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Items: 1 to 50 of 328

1.

Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication.

Dujardin M, Madan V, Gandhi NS, Cantrelle FX, Launay H, Huvent I, Bartenschlager R, Lippens G, Hanoulle X.

J Biol Chem. 2019 Jul 17. pii: jbc.RA119.009537. doi: 10.1074/jbc.RA119.009537. [Epub ahead of print]

2.

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment.

Lee JY, Cortese M, Haselmann U, Tabata K, Romero-Brey I, Funaya C, Schieber NL, Qiang Y, Bartenschlager M, Kallis S, Ritter C, Rohr K, Schwab Y, Ruggieri A, Bartenschlager R.

Cell Rep. 2019 Jun 18;27(12):3602-3617.e5. doi: 10.1016/j.celrep.2019.05.063.

3.

Hyperparameter optimization for image analysis: application to prostate tissue images and live cell data of virus-infected cells.

Ritter C, Wollmann T, Bernhard P, Gunkel M, Braun DM, Lee JY, Meiners J, Simon R, Sauter G, Erfle H, Rippe K, Bartenschlager R, Rohr K.

Int J Comput Assist Radiol Surg. 2019 Jun 8. doi: 10.1007/s11548-019-02010-3. [Epub ahead of print]

PMID:
31177423
4.

Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production.

Cortese M, Kumar A, Matula P, Kaderali L, Scaturro P, Erfle H, Acosta EG, Buehler S, Ruggieri A, Chatel-Chaix L, Rohr K, Bartenschlager R.

Cell Rep. 2019 May 28;27(9):2579-2592.e6. doi: 10.1016/j.celrep.2019.04.105.

5.

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.

Płaszczyca A, Scaturro P, Neufeldt CJ, Cortese M, Cerikan B, Ferla S, Brancale A, Pichlmair A, Bartenschlager R.

PLoS Pathog. 2019 May 9;15(5):e1007736. doi: 10.1371/journal.ppat.1007736. eCollection 2019 May.

6.

Indelibly Stamped by Hepatitis C Virus Infection: Persistent Epigenetic Signatures Increasing Liver Cancer Risk.

Lohmann V, Bartenschlager R.

Gastroenterology. 2019 Jun;156(8):2130-2133. doi: 10.1053/j.gastro.2019.04.033. Epub 2019 Apr 26. No abstract available.

PMID:
31034828
7.

[Hepatitis C: From Individual Cure to Worldwide Elimination?]

Boettler T, Lohmann V, Bartenschlager R.

Dtsch Med Wochenschr. 2019 Apr;144(8):535-542. doi: 10.1055/a-0837-2424. Epub 2019 Apr 15. German.

PMID:
30986861
8.

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development.

Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Jühling F, Oudot MA, Virzì A, Bandiera S, Jamey C, Meszaros G, Brumaru D, Mukherji A, Durand SC, Heydmann L, Verrier ER, El Saghire H, Hamdane N, Bartenschlager R, Fereshetian S, Ramberger E, Sinha R, Nabian M, Everaert C, Jovanovic M, Mertins P, Carr SA, Chayama K, Dali-Youcef N, Ricci R, Bardeesy NM, Fujiwara N, Gevaert O, Zeisel MB, Hoshida Y, Pochet N, Baumert TF.

Gastroenterology. 2019 Apr 9. pii: S0016-5085(19)35670-7. doi: 10.1053/j.gastro.2019.04.003. [Epub ahead of print]

PMID:
30978357
9.

Lipid droplet quantification based on iterative image processing.

Exner T, Beretta CA, Gao Q, Afting C, Romero-Brey I, Bartenschlager R, Fehring L, Poppelreuther M, Füllekrug J.

J Lipid Res. 2019 Jul;60(7):1333-1344. doi: 10.1194/jlr.D092841. Epub 2019 Mar 29.

PMID:
30926625
10.

Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes.

Deng L, Jiang W, Wang X, Merz A, Hiet MS, Chen Y, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G.

J Hepatol. 2019 Jul;71(1):52-61. doi: 10.1016/j.jhep.2019.03.006. Epub 2019 Mar 15.

PMID:
30880226
11.

An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1.

Exner T, Romero-Brey I, Yifrach E, Rivera-Monroy J, Schrul B, Zouboulis CC, Stremmel W, Honsho M, Bartenschlager R, Zalckvar E, Poppelreuther M, Füllekrug J.

J Cell Sci. 2019 Mar 18;132(6). pii: jcs223016. doi: 10.1242/jcs.223016.

PMID:
30745342
12.

Towards curative therapy of chronic viral hepatitis.

Bartenschlager R, Urban S, Protzer U.

Z Gastroenterol. 2019 Jan;57(1):61-73. doi: 10.1055/a-0824-1576. Epub 2019 Jan 14.

PMID:
30641605
13.

Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents.

Richter M, Boldescu V, Graf D, Streicher F, Dimoglo A, Bartenschlager R, Klein CD.

ChemMedChem. 2019 Feb 19;14(4):469-483. doi: 10.1002/cmdc.201800641. Epub 2019 Jan 25.

PMID:
30605241
14.

The Role of Tissue Oxygen Tension in Dengue Virus Replication.

Frakolaki E, Kaimou P, Moraiti M, Kalliampakou KI, Karampetsou K, Dotsika E, Liakos P, Vassilacopoulou D, Mavromara P, Bartenschlager R, Vassilaki N.

Cells. 2018 Dec 1;7(12). pii: E241. doi: 10.3390/cells7120241.

15.

Discovery of highly divergent lineages of plant-associated astro-like viruses sheds light on the emergence of potyviruses.

Lauber C, Seifert M, Bartenschlager R, Seitz S.

Virus Res. 2019 Jan 15;260:38-48. doi: 10.1016/j.virusres.2018.11.009. Epub 2018 Nov 16.

PMID:
30452944
16.

mRNAs biotinylated within the 5' cap and protected against decapping: new tools to capture RNA-protein complexes.

Bednarek S, Madan V, Sikorski PJ, Bartenschlager R, Kowalska J, Jemielity J.

Philos Trans R Soc Lond B Biol Sci. 2018 Nov 5;373(1762). pii: 20180167. doi: 10.1098/rstb.2018.0167.

PMID:
30397103
17.

Correlative Light Electron Microscopy (CLEM) for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells.

Santarella-Mellwig R, Haselmann U, Schieber NL, Walther P, Schwab Y, Antony C, Bartenschlager R, Romero-Brey I.

J Vis Exp. 2018 Sep 7;(139). doi: 10.3791/58154.

18.

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.

Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, Kouassi NM, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche VM, Käufer C, Waltl I, Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese MA, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter SM, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G.

Nat Microbiol. 2018 Oct;3(10):1161-1174. doi: 10.1038/s41564-018-0236-1. Epub 2018 Sep 10.

PMID:
30202017
19.

An orthogonal proteomic survey uncovers novel Zika virus host factors.

Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A.

Nature. 2018 Sep;561(7722):253-257. doi: 10.1038/s41586-018-0484-5. Epub 2018 Sep 3.

PMID:
30177828
20.

Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro.

Corcuera A, Stolle K, Hillmer S, Seitz S, Lee JY, Bartenschlager R, Birkmann A, Urban A.

Antiviral Res. 2018 Oct;158:135-142. doi: 10.1016/j.antiviral.2018.07.011. Epub 2018 Jul 20.

21.

A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy.

Münster M, Płaszczyca A, Cortese M, Neufeldt CJ, Goellner S, Long G, Bartenschlager R.

Viruses. 2018 Jul 12;10(7). pii: E368. doi: 10.3390/v10070368.

22.

Semen inhibits Zika virus infection of cells and tissues from the anogenital region.

Müller JA, Harms M, Krüger F, Groß R, Joas S, Hayn M, Dietz AN, Lippold S, von Einem J, Schubert A, Michel M, Mayer B, Cortese M, Jang KS, Sandi-Monroy N, Deniz M, Ebner F, Vapalahti O, Otto M, Bartenschlager R, Herbeuval JP, Schmidt-Chanasit J, Roan NR, Münch J.

Nat Commun. 2018 Jun 7;9(1):2207. doi: 10.1038/s41467-018-04442-y.

23.

HCV modifies EGF signalling and upregulates production of CXCR2 ligands: Role in inflammation and antiviral immune response.

Groepper C, Rufinatscha K, Schröder N, Stindt S, Ehlting C, Albrecht U, Bock HH, Bartenschlager R, Häussinger D, Bode JG.

J Hepatol. 2018 Sep;69(3):594-602. doi: 10.1016/j.jhep.2018.04.005. Epub 2018 Apr 27.

PMID:
29705238
24.

Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes.

Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V.

Gastroenterology. 2018 Jun;154(8):2237-2251.e16. doi: 10.1053/j.gastro.2018.03.020. Epub 2018 Mar 11.

25.

Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes.

Zhang Z, Filzmayer C, Ni Y, Sültmann H, Mutz P, Hiet MS, Vondran FWR, Bartenschlager R, Urban S.

J Hepatol. 2018 Jul;69(1):25-35. doi: 10.1016/j.jhep.2018.02.021. Epub 2018 Mar 8.

PMID:
29524530
26.

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.

Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T.

Virus Res. 2018 Mar 15;248:53-62. doi: 10.1016/j.virusres.2018.02.016. Epub 2018 Mar 2. Review.

27.

Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy.

David G, Fogeron ML, Schledorn M, Montserret R, Haselmann U, Penzel S, Badillo A, Lecoq L, André P, Nassal M, Bartenschlager R, Meier BH, Böckmann A.

Angew Chem Int Ed Engl. 2018 Apr 16;57(17):4787-4791. doi: 10.1002/anie.201712091. Epub 2018 Mar 25.

PMID:
29457857
28.

Rewiring cellular networks by members of the Flaviviridae family.

Neufeldt CJ, Cortese M, Acosta EG, Bartenschlager R.

Nat Rev Microbiol. 2018 Feb 12;16(3):125-142. doi: 10.1038/nrmicro.2017.170. Review.

PMID:
29430005
29.

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon.

Mutz P, Metz P, Lempp FA, Bender S, Qu B, Schöneweis K, Seitz S, Tu T, Restuccia A, Frankish J, Dächert C, Schusser B, Koschny R, Polychronidis G, Schemmer P, Hoffmann K, Baumert TF, Binder M, Urban S, Bartenschlager R.

Gastroenterology. 2018 May;154(6):1791-1804.e22. doi: 10.1053/j.gastro.2018.01.044. Epub 2018 Feb 1.

30.

Glycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles.

Paul D, Madan V, Ramirez O, Bencun M, Stoeck IK, Jirasko V, Bartenschlager R.

J Virol. 2018 Jan 30;92(4). pii: e01890-17. doi: 10.1128/JVI.01890-17. Print 2018 Feb 15.

31.

Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis.

Pollmann J, Götz JJ, Rupp D, Strauss O, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A.

J Hepatol. 2018 Mar;68(3):421-430. doi: 10.1016/j.jhep.2017.10.021. Epub 2017 Nov 1.

PMID:
29100993
32.

Membrane alterations induced by nonstructural proteins of human norovirus.

Doerflinger SY, Cortese M, Romero-Brey I, Menne Z, Tubiana T, Schenk C, White PA, Bartenschlager R, Bressanelli S, Hansman GS, Lohmann V.

PLoS Pathog. 2017 Oct 27;13(10):e1006705. doi: 10.1371/journal.ppat.1006705. eCollection 2017 Oct.

33.

Optimization of Substrate-Analogue Furin Inhibitors.

Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T.

ChemMedChem. 2017 Dec 7;12(23):1953-1968. doi: 10.1002/cmdc.201700596. Epub 2017 Nov 16.

PMID:
29059503
34.

Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis.

Stoeck IK, Lee JY, Tabata K, Romero-Brey I, Paul D, Schult P, Lohmann V, Kaderali L, Bartenschlager R.

J Virol. 2017 Dec 14;92(1). pii: e01196-17. doi: 10.1128/JVI.01196-17. Print 2018 Jan 1.

35.

Host-directed therapies for bacterial and viral infections.

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R.

Nat Rev Drug Discov. 2018 Jan;17(1):35-56. doi: 10.1038/nrd.2017.162. Epub 2017 Sep 22. Review.

PMID:
28935918
36.

Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses.

Lauber C, Seitz S, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs JAG, Bartenschlager R.

Cell Host Microbe. 2017 Sep 13;22(3):387-399.e6. doi: 10.1016/j.chom.2017.07.019. Epub 2017 Aug 31.

37.

Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network.

Shah PNM, Stanifer ML, Höhn K, Engel U, Haselmann U, Bartenschlager R, Kräusslich HG, Krijnse-Locker J, Boulant S.

Cell Microbiol. 2017 Dec;19(12). doi: 10.1111/cmi.12765. Epub 2017 Jul 21.

PMID:
28672089
38.

Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model.

Levander S, Holmström F, Frelin L, Ahlén G, Rupp D, Long G, Bartenschlager R, Sällberg M.

Gut. 2018 Aug;67(8):1525-1535. doi: 10.1136/gutjnl-2016-313579. Epub 2017 Jun 23.

39.

[Personalized treatment of viral hepatitis of the present and the future : Hepatitis B, C, delta, and E].

Bartenschlager R, Cornberg M, Pietschmann T.

Internist (Berl). 2017 Jul;58(7):666-674. doi: 10.1007/s00108-017-0262-8. Review. German.

PMID:
28631044
40.

Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.

Badillo A, Receveur-Brechot V, Sarrazin S, Cantrelle FX, Delolme F, Fogeron ML, Molle J, Montserret R, Bockmann A, Bartenschlager R, Lohmann V, Lippens G, Ricard-Blum S, Hanoulle X, Penin F.

Biochemistry. 2017 Jun 20;56(24):3029-3048. doi: 10.1021/acs.biochem.7b00212. Epub 2017 Jun 7.

PMID:
28535337
41.

Chronic viral hepatitis and its association with liver cancer.

Tu T, Bühler S, Bartenschlager R.

Biol Chem. 2017 Jul 26;398(8):817-837. doi: 10.1515/hsz-2017-0118. Review.

PMID:
28455951
42.

Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

Bankwitz D, Doepke M, Hueging K, Weller R, Bruening J, Behrendt P, Lee JY, Vondran FWR, Manns MP, Bartenschlager R, Pietschmann T.

J Hepatol. 2017 Sep;67(3):480-489. doi: 10.1016/j.jhep.2017.04.010. Epub 2017 Apr 22.

43.

Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses".

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A.

MBio. 2017 Apr 18;8(2). pii: e00488-17. doi: 10.1128/mBio.00488-17. No abstract available.

44.

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication.

Kouretova J, Hammamy MZ, Epp A, Hardes K, Kallis S, Zhang L, Hilgenfeld R, Bartenschlager R, Steinmetzer T.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):712-721. doi: 10.1080/14756366.2017.1306521.

45.

A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner.

Lee M, Yang J, Jo E, Lee JY, Kim HY, Bartenschlager R, Shin EC, Bae YS, Windisch MP.

Sci Rep. 2017 Mar 23;7:44676. doi: 10.1038/srep44676.

46.

Immune protection against reinfection with nonprimate hepacivirus.

Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JM, Steinmann E.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2430-E2439. doi: 10.1073/pnas.1619380114. Epub 2017 Mar 8.

47.

Ultrastructural Characterization of Zika Virus Replication Factories.

Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R.

Cell Rep. 2017 Feb 28;18(9):2113-2123. doi: 10.1016/j.celrep.2017.02.014.

48.

Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism.

Lougiakis N, Frakolaki E, Karmou P, Pouli N, Marakos P, Madan V, Bartenschlager R, Vassilaki N.

Chem Biol Drug Des. 2017 Sep;90(3):352-367. doi: 10.1111/cbdd.12966. Epub 2017 Mar 24.

PMID:
28245093
49.

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening.

Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M.

Mol Cell. 2017 Feb 2;65(3):403-415.e8. doi: 10.1016/j.molcel.2016.12.021. Epub 2017 Jan 26.

50.

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Florian WR, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.

Nat Microbiol. 2017 Jan 23;2:17012. doi: 10.1038/nmicrobiol.2017.12. No abstract available.

PMID:
28112725

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