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Items: 48


Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology.

Barrientos RM, Brunton PJ, Lenz KM, Pyter L, Spencer SJ.

Brain Behav Immun. 2019 Jul;79:39-55. doi: 10.1016/j.bbi.2019.03.010. Epub 2019 Mar 11. Review.


High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner.

Spencer SJ, Basri B, Sominsky L, Soch A, Ayala MT, Reineck P, Gibson BC, Barrientos RM.

Neurobiol Aging. 2019 Feb;74:121-134. doi: 10.1016/j.neurobiolaging.2018.10.018. Epub 2018 Oct 23.


Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium.

Tanaka N, Cortese GP, Barrientos RM, Maier SF, Patterson SL.

eNeuro. 2018 Jun 4;5(3). pii: ENEURO.0009-18.2018. doi: 10.1523/ENEURO.0009-18.2018. eCollection 2018 May-Jun.


The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics.

Gertz K, Uhlemann R, Foryst-Ludwig A, Barrientos RM, Kappert K, Thöne-Reineke C, Djoufack P, Kirschbaum C, Fink KB, Heinz A, Kintscher U, Endres M, Kronenberg G.

Exp Neurol. 2018 Aug;306:34-44. doi: 10.1016/j.expneurol.2018.04.004. Epub 2018 Apr 21.


High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory.

Spencer SJ, D'Angelo H, Soch A, Watkins LR, Maier SF, Barrientos RM.

Neurobiol Aging. 2017 Oct;58:88-101. doi: 10.1016/j.neurobiolaging.2017.06.014. Epub 2017 Jun 24.


Divergent effects of brain interleukin-1ß in mediating fever, lethargy, anorexia and conditioned fear memory.

Baartman TL, Swanepoel T, Barrientos RM, Laburn HP, Mitchell D, Harden LM.

Behav Brain Res. 2017 May 1;324:155-163. doi: 10.1016/j.bbr.2017.02.020. Epub 2017 Feb 14.


Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol.

Barrientos RM, Kitt MM, D'Angelo HM, Watkins LR, Rudy JW, Maier SF.

Learn Mem. 2016 Nov 15;23(12):699-702. doi: 10.1101/lm.043489.116. Print 2016 Dec.


Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.

Fonken LK, Kitt MM, Gaudet AD, Barrientos RM, Watkins LR, Maier SF.

Neurobiol Aging. 2016 Nov;47:102-112. doi: 10.1016/j.neurobiolaging.2016.07.019. Epub 2016 Aug 1.


Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1.

Sobesky JL, D'Angelo HM, Weber MD, Anderson ND, Frank MG, Watkins LR, Maier SF, Barrientos RM.

eNeuro. 2016 Aug 30;3(4). pii: ENEURO.0113-16.2016. doi: 10.1523/ENEURO.0113-16.2016. eCollection 2016 Jul-Aug.


The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.

Fonken LK, Frank MG, Kitt MM, D'Angelo HM, Norden DM, Weber MD, Barrientos RM, Godbout JP, Watkins LR, Maier SF.

J Neurosci. 2016 Jul 27;36(30):7946-56. doi: 10.1523/JNEUROSCI.1161-16.2016.


Neuroinflammation in the normal aging hippocampus.

Barrientos RM, Kitt MM, Watkins LR, Maier SF.

Neuroscience. 2015 Nov 19;309:84-99. doi: 10.1016/j.neuroscience.2015.03.007. Epub 2015 Mar 12. Review.


Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.

Barrientos RM, Thompson VM, Kitt MM, Amat J, Hale MW, Frank MG, Crysdale NY, Stamper CE, Hennessey PA, Watkins LR, Spencer RL, Lowry CA, Maier SF.

Neurobiol Aging. 2015 Mar;36(3):1483-95. doi: 10.1016/j.neurobiolaging.2014.12.003. Epub 2014 Dec 11.


Microglia inflammatory responses are controlled by an intrinsic circadian clock.

Fonken LK, Frank MG, Kitt MM, Barrientos RM, Watkins LR, Maier SF.

Brain Behav Immun. 2015 Mar;45:171-9. doi: 10.1016/j.bbi.2014.11.009. Epub 2014 Nov 26.


Reductions in frontocortical cytokine levels are associated with long-lasting alterations in reward valuation after methamphetamine.

Stolyarova A, Thompson AB, Barrientos RM, Izquierdo A.

Neuropsychopharmacology. 2015 Mar 13;40(5):1234-42. doi: 10.1038/npp.2014.309.


The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats.

Barrientos RM, Thompson VM, Arnold TH, Frank MG, Watkins LR, Maier SF.

Brain Behav Immun. 2015 Jan;43:60-7. doi: 10.1016/j.bbi.2014.07.004. Epub 2014 Jul 17.


High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism.

Sobesky JL, Barrientos RM, De May HS, Thompson BM, Weber MD, Watkins LR, Maier SF.

Brain Behav Immun. 2014 Nov;42:22-32. doi: 10.1016/j.bbi.2014.06.017. Epub 2014 Jul 3.


Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats.

Barrientos RM, Hein AM, Frank MG, Watkins LR, Maier SF.

J Neurosci. 2012 Oct 17;32(42):14641-8. doi: 10.1523/JNEUROSCI.2173-12.2012.


IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses.

Frank MG, Barrientos RM, Thompson BM, Weber MD, Watkins LR, Maier SF.

J Neuroimmunol. 2012 Nov 15;252(1-2):33-9. doi: 10.1016/j.jneuroim.2012.07.010. Epub 2012 Aug 4.


Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition.

Barrientos RM, Frank MG, Watkins LR, Maier SF.

Horm Behav. 2012 Aug;62(3):219-27. doi: 10.1016/j.yhbeh.2012.02.010. Epub 2012 Feb 18. Review.


Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus.

Chapman TR, Barrientos RM, Ahrendsen JT, Hoover JM, Maier SF, Patterson SL.

Neurobiol Aging. 2012 Apr;33(4):832.e1-14. doi: 10.1016/j.neurobiolaging.2011.07.015. Epub 2011 Sep 9.


Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.

Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR.

J Neuroimmunol. 2011 Oct 28;239(1-2):53-60. doi: 10.1016/j.jneuroim.2011.08.011. Epub 2011 Sep 9.


Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes.

Barrientos RM, Frank MG, Crysdale NY, Chapman TR, Ahrendsen JT, Day HE, Campeau S, Watkins LR, Patterson SL, Maier SF.

J Neurosci. 2011 Aug 10;31(32):11578-86. doi: 10.1523/JNEUROSCI.2266-11.2011.


Voluntary exercise as an anti-neuroinflammatory therapeutic.

Barrientos RM.

Brain Behav Immun. 2011 Aug;25(6):1061-2. doi: 10.1016/j.bbi.2011.05.004. Epub 2011 May 24. No abstract available.


Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes.

Cortese GP, Barrientos RM, Maier SF, Patterson SL.

J Neurosci. 2011 Mar 16;31(11):4274-9. doi: 10.1523/JNEUROSCI.5818-10.2011.


Memory impairments in healthy aging: Role of aging-induced microglial sensitization.

Barrientos RM, Frank MG, Watkins LR, Maier SF.

Aging Dis. 2010 Jan 1;1(3):212-231.


Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo.

Frank MG, Barrientos RM, Watkins LR, Maier SF.

J Neuroimmunol. 2010 Sep 14;226(1-2):181-4. doi: 10.1016/j.jneuroim.2010.05.022. Epub 2010 May 26.


Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1.

Chapman TR, Barrientos RM, Ahrendsen JT, Maier SF, Patterson SL.

J Neurosci. 2010 Jun 2;30(22):7598-603. doi: 10.1523/JNEUROSCI.5172-09.2010.


IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats.

Frank MG, Barrientos RM, Hein AM, Biedenkapp JC, Watkins LR, Maier SF.

Brain Behav Immun. 2010 Feb;24(2):254-62. doi: 10.1016/j.bbi.2009.10.005. Epub 2009 Oct 12.


Neonatal bacterial infection alters fever to live and simulated infections in adulthood.

Bilbo SD, Wieseler JL, Barrientos RM, Tsang V, Watkins LR, Maier SF.

Psychoneuroendocrinology. 2010 Apr;35(3):369-81. doi: 10.1016/j.psyneuen.2009.07.014. Epub 2009 Aug 13.


Characterization of the sickness response in young and aging rats following E. coli infection.

Barrientos RM, Watkins LR, Rudy JW, Maier SF.

Brain Behav Immun. 2009 May;23(4):450-4. doi: 10.1016/j.bbi.2009.01.016. Epub 2009 Feb 6.


Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.

Barrientos RM, Frank MG, Hein AM, Higgins EA, Watkins LR, Rudy JW, Maier SF.

Brain Behav Immun. 2009 Jan;23(1):46-54. doi: 10.1016/j.bbi.2008.07.002. Epub 2008 Jul 11.


Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus.

Hein AM, Stutzman DL, Bland ST, Barrientos RM, Watkins LR, Rudy JW, Maier SF.

Neuroscience. 2007 Dec 19;150(4):754-63. Epub 2007 Oct 12.


Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood.

Bilbo SD, Barrientos RM, Eads AS, Northcutt A, Watkins LR, Rudy JW, Maier SF.

Brain Behav Immun. 2008 May;22(4):451-5. Epub 2007 Nov 7.


Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress.

Bland ST, Tamlyn JP, Barrientos RM, Greenwood BN, Watkins LR, Campeau S, Day HE, Maier SF.

Neuroscience. 2007 Feb 23;144(4):1219-28. Epub 2006 Dec 29.


Peripheral infection and aging interact to impair hippocampal memory consolidation.

Barrientos RM, Higgins EA, Biedenkapp JC, Sprunger DB, Wright-Hardesty KJ, Watkins LR, Rudy JW, Maier SF.

Neurobiol Aging. 2006 May;27(5):723-32.


mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.

Frank MG, Barrientos RM, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF.

Neurobiol Aging. 2006 May;27(5):717-22.


Spinal gap junctions: potential involvement in pain facilitation.

Spataro LE, Sloane EM, Milligan ED, Wieseler-Frank J, Schoeniger D, Jekich BM, Barrientos RM, Maier SF, Watkins LR.

J Pain. 2004 Sep;5(7):392-405.


BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration.

Barrientos RM, Sprunger DB, Campeau S, Watkins LR, Rudy JW, Maier SF.

J Neuroimmunol. 2004 Oct;155(1-2):119-26.


Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.

Chacur M, Milligan ED, Sloan EM, Wieseler-Frank J, Barrientos RM, Martin D, Poole S, Lomonte B, Gutiérrez JM, Maier SF, Cury Y, Watkins LR.

Pain. 2004 Mar;108(1-2):180-91.


The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations.

Matus-Amat P, Higgins EA, Barrientos RM, Rudy JW.

J Neurosci. 2004 Mar 10;24(10):2431-9.


Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.

Barrientos RM, Sprunger DB, Campeau S, Higgins EA, Watkins LR, Rudy JW, Maier SF.

Neuroscience. 2003;121(4):847-53.


Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration.

Barrientos RM, O'Reilly RC, Rudy JW.

Behav Brain Res. 2002 Aug 21;134(1-2):299-306.


Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus.

Barrientos RM, Higgins EA, Sprunger DB, Watkins LR, Rudy JW, Maier SF.

Behav Brain Res. 2002 Aug 21;134(1-2):291-8.


Hippocampal formation supports conditioning to memory of a context.

Rudy JW, Barrientos RM, O'Reilly RC.

Behav Neurosci. 2002 Aug;116(4):530-8.


Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation.

Webster EL, Barrientos RM, Contoreggi C, Isaac MG, Ligier S, Gabry KE, Chrousos GP, McCarthy EF, Rice KC, Gold PW, Sternberg EM.

J Rheumatol. 2002 Jun;29(6):1252-61.


IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats.

Frost P, Barrientos RM, Makino S, Wong ML, Sternberg EM.

J Neuroimmunol. 2001 Dec 3;121(1-2):32-9.


Exclusion of angiotensin I-converting enzyme as a candidate gene involved in exudative inflammatory resistance in F344/N rats.

Jafarian-Tehrani M, Listwak S, Barrientos RM, Michaud A, Corvol P, Sternberg EM.

Mol Med. 2000 Apr;6(4):319-31.


Identification of a novel inflammation-protective locus in the Fischer rat.

Listwak S, Barrientos RM, Koike G, Ghosh S, Gomez M, Misiewicz B, Sternberg EM.

Mamm Genome. 1999 Apr;10(4):362-5.


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