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Items: 16


The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.

Haytural H, Mermelekas G, Emre C, Nigam SM, Carroll SL, Winblad B, Bogdanovic N, Barthet G, Granholm AC, Orre LM, Tjernberg LO, Frykman S.

Mol Cell Proteomics. 2020 Jan;19(1):128-141. doi: 10.1074/mcp.RA119.001737. Epub 2019 Nov 7.


Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies.

Haytural H, Lundgren JL, Köse TB, Jordà-Siquier T, Kalcheva M, Seed Ahmed M, Winblad B, Sundström E, Barthet G, Tjernberg LO, Frykman S.

Front Aging Neurosci. 2019 Oct 9;11:273. doi: 10.3389/fnagi.2019.00273. eCollection 2019.


Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.

Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Müller U, Mulle C.

Nat Commun. 2018 Nov 14;9(1):4780. doi: 10.1038/s41467-018-06813-x.


PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.

Maingret V, Barthet G, Deforges S, Jiang N, Mulle C, Amédée T.

Neurobiol Aging. 2017 Feb;50:13-24. doi: 10.1016/j.neurobiolaging.2016.10.012. Epub 2016 Oct 17.


Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B.

Xuan Z, Barthet G, Shioi J, Xu J, Georgakopoulos A, Bruban J, Robakis NK.

J Biol Chem. 2013 Oct 18;288(42):30495-501. doi: 10.1074/jbc.M113.499004. Epub 2013 Sep 11.


Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.

Barthet G, Georgakopoulos A, Robakis NK.

Prog Neurobiol. 2012 Aug;98(2):166-75. doi: 10.1016/j.pneurobio.2012.05.006. Epub 2012 May 20. Review.


Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors.

Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, Arbez N, Mauger G, Bruban J, Georgakopoulos A, Shioi J, Robakis NK.

Neurobiol Aging. 2013 Feb;34(2):499-510. doi: 10.1016/j.neurobiolaging.2012.02.024. Epub 2012 Apr 3.


Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein.

Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK.

FASEB J. 2011 Oct;25(10):3594-604. doi: 10.1096/fj.11-187856. Epub 2011 Jul 11.


Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.

Barthet G, Shioi J, Shao Z, Ren Y, Georgakopoulos A, Robakis NK.

FASEB J. 2011 Sep;25(9):2937-46. doi: 10.1096/fj.11-183806. Epub 2011 May 19.


G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.

Pellissier LP, Barthet G, Gaven F, Cassier E, Trinquet E, Pin JP, Marin P, Dumuis A, Bockaert J, Banères JL, Claeysen S.

J Biol Chem. 2011 Mar 25;286(12):9985-97. doi: 10.1074/jbc.M110.201939. Epub 2011 Jan 19.


Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A.

EMBO J. 2009 Sep 16;28(18):2706-18. doi: 10.1038/emboj.2009.215. Epub 2009 Aug 6.


p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.

Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK.

J Biol Chem. 2009 Jan 23;284(4):1954-61. doi: 10.1074/jbc.M806250200. Epub 2008 Nov 13.


5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.

Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J, Dumuis A.

Mol Biol Cell. 2007 Jun;18(6):1979-91. Epub 2007 Mar 21.


Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.

Barthet G, Gaven F, Framery B, Shinjo K, Nakamura T, Claeysen S, Bockaert J, Dumuis A.

J Biol Chem. 2005 Jul 29;280(30):27924-34. Epub 2005 May 26.


Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis.

Ponimaskin E, Dumuis A, Gaven F, Barthet G, Heine M, Glebov K, Richter DW, Oppermann M.

Mol Pharmacol. 2005 May;67(5):1434-43. Epub 2005 Feb 2.


New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.

Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J.

J Cell Sci. 2004 Oct 15;117(Pt 22):5367-79. Epub 2004 Oct 5.

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