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Items: 11


Reproducing human and cross-species drug toxicities using a Liver-Chip.

Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA.

Sci Transl Med. 2019 Nov 6;11(517). pii: eaax5516. doi: 10.1126/scitranslmed.aax5516.


Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.

Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN.

Cell Stem Cell. 2019 Jun 6;24(6):995-1005.e6. doi: 10.1016/j.stem.2019.05.011.


Stem cell-based Lung-on-Chips: The best of both worlds?

Nawroth JC, Barrile R, Conegliano D, van Riet S, Hiemstra PS, Villenave R.

Adv Drug Deliv Rev. 2019 Feb 1;140:12-32. doi: 10.1016/j.addr.2018.07.005. Epub 2018 Jul 25. Review.


Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems.

Barrile R, van der Meer AD, Park H, Fraser JP, Simic D, Teng F, Conegliano D, Nguyen J, Jain A, Zhou M, Karalis K, Ingber DE, Hamilton GA, Otieno MA.

Clin Pharmacol Ther. 2018 Dec;104(6):1240-1248. doi: 10.1002/cpt.1054. Epub 2018 Apr 30.


Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.

Jain A, Barrile R, van der Meer AD, Mammoto A, Mammoto T, De Ceunynck K, Aisiku O, Otieno MA, Louden CS, Hamilton GA, Flaumenhaft R, Ingber DE.

Clin Pharmacol Ther. 2018 Feb;103(2):332-340. doi: 10.1002/cpt.742. Epub 2017 Jul 14.


Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.

Jain A, van der Meer AD, Papa AL, Barrile R, Lai A, Schlechter BL, Otieno MA, Louden CS, Hamilton GA, Michelson AD, Frelinger AL 3rd, Ingber DE.

Biomed Microdevices. 2016 Aug;18(4):73. doi: 10.1007/s10544-016-0095-6.


Neisseria meningitidis subverts the polarized organization and intracellular trafficking of host cells to cross the epithelial barrier.

Barrile R, Kasendra M, Rossi-Paccani S, Merola M, Pizza M, Baldari C, Soriani M, Aricò B.

Cell Microbiol. 2015 Sep;17(9):1365-75. doi: 10.1111/cmi.12439. Epub 2015 Apr 23.


Role of ARF6, Rab11 and external Hsp90 in the trafficking and recycling of recombinant-soluble Neisseria meningitidis adhesin A (rNadA) in human epithelial cells.

Bozza G, Capitani M, Montanari P, Benucci B, Biancucci M, Nardi-Dei V, Caproni E, Barrile R, Picciani B, Savino S, Aricò B, Rappuoli R, Pizza M, Luini A, Sallese M, Merola M.

PLoS One. 2014 Oct 27;9(10):e110047. doi: 10.1371/journal.pone.0110047. eCollection 2014.


The C2 fragment from Neisseria meningitidis antigen NHBA increases endothelial permeability by destabilizing adherens junctions.

Casellato A, Rossi Paccani S, Barrile R, Bossi F, Ciucchi L, Codolo G, Pizza M, Aricò B, de Bernard M.

Cell Microbiol. 2014 Jun;16(6):925-37. doi: 10.1111/cmi.12250. Epub 2014 Jan 8.


Clostridium difficile toxins facilitate bacterial colonization by modulating the fence and gate function of colonic epithelium.

Kasendra M, Barrile R, Leuzzi R, Soriani M.

J Infect Dis. 2014 Apr 1;209(7):1095-104. doi: 10.1093/infdis/jit617. Epub 2013 Nov 22.


Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion.

Montanari P, Bozza G, Capecchi B, Caproni E, Barrile R, Norais N, Capitani M, Sallese M, Cecchini P, Ciucchi L, Gao Z, Rappuoli R, Pizza M, Aricò B, Merola M.

Cell Microbiol. 2012 Mar;14(3):368-85. doi: 10.1111/j.1462-5822.2011.01722.x. Epub 2011 Dec 8.


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