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Items: 1 to 50 of 82

1.

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation.

Macpherson JA, Theisen A, Masino L, Fets L, Driscoll PC, Encheva V, Snijders AP, Martin SR, Kleinjung J, Barran PE, Fraternali F, Anastasiou D.

Elife. 2019 Jul 2;8. pii: e45068. doi: 10.7554/eLife.45068.

2.

Hybrid mass spectrometry methods reveal lot-to-lot differences and delineate the effects of glycosylation on the tertiary structure of Herceptin®.

Upton R, Migas LG, Pacholarz KJ, Beniston RG, Estdale S, Firth D, Barran PE.

Chem Sci. 2019 Jan 17;10(9):2811-2820. doi: 10.1039/c8sc05029e. eCollection 2019 Mar 7.

3.

Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples.

Sinclair I, Bachman M, Addison D, Rohman M, Murray DC, Davies G, Mouchet E, Tonge ME, Stearns RG, Ghislain L, Datwani SS, Majlof L, Hall E, Jones GR, Hoyes E, Olechno J, Ellson RN, Barran PE, Pringle SD, Morris MR, Wingfield J.

Anal Chem. 2019 Mar 19;91(6):3790-3794. doi: 10.1021/acs.analchem.9b00142. Epub 2019 Mar 11.

PMID:
30835099
4.

Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins.

Beveridge R, Migas LG, Das RK, Pappu RV, Kriwacki RW, Barran PE.

J Am Chem Soc. 2019 Mar 27;141(12):4908-4918. doi: 10.1021/jacs.8b13483. Epub 2019 Mar 12.

5.

High throughput screening of complex biological samples with mass spectrometry - from bulk measurements to single cell analysis.

Kempa EE, Hollywood KA, Smith CA, Barran PE.

Analyst. 2019 Jan 28;144(3):872-891. doi: 10.1039/c8an01448e. Review.

PMID:
30601490
6.

Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A.

Beveridge R, Migas LG, Kriwacki RW, Barran PE.

Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3114-3118. doi: 10.1002/anie.201812697. Epub 2019 Jan 24.

PMID:
30570821
7.

The Use of Mass Spectrometry to Examine IDPs: Unique Insights and Caveats.

Stuchfield D, France AP, Migas LG, Thalhammer A, Bremer A, Bellina B, Barran PE.

Methods Enzymol. 2018;611:459-502. doi: 10.1016/bs.mie.2018.09.038. Epub 2018 Nov 7.

PMID:
30471696
8.

Initial Protein Unfolding Events in Ubiquitin, Cytochrome c and Myoglobin Are Revealed with the Use of 213 nm UVPD Coupled to IM-MS.

Theisen A, Black R, Corinti D, Brown JM, Bellina B, Barran PE.

J Am Soc Mass Spectrom. 2019 Jan;30(1):24-33. doi: 10.1007/s13361-018-1992-0. Epub 2018 Jun 13. Erratum in: J Am Soc Mass Spectrom. 2019 Feb 11;:.

9.

DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor.

Vonderach M, Byrne DP, Barran PE, Eyers PA, Eyers CE.

J Am Soc Mass Spectrom. 2019 Jan;30(1):128-138. doi: 10.1007/s13361-018-1984-0. Epub 2018 Jun 5. Erratum in: J Am Soc Mass Spectrom. 2019 Feb 11;:.

10.

UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides.

Mistarz UH, Bellina B, Jensen PF, Brown JM, Barran PE, Rand KD.

Anal Chem. 2018 Jan 16;90(2):1077-1080. doi: 10.1021/acs.analchem.7b04683. Epub 2017 Dec 28.

PMID:
29266933
11.

Initial Steps of Amyloidogenic Peptide Assembly Revealed by Cold-Ion Spectroscopy.

Ujma J, Kopysov V, Nagornova NS, Migas LG, Lizio MG, Blanch EW, MacPhee C, Boyarkin OV, Barran PE.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):213-217. doi: 10.1002/anie.201710188. Epub 2017 Dec 7.

PMID:
29087022
12.

Uncoupling conformational states from activity in an allosteric enzyme.

Pisco JP, de Chiara C, Pacholarz KJ, Garza-Garcia A, Ogrodowicz RW, Walker PA, Barran PE, Smerdon SJ, de Carvalho LPS.

Nat Commun. 2017 Aug 7;8(1):203. doi: 10.1038/s41467-017-00224-0.

13.

Charge Mediated Compaction and Rearrangement of Gas-Phase Proteins: A Case Study Considering Two Proteins at Opposing Ends of the Structure-Disorder Continuum.

Jhingree JR, Bellina B, Pacholarz KJ, Barran PE.

J Am Soc Mass Spectrom. 2017 Jul;28(7):1450-1461. doi: 10.1007/s13361-017-1692-1. Epub 2017 Jun 5.

14.

Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase.

Pacholarz KJ, Burnley RJ, Jowitt TA, Ordsmith V, Pisco JP, Porrini M, Larrouy-Maumus G, Garlish RA, Taylor RJ, de Carvalho LPS, Barran PE.

Structure. 2017 May 2;25(5):730-738.e4. doi: 10.1016/j.str.2017.03.005. Epub 2017 Apr 6.

15.

Bottom-Up Elucidation of Glycosidic Bond Stereochemistry.

Gray CJ, Schindler B, Migas LG, Pičmanová M, Allouche AR, Green AP, Mandal S, Motawia MS, Sánchez-Pérez R, Bjarnholt N, Møller BL, Rijs AM, Barran PE, Compagnon I, Eyers CE, Flitsch SL.

Anal Chem. 2017 Apr 18;89(8):4540-4549. doi: 10.1021/acs.analchem.6b04998. Epub 2017 Apr 6.

PMID:
28350444
16.

Real-Time Screening of Biocatalysts in Live Bacterial Colonies.

Yan C, Parmeggiani F, Jones EA, Claude E, Hussain SA, Turner NJ, Flitsch SL, Barran PE.

J Am Chem Soc. 2017 Feb 1;139(4):1408-1411. doi: 10.1021/jacs.6b12165. Epub 2017 Jan 19.

PMID:
28084735
17.

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips AR, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJ.

Data Brief. 2016 Nov 29;10:298-303. eCollection 2017 Feb.

18.

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):625-631. doi: 10.1016/j.bbrc.2016.11.083. Epub 2016 Nov 16.

PMID:
27865831
19.

Orthogonal Assessment of Biotherapeutic Glycosylation: A Case Study Correlating N-Glycan Core Afucosylation of Herceptin with Mechanism of Action.

Upton R, Bell L, Guy C, Caldwell P, Estdale S, Barran PE, Firth D.

Anal Chem. 2016 Oct 18;88(20):10259-10265. Epub 2016 Sep 26.

PMID:
27620140
20.

Structurally Flexible and Solution Stable [Ln4TM8(OH)8(L)8(O2CR)8(MeOH)y](ClO4)4: A Playground for Magnetic Refrigeration.

Hooper TN, Inglis R, Lorusso G, Ujma J, Barran PE, Uhrin D, Schnack J, Piligkos S, Evangelisti M, Brechin EK.

Inorg Chem. 2016 Oct 17;55(20):10535-10546. Epub 2016 Sep 29.

PMID:
27685336
21.

Use of Ultraviolet Photodissociation Coupled with Ion Mobility Mass Spectrometry To Determine Structure and Sequence from Drift Time Selected Peptides and Proteins.

Theisen A, Yan B, Brown JM, Morris M, Bellina B, Barran PE.

Anal Chem. 2016 Oct 18;88(20):9964-9971. doi: 10.1021/acs.analchem.6b01705. Epub 2016 Oct 3.

PMID:
27631466
22.

New High Resolution Ion Mobility Mass Spectrometer Capable of Measurements of Collision Cross Sections from 150 to 520 K.

Ujma J, Giles K, Morris M, Barran PE.

Anal Chem. 2016 Oct 4;88(19):9469-9478. Epub 2016 Sep 15.

PMID:
27573618
23.

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding.

Beveridge R, Migas LG, Payne KAP, Scrutton NS, Leys D, Barran PE.

Nat Commun. 2016 Jul 15;7:12163. doi: 10.1038/ncomms12163.

24.

Consequences of point mutations in melanoma-associated antigen 4 (MAGE-A4) protein: Insights from structural and biophysical studies.

Hagiwara Y, Sieverling L, Hanif F, Anton J, Dickinson ER, Bui TT, Andreeva A, Barran PE, Cota E, Nikolova PV.

Sci Rep. 2016 Apr 28;6:25182. doi: 10.1038/srep25182.

25.

Use of a charge reducing agent to enable intact mass analysis of cysteine-linked antibody-drug-conjugates by native mass spectrometry.

Pacholarz KJ, Barran PE.

EuPA Open Proteom. 2016 Mar 4;11:23-27. doi: 10.1016/j.euprot.2016.02.004. eCollection 2016 Jun.

26.

Sizing and Discovery of Nanosized Polyoxometalate Clusters by Mass Spectrometry.

Surman AJ, Robbins PJ, Ujma J, Zheng Q, Barran PE, Cronin L.

J Am Chem Soc. 2016 Mar 23;138(11):3824-30. doi: 10.1021/jacs.6b00070. Epub 2016 Mar 14.

27.

Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis.

Gray CJ, Thomas B, Upton R, Migas LG, Eyers CE, Barran PE, Flitsch SL.

Biochim Biophys Acta. 2016 Aug;1860(8):1688-709. doi: 10.1016/j.bbagen.2016.02.003. Epub 2016 Feb 22. Review.

PMID:
26854953
28.

Making hybrid [n]-rotaxanes as supramolecular arrays of molecular electron spin qubits.

Fernandez A, Ferrando-Soria J, Pineda EM, Tuna F, Vitorica-Yrezabal IJ, Knappke C, Ujma J, Muryn CA, Timco GA, Barran PE, Ardavan A, Winpenny RE.

Nat Commun. 2016 Jan 8;7:10240. doi: 10.1038/ncomms10240.

29.

Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry.

Pacholarz KJ, Peters SJ, Garlish RA, Henry AJ, Taylor RJ, Humphreys DP, Barran PE.

Chembiochem. 2016 Jan 1;17(1):46-51. doi: 10.1002/cbic.201500574. Epub 2015 Dec 3.

PMID:
26534882
30.

The association and aggregation of the metamorphic chemokine lymphotactin with fondaparinux: from nm molecular complexes to μm molecular assemblies.

Harvey SR, MacPhee CE, Volkman BF, Barran PE.

Chem Commun (Camb). 2016 Jan 7;52(2):394-7. doi: 10.1039/c5cc05801e. Epub 2015 Nov 2.

PMID:
26523295
31.

Early stages of insulin fibrillogenesis examined with ion mobility mass spectrometry and molecular modelling.

Cole H, Porrini M, Morris R, Smith T, Kalapothakis J, Weidt S, Mackay CL, MacPhee CE, Barran PE.

Analyst. 2015 Oct 21;140(20):7000-11. doi: 10.1039/c5an01253h.

32.

The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors.

Dickinson ER, Jurneczko E, Nicholson J, Hupp TR, Zawacka-Pankau J, Selivanova G, Barran PE.

Front Mol Biosci. 2015 Jul 10;2:39. doi: 10.3389/fmolb.2015.00039. eCollection 2015.

33.

Distinguishing Loss of Structure from Subunit Dissociation for Protein Complexes with Variable Temperature Ion Mobility Mass Spectrometry.

Pacholarz KJ, Barran PE.

Anal Chem. 2015 Jun 16;87(12):6271-9. doi: 10.1021/acs.analchem.5b01063. Epub 2015 Jun 3.

PMID:
25993423
34.

A kinetic study of ovalbumin fibril formation: the importance of fragmentation and end-joining.

Kalapothakis JM, Morris RJ, Szavits-Nossan J, Eden K, Covill S, Tabor S, Gillam J, Barran PE, Allen RJ, MacPhee CE.

Biophys J. 2015 May 5;108(9):2300-11. doi: 10.1016/j.bpj.2015.03.021.

35.

Relating gas phase to solution conformations: Lessons from disordered proteins.

Beveridge R, Phillips AS, Denbigh L, Saleem HM, MacPhee CE, Barran PE.

Proteomics. 2015 Aug;15(16):2872-83. doi: 10.1002/pmic.201400605. Epub 2015 Jun 5.

36.

Electron capture dissociation and drift tube ion mobility-mass spectrometry coupled with site directed mutations provide insights into the conformational diversity of a metamorphic protein.

Harvey SR, Porrini M, Tyler RC, MacPhee CE, Volkman BF, Barran PE.

Phys Chem Chem Phys. 2015 Apr 28;17(16):10538-50. doi: 10.1039/c4cp05136j.

PMID:
25805055
37.

Conformational dynamics of α-synuclein: insights from mass spectrometry.

Phillips AS, Gomes AF, Kalapothakis JM, Gillam JE, Gasparavicius J, Gozzo FC, Kunath T, MacPhee C, Barran PE.

Analyst. 2015 May 7;140(9):3070-81. doi: 10.1039/c4an02306d. Epub 2015 Mar 10.

PMID:
25756329
38.

The use of ion mobility mass spectrometry to assist protein design: a case study on zinc finger fold versus coiled coil interactions.

Berezovskaya Y, Porrini M, Nortcliffe C, Barran PE.

Analyst. 2015 Apr 21;140(8):2847-56. doi: 10.1039/c4an00427b.

PMID:
25734188
39.

Insights into the conformations of three structurally diverse proteins: cytochrome c, p53, and MDM2, provided by variable-temperature ion mobility mass spectrometry.

Dickinson ER, Jurneczko E, Pacholarz KJ, Clarke DJ, Reeves M, Ball KL, Hupp T, Campopiano D, Nikolova PV, Barran PE.

Anal Chem. 2015 Mar 17;87(6):3231-8. doi: 10.1021/ac503720v. Epub 2015 Feb 25.

PMID:
25629302
40.

A mass-spectrometry-based framework to define the extent of disorder in proteins.

Beveridge R, Covill S, Pacholarz KJ, Kalapothakis JM, MacPhee CE, Barran PE.

Anal Chem. 2014 Nov 18;86(22):10979-91. doi: 10.1021/ac5027435. Epub 2014 Oct 29.

PMID:
25353392
41.

UV photodissociation of trapped ions following ion mobility separation in a Q-ToF mass spectrometer.

Bellina B, Brown JM, Ujma J, Murray P, Giles K, Morris M, Compagnon I, Barran PE.

Analyst. 2014 Dec 21;139(24):6348-51. doi: 10.1039/c4an01656d.

PMID:
25349872
42.

Dissecting the dynamic conformations of the metamorphic protein lymphotactin.

Harvey SR, Porrini M, Konijnenberg A, Clarke DJ, Tyler RC, Langridge-Smith PR, MacPhee CE, Volkman BF, Barran PE.

J Phys Chem B. 2014 Oct 30;118(43):12348-59. doi: 10.1021/jp504997k. Epub 2014 Oct 20.

PMID:
25259958
43.

Dynamics of intact immunoglobulin G explored by drift-tube ion-mobility mass spectrometry and molecular modeling.

Pacholarz KJ, Porrini M, Garlish RA, Burnley RJ, Taylor RJ, Henry AJ, Barran PE.

Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7765-9. doi: 10.1002/anie.201402863. Epub 2014 Jun 10.

PMID:
24916519
44.

Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide.

Kalapothakis JM, Berezovskaya Y, Zampronio CG, Faull PA, Barran PE, Cooper HJ.

Chem Commun (Camb). 2014 Jan 7;50(2):198-200. doi: 10.1039/c3cc46356g.

PMID:
24217599
45.

Effect of Protonation State on the Stability of Amyloid Oligomers Assembled from TTR(105-115).

Porrini M, Zachariae U, Barran PE, MacPhee CE.

J Phys Chem Lett. 2013 Apr 18;4(8):1233-8. doi: 10.1021/jz400372u. Epub 2013 Mar 28.

PMID:
26282135
46.

Probing the conformational diversity of cancer-associated mutations in p53 with ion-mobility mass spectrometry.

Jurneczko E, Cruickshank F, Porrini M, Clarke DJ, Campuzano ID, Morris M, Nikolova PV, Barran PE.

Angew Chem Int Ed Engl. 2013 Apr 15;52(16):4370-4. doi: 10.1002/anie.201210015. Epub 2013 Mar 14. No abstract available.

PMID:
23494921
47.

Luminescent, enantiopure, phenylatopyridine iridium-based coordination capsules.

Chepelin O, Ujma J, Wu X, Slawin AM, Pitak MB, Coles SJ, Michel J, Jones AC, Barran PE, Lusby PJ.

J Am Chem Soc. 2012 Nov 28;134(47):19334-7. doi: 10.1021/ja309031h. Epub 2012 Nov 16.

48.

Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry.

Harvey SR, Porrini M, Stachl C, MacMillan D, Zinzalla G, Barran PE.

J Am Chem Soc. 2012 Nov 28;134(47):19384-92. doi: 10.1021/ja306519h. Epub 2012 Nov 12.

PMID:
23106332
49.

Intrinsic disorder in proteins: a challenge for (un)structural biology met by ion mobility-mass spectrometry.

Jurneczko E, Cruickshank F, Porrini M, Nikolova P, Campuzano ID, Morris M, Barran PE.

Biochem Soc Trans. 2012 Oct;40(5):1021-6. Review.

PMID:
22988858
50.

QconCAT standard for calibration of ion mobility-mass spectrometry systems.

Chawner R, McCullough B, Giles K, Barran PE, Gaskell SJ, Eyers CE.

J Proteome Res. 2012 Nov 2;11(11):5564-72. doi: 10.1021/pr3005327. Epub 2012 Oct 9.

PMID:
22985290

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