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Items: 23


Recent advances in understanding the regulation of metalloproteinases.

Young DA, Barter MJ, Wilkinson DJ.

F1000Res. 2019 Feb 18;8. pii: F1000 Faculty Rev-195. doi: 10.12688/f1000research.17471.1. eCollection 2019. Review.


Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage.

Ajekigbe B, Cheung K, Xu Y, Skelton AJ, Panagiotopoulos A, Soul J, Hardingham TE, Deehan DJ, Barter MJ, Young DA.

Osteoarthritis Cartilage. 2019 Apr;27(4):694-702. doi: 10.1016/j.joca.2018.12.015. Epub 2019 Jan 3.


miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse.

Woods S, Barter MJ, Elliott HR, McGillivray CM, Birch MA, Clark IM, Young DA.

Matrix Biol. 2019 Apr;77:87-100. doi: 10.1016/j.matbio.2018.08.009. Epub 2018 Sep 5.


The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells.

Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton AJ, Xu Y, Clark IM, Young DA.

Development. 2017 Dec 15;144(24):4510-4521. doi: 10.1242/dev.152504. Epub 2017 Oct 30.


Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role.

Snelling SJ, Davidson RK, Swingler TE, Le LT, Barter MJ, Culley KL, Price A, Carr AJ, Clark IM.

Osteoarthritis Cartilage. 2016 May;24(5):883-91. doi: 10.1016/j.joca.2015.11.021. Epub 2015 Dec 12.


The microRNA-29 family in cartilage homeostasis and osteoarthritis.

Le LT, Swingler TE, Crowe N, Vincent TL, Barter MJ, Donell ST, Delany AM, Dalmay T, Young DA, Clark IM.

J Mol Med (Berl). 2016 May;94(5):583-96. doi: 10.1007/s00109-015-1374-z. Epub 2015 Dec 19.


Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA.

Crowe N, Swingler TE, Le LT, Barter MJ, Wheeler G, Pais H, Donell ST, Young DA, Dalmay T, Clark IM.

Osteoarthritis Cartilage. 2016 Mar;24(3):534-43. doi: 10.1016/j.joca.2015.10.002. Epub 2015 Oct 20.


Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p.

Barter MJ, Tselepi M, Gómez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA.

Stem Cells. 2015 Nov;33(11):3266-80. doi: 10.1002/stem.2093. Epub 2015 Jul 29.


Characterization of the cartilage DNA methylome in knee and hip osteoarthritis.

Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J.

Arthritis Rheumatol. 2014 Sep;66(9):2450-60. doi: 10.1002/art.38713.


Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination.

Radwan M, Wilkinson DJ, Hui W, Destrument AP, Charlton SH, Barter MJ, Gibson B, Coulombe J, Gray DA, Rowan AD, Young DA.

Ann Rheum Dis. 2015 Aug;74(8):1580-7. doi: 10.1136/annrheumdis-2013-204962. Epub 2014 Apr 8.


Epigenetic mechanisms and non-coding RNAs in osteoarthritis.

Barter MJ, Young DA.

Curr Rheumatol Rep. 2013 Sep;15(9):353. doi: 10.1007/s11926-013-0353-z. Review.


Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.

Culley KL, Hui W, Barter MJ, Davidson RK, Swingler TE, Destrument AP, Scott JL, Donell ST, Fenwick S, Rowan AD, Young DA, Clark IM.

Arthritis Rheum. 2013 Jul;65(7):1822-30. doi: 10.1002/art.37965.


Understanding CpG methylation in the context of osteoarthritis.

Young DA, Bui C, Barter MJ.

Epigenomics. 2012 Dec;4(6):593-5. doi: 10.2217/epi.12.63. No abstract available.


Multigenerational epigenetic adaptation of the hepatic wound-healing response.

Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A, Oakley F, Burt AD, Wilson CL, Anstee QM, Barter MJ, Masson S, Elsharkawy AM, Mann DA, Mann J.

Nat Med. 2012 Sep;18(9):1369-77. Erratum in: Nat Med. 2012 Oct;18(10):1592.


Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA.

Xu Y, Barter MJ, Swan DC, Rankin KS, Rowan AD, Santibanez-Koref M, Loughlin J, Young DA.

Osteoarthritis Cartilage. 2012 Sep;20(9):1029-38. doi: 10.1016/j.joca.2012.05.006. Epub 2012 May 31.


cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.

Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA.

FASEB J. 2012 Jul;26(7):3000-11. doi: 10.1096/fj.12-206367. Epub 2012 Apr 13.


Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.

Barter MJ, Bui C, Young DA.

Osteoarthritis Cartilage. 2012 May;20(5):339-49. doi: 10.1016/j.joca.2011.12.012. Epub 2012 Jan 10. Review.


The expression and function of microRNAs in chondrogenesis and osteoarthritis.

Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, Münsterberg A, Dalmay T, Young DA, Clark IM.

Arthritis Rheum. 2012 Jun;64(6):1909-19. doi: 10.1002/art.34314. Epub 2011 Dec 5.


Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.

Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA.

Ann Rheum Dis. 2010 Dec;69(12):2189-98. doi: 10.1136/ard.2010.129197. Epub 2010 Aug 6.


Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.

Hui W, Litherland GJ, Jefferson M, Barter MJ, Elias MS, Cawston TE, Rowan AD, Young DA.

Rheumatology (Oxford). 2010 Nov;49(11):2043-53. doi: 10.1093/rheumatology/keq217. Epub 2010 Jul 15.


HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.

Barter MJ, Pybus L, Litherland GJ, Rowan AD, Clark IM, Edwards DR, Cawston TE, Young DA.

Matrix Biol. 2010 Sep;29(7):602-12. doi: 10.1016/j.matbio.2010.05.002. Epub 2010 May 12.


Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.

Litherland GJ, Elias MS, Hui W, Macdonald CD, Catterall JB, Barter MJ, Farren MJ, Jefferson M, Rowan AD.

J Biol Chem. 2010 Jul 16;285(29):22414-25. doi: 10.1074/jbc.M110.120121. Epub 2010 May 12.


Differential Toll-like receptor-dependent collagenase expression in chondrocytes.

Zhang Q, Hui W, Litherland GJ, Barter MJ, Davidson R, Darrah C, Donell ST, Clark IM, Cawston TE, Robinson JH, Rowan AD, Young DA.

Ann Rheum Dis. 2008 Nov;67(11):1633-41. doi: 10.1136/ard.2007.079574. Epub 2008 Feb 7.


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