, Zhimulev IF, Skoultchi AI, Fyodorov DV.

Genes Dev. 2017 Mar 15;31(6):603-616. doi: 10.1101/gad.295717.116.

8.

A myeloid tumor suppressor role for NOL3.

Stanley RF, Piszczatowski RT, Bartholdy B, Mitchell K, McKimpson WM, Narayanagari S, Walter D, Todorova TI, Hirsch C, Makishima H, Will B, McMahon C, Gritsman K, Maciejewski JP, Kitsis RN, Steidl U.

J Exp Med. 2017 Mar 6;214(3):753-771. doi: 10.1084/jem.20162089. Epub 2017 Feb 23.

9.

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL.

Mai Y, Yu JJ, Bartholdy B, Xu-Monette ZY, Knapp EE, Yuan F, Chen H, Ding BB, Yao Z, Das B, Zou Y, Young KH, Parekh S, Ye BH.

Blood. 2016 Dec 15;128(24):2797-2807. Epub 2016 Oct 13.

10.

Local compartment changes and regulatory landscape alterations in histone H1-depleted cells.

Geeven G, Zhu Y, Kim BJ, Bartholdy BA, Yang SM, Macfarlan TS, Gifford WD, Pfaff SL, Verstegen MJ, Pinto H, Vermunt MW, Creyghton MP, Wijchers PJ, Stamatoyannopoulos JA, Skoultchi AI, de Laat W.

Genome Biol. 2015 Dec 23;16:289. doi: 10.1186/s13059-015-0857-0.

11.

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.

Okoye-Okafor UC, Bartholdy B, Cartier J, Gao EN, Pietrak B, Rendina AR, Rominger C, Quinn C, Smallwood A, Wiggall KJ, Reif AJ, Schmidt SJ, Qi H, Zhao H, Joberty G, Faelth-Savitski M, Bantscheff M, Drewes G, Duraiswami C, Brady P, Groy A, Narayanagari SR, Antony-Debre I, Mitchell K, Wang HR, Kao YR, Christopeit M, Carvajal L, Barreyro L, Paietta E, Makishima H, Will B, Concha N, Adams ND, Schwartz B, McCabe MT, Maciejewski J, Verma A, Steidl U.

Nat Chem Biol. 2015 Nov;11(11):878-86. doi: 10.1038/nchembio.1930. Epub 2015 Oct 5.

12.

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

Will B, Vogler TO, Narayanagari S, Bartholdy B, Todorova TI, da Silva Ferreira M, Chen J, Yu Y, Mayer J, Barreyro L, Carvajal L, Neriah DB, Roth M, van Oers J, Schaetzlein S, McMahon C, Edelmann W, Verma A, Steidl U.

Nat Med. 2015 Oct;21(10):1172-81. doi: 10.1038/nm.3936. Epub 2015 Sep 7.

13.

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

Pandolfi A, Stanley RF, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U.

Blood. 2015 Aug 27;126(9):1118-27. doi: 10.1182/blood-2014-12-618801. Epub 2015 Jul 13.

14.

Allele-specific analysis of DNA replication origins in mammalian cells.

Bartholdy B, Mukhopadhyay R, Lajugie J, Aladjem MI, Bouhassira EE.

Nat Commun. 2015 May 19;6:7051. doi: 10.1038/ncomms8051.

15.

A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1.

Kavi H, Lu X, Xu N, Bartholdy BA, Vershilova E, Skoultchi AI, Fyodorov DV.

G3 (Bethesda). 2015 Jan 27;5(4):677-87. doi: 10.1534/g3.115.016709.

16.

Epigenetic signatures as prognostic tools in acute myeloid leukemia and myelodysplastic syndromes.

Christopeit M, Bartholdy B.

Epigenomics. 2014;6(4):371-4. doi: 10.2217/epi.14.32. No abstract available.

PMID:
25333846
17.

Allele-specific genome-wide profiling in human primary erythroblasts reveal replication program organization.

Mukhopadhyay R, Lajugie J, Fourel N, Selzer A, Schizas M, Bartholdy B, Mar J, Lin CM, Martin MM, Ryan M, Aladjem MI, Bouhassira EE.

PLoS Genet. 2014 May 1;10(5):e1004319. doi: 10.1371/journal.pgen.1004319. eCollection 2014 May.

18.

HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia.

Bartholdy B, Christopeit M, Will B, Mo Y, Barreyro L, Yu Y, Bhagat TD, Okoye-Okafor UC, Todorova TI, Greally JM, Levine RL, Melnick A, Verma A, Steidl U.

J Clin Invest. 2014 Mar;124(3):1158-67.

19.

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

Will B, Vogler TO, Bartholdy B, Garrett-Bakelman F, Mayer J, Barreyro L, Pandolfi A, Todorova TI, Okoye-Okafor UC, Stanley RF, Bhagat TD, Verma A, Figueroa ME, Melnick A, Roth M, Steidl U.

Nat Immunol. 2013 May;14(5):437-45. doi: 10.1038/ni.2572. Epub 2013 Apr 7.

20.

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG.

Mol Cell. 2013 Mar 7;49(5):934-46. doi: 10.1016/j.molcel.2013.01.007. Epub 2013 Feb 8.

21.

H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia.

Kawahara M, Pandolfi A, Bartholdy B, Barreyro L, Will B, Roth M, Okoye-Okafor UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U.

Cancer Cell. 2012 Aug 14;22(2):194-208. doi: 10.1016/j.ccr.2012.06.027.

22.

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

Barreyro L, Will B, Bartholdy B, Zhou L, Todorova TI, Stanley RF, Ben-Neriah S, Montagna C, Parekh S, Pellagatti A, Boultwood J, Paietta E, Ketterling RP, Cripe L, Fernandez HF, Greenberg PL, Tallman MS, Steidl C, Mitsiades CS, Verma A, Steidl U.

Blood. 2012 Aug 9;120(6):1290-8. doi: 10.1182/blood-2012-01-404699. Epub 2012 Jun 21.

23.

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.

Roth M, Will B, Simkin G, Narayanagari S, Barreyro L, Bartholdy B, Tamari R, Mitsiades CS, Verma A, Steidl U.

Blood. 2012 Jul 12;120(2):386-94. doi: 10.1182/blood-2011-12-399667. Epub 2012 May 24.

24.

Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development.

Bordon A, Bosco N, Du Roure C, Bartholdy B, Kohler H, Matthias G, Rolink AG, Matthias P.

PLoS One. 2008;3(12):e4007. doi: 10.1371/journal.pone.0004007. Epub 2008 Dec 23.

25.

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V, Rosenbauer F, Huang G, Dayaram T, Klupp J, O'Brien KB, Will B, Hoogenkamp M, Borden KL, Bonifer C, Tenen DG.

Genes Dev. 2008 Aug 1;22(15):2085-92. doi: 10.1101/gad.1654808.

26.

The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.

Bartholdy B, Du Roure C, Bordon A, Emslie D, Corcoran LM, Matthias P.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11665-70. Epub 2006 Jul 21.

27.

Transcriptional control of B cell development and function.

Bartholdy B, Matthias P.

Gene. 2004 Feb 18;327(1):1-23. Review.

PMID:
14960357
28.

The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.

Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P.

EMBO J. 2001 Aug 1;20(15):4143-52.

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