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Items: 1 to 50 of 116

1.

Thermodynamically driven self-assembly of pyridinearene to hexameric capsules.

Kiesilä A, Beyeh NK, Moilanen JO, Puttreddy R, Götz S, Rissanen K, Barran P, Lützen A, Kalenius E.

Org Biomol Chem. 2019 Jul 5. doi: 10.1039/c9ob01383k. [Epub ahead of print]

PMID:
31276147
2.

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation.

Macpherson JA, Theisen A, Masino L, Fets L, Driscoll PC, Encheva V, Snijders AP, Martin SR, Kleinjung J, Barran PE, Fraternali F, Anastasiou D.

Elife. 2019 Jul 2;8. pii: e45068. doi: 10.7554/eLife.45068.

3.

Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.

Trivedi DK, Sinclair E, Xu Y, Sarkar D, Walton-Doyle C, Liscio C, Banks P, Milne J, Silverdale M, Kunath T, Goodacre R, Barran P.

ACS Cent Sci. 2019 Apr 24;5(4):599-606. doi: 10.1021/acscentsci.8b00879. Epub 2019 Mar 20.

4.

Hybrid mass spectrometry methods reveal lot-to-lot differences and delineate the effects of glycosylation on the tertiary structure of Herceptin®.

Upton R, Migas LG, Pacholarz KJ, Beniston RG, Estdale S, Firth D, Barran PE.

Chem Sci. 2019 Jan 17;10(9):2811-2820. doi: 10.1039/c8sc05029e. eCollection 2019 Mar 7.

5.

Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples.

Sinclair I, Bachman M, Addison D, Rohman M, Murray DC, Davies G, Mouchet E, Tonge ME, Stearns RG, Ghislain L, Datwani SS, Majlof L, Hall E, Jones GR, Hoyes E, Olechno J, Ellson RN, Barran PE, Pringle SD, Morris MR, Wingfield J.

Anal Chem. 2019 Mar 19;91(6):3790-3794. doi: 10.1021/acs.analchem.9b00142. Epub 2019 Mar 11.

PMID:
30835099
6.

Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins.

Beveridge R, Migas LG, Das RK, Pappu RV, Kriwacki RW, Barran PE.

J Am Chem Soc. 2019 Mar 27;141(12):4908-4918. doi: 10.1021/jacs.8b13483. Epub 2019 Mar 12.

7.

Recommendations for reporting ion mobility Mass Spectrometry measurements.

Gabelica V, Shvartsburg AA, Afonso C, Barran P, Benesch JLP, Bleiholder C, Bowers MT, Bilbao A, Bush MF, Campbell JL, Campuzano IDG, Causon T, Clowers BH, Creaser CS, De Pauw E, Far J, Fernandez-Lima F, Fjeldsted JC, Giles K, Groessl M, Hogan CJ Jr, Hann S, Kim HI, Kurulugama RT, May JC, McLean JA, Pagel K, Richardson K, Ridgeway ME, Rosu F, Sobott F, Thalassinos K, Valentine SJ, Wyttenbach T.

Mass Spectrom Rev. 2019 May;38(3):291-320. doi: 10.1002/mas.21585. Epub 2019 Feb 1. Review.

8.

Native mass spectrometry reveals the conformational diversity of the UVR8 photoreceptor.

Camacho IS, Theisen A, Johannissen LO, Díaz-Ramos LA, Christie JM, Jenkins GI, Bellina B, Barran P, Jones AR.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1116-1125. doi: 10.1073/pnas.1813254116. Epub 2019 Jan 4.

9.

High throughput screening of complex biological samples with mass spectrometry - from bulk measurements to single cell analysis.

Kempa EE, Hollywood KA, Smith CA, Barran PE.

Analyst. 2019 Jan 28;144(3):872-891. doi: 10.1039/c8an01448e. Review.

PMID:
30601490
10.

Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A.

Beveridge R, Migas LG, Kriwacki RW, Barran PE.

Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3114-3118. doi: 10.1002/anie.201812697. Epub 2019 Jan 24.

PMID:
30570821
11.

The Use of Mass Spectrometry to Examine IDPs: Unique Insights and Caveats.

Stuchfield D, France AP, Migas LG, Thalhammer A, Bremer A, Bellina B, Barran PE.

Methods Enzymol. 2018;611:459-502. doi: 10.1016/bs.mie.2018.09.038. Epub 2018 Nov 7.

PMID:
30471696
12.

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals.

Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon JL, Scrutton NS.

Commun Biol. 2018 Jun 8;1:66. doi: 10.1038/s42003-018-0076-9. eCollection 2018.

13.

Mobilising ion mobility mass spectrometry for metabolomics.

Sinclair E, Hollywood KA, Yan C, Blankley R, Breitling R, Barran P.

Analyst. 2018 Sep 24;143(19):4783-4788. doi: 10.1039/c8an00902c.

PMID:
30209461
14.

Initial Protein Unfolding Events in Ubiquitin, Cytochrome c and Myoglobin Are Revealed with the Use of 213 nm UVPD Coupled to IM-MS.

Theisen A, Black R, Corinti D, Brown JM, Bellina B, Barran PE.

J Am Soc Mass Spectrom. 2019 Jan;30(1):24-33. doi: 10.1007/s13361-018-1992-0. Epub 2018 Jun 13. Erratum in: J Am Soc Mass Spectrom. 2019 Feb 11;:.

15.

DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor.

Vonderach M, Byrne DP, Barran PE, Eyers PA, Eyers CE.

J Am Soc Mass Spectrom. 2019 Jan;30(1):128-138. doi: 10.1007/s13361-018-1984-0. Epub 2018 Jun 5. Erratum in: J Am Soc Mass Spectrom. 2019 Feb 11;:.

16.

Editorial overview: Omics.

Barran P, Baker E.

Curr Opin Chem Biol. 2018 Feb;42:A1-A2. doi: 10.1016/j.cbpa.2018.02.007. No abstract available.

PMID:
29482723
17.

Unique insights to intrinsically disordered proteins provided by ion mobility mass spectrometry.

Stuchfield D, Barran P.

Curr Opin Chem Biol. 2018 Feb;42:177-185. doi: 10.1016/j.cbpa.2018.01.007. Epub 2018 Feb 9. Review.

PMID:
29428839
18.

UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides.

Mistarz UH, Bellina B, Jensen PF, Brown JM, Barran PE, Rand KD.

Anal Chem. 2018 Jan 16;90(2):1077-1080. doi: 10.1021/acs.analchem.7b04683. Epub 2017 Dec 28.

PMID:
29266933
19.

Initial Steps of Amyloidogenic Peptide Assembly Revealed by Cold-Ion Spectroscopy.

Ujma J, Kopysov V, Nagornova NS, Migas LG, Lizio MG, Blanch EW, MacPhee C, Boyarkin OV, Barran PE.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):213-217. doi: 10.1002/anie.201710188. Epub 2017 Dec 7.

PMID:
29087022
20.

Cisplatin and transplatin interaction with methionine: bonding motifs assayed by vibrational spectroscopy in the isolated ionic complexes.

Paciotti R, Corinti D, De Petris A, Ciavardini A, Piccirillo S, Coletti C, Re N, Maitre P, Bellina B, Barran P, Chiavarino B, Elisa Crestoni M, Fornarini S.

Phys Chem Chem Phys. 2017 Oct 11;19(39):26697-26707. doi: 10.1039/c7cp05203k.

PMID:
28876340
21.

Uncoupling conformational states from activity in an allosteric enzyme.

Pisco JP, de Chiara C, Pacholarz KJ, Garza-Garcia A, Ogrodowicz RW, Walker PA, Barran PE, Smerdon SJ, de Carvalho LPS.

Nat Commun. 2017 Aug 7;8(1):203. doi: 10.1038/s41467-017-00224-0.

22.

Charge Mediated Compaction and Rearrangement of Gas-Phase Proteins: A Case Study Considering Two Proteins at Opposing Ends of the Structure-Disorder Continuum.

Jhingree JR, Bellina B, Pacholarz KJ, Barran PE.

J Am Soc Mass Spectrom. 2017 Jul;28(7):1450-1461. doi: 10.1007/s13361-017-1692-1. Epub 2017 Jun 5.

23.

Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase.

Pacholarz KJ, Burnley RJ, Jowitt TA, Ordsmith V, Pisco JP, Porrini M, Larrouy-Maumus G, Garlish RA, Taylor RJ, de Carvalho LPS, Barran PE.

Structure. 2017 May 2;25(5):730-738.e4. doi: 10.1016/j.str.2017.03.005. Epub 2017 Apr 6.

24.

From Microsolvation to Cell Permeation: Novel Separation Science for Drug Discovery.

Barran P.

ACS Cent Sci. 2017 Mar 22;3(3):158-160. doi: 10.1021/acscentsci.7b00092. Epub 2017 Mar 8. No abstract available.

25.

Bottom-Up Elucidation of Glycosidic Bond Stereochemistry.

Gray CJ, Schindler B, Migas LG, Pičmanová M, Allouche AR, Green AP, Mandal S, Motawia MS, Sánchez-Pérez R, Bjarnholt N, Møller BL, Rijs AM, Barran PE, Compagnon I, Eyers CE, Flitsch SL.

Anal Chem. 2017 Apr 18;89(8):4540-4549. doi: 10.1021/acs.analchem.6b04998. Epub 2017 Apr 6.

PMID:
28350444
26.

Real-Time Screening of Biocatalysts in Live Bacterial Colonies.

Yan C, Parmeggiani F, Jones EA, Claude E, Hussain SA, Turner NJ, Flitsch SL, Barran PE.

J Am Chem Soc. 2017 Feb 1;139(4):1408-1411. doi: 10.1021/jacs.6b12165. Epub 2017 Jan 19.

PMID:
28084735
27.

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips AR, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJ.

Data Brief. 2016 Nov 29;10:298-303. eCollection 2017 Feb.

28.

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):625-631. doi: 10.1016/j.bbrc.2016.11.083. Epub 2016 Nov 16.

PMID:
27865831
29.

Orthogonal Assessment of Biotherapeutic Glycosylation: A Case Study Correlating N-Glycan Core Afucosylation of Herceptin with Mechanism of Action.

Upton R, Bell L, Guy C, Caldwell P, Estdale S, Barran PE, Firth D.

Anal Chem. 2016 Oct 18;88(20):10259-10265. Epub 2016 Sep 26.

PMID:
27620140
30.

Structurally Flexible and Solution Stable [Ln4TM8(OH)8(L)8(O2CR)8(MeOH)y](ClO4)4: A Playground for Magnetic Refrigeration.

Hooper TN, Inglis R, Lorusso G, Ujma J, Barran PE, Uhrin D, Schnack J, Piligkos S, Evangelisti M, Brechin EK.

Inorg Chem. 2016 Oct 17;55(20):10535-10546. Epub 2016 Sep 29.

PMID:
27685336
31.

Use of Ultraviolet Photodissociation Coupled with Ion Mobility Mass Spectrometry To Determine Structure and Sequence from Drift Time Selected Peptides and Proteins.

Theisen A, Yan B, Brown JM, Morris M, Bellina B, Barran PE.

Anal Chem. 2016 Oct 18;88(20):9964-9971. doi: 10.1021/acs.analchem.6b01705. Epub 2016 Oct 3.

PMID:
27631466
32.

New High Resolution Ion Mobility Mass Spectrometer Capable of Measurements of Collision Cross Sections from 150 to 520 K.

Ujma J, Giles K, Morris M, Barran PE.

Anal Chem. 2016 Oct 4;88(19):9469-9478. Epub 2016 Sep 15.

PMID:
27573618
33.

SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production.

Ra LF, P C, A C, M D, D F, Aj J, Njw R, Cj R, N S, M V, A W, C Y, P B, R B, Gg C, Jl F, C G, R G, Db K, J M, Ns S, P S, E T, Nj T.

Synth Syst Biotechnol. 2016 Aug 25;1(4):271-275. doi: 10.1016/j.synbio.2016.07.001. eCollection 2016 Dec.

34.

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding.

Beveridge R, Migas LG, Payne KAP, Scrutton NS, Leys D, Barran PE.

Nat Commun. 2016 Jul 15;7:12163. doi: 10.1038/ncomms12163.

35.

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.

Carbonell P, Currin A, Dunstan M, Fellows D, Jervis A, Rattray NJ, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon JL, Goble C, Goodacre R, Kell DB, Feuvre RL, Micklefield J, Scrutton NS, Shapira P, Takano E, Turner NJ.

Biochem Soc Trans. 2016 Jun 15;44(3):675-7. doi: 10.1042/BST20160009.

36.

Consequences of point mutations in melanoma-associated antigen 4 (MAGE-A4) protein: Insights from structural and biophysical studies.

Hagiwara Y, Sieverling L, Hanif F, Anton J, Dickinson ER, Bui TT, Andreeva A, Barran PE, Cota E, Nikolova PV.

Sci Rep. 2016 Apr 28;6:25182. doi: 10.1038/srep25182.

37.

The effect of thermal processing on the behaviour of peanut allergen peptide targets used in multiple reaction monitoring mass spectrometry experiments.

Sayers RL, Johnson PE, Marsh JT, Barran P, Brown H, Mills EN.

Analyst. 2016 Jun 20;141(13):4130-41. doi: 10.1039/c6an00359a.

PMID:
27113917
38.

Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry.

Yan C, Schmidberger JW, Parmeggiani F, Hussain SA, Turner NJ, Flitsch SL, Barran P.

Analyst. 2016 Apr 21;141(8):2351-5. doi: 10.1039/c6an00617e. Epub 2016 Mar 21.

PMID:
26999769
39.

Use of a charge reducing agent to enable intact mass analysis of cysteine-linked antibody-drug-conjugates by native mass spectrometry.

Pacholarz KJ, Barran PE.

EuPA Open Proteom. 2016 Mar 4;11:23-27. doi: 10.1016/j.euprot.2016.02.004. eCollection 2016 Jun.

40.

Sizing and Discovery of Nanosized Polyoxometalate Clusters by Mass Spectrometry.

Surman AJ, Robbins PJ, Ujma J, Zheng Q, Barran PE, Cronin L.

J Am Chem Soc. 2016 Mar 23;138(11):3824-30. doi: 10.1021/jacs.6b00070. Epub 2016 Mar 14.

41.

Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis.

Gray CJ, Thomas B, Upton R, Migas LG, Eyers CE, Barran PE, Flitsch SL.

Biochim Biophys Acta. 2016 Aug;1860(8):1688-709. doi: 10.1016/j.bbagen.2016.02.003. Epub 2016 Feb 22. Review.

PMID:
26854953
42.

Making hybrid [n]-rotaxanes as supramolecular arrays of molecular electron spin qubits.

Fernandez A, Ferrando-Soria J, Pineda EM, Tuna F, Vitorica-Yrezabal IJ, Knappke C, Ujma J, Muryn CA, Timco GA, Barran PE, Ardavan A, Winpenny RE.

Nat Commun. 2016 Jan 8;7:10240. doi: 10.1038/ncomms10240.

43.

Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry.

Pacholarz KJ, Peters SJ, Garlish RA, Henry AJ, Taylor RJ, Humphreys DP, Barran PE.

Chembiochem. 2016 Jan 1;17(1):46-51. doi: 10.1002/cbic.201500574. Epub 2015 Dec 3.

PMID:
26534882
44.

The association and aggregation of the metamorphic chemokine lymphotactin with fondaparinux: from nm molecular complexes to μm molecular assemblies.

Harvey SR, MacPhee CE, Volkman BF, Barran PE.

Chem Commun (Camb). 2016 Jan 7;52(2):394-7. doi: 10.1039/c5cc05801e. Epub 2015 Nov 2.

PMID:
26523295
45.

Ion Mobility Mass Spectrometry.

Barran P, Ruotolo B.

Analyst. 2015 Oct 21;140(20):6772-4. doi: 10.1039/c5an90076j. Epub 2015 Sep 21. No abstract available.

PMID:
26389139
46.

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification.

Payne KA, Fisher K, Sjuts H, Dunstan MS, Bellina B, Johannissen L, Barran P, Hay S, Rigby SE, Leys D.

J Biol Chem. 2015 Nov 13;290(46):27572-81. doi: 10.1074/jbc.M115.685693. Epub 2015 Sep 16.

47.

Early stages of insulin fibrillogenesis examined with ion mobility mass spectrometry and molecular modelling.

Cole H, Porrini M, Morris R, Smith T, Kalapothakis J, Weidt S, Mackay CL, MacPhee CE, Barran PE.

Analyst. 2015 Oct 21;140(20):7000-11. doi: 10.1039/c5an01253h.

48.

The photochemical mechanism of a B12-dependent photoreceptor protein.

Kutta RJ, Hardman SJO, Johannissen LO, Bellina B, Messiha HL, Ortiz-Guerrero JM, Elías-Arnanz M, Padmanabhan S, Barran P, Scrutton NS, Jones AR.

Nat Commun. 2015 Aug 12;6:7907. doi: 10.1038/ncomms8907.

49.

Protein Structure.

Barran P, Cooper H, Eyers C.

Proteomics. 2015 Aug;15(16):2731-2. doi: 10.1002/pmic.201570143. No abstract available.

PMID:
26249796
50.

The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors.

Dickinson ER, Jurneczko E, Nicholson J, Hupp TR, Zawacka-Pankau J, Selivanova G, Barran PE.

Front Mol Biosci. 2015 Jul 10;2:39. doi: 10.3389/fmolb.2015.00039. eCollection 2015.

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