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The human cathelicidin LL-37 is a nanomolar inhibitor of amyloid self-assembly of islet amyloid polypeptide (IAPP).

Armiento V, Hille K, Naltsas D, Lin JS, Barron AE, Kapurniotu A.

Angew Chem Int Ed Engl. 2020 Jan 30. doi: 10.1002/anie.202000148. [Epub ahead of print]


Helical side chain chemistry of a peptoid-based SP-C analogue: Balancing structural rigidity and biomimicry.

Brown NJ, Lin JS, Barron AE.

Biopolymers. 2019 Jun;110(6):e23277. doi: 10.1002/bip.23277. Epub 2019 Apr 10.


Role of Microbes in the Development of Alzheimer's Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco.

Fülöp T, Itzhaki RF, Balin BJ, Miklossy J, Barron AE.

Front Genet. 2018 Sep 10;9:362. doi: 10.3389/fgene.2018.00362. eCollection 2018. Review.


Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins.

Czyzewski AM, McCaig LM, Dohm MT, Broering LA, Yao LJ, Brown NJ, Didwania MK, Lin JS, Lewis JF, Veldhuizen R, Barron AE.

Sci Rep. 2018 May 1;8(1):6795. doi: 10.1038/s41598-018-25009-3.


Periprosthetic bacterial biofilm and quorum sensing.

Mooney JA, Pridgen EM, Manasherob R, Suh G, Blackwell HE, Barron AE, Bollyky PL, Goodman SB, Amanatullah DF.

J Orthop Res. 2018 Sep;36(9):2331-2339. doi: 10.1002/jor.24019. Epub 2018 May 24. Review.


Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids.

Lee J, Kang D, Choi J, Huang W, Wadman M, Barron AE, Seo J.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):170-173. doi: 10.1016/j.bmcl.2017.11.034. Epub 2017 Nov 23.


Intracellular biomass flocculation as a key mechanism of rapid bacterial killing by cationic, amphipathic antimicrobial peptides and peptoids.

Chongsiriwatana NP, Lin JS, Kapoor R, Wetzler M, Rea JAC, Didwania MK, Contag CH, Barron AE.

Sci Rep. 2017 Dec 1;7(1):16718. doi: 10.1038/s41598-017-16180-0.


Evidence that the Human Innate Immune Peptide LL-37 may be a Binding Partner of Amyloid-β and Inhibitor of Fibril Assembly.

De Lorenzi E, Chiari M, Colombo R, Cretich M, Sola L, Vanna R, Gagni P, Bisceglia F, Morasso C, Lin JS, Lee M, McGeer PL, Barron AE.

J Alzheimers Dis. 2017;59(4):1213-1226. doi: 10.3233/JAD-170223.


In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents.

Czyzewski AM, Jenssen H, Fjell CD, Waldbrook M, Chongsiriwatana NP, Yuen E, Hancock RE, Barron AE.

PLoS One. 2016 Feb 5;11(2):e0135961. doi: 10.1371/journal.pone.0135961. eCollection 2016.


Prostate tumor specific peptide-peptoid hybrid prodrugs.

Lee J, Huang W, Broering JM, Barron AE, Seo J.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2849-52. doi: 10.1016/j.bmcl.2015.04.092. Epub 2015 May 6.


Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation.

Lee M, Shi X, Barron AE, McGeer E, McGeer PL.

Biochem Pharmacol. 2015 Mar 15;94(2):130-41. doi: 10.1016/j.bcp.2015.02.003. Epub 2015 Feb 14.


No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis.

Kienhöfer D, Hahn J, Schubert I, Reinwald C, Ipseiz N, Lang SC, Borràs ÈB, Amann K, Sjöwall C, Barron AE, Hueber AJ, Agerberth B, Schett G, Hoffmann MH.

PLoS One. 2014 Dec 23;9(12):e115474. doi: 10.1371/journal.pone.0115474. eCollection 2014.


Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers.

Falcao CB, de La Torre BG, Pérez-Peinado C, Barron AE, Andreu D, Rádis-Baptista G.

Amino Acids. 2014 Nov;46(11):2561-71. doi: 10.1007/s00726-014-1801-4. Epub 2014 Aug 7.


Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity.

Huang W, Seo J, Willingham SB, Czyzewski AM, Gonzalgo ML, Weissman IL, Barron AE.

PLoS One. 2014 Feb 28;9(2):e90397. doi: 10.1371/journal.pone.0090397. eCollection 2014.


A tunable silk-alginate hydrogel scaffold for stem cell culture and transplantation.

Ziv K, Nuhn H, Ben-Haim Y, Sasportas LS, Kempen PJ, Niedringhaus TP, Hrynyk M, Sinclair R, Barron AE, Gambhir SS.

Biomaterials. 2014 Apr;35(12):3736-43. doi: 10.1016/j.biomaterials.2014.01.029. Epub 2014 Jan 28.


The incorporation of extracellular matrix proteins in protein polymer hydrogels to improve encapsulated beta-cell function.

Beenken-Rothkopf LN, Karfeld-Sulzer LS, Davis NE, Forster R, Barron AE, Fontaine MJ.

Ann Clin Lab Sci. 2013 Spring;43(2):111-21.


A readily applicable strategy to convert peptides to peptoid-based therapeutics.

Park M, Wetzler M, Jardetzky TS, Barron AE.

PLoS One. 2013;8(3):e58874. doi: 10.1371/journal.pone.0058874. Epub 2013 Mar 21.


Simultaneous detection of 19 K-ras mutations by free-solution conjugate electrophoresis of ligase detection reaction products on glass microchips.

Albrecht JC, Kotani A, Lin JS, Soper SA, Barron AE.

Electrophoresis. 2013 Feb;34(4):590-7. doi: 10.1002/elps.201200462. Epub 2013 Jan 24.


Microfabricated devices for biomolecule encapsulation.

Desmarais SM, Haagsman HP, Barron AE.

Electrophoresis. 2012 Sep;33(17):2639-49. doi: 10.1002/elps.201200189. Review.


Protein polymer hydrogels: effects of endotoxin on biocompatibility.

Beenken-Rothkopf LN, Karfeld-Sulzer LS, Zhang X, Kissler H, Michie SA, Kaufman DB, Fontaine MJ, Barron AE.

J Biomater Appl. 2013 Sep;28(3):395-406. doi: 10.1177/0885328212454555. Epub 2012 Jul 24.


Peptoid transporters: effects of cationic, amphipathic structure on their cellular uptake.

Huang W, Seo J, Lin JS, Barron AE.

Mol Biosyst. 2012 Oct;8(10):2626-8. doi: 10.1039/c2mb25197c.


Encapsulation of protein microfiber networks supporting pancreatic islets.

Steele JA, Barron AE, Carmona E, Hallé JP, Neufeld RJ.

J Biomed Mater Res A. 2012 Dec;100(12):3384-91. doi: 10.1002/jbm.a.34281. Epub 2012 Jul 6.


Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel.

Davis NE, Beenken-Rothkopf LN, Mirsoian A, Kojic N, Kaplan DL, Barron AE, Fontaine MJ.

Biomaterials. 2012 Oct;33(28):6691-7. doi: 10.1016/j.biomaterials.2012.06.015. Epub 2012 Jul 4.


Divergent dispersion behavior of ssDNA fragments during microchip electrophoresis in pDMA and LPA entangled polymer networks.

Fredlake CP, Hert DG, Niedringhaus TP, Lin JS, Barron AE.

Electrophoresis. 2012 May;33(9-10):1411-20. doi: 10.1002/elps.201100686.


Alginate-PEG sponge architecture and role in the design of insulin release dressings.

Hrynyk M, Martins-Green M, Barron AE, Neufeld RJ.

Biomacromolecules. 2012 May 14;13(5):1478-85. doi: 10.1021/bm300186k. Epub 2012 Apr 24.


In vivo biodistribution and small animal PET of (64)Cu-labeled antimicrobial peptoids.

Seo J, Ren G, Liu H, Miao Z, Park M, Wang Y, Miller TM, Barron AE, Cheng Z.

Bioconjug Chem. 2012 May 16;23(5):1069-79. doi: 10.1021/bc300091d. Epub 2012 Apr 19.


Synthesis and assembly of functional high molecular weight adiponectin multimers in an engineered strain of Escherichia coli.

Ding S, Pinkas DM, Barron AE.

Biomacromolecules. 2012 Apr 9;13(4):1035-42. doi: 10.1021/bm2017367. Epub 2012 Mar 16.


Quantitative experimental determination of primer-dimer formation risk by free-solution conjugate electrophoresis.

Desmarais SM, Leitner T, Barron AE.

Electrophoresis. 2012 Feb;33(3):483-91. doi: 10.1002/elps.201100452. Epub 2012 Jan 10.


Visualizing and quantifying cell phenotype using soft X-ray tomography.

McDermott G, Fox DM, Epperly L, Wetzler M, Barron AE, Le Gros MA, Larabell CA.

Bioessays. 2012 Apr;34(4):320-7. doi: 10.1002/bies.201100125. Epub 2012 Jan 30. Review.


Progress in the de novo design of structured peptoid protein mimics.

Wetzler M, Barron AE.

Biopolymers. 2011;96(5):556-60. Review.


Monodisperse, "highly" positively charged protein polymer drag-tags generated in an intein-mediated purification system used in free-solution electrophoretic separations of DNA.

Wang X, Albrecht JC, Lin JS, Barron AE.

Biomacromolecules. 2012 Jan 9;13(1):117-23. doi: 10.1021/bm2013313. Epub 2011 Dec 23.


Ultrafast, efficient separations of large-sized dsDNA in a blended polymer matrix by microfluidic chip electrophoresis: a design of experiments approach.

Sun M, Lin JS, Barron AE.

Electrophoresis. 2011 Nov;32(22):3233-40. doi: 10.1002/elps.201100260. Epub 2011 Oct 18.


Blinded study determination of high sensitivity and specificity microchip electrophoresis-SSCP/HA to detect mutations in the p53 gene.

Hestekin CN, Lin JS, Senderowicz L, Jakupciak JP, O'Connell C, Rademaker A, Barron AE.

Electrophoresis. 2011 Nov;32(21):2921-9. doi: 10.1002/elps.201100396. Epub 2011 Oct 17.


Biomimetic N-terminal alkylation of peptoid analogues of surfactant protein C.

Brown NJ, Dohm MT, Bernardino de la Serna J, Barron AE.

Biophys J. 2011 Sep 7;101(5):1076-85. doi: 10.1016/j.bpj.2011.04.055.


Functional synergy between antimicrobial peptoids and peptides against Gram-negative bacteria.

Chongsiriwatana NP, Wetzler M, Barron AE.

Antimicrob Agents Chemother. 2011 Nov;55(11):5399-402. doi: 10.1128/AAC.00578-11. Epub 2011 Aug 22.


Peptoids: bio-inspired polymers as potential pharmaceuticals.

Dohm MT, Kapoor R, Barron AE.

Curr Pharm Des. 2011;17(25):2732-47. Review.


Landscape of next-generation sequencing technologies.

Niedringhaus TP, Milanova D, Kerby MB, Snyder MP, Barron AE.

Anal Chem. 2011 Jun 15;83(12):4327-41. doi: 10.1021/ac2010857. Epub 2011 May 25. Review. No abstract available.


Completely monodisperse, highly repetitive proteins for bioconjugate capillary electrophoresis: development and characterization.

Lin JS, Albrecht JC, Meagher RJ, Wang X, Barron AE.

Biomacromolecules. 2011 Jun 13;12(6):2275-84. doi: 10.1021/bm200358r. Epub 2011 May 24.


Free-solution electrophoretic separations of DNA-drag-tag conjugates on glass microchips with no polymer network and no loss of resolution at increased electric field strength.

Albrecht JC, Kerby MB, Niedringhaus TP, Lin JS, Wang X, Barron AE.

Electrophoresis. 2011 May;32(10):1201-8. doi: 10.1002/elps.201000574. Epub 2011 Apr 18.


Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis.

Kapoor R, Eimerman PR, Hardy JW, Cirillo JD, Contag CH, Barron AE.

Antimicrob Agents Chemother. 2011 Jun;55(6):3058-62. doi: 10.1128/AAC.01667-10. Epub 2011 Apr 4.


Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms.

Kapoor R, Wadman MW, Dohm MT, Czyzewski AM, Spormann AM, Barron AE.

Antimicrob Agents Chemother. 2011 Jun;55(6):3054-7. doi: 10.1128/AAC.01516-10. Epub 2011 Mar 21.


Non-ionic, thermo-responsive DEA/DMA nanogels: synthesis, characterization, and use for DNA separations by microchip electrophoresis.

Lu X, Sun M, Barron AE.

J Colloid Interface Sci. 2011 May 15;357(2):345-53. doi: 10.1016/j.jcis.2011.01.079. Epub 2011 Feb 1.


Protein polymer: Gene libraries open up.

Ding S, Wang X, Barron AE.

Nat Mater. 2011 Feb;10(2):83-4. doi: 10.1038/nmat2955. No abstract available.


Purification of HIV RNA from serum using a polymer capture matrix in a microfluidic device.

Root BE, Agarwal AK, Kelso DM, Barron AE.

Anal Chem. 2011 Feb 1;83(3):982-8. doi: 10.1021/ac102736g. Epub 2011 Jan 7.


Tunable, post-translational hydroxylation of collagen Domains in Escherichia coli.

Pinkas DM, Ding S, Raines RT, Barron AE.

ACS Chem Biol. 2011 Apr 15;6(4):320-4. doi: 10.1021/cb100298r. Epub 2011 Jan 14.


A 265-base DNA sequencing read by capillary electrophoresis with no separation matrix.

Albrecht JC, Lin JS, Barron AE.

Anal Chem. 2011 Jan 15;83(2):509-15. doi: 10.1021/ac102188p. Epub 2010 Dec 23.


A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform.

Park M, Matsuura H, Lamb RA, Barron AE, Jardetzky TS.

Anal Biochem. 2011 Feb 15;409(2):195-201. doi: 10.1016/j.ab.2010.10.020. Epub 2010 Nov 5.


Short alkylated peptoid mimics of antimicrobial lipopeptides.

Chongsiriwatana NP, Miller TM, Wetzler M, Vakulenko S, Karlsson AJ, Palecek SP, Mobashery S, Barron AE.

Antimicrob Agents Chemother. 2011 Jan;55(1):417-20. doi: 10.1128/AAC.01080-10. Epub 2010 Oct 18.

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