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Mining for natural product antileishmanials in a fungal extract library.

Mbekeani AJ, Jones RS, Bassas Llorens M, Elliot J, Regnault C, Barrett MP, Steele J, Kebede B, Wrigley SK, Evans L, Denny PW.

Int J Parasitol Drugs Drug Resist. 2019 Jun 11. pii: S2211-3207(19)30026-0. doi: 10.1016/j.ijpddr.2019.05.003. [Epub ahead of print]


Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC-MS.

Johnston K, Kim DH, Kerkhoven EJ, Burchmore R, Barrett MP, Achcar F.

Biosci Rep. 2019 May 17;39(5). pii: BSR20181601. doi: 10.1042/BSR20181601. Print 2019 May 31.


New drug, new problem: do hip fracture patients taking NOACs experience delayed surgery, longer hospital stay, or poorer outcomes?

Hourston GJ, Barrett MP, Khan WS, Vindlacheruvu M, McDonnell SM.

Hip Int. 2019 Apr 25:1120700019841351. doi: 10.1177/1120700019841351. [Epub ahead of print]


Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.

Giordani F, Khalaf AI, Gillingwater K, Munday JC, de Koning HP, Suckling CJ, Barrett MP, Scott FJ.

J Med Chem. 2019 Mar 28;62(6):3021-3035. doi: 10.1021/acs.jmedchem.8b01847. Epub 2019 Mar 13.


Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites.

Pountain AW, Weidt SK, Regnault C, Bates PA, Donachie AM, Dickens NJ, Barrett MP.

PLoS Negl Trop Dis. 2019 Feb 4;13(2):e0007052. doi: 10.1371/journal.pntd.0007052. eCollection 2019 Feb.


Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children.

Hurley E, Barrett MPJ, Kinirons M, Whelton H, Ryan CA, Stanton C, Harris HMB, O'Toole PW.

BMC Oral Health. 2019 Jan 14;19(1):13. doi: 10.1186/s12903-018-0693-1.


Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei.

Kovářová J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D.

PLoS Pathog. 2018 Dec 27;14(12):e1007475. doi: 10.1371/journal.ppat.1007475. eCollection 2018 Dec.


Drug Discovery for Kinetoplastid Diseases: Future Directions.

Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT.

ACS Infect Dis. 2019 Feb 8;5(2):152-157. doi: 10.1021/acsinfecdis.8b00298. Epub 2018 Dec 13.


The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis.

Barrett MP.

PLoS Negl Trop Dis. 2018 Dec 6;12(12):e0006925. doi: 10.1371/journal.pntd.0006925. eCollection 2018 Dec. No abstract available.


The impact of body mass index on mortality in patients with acute kidney injury: a systematic review protocol.

Barrett MP, Moore D, Smith FG, Dasgupta I.

Syst Rev. 2018 Oct 22;7(1):173. doi: 10.1186/s13643-018-0825-3.


The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.

Begolo D, Vincent IM, Giordani F, Pöhner I, Witty MJ, Rowan TG, Bengaly Z, Gillingwater K, Freund Y, Wade RC, Barrett MP, Clayton C.

PLoS Pathog. 2018 Sep 25;14(9):e1007315. doi: 10.1371/journal.ppat.1007315. eCollection 2018 Sep.


An integrated portable system for single chip simultaneous measurement of multiple disease associated metabolites.

Patil SB, Dheeman DS, Al-Rawhani MA, Velugotla S, Nagy B, Cheah BC, Grant JP, Accarino C, Barrett MP, Cumming DRS.

Biosens Bioelectron. 2018 Dec 30;122:88-94. doi: 10.1016/j.bios.2018.09.013. Epub 2018 Sep 5.


Minimally-destructive atmospheric ionisation mass spectrometry authenticates authorship of historical manuscripts.

Newton J, Ramage G, Gadegaard N, Zachs W, Rogers S, Barrett MP, Carruthers G, Burgess K.

Sci Rep. 2018 Jul 26;8(1):10944. doi: 10.1038/s41598-018-28810-2.


Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP.

PLoS Negl Trop Dis. 2018 May 14;12(5):e0006450. doi: 10.1371/journal.pntd.0006450. eCollection 2018 May.


Metabolic Clustering Analysis as a Strategy for Compound Selection in the Drug Discovery Pipeline for Leishmaniasis.

Armitage EG, Godzien J, Peña I, López-Gonzálvez Á, Angulo S, Gradillas A, Alonso-Herranz V, Martín J, Fiandor JM, Barrett MP, Gabarro R, Barbas C.

ACS Chem Biol. 2018 May 18;13(5):1361-1369. doi: 10.1021/acschembio.8b00204. Epub 2018 Apr 24.


Immunoassay Multiplexing on a Complementary Metal Oxide Semiconductor Photodiode Array.

Nagy B, Al-Rawhani MA, Cheah BC, Barrett MP, Cumming DRS.

ACS Sens. 2018 May 25;3(5):953-959. doi: 10.1021/acssensors.7b00972. Epub 2018 Apr 19.


Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana.

Kovářová J, Pountain AW, Wildridge D, Weidt S, Bringaud F, Burchmore RJS, Achcar F, Barrett MP.

PLoS Pathog. 2018 Mar 19;14(3):e1006953. doi: 10.1371/journal.ppat.1006953. eCollection 2018 Mar.


Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli.

Rattigan KM, Pountain AW, Regnault C, Achcar F, Vincent IM, Goodyear CS, Barrett MP.

PLoS One. 2018 Mar 14;13(3):e0194126. doi: 10.1371/journal.pone.0194126. eCollection 2018.


Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine.

Armitage EG, Alqaisi AQI, Godzien J, Peña I, Mbekeani AJ, Alonso-Herranz V, López-Gonzálvez Á, Martín J, Gabarro R, Denny PW, Barrett MP, Barbas C.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02095-17. doi: 10.1128/AAC.02095-17. Print 2018 May.


Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung KF, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang YK, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC.

PLoS Pathog. 2018 Feb 9;14(2):e1006850. doi: 10.1371/journal.ppat.1006850. eCollection 2018 Feb.


Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.

Ponte-Sucre A, Gamarro F, Dujardin JC, Barrett MP, López-Vélez R, García-Hernández R, Pountain AW, Mwenechanya R, Papadopoulou B.

PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006052. doi: 10.1371/journal.pntd.0006052. eCollection 2017 Dec. Review.


The oral microbiota in colorectal cancer is distinctive and predictive.

Flemer B, Warren RD, Barrett MP, Cisek K, Das A, Jeffery IB, Hurley E, O'Riordain M, Shanahan F, O'Toole PW.

Gut. 2018 Aug;67(8):1454-1463. doi: 10.1136/gutjnl-2017-314814. Epub 2017 Oct 7.


Microfluidics-Based Approaches to the Isolation of African Trypanosomes.

Barrett MP, Cooper JM, Regnault C, Holm SH, Beech JP, Tegenfeldt JO, Hochstetter A.

Pathogens. 2017 Oct 5;6(4). pii: E47. doi: 10.3390/pathogens6040047.

24. web-based topic modelling for substructure discovery in mass spectrometry.

Wandy J, Zhu Y, van der Hooft JJJ, Daly R, Barrett MP, Rogers S.

Bioinformatics. 2017 Sep 14. doi: 10.1093/bioinformatics/btx582. [Epub ahead of print]


Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

Mwenechanya R, Kovářová J, Dickens NJ, Mudaliar M, Herzyk P, Vincent IM, Weidt SK, Burgess KE, Burchmore RJS, Pountain AW, Smith TK, Creek DJ, Kim DH, Lepesheva GI, Barrett MP.

PLoS Negl Trop Dis. 2017 Jun 16;11(6):e0005649. doi: 10.1371/journal.pntd.0005649. eCollection 2017 Jun.


Unsupervised Discovery and Comparison of Structural Families Across Multiple Samples in Untargeted Metabolomics.

van der Hooft JJJ, Wandy J, Young F, Padmanabhan S, Gerasimidis K, Burgess KEV, Barrett MP, Rogers S.

Anal Chem. 2017 Jul 18;89(14):7569-7577. doi: 10.1021/acs.analchem.7b01391. Epub 2017 Jul 5.


Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.

Alzahrani KJH, Ali JAM, Eze AA, Looi WL, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP.

Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):206-226. doi: 10.1016/j.ijpddr.2017.04.003. Epub 2017 Apr 20.


Bioimpedance Analysis and Acute Kidney Injury.

Barrett MP.

J Ren Nutr. 2017 May;27(3):216. doi: 10.1053/j.jrn.2016.12.004. Epub 2017 Jan 23. No abstract available.


Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.

Srivastava A, Philip N, Hughes KR, Georgiou K, MacRae JI, Barrett MP, Creek DJ, McConville MJ, Waters AP.

PLoS Pathog. 2016 Dec 27;12(12):e1006094. doi: 10.1371/journal.ppat.1006094. eCollection 2016 Dec.


Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis.

Vincent IM, Daly R, Courtioux B, Cattanach AM, Biéler S, Ndung'u JM, Bisser S, Barrett MP.

PLoS Negl Trop Dis. 2016 Dec 12;10(12):e0005140. doi: 10.1371/journal.pntd.0005140. eCollection 2016 Dec.


Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis.

Biéler S, Waltenberger H, Barrett MP, McCulloch R, Mottram JC, Carrington M, Schwaeble W, McKerrow J, Phillips MA, Michels PA, Büscher P, Sanchez JC, Bishop R, Robinson DR, Bangs J, Ferguson M, Nerima B, Albertini A, Michel G, Radwandska M, Ndung'u JM.

PLoS One. 2016 Dec 9;11(12):e0168074. doi: 10.1371/journal.pone.0168074. eCollection 2016.


Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease.

Barrett MP, Giordani F.

Parasitology. 2017 Oct;144(12):1652-1662. doi: 10.1017/S003118201600202X. Epub 2016 Dec 8.


Topic modeling for untargeted substructure exploration in metabolomics.

van der Hooft JJ, Wandy J, Barrett MP, Burgess KE, Rogers S.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13738-13743. Epub 2016 Nov 16.


The animal trypanosomiases and their chemotherapy: a review.

Giordani F, Morrison LJ, Rowan TG, DE Koning HP, Barrett MP.

Parasitology. 2016 Dec;143(14):1862-1889. Epub 2016 Oct 10. Review.


Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation.

van der Hooft JJ, Padmanabhan S, Burgess KE, Barrett MP.

Metabolomics. 2016;12:125. Epub 2016 Jul 5.


The Pentose Phosphate Pathway in Parasitic Trypanosomatids.

Kovářová J, Barrett MP.

Trends Parasitol. 2016 Aug;32(8):622-634. doi: 10.1016/ Epub 2016 May 9. Review.


Untargeted Metabolomics To Ascertain Antibiotic Modes of Action.

Vincent IM, Ehmann DE, Mills SD, Perros M, Barrett MP.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2281-91. doi: 10.1128/AAC.02109-15. Print 2016 Apr.


An Integrated Circuit for Chip-Based Analysis of Enzyme Kinetics and Metabolite Quantification.

Cheah BC, Macdonald AI, Martin C, Streklas AJ, Campbell G, Al-Rawhani MA, Nemeth B, Grant JP, Barrett MP, Cumming DR.

IEEE Trans Biomed Circuits Syst. 2016 Jun;10(3):721-30. doi: 10.1109/TBCAS.2015.2487603. Epub 2016 Jan 6.


LC-MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes.

Kim DH, Achcar F, Breitling R, Burgess KE, Barrett MP.

Metabolomics. 2015;11(6):1721-1732. Epub 2015 Jul 9.


Hip pain after a fall.

Barrett MP, McDonnell SM.

BMJ. 2015 Sep 22;351:h4785. doi: 10.1136/bmj.h4785. No abstract available.


Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.

Baker N, Hamilton G, Wilkes JM, Hutchinson S, Barrett MP, Horn D.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9112-7. doi: 10.1073/pnas.1505411112. Epub 2015 Jul 6.


Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites.

Srivastava A, Creek DJ, Evans KJ, De Souza D, Schofield L, Müller S, Barrett MP, McConville MJ, Waters AP.

PLoS Pathog. 2015 Jun 4;11(6):e1004882. doi: 10.1371/journal.ppat.1004882. eCollection 2015 Jun.


An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.

de Macêdo JP, Schumann Burkard G, Niemann M, Barrett MP, Vial H, Mäser P, Roditi I, Schneider A, Bütikofer P.

PLoS Pathog. 2015 May 6;11(5):e1004875. doi: 10.1371/journal.ppat.1004875. eCollection 2015 May.


Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.

Coles JA, Myburgh E, Ritchie R, Hamilton A, Rodgers J, Mottram JC, Barrett MP, Brewer JM.

PLoS Negl Trop Dis. 2015 Apr 16;9(4):e0003714. doi: 10.1371/journal.pntd.0003714. eCollection 2015 Apr.


Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines.

van der Hooft JJ, Ridder L, Barrett MP, Burgess KE.

Front Bioeng Biotechnol. 2015 Mar 9;3:26. doi: 10.3389/fbioe.2015.00026. eCollection 2015.


Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.

Creek DJ, Mazet M, Achcar F, Anderson J, Kim DH, Kamour R, Morand P, Millerioux Y, Biran M, Kerkhoven EJ, Chokkathukalam A, Weidt SK, Burgess KE, Breitling R, Watson DG, Bringaud F, Barrett MP.

PLoS Pathog. 2015 Mar 16;11(3):e1004689. doi: 10.1371/journal.ppat.1004689. eCollection 2015 Mar.


Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.

Trochine A, Creek DJ, Faral-Tello P, Barrett MP, Robello C.

Antimicrob Agents Chemother. 2015 May;59(5):2921-5. doi: 10.1128/AAC.05046-14. Epub 2015 Feb 23.


Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.

Hai Y, Kerkhoven EJ, Barrett MP, Christianson DW.

Biochemistry. 2015 Jan 20;54(2):458-71. doi: 10.1021/bi501366a. Epub 2014 Dec 23.


Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.

Alkhaldi AA, Creek DJ, Ibrahim H, Kim DH, Quashie NB, Burgess KE, Changtam C, Barrett MP, Suksamrarn A, de Koning HP.

Mol Pharmacol. 2015;87(3):451-64. doi: 10.1124/mol.114.096016. Epub 2014 Dec 19.


TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F.

Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44. doi: 10.1093/nar/gku944. Epub 2014 Oct 9.

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