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Items: 1 to 50 of 113


New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.

Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Liu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA.

Biochem J. 2018 Aug 14;475(15):2417-2433. doi: 10.1042/BCJ20180265.


Oscillatory interlayer coupling in spin Hall systems.

Gonçalves AM, Garcia F, Lee HK, Smith A, Soledade PR, Passos CAC, Costa M, Souza-Neto NM, Krivorotov IN, Sampaio LC, Barsukov I.

Sci Rep. 2018 Feb 2;8(1):2318. doi: 10.1038/s41598-018-20685-7.


Spin Hall-induced auto-oscillations in ultrathin YIG grown on Pt.

Evelt M, Safranski C, Aldosary M, Demidov VE, Barsukov I, Nosov AP, Rinkevich AB, Sobotkiewich K, Li X, Shi J, Krivorotov IN, Demokritov SO.

Sci Rep. 2018 Jan 19;8(1):1269. doi: 10.1038/s41598-018-19606-5.


Pressure-Dependent Chemical Shifts in the R3 Domain of Talin Show that It Is Thermodynamically Poised for Binding to Either Vinculin or RIAM.

Baxter NJ, Zacharchenko T, Barsukov IL, Williamson MP.

Structure. 2017 Dec 5;25(12):1856-1866.e2. doi: 10.1016/j.str.2017.10.008. Epub 2017 Nov 16.


Targeting SxIP-EB1 interaction: An integrated approach to the discovery of small molecule modulators of dynamic binding sites.

Almeida TB, Carnell AJ, Barsukov IL, Berry NG.

Sci Rep. 2017 Nov 14;7(1):15533. doi: 10.1038/s41598-017-15502-6.


Spin caloritronic nano-oscillator.

Safranski C, Barsukov I, Lee HK, Schneider T, Jara AA, Smith A, Chang H, Lenz K, Lindner J, Tserkovnyak Y, Wu M, Krivorotov IN.

Nat Commun. 2017 Jul 18;8(1):117. doi: 10.1038/s41467-017-00184-5.


SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.

Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J.

Nat Cell Biol. 2017 Apr;19(4):292-305. doi: 10.1038/ncb3487. Epub 2017 Mar 6.


Parametric Resonance of Magnetization Excited by Electric Field.

Chen YJ, Lee HK, Verba R, Katine JA, Barsukov I, Tiberkevich V, Xiao JQ, Slavin AN, Krivorotov IN.

Nano Lett. 2017 Jan 11;17(1):572-577. doi: 10.1021/acs.nanolett.6b04725. Epub 2016 Dec 23.


CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex.

Zhou T, Fleming JR, Franke B, Bogomolovas J, Barsukov I, Rigden DJ, Labeit S, Mayans O.

FEBS Lett. 2016 Sep;590(18):3098-110. doi: 10.1002/1873-3468.12362. Epub 2016 Sep 2.


LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.

Zacharchenko T, Qian X, Goult BT, Jethwa D, Almeida TB, Ballestrem C, Critchley DR, Lowy DR, Barsukov IL.

Structure. 2016 Jul 6;24(7):1130-41. doi: 10.1016/j.str.2016.04.016. Epub 2016 Jun 2.


Vinculin controls talin engagement with the actomyosin machinery.

Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C.

Nat Commun. 2015 Dec 4;6:10038. doi: 10.1038/ncomms10038.


[Using "Collegel" complex in combined therapy of rectum cancer].

Oltarzhevskaia ND, Korovina MA, Barsukov IuA, Kuz'michev DV, Malikhova OA.

Eksp Klin Gastroenterol. 2015;(4):77-82. Russian.


Parallel evolution or purifying selection, not introgression, explains similarity in the pyrethroid detoxification linked GSTE4 of Anopheles gambiae and An. arabiensis.

Wilding CS, Weetman D, Rippon EJ, Steen K, Mawejje HD, Barsukov I, Donnelly MJ.

Mol Genet Genomics. 2015 Feb;290(1):201-15. doi: 10.1007/s00438-014-0910-9. Epub 2014 Sep 12.


S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis.

Brisslert M, Bian L, Svensson MN, Santos RF, Jonsson IM, Barsukov I, Erlandsson M, Andersson K, Carmo AM, Bokarewa MI.

Biochim Biophys Acta. 2014 Nov;1842(11):2049-59. doi: 10.1016/j.bbadis.2014.07.003. Epub 2014 Jul 15.


Prevalence of diabetes mellitus in patients with acromegaly.

Dreval AV, Trigolosova IV, Misnikova IV, Kovalyova YA, Tishenina RS, Barsukov IA, Vinogradova AV, Wolffenbuttel BH.

Endocr Connect. 2014 Apr 29;3(2):93-8. doi: 10.1530/EC-14-0021. Print 2014.


Deubiquitylases from genes to organism.

Clague MJ, Barsukov I, Coulson JM, Liu H, Rigden DJ, Urbé S.

Physiol Rev. 2013 Jul;93(3):1289-315. doi: 10.1152/physrev.00002.2013. Review.


SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.

Mameza MG, Dvoretskova E, Bamann M, Hönck HH, Güler T, Boeckers TM, Schoen M, Verpelli C, Sala C, Barsukov I, Dityatev A, Kreienkamp HJ.

J Biol Chem. 2013 Sep 13;288(37):26697-708. doi: 10.1074/jbc.M112.424747. Epub 2013 Jul 29.


Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.

Goult BT, Xu XP, Gingras AR, Swift M, Patel B, Bate N, Kopp PM, Barsukov IL, Critchley DR, Volkmann N, Hanein D.

J Struct Biol. 2013 Oct;184(1):21-32. doi: 10.1016/j.jsb.2013.05.014. Epub 2013 May 30.


RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.

Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GC, Ballestrem C, Critchley DR, Barsukov IL.

J Biol Chem. 2013 Mar 22;288(12):8238-49. doi: 10.1074/jbc.M112.438119. Epub 2013 Feb 6.


In support of the BMRB.

Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S.

Nat Struct Mol Biol. 2012 Sep;19(9):854-60. doi: 10.1038/nsmb.2371. No abstract available.


Asymmetric mode of Ca²⁺-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling.

Elliott PR, Irvine AF, Jung HS, Tozawa K, Pastok MW, Picone R, Badyal SK, Basran J, Rudland PS, Barraclough R, Lian LY, Bagshaw CR, Kriajevska M, Barsukov IL.

Structure. 2012 Apr 4;20(4):654-66. doi: 10.1016/j.str.2012.02.002. Epub 2012 Apr 3.


The intracellular Ig fold: a robust protein scaffold for the engineering of molecular recognition.

Bruning M, Barsukov I, Franke B, Barbieri S, Volk M, Leopoldseder S, Ucurum Z, Mayans O.

Protein Eng Des Sel. 2012 May;25(5):205-12. doi: 10.1093/protein/gzs007. Epub 2012 Feb 20.


A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.

Bouaouina M, Goult BT, Huet-Calderwood C, Bate N, Brahme NN, Barsukov IL, Critchley DR, Calderwood DA.

J Biol Chem. 2012 Mar 2;287(10):6979-90. doi: 10.1074/jbc.M111.330845. Epub 2012 Jan 10.


[Major risk factors of glucose metabolism abnormalities].

Misnikova IV, Dreval' AV, Barsukov IA, Dzebisashvili TG.

Vopr Pitan. 2011;80(4):68-72. Russian.


[Risk of type 2 diabetes mellitus and acute cardiovascular disorders in patients with early disturbances of carbohydrate metabolism].

Dreval' AV, Misnikova IV, Barsukov IA, Dzebisashvili GT.

Klin Med (Mosk). 2012;90(11):30-4. Russian.


Structural variability of the ubiquitin specific protease DUSP-UBL double domains.

Elliott PR, Liu H, Pastok MW, Grossmann GJ, Rigden DJ, Clague MJ, Urbé S, Barsukov IL.

FEBS Lett. 2011 Nov 4;585(21):3385-90. doi: 10.1016/j.febslet.2011.09.040. Epub 2011 Oct 10.


[Effectiveness of neoadjuvant chemoradiotherapy of locally advanced rectal cancer in conjunction with local hyperthermia and metronidazole].

Barsukov IuA, Tkachev SI, Tsariuk VF, Gordeev SS, Perevoshchikov AG, Malikhov AG, Oltarzhevskaia ND, Aliev VA, Kuz'michev DV, Glebovskaia VV, Osombaev MSh.

Vopr Onkol. 2011;57(3):373-7. Russian.


[New technologies in the diagnosis and treatment of patients with squamous cell carcinoma of the anal canal].

Malikhov AG, Barsukov IuA, Malikhova OA, Ungiadze GV, Timofeev IuM, Perfil'ev IB.

Eksp Klin Gastroenterol. 2011;(10):73-7. Russian.


Magnetism of single-crystalline Fe nanostructures.

Lindner J, Hassel C, Trunova AV, Römer FM, Stienen S, Barsukov I.

J Nanosci Nanotechnol. 2010 Sep;10(9):6161-7.


A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain.

Hughes E, Whittaker CA, Barsukov IL, Esmann M, Middleton DA.

Biochim Biophys Acta. 2011 Apr;1808(4):1021-31. doi: 10.1016/j.bbamem.2010.11.024. Epub 2010 Dec 2.


Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA.

Badyal SK, Basran J, Bhanji N, Kim JH, Chavda AP, Jung HS, Craig R, Elliott PR, Irvine AF, Barsukov IL, Kriajevska M, Bagshaw CR.

J Mol Biol. 2011 Jan 28;405(4):1004-26. doi: 10.1016/j.jmb.2010.11.036. Epub 2010 Nov 24.


The Structure of the talin head reveals a novel extended conformation of the FERM domain.

Elliott PR, Goult BT, Kopp PM, Bate N, Grossmann JG, Roberts GC, Critchley DR, Barsukov IL.

Structure. 2010 Oct 13;18(10):1289-99. doi: 10.1016/j.str.2010.07.011.


Central region of talin has a unique fold that binds vinculin and actin.

Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR.

J Biol Chem. 2010 Sep 17;285(38):29577-87. doi: 10.1074/jbc.M109.095455. Epub 2010 Jul 7.


The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.

Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC.

FEBS Lett. 2010 Jun 3;584(11):2237-41. doi: 10.1016/j.febslet.2010.04.028. Epub 2010 Apr 20.


[Polyradiomodification as component of combined treatment of rectal cancer: rationale and results].

Barsukov IuA, Tkachev SI, Oltarzhevskaia ND, Perevoshchikov AG, Korovina MA, Nikolaev AV, Glebovskaia VV, Kuz'michev DV, Aliev VA, Mamedli ZZ, Pavlova AM.

Vopr Onkol. 2010;56(1):66-9. Russian.


Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.

Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL.

EMBO J. 2010 Mar 17;29(6):1069-80. doi: 10.1038/emboj.2010.4. Epub 2010 Feb 11.


Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.

Ellis J, Gutierrez A, Barsukov IL, Huang WC, Grossmann JG, Roberts GC.

J Biol Chem. 2009 Dec 25;284(52):36628-37. doi: 10.1074/jbc.M109.054304. Epub 2009 Oct 26.


The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.

Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR.

J Mol Biol. 2009 Dec 18;394(5):944-56. doi: 10.1016/j.jmb.2009.09.061. Epub 2009 Oct 3.


NMR assignment of the C-terminal actin-binding domain of talin.

Goult BT, Gingras AR, Bate N, Roberts GC, Critchley DR, Barsukov IL.

Biomol NMR Assign. 2008 Jun;2(1):17-9. doi: 10.1007/s12104-007-9073-5. Epub 2007 Dec 22.


The structure of an interdomain complex that regulates talin activity.

Goult BT, Bate N, Anthis NJ, Wegener KL, Gingras AR, Patel B, Barsukov IL, Campbell ID, Roberts GC, Critchley DR.

J Biol Chem. 2009 May 29;284(22):15097-106. doi: 10.1074/jbc.M900078200. Epub 2009 Mar 18.


Structural determinants of integrin binding to the talin rod.

Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg MH, Critchley DR.

J Biol Chem. 2009 Mar 27;284(13):8866-76. doi: 10.1074/jbc.M805937200. Epub 2009 Jan 27.


[Surgical treatment of patients with colorectal cancer and severe concurrent cardio-vascular diseases].

Davydov MI, Gerasimov SS, Shestopalova IM, Barsukov IuA, Patiutko IuI, Akchurin RS, Bokeriia LA, Brand IaB, Arakelian VS, Dolgov IM.

Khirurgiia (Mosk). 2008;(8):10-7. Russian.


[Combined treatment for rectal cancer using different radiomodification means].

Barsukov IuA, Tkachev SI, Oltarzhevskaia ND, Korovina MA, Iarmolenko SP, Vaĭnson AA, Perevoshchikov AG, Nikolaev AV, Gradiushko AT, Kutateladze TO, Vlasov OA, Malikho AG, Tamrazov RI, Kuz'michev DV, Aliev VA, Mamedli ZZ.

Vopr Onkol. 2008;54(3):350-3. Russian.


Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

Wegener KL, Basran J, Bagshaw CR, Campbell ID, Roberts GC, Critchley DR, Barsukov IL.

J Mol Biol. 2008 Sep 26;382(1):112-26. doi: 10.1016/j.jmb.2008.06.087. Epub 2008 Jul 7.


Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4.

Gingras AR, Basran J, Prescott A, Kriajevska M, Bagshaw CR, Barsukov IL.

FEBS Lett. 2008 May 28;582(12):1651-6. doi: 10.1016/j.febslet.2008.04.017. Epub 2008 Apr 22.


The structure of the C-terminal actin-binding domain of talin.

Gingras AR, Bate N, Goult BT, Hazelwood L, Canestrelli I, Grossmann JG, Liu H, Putz NS, Roberts GC, Volkmann N, Hanein D, Barsukov IL, Critchley DR.

EMBO J. 2008 Jan 23;27(2):458-69. Epub 2007 Dec 20.


[Detection of genetic mutations in clinical specimens from cancer patients: comparison of NIRCA and SSCP scanning methods].

Botezatu IV, Kondratova VN, Cherkes VL, Barsukov IuA, Aliev VE, Shelepov VP, Likhtenshteĭn AV.

Vopr Onkol. 2007;53(5):549-53. Russian.


Low relaxation rate in epitaxial vanadium-doped ultrathin iron films.

Scheck C, Cheng L, Barsukov I, Frait Z, Bailey WE.

Phys Rev Lett. 2007 Mar 16;98(11):117601. Epub 2007 Mar 12.


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