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Items: 44


Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8.

Ah Kioon MD, Tripodo C, Fernandez D, Kirou KA, Spiera RF, Crow MK, Gordon JK, Barrat FJ.

Sci Transl Med. 2018 Jan 10;10(423). pii: eaam8458. doi: 10.1126/scitranslmed.aam8458.


Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.

Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, Barrat FJ, Nathan CF, Lin G, Azzi J.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8425-E8432. doi: 10.1073/pnas.1618548114. Epub 2016 Dec 12.


Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.

Barrat FJ, Elkon KB, Fitzgerald KA.

Annu Rev Med. 2016;67:323-36. doi: 10.1146/annurev-med-052814-023338. Epub 2015 Nov 2. Review.


Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells.

Wang J, Lau KY, Jung J, Ravindran P, Barrat FJ.

Eur J Immunol. 2014 Apr;44(4):1130-6. doi: 10.1002/eji.201344030. Epub 2014 Jan 20.


RNA recognition by human TLR8 can lead to autoimmune inflammation.

Guiducci C, Gong M, Cepika AM, Xu Z, Tripodo C, Bennett L, Crain C, Quartier P, Cush JJ, Pascual V, Coffman RL, Barrat FJ.

J Exp Med. 2013 Dec 16;210(13):2903-19. doi: 10.1084/jem.20131044. Epub 2013 Nov 25.


Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection.

Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM.

PLoS Pathog. 2013;9(7):e1003530. doi: 10.1371/journal.ppat.1003530. Epub 2013 Jul 25.


A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block.

Alvarez D, Briassouli P, Clancy RM, Zavadil J, Reed JH, Abellar RG, Halushka M, Fox-Talbot K, Barrat FJ, Buyon JP.

J Biol Chem. 2011 Sep 2;286(35):30444-54. doi: 10.1074/jbc.M111.263657. Epub 2011 Jul 5.


Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus.

Garcia-Romo GS, Caielli S, Vega B, Connolly J, Allantaz F, Xu Z, Punaro M, Baisch J, Guiducci C, Coffman RL, Barrat FJ, Banchereau J, Pascual V.

Sci Transl Med. 2011 Mar 9;3(73):73ra20. doi: 10.1126/scitranslmed.3001201.


Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.

Guiducci C, Tripodo C, Gong M, Sangaletti S, Colombo MP, Coffman RL, Barrat FJ.

J Exp Med. 2010 Dec 20;207(13):2931-42. doi: 10.1084/jem.20101048. Epub 2010 Nov 29.


TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, Chan JH, Wright T, Punaro M, Bolland S, Soumelis V, Banchereau J, Coffman RL, Pascual V, Barrat FJ.

Nature. 2010 Jun 17;465(7300):937-41. doi: 10.1038/nature09102.


Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.

Clancy RM, Alvarez D, Komissarova E, Barrat FJ, Swartz J, Buyon JP.

J Immunol. 2010 Feb 15;184(4):2148-55. doi: 10.4049/jimmunol.0902248. Epub 2010 Jan 20.


Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, Homey B, Barrat FJ, Zal T, Gilliet M.

J Exp Med. 2009 Aug 31;206(9):1983-94. doi: 10.1084/jem.20090480. Epub 2009 Aug 24.


Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury.

Qing X, Pitashny M, Thomas DB, Barrat FJ, Hogarth MP, Putterman C.

Immunol Lett. 2008 Nov 16;121(1):61-73. doi: 10.1016/j.imlet.2008.08.007. Epub 2008 Sep 24.


Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.

Mandl JN, Barry AP, Vanderford TH, Kozyr N, Chavan R, Klucking S, Barrat FJ, Coffman RL, Staprans SI, Feinberg MB.

Nat Med. 2008 Oct;14(10):1077-87. doi: 10.1038/nm.1871. Epub 2008 Sep 14.


Development of TLR inhibitors for the treatment of autoimmune diseases.

Barrat FJ, Coffman RL.

Immunol Rev. 2008 Jun;223:271-83. doi: 10.1111/j.1600-065X.2008.00630.x. Review.


Strategies for use of IL-10 or its antagonists in human disease.

O'Garra A, Barrat FJ, Castro AG, Vicari A, Hawrylowicz C.

Immunol Rev. 2008 Jun;223:114-31. doi: 10.1111/j.1600-065X.2008.00635.x. Review.


PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.

Guiducci C, Ghirelli C, Marloie-Provost MA, Matray T, Coffman RL, Liu YJ, Barrat FJ, Soumelis V.

J Exp Med. 2008 Feb 18;205(2):315-22. doi: 10.1084/jem.20070763. Epub 2008 Jan 28.


Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Maródi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, Casanova JL.

J Exp Med. 2007 Oct 1;204(10):2407-22. Epub 2007 Sep 24.


Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, Ryffel B, Barrat FJ, Saftig P, Levi F, Lidereau R, Nogues C, Mira JP, Chompret A, Joulin V, Clavel-Chapelon F, Bourhis J, André F, Delaloge S, Tursz T, Kroemer G, Zitvogel L.

Nat Med. 2007 Sep;13(9):1050-9. Epub 2007 Aug 19.


Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis.

Denny MF, Thacker S, Mehta H, Somers EC, Dodick T, Barrat FJ, McCune WJ, Kaplan MJ.

Blood. 2007 Oct 15;110(8):2907-15. Epub 2007 Jul 16.


Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

Kanzler H, Barrat FJ, Hessel EM, Coffman RL.

Nat Med. 2007 May;13(5):552-9. Review.


Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation.

Guiducci C, Ott G, Chan JH, Damon E, Calacsan C, Matray T, Lee KD, Coffman RL, Barrat FJ.

J Exp Med. 2006 Aug 7;203(8):1999-2008. Epub 2006 Jul 24.


Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.

Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, Adikibi T, Pridgeon C, Dallman M, Loke TK, Robinson DS, Barrat FJ, O'Garra A, Lavender P, Lee TH, Corrigan C, Hawrylowicz CM.

J Clin Invest. 2006 Jan;116(1):146-55. Epub 2005 Dec 8.


Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

Yang K, Puel A, Zhang S, Eidenschenk C, Ku CL, Casrouge A, Picard C, von Bernuth H, Senechal B, Plancoulaine S, Al-Hajjar S, Al-Ghonaium A, Maródi L, Davidson D, Speert D, Roifman C, Garty BZ, Ozinsky A, Barrat FJ, Coffman RL, Miller RL, Li X, Lebon P, Rodriguez-Gallego C, Chapel H, Geissmann F, Jouanguy E, Casanova JL.

Immunity. 2005 Nov;23(5):465-78.


Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.

Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL.

J Exp Med. 2005 Oct 17;202(8):1131-9.


Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation.

Duramad O, Fearon KL, Chang B, Chan JH, Gregorio J, Coffman RL, Barrat FJ.

J Immunol. 2005 May 1;174(9):5193-200.


IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells.

Vieira PL, Christensen JR, Minaee S, O'Neill EJ, Barrat FJ, Boonstra A, Barthlott T, Stockinger B, Wraith DC, O'Garra A.

J Immunol. 2004 May 15;172(10):5986-93.


IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences.

Duramad O, Fearon KL, Chan JH, Kanzler H, Marshall JD, Coffman RL, Barrat FJ.

Blood. 2003 Dec 15;102(13):4487-92. Epub 2003 Aug 28.


In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, de Waal-Malefyt R, Coffman RL, Hawrylowicz CM, O'Garra A.

J Exp Med. 2002 Mar 4;195(5):603-16.


1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.

Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A.

J Immunol. 2001 Nov 1;167(9):4974-80.


A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.

Neighbors M, Xu X, Barrat FJ, Ruuls SR, Churakova T, Debets R, Bazan JF, Kastelein RA, Abrams JS, O'Garra A.

J Exp Med. 2001 Aug 6;194(3):343-54.


Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice.

Chensue SW, Lukacs NW, Yang TY, Shang X, Frait KA, Kunkel SL, Kung T, Wiekowski MT, Hedrick JA, Cook DN, Zingoni A, Narula SK, Zlotnik A, Barrat FJ, O'Garra A, Napolitano M, Lira SA.

J Exp Med. 2001 Mar 5;193(5):573-84.


Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation.

Barrat FJ, Le Deist F, Benkerrou M, Bousso P, Feldmann J, Fischer A, de Saint Basile G.

Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8645-50.


Genetic basis of hemophagocytic lymphohistiocytosis syndrome (Review).

Dufourcq-Lagelouse R, Pastural E, Barrat FJ, Feldmann J, Le Deist F, Fischer A, De Saint Basile G.

Int J Mol Med. 1999 Aug;4(2):127-33. Review.


[Genetic defects in control of T cell activation evolving in a syndrome of lymphohistiocytic activation].

Dufourcq-Lagelouse R, Pastural E, Barrat FJ, Le Deist F, Fischer A, de Saint Basile G.

Arch Pediatr. 1999;6 Suppl 2:417s-419s. French. No abstract available.


Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse.

Barbosa MD, Barrat FJ, Tchernev VT, Nguyen QA, Mishra VS, Colman SD, Pastural E, Dufourcq-Lagelouse R, Fischer A, Holcombe RF, Wallace MR, Brandt SJ, de Saint Basile G, Kingsmore SF.

Hum Mol Genet. 1997 Jul;6(7):1091-8.


Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene.

Pastural E, Barrat FJ, Dufourcq-Lagelouse R, Certain S, Sanal O, Jabado N, Seger R, Griscelli C, Fischer A, de Saint Basile G.

Nat Genet. 1997 Jul;16(3):289-92. Erratum in: Nat Genet 1999 Nov;23(3):373.


Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43.

Barrat FJ, Auloge L, Pastural E, Lagelouse RD, Vilmer E, Cant AJ, Weissenbach J, Le Paslier D, Fischer A, de Saint Basile G.

Am J Hum Genet. 1996 Sep;59(3):625-32.

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