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Items: 21


Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes.

Kiselev E, Barrett MO, Katritch V, Paoletta S, Weitzer CD, Brown KA, Hammes E, Yin AL, Zhao Q, Stevens RC, Harden TK, Jacobson KA.

ACS Chem Biol. 2014 Dec 19;9(12):2833-42. doi: 10.1021/cb500614p. Epub 2014 Oct 20.


Membrane-induced allosteric control of phospholipase C-β isozymes.

Charpentier TH, Waldo GL, Barrett MO, Huang W, Zhang Q, Harden TK, Sondek J.

J Biol Chem. 2014 Oct 24;289(43):29545-57. doi: 10.1074/jbc.M114.586784. Epub 2014 Sep 5.


Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand.

Song L, Risseeuw MD, Karalic I, Barrett MO, Brown KA, Harden TK, Van Calenbergh S.

Molecules. 2014 Apr 4;19(4):4313-25. doi: 10.3390/molecules19044313.


4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.

Jayasekara PS, Barrett MO, Ball CB, Brown KA, Hammes E, Balasubramanian R, Harden TK, Jacobson KA.

J Med Chem. 2014 May 8;57(9):3874-83. doi: 10.1021/jm500367e. Epub 2014 Apr 18.


4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.

Jayasekara PS, Barrett MO, Ball CB, Brown KA, Kozma E, Costanzi S, Squarcialupi L, Balasubramanian R, Maruoka H, Jacobson KA.

Medchemcomm. 2013 May 30;4:1156-1165.


A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Barrett MO, Sesma JI, Ball CB, Jayasekara PS, Jacobson KA, Lazarowski ER, Harden TK.

Mol Pharmacol. 2013 Jul;84(1):41-9. doi: 10.1124/mol.113.085654. Epub 2013 Apr 16.


G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.


Synthesis and P2Y₂ receptor agonist activities of uridine 5'-phosphonate analogues.

Van Poecke S, Barrett MO, Santhosh Kumar T, Sinnaeve D, Martins JC, Jacobson KA, Kendall Harden T, Van Calenbergh S.

Bioorg Med Chem. 2012 Apr 1;20(7):2304-15. doi: 10.1016/j.bmc.2012.02.012. Epub 2012 Feb 15.


Mechanical failure of marathon cross-linked polyethylene acetabular liner after total hip arthroplasty.

Barrett MO, Van Citters DW, Hamilton WG.

Am J Orthop (Belle Mead NJ). 2011 Oct;40(10):523-6. No abstract available.


Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.

Maruoka H, Jayasekara MP, Barrett MO, Franklin DA, de Castro S, Kim N, Costanzi S, Harden TK, Jacobson KA.

J Med Chem. 2011 Jun 23;54(12):4018-33. doi: 10.1021/jm101591j. Epub 2011 May 20.


Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.

Maruoka H, Barrett MO, Ko H, Tosh DK, Melman A, Burianek LE, Balasubramanian R, Berk B, Costanzi S, Harden TK, Jacobson KA.

J Med Chem. 2010 Jun 10;53(11):4488-501. doi: 10.1021/jm100287t.


Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.

Tosh DK, Yoo LS, Chinn M, Hong K, Kilbey SM 2nd, Barrett MO, Fricks IP, Harden TK, Gao ZG, Jacobson KA.

Bioconjug Chem. 2010 Feb 17;21(2):372-84. doi: 10.1021/bc900473v.


Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.

Das A, Ko H, Burianek LE, Barrett MO, Harden TK, Jacobson KA.

J Med Chem. 2010 Jan 14;53(1):471-80. doi: 10.1021/jm901432g.


Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.

Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK.

Mol Pharmacol. 2009 Dec;76(6):1341-8. doi: 10.1124/mol.109.058578. Epub 2009 Sep 16.


Multilevel pediatric cervicothoracic intervertebral disc calcifications.

Barrett MO, Anderson JT, Rao B, Vaslow D, Hoernschemeyer DG.

Am J Orthop (Belle Mead NJ). 2008 Jul;37(7):E126-8. No abstract available.


The safety of forefoot metatarsal pins in external fixation of the lower extremity.

Barrett MO, Wade AM, Della Rocca GJ, Crist BD, Anglen JO.

J Bone Joint Surg Am. 2008 Mar;90(3):560-4. doi: 10.2106/JBJS.G.00743.


Case report: associated both-column acetabulum fracture with an ipsilateral centrally dislocated intertrochanteric femur fracture.

Barrett MO, Anglen JO, Hoernschemeyer DG, Schnetzler KA.

J Trauma. 2009 Mar;66(3):918-21. doi: 10.1097/01.ta.0000224118.24154.39. No abstract available.


Medial clavicular epiphyseal fracture with ipsilateral acromioclavicular dislocation: a case report of panclavicular fracture dislocation.

Wade AM, Barrett MO, Crist BD, Della Rocca GJ, Kane SM.

J Orthop Trauma. 2007 Jul;21(6):418-21.


Septic arthritis of the hip in an immune competent adult: the significance of the differential diagnosis.

Barrett MO, Bal BS.

J Am Board Fam Med. 2007 May-Jun;20(3):307-9. No abstract available.


Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway.

Li G, Barrett EJ, Barrett MO, Cao W, Liu Z.

Endocrinology. 2007 Jul;148(7):3356-63. Epub 2007 Apr 19.


Repair or reattachment of the meniscus after fixation of a tibial plateau fracture.

Barrett MO, Kazmier P, Anglen JO.

J Orthop Trauma. 2005 Mar;19(3):198-200.


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