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COPD: preclinical models and emerging therapeutic targets.

Barreiro E, Wang X, Tang J.

Expert Opin Ther Targets. 2019 Sep 12. doi: 10.1080/14728222.2019.1667976. [Epub ahead of print]


Gastroprotective effects of N-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the NO/cGMP/KATP pathway.

da Silva Monteiro CE, Franco ÁX, Sousa JAO, Matos VEA, de Souza EP, Fraga CAM, Barreiro EJ, de Souza MHLP, Soares PMG, Barbosa ALR.

Biochem Pharmacol. 2019 Sep 3;169:113629. doi: 10.1016/j.bcp.2019.113629. [Epub ahead of print]


Immunotherapy with Monoclonal Antibodies in Lung Cancer of Mice: Oxidative Stress and Other Biological Events.

Tang J, Ramis-Cabrer D, Wang X, Barreiro E.

Cancers (Basel). 2019 Sep 4;11(9). pii: E1301. doi: 10.3390/cancers11091301.


Stromal markers of activated tumor associated fibroblasts predict poor survival and are associated with necrosis in non-small cell lung cancer.

Alcaraz J, Carrasco JL, Millares L, Luis IC, Fernández-Porras FJ, Martínez-Romero A, Diaz-Valdivia N, De Cos JS, Rami-Porta R, Seijo L, Ramírez J, Pajares MJ, Reguart N, Barreiro E, Monsó E.

Lung Cancer. 2019 Sep;135:151-160. doi: 10.1016/j.lungcan.2019.07.020. Epub 2019 Jul 24.


What is hidden in the biodiversity? The role of natural products and medicinal chemistry in the drug discovery process.

Barreiro EJ.

An Acad Bras Cienc. 2019 Jul 29;91(supp 3):e20190306. doi: 10.1590/0001-3765201920190306.


Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill.

Peñuelas O, Keough E, López-Rodríguez L, Carriedo D, Gonçalves G, Barreiro E, Lorente JÁ.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):48. doi: 10.1186/s40635-019-0259-9. Review.


Exposure to disinfection by-products in swimming pools and biomarkers of genotoxicity and respiratory damage - The PISCINA2 Study.

Font-Ribera L, Marco E, Grimalt JO, Pastor S, Marcos R, Abramsson-Zetterberg L, Pedersen M, Grummt T, Junek R, Barreiro E, Heederik D, Spithoven J, Critelli R, Naccarati A, Schmalz C, Zwiener C, Liu J, Zhang X, Mitch W, Gracia-Lavedan E, Arjona L, de Bont J, Tarès L, Vineis P, Kogevinas M, Villanueva CM.

Environ Int. 2019 Oct;131:104988. doi: 10.1016/j.envint.2019.104988. Epub 2019 Jul 16.


Don't Put the Cart Before the Horse (If You want to Publish in a Journal with Impact Factor).

Santibáñez M, García-Rivero JL, Barreiro E.

Arch Bronconeumol. 2019 Jul 9. pii: S0300-2896(19)30279-0. doi: 10.1016/j.arbres.2019.05.019. [Epub ahead of print] English, Spanish. No abstract available.


Chemical Intuition in Drug Design and Discovery.

Pedreira JGB, Franco LS, Barreiro EJ.

Curr Top Med Chem. 2019 Jun 20. doi: 10.2174/1568026619666190620144142. [Epub ahead of print]


Differential structural features in soleus and gastrocnemius of carnitine-treated cancer cachectic rats.

Busquets S, Pérez-Peiró M, Salazar-Degracia A, Argilés JM, Serpe R, Rojano-Toimil A, López-Soriano FJ, Barreiro E.

J Cell Physiol. 2019 Jun 26. doi: 10.1002/jcp.28992. [Epub ahead of print]


Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.

Silva RR, Parreiras-E-Silva LT, Pompeu TET, Duarte DA, Fraga CAM, Barreiro EJ, Menegatti R, Costa-Neto CM, Noël F.

Front Pharmacol. 2019 Jun 4;10:628. doi: 10.3389/fphar.2019.00628. eCollection 2019.


Impact of Physical Activity and Exercise on Chronic Obstructive Pulmonary Disease Phenotypes: The Relevance of Muscle Adaptation.

Barreiro E.

Arch Bronconeumol. 2019 Jun 7. pii: S0300-2896(19)30252-2. doi: 10.1016/j.arbres.2019.04.024. [Epub ahead of print] English, Spanish. No abstract available.


Nutritional abnormalities and chronic obstructive pulmonary disease.

Gea J, Barreiro E.

Int J Tuberc Lung Dis. 2019 May 1;23(5):531-532. doi: 10.5588/ijtld.19.0160. No abstract available.


Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis.

Cavalcanti de Queiroz A, Alves MA, Barreiro EJ, Lima LM, Alexandre-Moreira MS.

Exp Parasitol. 2019 Jun;201:57-66. doi: 10.1016/j.exppara.2019.04.003. Epub 2019 Apr 17.


Endoplasmic reticulum stress and unfolded protein response in diaphragm muscle dysfunction of patients with stable chronic obstructive pulmonary disease.

Barreiro E, Salazar-Degracia A, Sancho-Muñoz A, Aguiló R, Rodríguez-Fuster A, Gea J.

J Appl Physiol (1985). 2019 Jun 1;126(6):1572-1586. doi: 10.1152/japplphysiol.00670.2018. Epub 2019 Apr 18.


ERS statement on respiratory muscle testing at rest and during exercise.

Laveneziana P, Albuquerque A, Aliverti A, Babb T, Barreiro E, Dres M, Dubé BP, Fauroux B, Gea J, Guenette JA, Hudson AL, Kabitz HJ, Laghi F, Langer D, Luo YM, Neder JA, O'Donnell D, Polkey MI, Rabinovich RA, Rossi A, Series F, Similowski T, Spengler CM, Vogiatzis I, Verges S.

Eur Respir J. 2019 Jun 13;53(6). pii: 1801214. doi: 10.1183/13993003.01214-2018. Print 2019 Jun.


Reduced lung cancer burden by selective immunomodulators elicits improvements in muscle proteolysis and strength in cachectic mice.

Salazar-Degracia A, Granado-Martínez P, Millán-Sánchez A, Tang J, Pons-Carreto A, Barreiro E.

J Cell Physiol. 2019 Aug;234(10):18041-18052. doi: 10.1002/jcp.28437. Epub 2019 Mar 9.


Relevance of Controling for Confounding in Observational Studies.

Barreiro E, Muñoz X, González-Barcala FJ, Bustamante V, Granda-Orive JI.

Arch Bronconeumol. 2019 Mar;55(3):117. doi: 10.1016/j.arbres.2019.01.001. Epub 2019 Jan 25. English, Spanish. No abstract available.


Is iron deficiency modulating physical activity in COPD?

Martín-Ontiyuelo C, Rodó-Pin A, Sancho-Muñoz A, Martinez-Llorens JM, Admetlló M, Molina L, Gea J, Barreiro E, Chiaradía DAR.

Int J Chron Obstruct Pulmon Dis. 2019 Jan 11;14:211-214. doi: 10.2147/COPD.S182700. eCollection 2019.


A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives.

do Amaral DN, Lategahn J, Fokoue HH, da Silva EMB, Sant'Anna CMR, Rauh D, Barreiro EJ, Laufer S, Lima LM.

Sci Rep. 2019 Jan 9;9(1):14. doi: 10.1038/s41598-018-36846-7.


Diesel exhausts particles: Their role in increasing the incidence of asthma. Reviewing the evidence of a causal link.

Muñoz X, Barreiro E, Bustamante V, Lopez-Campos JL, González-Barcala FJ, Cruz MJ.

Sci Total Environ. 2019 Feb 20;652:1129-1138. doi: 10.1016/j.scitotenv.2018.10.188. Epub 2018 Oct 15. Review.


Endoplasmic reticulum stress and unfolded protein response profile in quadriceps of sarcopenic patients with respiratory diseases.

Barreiro E, Salazar-Degracia A, Sancho-Muñoz A, Gea J.

J Cell Physiol. 2019 Jul;234(7):11315-11329. doi: 10.1002/jcp.27789. Epub 2018 Nov 22.


Differences in micro-RNA expression profile between vastus lateralis samples and myotubes in COPD cachexia.

Barreiro E, Sancho-Muñoz A, Puig-Vilanova E, Salazar-Degracia A, Pascual-Guardia S, Casadevall C, Gea J.

J Appl Physiol (1985). 2019 Feb 1;126(2):403-412. doi: 10.1152/japplphysiol.00611.2018. Epub 2018 Dec 13.


Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative.

Bastos ITS, Pinheiro PSM, Costa FN, Rocha MD, Sant'Anna CMR, Braz D, Souza ET, Martins MA, Barreiro EJ, Ferreira FF, Barroso RC, Fraga CAM.

Pharmaceuticals (Basel). 2018 Nov 1;11(4). pii: E119. doi: 10.3390/ph11040119.


Potent immunosuppressive activity of a phosphodiesterase-4 inhibitor N-acylhydrazone in models of lipopolysaccharide-induced shock and delayed-type hypersensitivity reaction.

Guimarães ET, Dos Santos TB, Silva DKC, Meira CS, Moreira DRM, da Silva TF, Salmon D, Barreiro EJ, Soares MBP.

Int Immunopharmacol. 2018 Dec;65:108-118. doi: 10.1016/j.intimp.2018.09.047. Epub 2018 Oct 9.


Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals.

Lederer DJ, Bell SC, Branson RD, Chalmers JD, Marshall R, Maslove DM, Ost DE, Punjabi NM, Schatz M, Smyth AR, Stewart PW, Suissa S, Adjei AA, Akdis CA, Azoulay É, Bakker J, Ballas ZK, Bardin PG, Barreiro E, Bellomo R, Bernstein JA, Brusasco V, Buchman TG, Chokroverty S, Collop NA, Crapo JD, Fitzgerald DA, Hale L, Hart N, Herth FJ, Iwashyna TJ, Jenkins G, Kolb M, Marks GB, Mazzone P, Moorman JR, Murphy TM, Noah TL, Reynolds P, Riemann D, Russell RE, Sheikh A, Sotgiu G, Swenson ER, Szczesniak R, Szymusiak R, Teboul JL, Vincent JL.

Ann Am Thorac Soc. 2019 Jan;16(1):22-28. doi: 10.1513/AnnalsATS.201808-564PS. No abstract available. Erratum in: Ann Am Thorac Soc. 2019 Feb;16(2):283.


Immune phenotypes in lung cancer patients with COPD: potential implications for immunotherapy.

Chalela R, Gea J, Barreiro E.

J Thorac Dis. 2018 Jul;10(Suppl 18):S2186-S2189. doi: 10.21037/jtd.2018.06.143. No abstract available.


Net-Net Auto Machine Learning (AutoML) Prediction of Complex Ecosystems.

Barreiro E, Munteanu CR, Cruz-Monteagudo M, Pazos A, González-Díaz H.

Sci Rep. 2018 Aug 17;8(1):12340. doi: 10.1038/s41598-018-30637-w.


LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice.

Silva JC, Oliveira Júnior RG, Silva MGE, Lavor ÉM, Soares JMD, Lima-Saraiva SRG, Diniz TC, Mendes RL, Alencar Filho EB, Barreiro EJL, Lima LM, Almeida JRGDS.

PLoS One. 2018 Jul 30;13(7):e0199009. doi: 10.1371/journal.pone.0199009. eCollection 2018.


Tumor-associated metabolic and inflammatory responses in early stage non-small cell lung cancer: Local patterns and prognostic significance.

Millares L, Barreiro E, Cortes R, Martinez-Romero A, Balcells C, Cascante M, Enguita AB, Alvarez C, Rami-Porta R, Sánchez de Cos J, Seijo L, Monsó E; Grupo Colaborativo en Cáncer de Pulmón CIBERES- CIBERONC- SEPAR - Plataforma Biobanco Pulmonar.

Lung Cancer. 2018 Aug;122:124-130. doi: 10.1016/j.lungcan.2018.06.015. Epub 2018 Jun 10.


N-Acylhydrazones as drugs.

Thota S, Rodrigues DA, Pinheiro PSM, Lima LM, Fraga CAM, Barreiro EJ.

Bioorg Med Chem Lett. 2018 Sep 15;28(17):2797-2806. doi: 10.1016/j.bmcl.2018.07.015. Epub 2018 Jul 9. Review.


Combined aerobic exercise and high-intensity respiratory muscle training in patients surgically treated for non-small cell lung cancer: a pilot randomized clinical trial.

Messaggi-Sartor M, Marco E, Martínez-Téllez E, Rodriguez-Fuster A, Palomares C, Chiarella S, Muniesa JM, Orozco-Levi M, Barreiro E, Güell MR.

Eur J Phys Rehabil Med. 2019 Feb;55(1):113-122. doi: 10.23736/S1973-9087.18.05156-0. Epub 2018 Jul 6.


Muscle atrophy in chronic obstructive pulmonary disease: molecular basis and potential therapeutic targets.

Barreiro E, Jaitovich A.

J Thorac Dis. 2018 May;10(Suppl 12):S1415-S1424. doi: 10.21037/jtd.2018.04.168. Review.


Skeletal muscle dysfunction in COPD: relevance of nutritional support and pulmonary rehabilitation.

Barreiro E, Jaitovich A.

J Thorac Dis. 2018 May;10(Suppl 12):S1330-S1331. doi: 10.21037/jtd.2018.05.114. No abstract available.


Current controversies in the stepping up and stepping down of inhaled therapies for COPD at the patient level.

Lopez-Campos JL, Carrasco Hernández L, Muñoz X, Bustamante V, Barreiro E.

Respirology. 2018 Jun 20. doi: 10.1111/resp.13341. [Epub ahead of print] Review.


Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones.

Herrmann S, Schübel T, Costa FN, Barbosa MLC, Ferreira FF, Dias TLMF, Araújo MV, Alexandre-Moreira MS, Lima LM, Laufer S, Barreiro EJ.

An Acad Bras Cienc. 2018;90(1 Suppl 2):1073-1088. doi: 10.1590/0001-3765201820170796.


Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats.

Alencar AK, Carvalho FI, Silva AM, Martinez ST, Calasans-Maia JA, Fraga CM, Barreiro EJ, Zapata-Sudo G, Sudo RT.

PLoS One. 2018 Apr 20;13(4):e0195047. doi: 10.1371/journal.pone.0195047. eCollection 2018.


Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength.

Greising SM, Ottenheijm CAC, O'Halloran KD, Barreiro E.

J Appl Physiol (1985). 2018 Aug 1;125(2):243-253. doi: 10.1152/japplphysiol.01059.2017. Epub 2018 Apr 19.


Effects of the beta2 agonist formoterol on atrophy signaling, autophagy, and muscle phenotype in respiratory and limb muscles of rats with cancer-induced cachexia.

Salazar-Degracia A, Busquets S, Argilés JM, Bargalló-Gispert N, López-Soriano FJ, Barreiro E.

Biochimie. 2018 Jun;149:79-91. doi: 10.1016/j.biochi.2018.04.009. Epub 2018 Apr 12.


The phosphodiesterase-4 inhibitor roflumilast reverts proteolysis in skeletal muscle cells of patients with COPD cachexia.

Barreiro E, Puig-Vilanova E, Salazar-Degracia A, Pascual-Guardia S, Casadevall C, Gea J.

J Appl Physiol (1985). 2018 Aug 1;125(2):287-303. doi: 10.1152/japplphysiol.00798.2017. Epub 2018 Apr 12.


The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment.

Costa FB, Cortez AP, de Ávila RI, de Carvalho FS, Andrade WM, da Cruz AF, Reis KB, Menegatti R, Lião LM, Romeiro LAS, Noël F, Fraga CAM, Barreiro EJ, Sanz G, Rodrigues MF, Vaz BG, Valadares MC.

Biomed Pharmacother. 2018 Jun;102:481-493. doi: 10.1016/j.biopha.2018.02.120. Epub 2018 Apr 5.


Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. What We Know and Can Do for Our Patients.

Jaitovich A, Barreiro E.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):175-186. doi: 10.1164/rccm.201710-2140CI. Erratum in: Am J Respir Crit Care Med. 2018 Sep 15;198(6):824-825.


Recent Advances in Development of Polyphenols as Anticancer Agents.

Thota S, Rodrigues DA, Barreiro EJ.

Mini Rev Med Chem. 2018;18(15):1265-1269. doi: 10.2174/1389557518666180220122113. Review.


Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients.

Tényi Á, Cano I, Marabita F, Kiani N, Kalko SG, Barreiro E, de Atauri P, Cascante M, Gomez-Cabrero D, Roca J.

J Transl Med. 2018 Feb 20;16(1):34. doi: 10.1186/s12967-018-1405-y.


Oxidative imbalance in mice intoxicated by microcystin-LR can be minimized.

Casquilho NV, Moreira-Gomes MD, Magalhães CB, Okuro RT, Ortenzi VH, Feitosa-Lima EK, Lima LM, Barreiro EJ, Soares RM, Azevedo SMFO, Valença SS, Fortunato RS, Carvalho AR, Zin WA.

Toxicon. 2018 Mar 15;144:75-82. doi: 10.1016/j.toxicon.2018.02.008. Epub 2018 Feb 16.


Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

Thota S, Rodrigues DA, Crans DC, Barreiro EJ.

J Med Chem. 2018 Jul 26;61(14):5805-5821. doi: 10.1021/acs.jmedchem.7b01689. Epub 2018 Feb 26. Review.


Models of disuse muscle atrophy: therapeutic implications in critically ill patients.

Barreiro E.

Ann Transl Med. 2018 Jan;6(2):29. doi: 10.21037/atm.2017.12.12. Review.


Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions.

Mateu-Jimenez M, Curull V, Rodríguez-Fuster A, Aguiló R, Sánchez-Font A, Pijuan L, Gea J, Barreiro E.

Clin Epigenetics. 2018 Jan 16;10:7. doi: 10.1186/s13148-017-0437-0. eCollection 2018.


Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease.

Paul T, Salazar-Degracia A, Peinado VI, Tura-Ceide O, Blanco I, Barreiro E, Barberà JA.

PLoS One. 2018 Jan 5;13(1):e0190628. doi: 10.1371/journal.pone.0190628. eCollection 2018.


Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats.

Salazar-Degracia A, Busquets S, Argilés JM, López-Soriano FJ, Barreiro E.

PeerJ. 2017 Dec 13;5:e4109. doi: 10.7717/peerj.4109. eCollection 2017.

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