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Items: 1 to 50 of 84

1.

Treatment with corn oil improves neurogenesis and cognitive performance in the Ts65Dn mouse model of Down syndrome.

Giacomini A, Stagni F, Emili M, Guidi S, Salvalai ME, Grilli M, Vidal-Sanchez V, Martinez-Cué C, Bartesaghi R.

Brain Res Bull. 2018 Jun;140:378-391. doi: 10.1016/j.brainresbull.2018.06.009. Epub 2018 Jun 20.

PMID:
29935232
2.

Translating molecular advances in Down syndrome and Fragile X syndrome into therapies.

Faundez V, De Toma I, Bardoni B, Bartesaghi R, Nizetic D, de la Torre R, Cohen Kadosh R, Herault Y, Dierssen M, Potier MC; Down Syndrome and Other Genetic Developmental Disorders ECNP Network.

Eur Neuropsychopharmacol. 2018 Jun;28(6):675-690. doi: 10.1016/j.euroneuro.2018.03.006. Epub 2018 Jun 7. Review.

PMID:
29887288
3.

Abnormal development of the inferior temporal region in fetuses with Down syndrome.

Guidi S, Giacomini A, Stagni F, Emili M, Uguagliati B, Bonasoni MP, Bartesaghi R.

Brain Pathol. 2018 Mar 6. doi: 10.1111/bpa.12605. [Epub ahead of print]

PMID:
29509279
4.

CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder.

Trazzi S, De Franceschi M, Fuchs C, Bastianini S, Viggiano R, Lupori L, Mazziotti R, Medici G, Lo Martire V, Ren E, Rimondini R, Zoccoli G, Bartesaghi R, Pizzorusso T, Ciani E.

Hum Mol Genet. 2018 May 1;27(9):1572-1592. doi: 10.1093/hmg/ddy064.

PMID:
29474534
5.

A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS.

Stagni F, Giacomini A, Guidi S, Emili M, Uguagliati B, Salvalai ME, Bortolotto V, Grilli M, Rimondini R, Bartesaghi R.

Exp Neurol. 2017 Dec;298(Pt A):79-96. doi: 10.1016/j.expneurol.2017.08.018. Epub 2017 Sep 4.

PMID:
28882412
6.

Targeting APP/AICD in Down syndrome.

Guidi S, Stagni F, Bartesaghi R.

Oncotarget. 2017 Jun 30;8(31):50333-50334. doi: 10.18632/oncotarget.18860. eCollection 2017 Aug 1. No abstract available.

7.

Neurogenesis impairment: An early developmental defect in Down syndrome.

Stagni F, Giacomini A, Emili M, Guidi S, Bartesaghi R.

Free Radic Biol Med. 2018 Jan;114:15-32. doi: 10.1016/j.freeradbiomed.2017.07.026. Epub 2017 Jul 27. Review.

PMID:
28756311
8.

Neuroanatomical alterations and synaptic plasticity impairment in the perirhinal cortex of the Ts65Dn mouse model of Down syndrome.

Roncacé V, Burattini C, Stagni F, Guidi S, Giacomini A, Emili M, Aicardi G, Bartesaghi R.

Neurobiol Dis. 2017 Oct;106:89-100. doi: 10.1016/j.nbd.2017.06.017. Epub 2017 Jun 23.

PMID:
28651891
9.

Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome.

Stagni F, Raspanti A, Giacomini A, Guidi S, Emili M, Ciani E, Giuliani A, Bighinati A, Calzà L, Magistretti J, Bartesaghi R.

Neurobiol Dis. 2017 Jul;103:11-23. doi: 10.1016/j.nbd.2017.03.012. Epub 2017 Mar 28.

10.

Epigallocatechin gallate: A useful therapy for cognitive disability in Down syndrome?

Stagni F, Giacomini A, Emili M, Guidi S, Ciani E, Bartesaghi R.

Neurogenesis (Austin). 2017 Feb 2;4(1):e1270383. doi: 10.1080/23262133.2016.1270383. eCollection 2017.

11.

Lithium Restores Age-related Olfactory Impairment in the Ts65Dn Mouse Model of Down Syndrome.

Guidi S, Bianchi P, Stagni F, Giacomini A, Emili M, Trazzi S, Ciani E, Bartesaghi R.

CNS Neurol Disord Drug Targets. 2017;16(7):812-819. doi: 10.2174/1871527315666160801143108.

PMID:
27488422
12.

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.

Trazzi S, Fuchs C, Viggiano R, De Franceschi M, Valli E, Jedynak P, Hansen FK, Perini G, Rimondini R, Kurz T, Bartesaghi R, Ciani E.

Hum Mol Genet. 2016 Sep 15;25(18):3887-3907. doi: 10.1093/hmg/ddw231. Epub 2016 Jul 27.

PMID:
27466189
13.

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome.

Stagni F, Giacomini A, Emili M, Trazzi S, Guidi S, Sassi M, Ciani E, Rimondini R, Bartesaghi R.

Neuroscience. 2016 Oct 1;333:277-301. doi: 10.1016/j.neuroscience.2016.07.031. Epub 2016 Jul 25.

PMID:
27457036
14.

SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.

Meraviglia V, Ulivi AF, Boccazzi M, Valenza F, Fratangeli A, Passafaro M, Lecca D, Stagni F, Giacomini A, Bartesaghi R, Abbracchio MP, Ceruti S, Rosa P.

Glia. 2016 Aug;64(8):1437-60. doi: 10.1002/glia.23015. Epub 2016 Jun 6.

15.

Timing of therapies for Down syndrome: the sooner, the better.

Stagni F, Giacomini A, Guidi S, Ciani E, Bartesaghi R.

Front Behav Neurosci. 2015 Oct 6;9:265. doi: 10.3389/fnbeh.2015.00265. eCollection 2015. Review.

16.

New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.

Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW.

J Neurosci. 2015 Oct 14;35(41):13843-52. doi: 10.1523/JNEUROSCI.2775-15.2015.

17.

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.

Giacomini A, Stagni F, Trazzi S, Guidi S, Emili M, Brigham E, Ciani E, Bartesaghi R.

Neurobiol Dis. 2015 Oct;82:385-396. doi: 10.1016/j.nbd.2015.08.001. Epub 2015 Aug 5.

18.

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder.

Fuchs C, Rimondini R, Viggiano R, Trazzi S, De Franceschi M, Bartesaghi R, Ciani E.

Neurobiol Dis. 2015 Oct;82:298-310. doi: 10.1016/j.nbd.2015.06.018. Epub 2015 Jul 2.

PMID:
26143616
19.

Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice.

Stagni F, Giacomini A, Guidi S, Ciani E, Ragazzi E, Filonzi M, De Iasio R, Rimondini R, Bartesaghi R.

Neurobiol Dis. 2015 Feb;74:204-18. doi: 10.1016/j.nbd.2014.12.005. Epub 2014 Dec 10.

PMID:
25497735
20.

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.

Fuchs C, Trazzi S, Torricella R, Viggiano R, De Franceschi M, Amendola E, Gross C, Calzà L, Bartesaghi R, Ciani E.

Neurobiol Dis. 2014 Oct;70:53-68. doi: 10.1016/j.nbd.2014.06.006. Epub 2014 Jun 18.

21.

APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome.

Trazzi S, Fuchs C, De Franceschi M, Mitrugno VM, Bartesaghi R, Ciani E.

Neurobiol Dis. 2014 Jul;67:24-36. doi: 10.1016/j.nbd.2014.03.003. Epub 2014 Mar 15.

PMID:
24636797
22.

Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model.

Guidi S, Stagni F, Bianchi P, Ciani E, Giacomini A, De Franceschi M, Moldrich R, Kurniawan N, Mardon K, Giuliani A, Calzà L, Bartesaghi R.

Brain. 2014 Feb;137(Pt 2):380-401. doi: 10.1093/brain/awt340. Epub 2013 Dec 12.

PMID:
24334313
23.

Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome.

Bianchi P, Bettini S, Guidi S, Ciani E, Trazzi S, Stagni F, Ragazzi E, Franceschini V, Bartesaghi R.

Exp Neurol. 2014 Jan;251:1-11. doi: 10.1016/j.expneurol.2013.10.018. Epub 2013 Nov 2.

PMID:
24192151
24.

The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome.

Trazzi S, Fuchs C, Valli E, Perini G, Bartesaghi R, Ciani E.

J Biol Chem. 2013 Jul 19;288(29):20817-29. doi: 10.1074/jbc.M113.451088. Epub 2013 Jun 5.

25.

Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome.

Stagni F, Magistretti J, Guidi S, Ciani E, Mangano C, Calzà L, Bartesaghi R.

PLoS One. 2013 Apr 19;8(4):e61689. doi: 10.1371/journal.pone.0061689. Print 2013.

26.

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.

Valli E, Trazzi S, Fuchs C, Erriquez D, Bartesaghi R, Perini G, Ciani E.

Biochim Biophys Acta. 2012 Nov-Dec;1819(11-12):1173-85. doi: 10.1016/j.bbagrm.2012.08.001. Epub 2012 Aug 19.

27.

Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression.

Fuchs C, Ciani E, Guidi S, Trazzi S, Bartesaghi R.

Lab Invest. 2012 Nov;92(11):1648-60. doi: 10.1038/labinvest.2012.117. Epub 2012 Aug 13.

28.

Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome.

Guidi S, Stagni F, Bianchi P, Ciani E, Ragazzi E, Trazzi S, Grossi G, Mangano C, Calzà L, Bartesaghi R.

Brain Pathol. 2013 Mar;23(2):129-43. doi: 10.1111/j.1750-3639.2012.00624.x. Epub 2012 Sep 3.

PMID:
22817700
29.

Impact of environmental enrichment on neurogenesis in the dentate gyrus during the early postnatal period.

Rizzi S, Bianchi P, Guidi S, Ciani E, Bartesaghi R.

Brain Res. 2011 Sep 30;1415:23-33. doi: 10.1016/j.brainres.2011.08.007. Epub 2011 Aug 9.

PMID:
21885039
30.

Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

Bartesaghi R, Guidi S, Ciani E.

Rev Neurosci. 2011;22(4):419-55. doi: 10.1515/RNS.2011.037. Review.

PMID:
21819263
31.

Postnatal neurogenesis in the hippocampal dentate gyrus and subventricular zone of the Göttingen minipig.

Guidi S, Bianchi P, Alstrup AK, Henningsen K, Smith DF, Bartesaghi R.

Brain Res Bull. 2011 May 30;85(3-4):169-79. doi: 10.1016/j.brainresbull.2011.03.028. Epub 2011 Apr 8.

PMID:
21501667
32.

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

Trazzi S, Mitrugno VM, Valli E, Fuchs C, Rizzi S, Guidi S, Perini G, Bartesaghi R, Ciani E.

Hum Mol Genet. 2011 Apr 15;20(8):1560-73. doi: 10.1093/hmg/ddr033. Epub 2011 Jan 25.

PMID:
21266456
33.

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

Guidi S, Ciani E, Bonasoni P, Santini D, Bartesaghi R.

Brain Pathol. 2011 Jul;21(4):361-73. doi: 10.1111/j.1750-3639.2010.00459.x. Epub 2010 Dec 6.

PMID:
21040072
34.

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome.

Bianchi P, Ciani E, Guidi S, Trazzi S, Felice D, Grossi G, Fernandez M, Giuliani A, Calzà L, Bartesaghi R.

J Neurosci. 2010 Jun 30;30(26):8769-79. doi: 10.1523/JNEUROSCI.0534-10.2010.

35.

CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling.

Trazzi S, Steger M, Mitrugno VM, Bartesaghi R, Ciani E.

J Biol Chem. 2010 Mar 26;285(13):10098-109. doi: 10.1074/jbc.M109.043711. Epub 2010 Jan 18.

36.

Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation.

Fila T, Trazzi S, Crochemore C, Bartesaghi R, Ciani E.

J Biol Chem. 2009 May 29;284(22):15325-38. doi: 10.1074/jbc.M109.002329. Epub 2009 Apr 3.

37.

Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.

Contestabile A, Fila T, Cappellini A, Bartesaghi R, Ciani E.

Cell Prolif. 2009 Apr;42(2):171-81. doi: 10.1111/j.1365-2184.2009.00587.x.

PMID:
19317805
38.

Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome.

Bianchi P, Ciani E, Contestabile A, Guidi S, Bartesaghi R.

Brain Pathol. 2010 Jan;20(1):106-18. doi: 10.1111/j.1750-3639.2008.00246.x. Epub 2009 Mar 3.

PMID:
19298631
39.

Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood.

Rubino T, Realini N, Braida D, Guidi S, Capurro V, Viganò D, Guidali C, Pinter M, Sala M, Bartesaghi R, Parolaro D.

Hippocampus. 2009 Aug;19(8):763-72. doi: 10.1002/hipo.20554.

PMID:
19156848
40.

Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome.

Contestabile A, Fila T, Bartesaghi R, Ciani E.

Brain Pathol. 2009 Apr;19(2):224-37. doi: 10.1111/j.1750-3639.2008.00168.x. Epub 2008 May 14.

PMID:
18482164
41.

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

Guidi S, Bonasoni P, Ceccarelli C, Santini D, Gualtieri F, Ciani E, Bartesaghi R.

Brain Pathol. 2008 Apr;18(2):180-97. Epub 2007 Dec 17.

PMID:
18093248
42.

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice.

Contestabile A, Fila T, Ceccarelli C, Bonasoni P, Bonapace L, Santini D, Bartesaghi R, Ciani E.

Hippocampus. 2007;17(8):665-78.

PMID:
17546680
43.

Neonatal isolation impairs neurogenesis in the dentate gyrus of the guinea pig.

Rizzi S, Bianchi P, Guidi S, Ciani E, Bartesaghi R.

Hippocampus. 2007;17(1):78-91.

PMID:
17143902
44.

Input-output relations in the entorhinal cortex-dentate-hippocampal system: evidence for a non-linear transfer of signals.

Bartesaghi R, Migliore M, Gessi T.

Neuroscience. 2006 Sep 29;142(1):247-65. Epub 2006 Jul 14.

PMID:
16844310
45.

Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn rat.

Ciani E, Calvanese V, Crochemore C, Bartesaghi R, Contestabile A.

J Cell Sci. 2006 Aug 1;119(Pt 15):3161-70. Epub 2006 Jul 11.

46.

Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases.

Contestabile A, Fila T, Bartesaghi R, Contestabile A, Ciani E.

J Neurochem. 2006 Apr;97(2):515-26. Epub 2006 Mar 15.

47.

Sex differences in the hilar mossy cells of the guinea-pig before puberty.

Guidi S, Severi S, Ciani E, Bartesaghi R.

Neuroscience. 2006 May 12;139(2):565-76. Epub 2006 Feb 3.

PMID:
16458436
48.

Effect of early isolation on signal transfer in the entorhinal cortex-dentate-hippocampal system.

Bartesaghi R, Raffi M, Ciani E.

Neuroscience. 2006 Feb;137(3):875-90. Epub 2005 Dec 1.

PMID:
16325342
49.

Cyclic AMP-mediated regulation of transcription factor Lot1 expression in cerebellar granule cells.

Contestabile A, Fila T, Bartesaghi R, Ciani E.

J Biol Chem. 2005 Sep 30;280(39):33541-51. Epub 2005 Aug 1.

50.

Neurochemical correlates of nicotine neurotoxicity on rat habenulo-interpeduncular cholinergic neurons.

Ciani E, Severi S, Bartesaghi R, Contestabile A.

Neurotoxicology. 2005 Jun;26(3):467-74.

PMID:
15935216

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