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Items: 41


A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration.

Alves DS, Westerfield JM, Shi X, Nguyen VP, Stefanski KM, Booth KR, Kim S, Morrell-Falvey J, Wang BC, Abel SM, Smith AW, Barrera FN.

Elife. 2018 Sep 17;7. pii: e36645. doi: 10.7554/eLife.36645.


Labeling of Phosphatidylinositol Lipid Products in Cells through Metabolic Engineering by Using a Clickable myo-Inositol Probe.

Ricks TJ, Cassilly CD, Carr AJ, Alves DS, Alam S, Tscherch K, Yokley TW, Workman CE, Morrell-Falvey JL, Barrera FN, Reynolds TB, Best MD.

Chembiochem. 2018 Aug 11. doi: 10.1002/cbic.201800248. [Epub ahead of print]


Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane Peptide.

Usery RD, Enoki TA, Wickramasinghe SP, Nguyen VP, Ackerman DG, Greathouse DV, Koeppe RE, Barrera FN, Feigenson GW.

Biophys J. 2018 Jul 3;115(1):164. doi: 10.1016/j.bpj.2018.06.002. No abstract available.


Boronic acid liposomes for cellular delivery and content release driven by carbohydrate binding.

Zhang X, Alves DS, Lou J, Hill SD, Barrera FN, Best MD.

Chem Commun (Camb). 2018 Jun 12;54(48):6169-6172. doi: 10.1039/c8cc00820e.


Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane Peptide.

Usery RD, Enoki TA, Wickramasinghe SP, Nguyen VP, Ackerman DG, Greathouse DV, Koeppe RE, Barrera FN, Feigenson GW.

Biophys J. 2018 May 8;114(9):2152-2164. doi: 10.1016/j.bpj.2018.03.026. Erratum in: Biophys J. 2018 Jul 3;115(1):164.


Determination of the Membrane Translocation pK of the pH-Low Insertion Peptide.

Scott HL, Westerfield JM, Barrera FN.

Biophys J. 2017 Aug 22;113(4):869-879. doi: 10.1016/j.bpj.2017.06.065.


Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation.

Karabadzhak AG, Petti LM, Barrera FN, Edwards APB, Moya-Rodríguez A, Polikanov YS, Freites JA, Tobias DJ, Engelman DM, DiMaio D.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7262-E7271. doi: 10.1073/pnas.1705622114. Epub 2017 Aug 14.


A Novel Soluble Peptide with pH-Responsive Membrane Insertion.

Nguyen VP, Alves DS, Scott HL, Davis FL, Barrera FN.

Biochemistry. 2015 Nov 3;54(43):6567-75. doi: 10.1021/acs.biochem.5b00856. Epub 2015 Oct 24.


A clickable and photocleavable lipid analogue for cell membrane delivery and release.

Alam S, Alves DS, Whitehead SA, Bayer AM, McNitt CD, Popik VV, Barrera FN, Best MD.

Bioconjug Chem. 2015 Jun 17;26(6):1021-31. doi: 10.1021/acs.bioconjchem.5b00044. Epub 2015 May 15.


The negative charge of the membrane has opposite effects on the membrane entry and exit of pH-low insertion peptide.

Scott HL, Nguyen VP, Alves DS, Davis FL, Booth KR, Bryner J, Barrera FN.

Biochemistry. 2015 Mar 10;54(9):1709-12. doi: 10.1021/acs.biochem.5b00069. Epub 2015 Feb 27.


Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP.

Deacon JC, Engelman DM, Barrera FN.

Arch Biochem Biophys. 2015 Jan 1;565:40-8. doi: 10.1016/ Epub 2014 Nov 18.


Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor.

Cohen EB, Jun SJ, Bears Z, Barrera FN, Alonso M, Engelman DM, DiMaio D.

PLoS One. 2014 Apr 30;9(4):e95593. doi: 10.1371/journal.pone.0095593. eCollection 2014.


Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain.

Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD.

J Virol. 2014 Jan;88(1):628-42. doi: 10.1128/JVI.02052-13. Epub 2013 Oct 30.


Aspartate embedding depth affects pHLIP's insertion pKa.

Fendos J, Barrera FN, Engelman DM.

Biochemistry. 2013 Jul 9;52(27):4595-604. doi: 10.1021/bi400252k. Epub 2013 Jun 27.


Turbulent times in southern European science.

Barrera FN, Neira JL.

Lancet. 2012 Oct 6;380(9849):1229-30. doi: 10.1016/S0140-6736(12)61715-2. No abstract available.


Membrane physical properties influence transmembrane helix formation.

Barrera FN, Fendos J, Engelman DM.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14422-7. doi: 10.1073/pnas.1212665109. Epub 2012 Aug 20.


Roles of carboxyl groups in the transmembrane insertion of peptides.

Barrera FN, Weerakkody D, Anderson M, Andreev OA, Reshetnyak YK, Engelman DM.

J Mol Biol. 2011 Oct 21;413(2):359-71. doi: 10.1016/j.jmb.2011.08.010. Epub 2011 Aug 23.


Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein.

Triano I, Barrera FN, Renart ML, Molina ML, Fernández-Ballester G, Poveda JA, Fernández AM, Encinar JA, Ferrer-Montiel AV, Otzen D, González-Ros JM.

Biochemistry. 2010 Jun 29;49(25):5397-404. doi: 10.1021/bi1003712.


Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor.

Cammett TJ, Jun SJ, Cohen EB, Barrera FN, Engelman DM, Dimaio D.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3447-52. doi: 10.1073/pnas.0915057107. Epub 2010 Feb 8.


Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor.

Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM, Dimaio D.

J Virol. 2009 Oct;83(19):9773-85. doi: 10.1128/JVI.00946-09. Epub 2009 Jul 15.


The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA.

Neira JL, Román-Trufero M, Contreras LM, Prieto J, Singh G, Barrera FN, Renart ML, Vidal M.

Biochemistry. 2009 Feb 17;48(6):1348-60. doi: 10.1021/bi801933c.


Into the lipid realm: stability and thermodynamics of membrane proteins.

Barrera FN, Alcaraz LA, Hurtado-Gómez E, Neira JL.

Curr Protein Pept Sci. 2008 Dec;9(6):626-37. Review.


N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.

Molina ML, Barrera FN, Encinar JA, Renart ML, Fernández AM, Poveda JA, Santoro J, Bruix M, Gavilanes F, Fernández-Ballester G, Neira JL, González-Ros JM.

J Biol Chem. 2008 Jun 27;283(26):18076-85. doi: 10.1074/jbc.M710132200. Epub 2008 Apr 22.


Protein self-assembly and lipid binding in the folding of the potassium channel KcsA.

Barrera FN, Renart ML, Poveda JA, de Kruijff B, Killian JA, González-Ros JM.

Biochemistry. 2008 Feb 19;47(7):2123-33. doi: 10.1021/bi700778c. Epub 2008 Jan 19.


Envelope lipids regulate the in vitro assembly of the HIV-1 capsid.

Barrera FN, del Alamo M, Mateu MG, Neira JL.

Biophys J. 2008 Jan 15;94(2):L8-10. Epub 2007 Nov 2.


The isolated C-terminal domain of Ring1B is a dimer made of stable, well-structured monomers.

Czypionka A, de los Paños OR, Mateu MG, Barrera FN, Hurtado-Gómez E, Gómez J, Vidal M, Neira JL.

Biochemistry. 2007 Nov 6;46(44):12764-76. Epub 2007 Oct 13.


Flexibility in HIV-1 assembly subunits: solution structure of the monomeric C-terminal domain of the capsid protein.

Alcaraz LA, del Alamo M, Barrera FN, Mateu MG, Neira JL.

Biophys J. 2007 Aug 15;93(4):1264-76. Epub 2007 May 25.


Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA.

Renart ML, Barrera FN, Molina ML, Encinar JA, Poveda JA, Fernández AM, Gómez J, González-Ros JM.

J Biol Chem. 2006 Oct 6;281(40):29905-15. Epub 2006 Jun 30.


Clustering and coupled gating modulate the activity in KcsA, a potassium channel model.

Molina ML, Barrera FN, Fernández AM, Poveda JA, Renart ML, Encinar JA, Riquelme G, González-Ros JM.

J Biol Chem. 2006 Jul 7;281(27):18837-48. Epub 2006 May 2.


Binding of the C-terminal domain of the HIV-1 capsid protein to lipid membranes: a biophysical characterization.

Barrera FN, Hurtado-Gómez E, Lidón-Moya MC, Neira JL.

Biochem J. 2006 Feb 15;394(Pt 1):345-53.


Unfolding and refolding in vitro of a tetrameric, alpha-helical membrane protein: the prokaryotic potassium channel KcsA.

Barrera FN, Renart ML, Molina ML, Poveda JA, Encinar JA, Fernández AM, Neira JL, González-Ros JM.

Biochemistry. 2005 Nov 1;44(43):14344-52.


The conformational stability and thermodynamics of Fur A (ferric uptake regulator) from Anabaena sp. PCC 7119.

Hernández JA, Meier J, Barrera FN, de los Paños OR, Hurtado-Gómez E, Bes MT, Fillat MF, Peleato ML, Cavasotto CN, Neira JL.

Biophys J. 2005 Dec;89(6):4188-200. Epub 2005 Sep 16.


The influence of a membrane environment on the structure and stability of a prokaryotic potassium channel, KcsA.

Encinar JA, Molina ML, Poveda JA, Barrera FN, Renart ML, Fernández AM, González-Ros JM.

FEBS Lett. 2005 Sep 26;579(23):5199-204.


An extensive thermodynamic characterization of the dimerization domain of the HIV-1 capsid protein.

Lidón-Moya MC, Barrera FN, Bueno M, Pérez-Jiménez R, Sancho J, Mateu MG, Neira JL.

Protein Sci. 2005 Sep;14(9):2387-404.


Structure and conformational stability of the enzyme I of Streptomyces coelicolor explored by FTIR and circular dichroism.

Hurtado-Gómez E, Barrera FN, Neira JL.

Biophys Chem. 2005 Apr 1;115(2-3):229-33. Epub 2004 Dec 24.


Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel KcsA.

Molina ML, Encinar JA, Barrera FN, Fernández-Ballester G, Riquelme G, González-Ros JM.

Biochemistry. 2004 Nov 30;43(47):14924-31.


The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: a biophysical characterization.

Garzón MT, Lidón-Moya MC, Barrera FN, Prieto A, Gómez J, Mateu MG, Neira JL.

Protein Sci. 2004 Jun;13(6):1512-23.


Binding of the C-terminal sterile alpha motif (SAM) domain of human p73 to lipid membranes.

Barrera FN, Poveda JA, González-Ros JM, Neira JL.

J Biol Chem. 2003 Nov 21;278(47):46878-85. Epub 2003 Sep 3.


The inactivating factor of glutamine synthetase, IF7, is a "natively unfolded" protein.

Muro-Pastor MI, Barrera FN, Reyes JC, Florencio FJ, Neira JL.

Protein Sci. 2003 Jul;12(7):1443-54.


Equilibrium unfolding of the C-terminal SAM domain of p73.

Barrera FN, Garzón MT, Gómez J, Neira JL.

Biochemistry. 2002 May 7;41(18):5743-53.


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