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Items: 42


Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.

Dimitriou ID, Lee K, Akpan I, Lind EF, Barr VA, Ohashi PS, Samelson LE, Rottapel R.

Cell Rep. 2018 Jul 31;24(5):1123-1135. doi: 10.1016/j.celrep.2018.06.075.


The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

Guittard G, Dios-Esponera A, Palmer DC, Akpan I, Barr VA, Manna A, Restifo NP, Samelson LE.

Sci Rep. 2018 Mar 28;8(1):5336. doi: 10.1038/s41598-018-23549-2.


Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.

Giardino Torchia ML, Dutta D, Mittelstadt PR, Guha J, Gaida MM, Fish K, Barr VA, Akpan IO, Samelson LE, Tagad HD, Debnath S, Miller Jenkins LM, Appella E, Ashwell JD.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2174-2179. doi: 10.1073/pnas.1713301115. Epub 2018 Feb 12.


Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM.

Yi J, Manna A, Barr VA, Hong J, Neuman KC, Samelson LE.

J Vis Exp. 2017 Jun 24;(124). doi: 10.3791/55997.


Super-resolution Analysis of TCR-Dependent Signaling: Single-Molecule Localization Microscopy.

Barr VA, Yi J, Samelson LE.

Methods Mol Biol. 2017;1584:183-206. doi: 10.1007/978-1-4939-6881-7_13.


Recruitment of calcineurin to the TCR positively regulates T cell activation.

Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD.

Nat Immunol. 2017 Feb;18(2):196-204. doi: 10.1038/ni.3640. Epub 2016 Dec 12.


Development of nanoscale structure in LAT-based signaling complexes.

Barr VA, Sherman E, Yi J, Akpan I, Rouquette-Jazdanian AK, Samelson LE.

J Cell Sci. 2016 Dec 15;129(24):4548-4562. Epub 2016 Nov 10.


madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy.

Yi J, Manna A, Barr VA, Hong J, Neuman KC, Samelson LE.

Mol Biol Cell. 2016 Nov 7;27(22):3591-3600. Epub 2016 Oct 5.


Hierarchical nanostructure and synergy of multimolecular signalling complexes.

Sherman E, Barr VA, Merrill RK, Regan CK, Sommers CL, Samelson LE.

Nat Commun. 2016 Jul 11;7:12161. doi: 10.1038/ncomms12161.


The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE.

J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9. Review.


Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.

Mol Cell Biol. 2013 Nov;33(21):4140-51. doi: 10.1128/MCB.00410-13. Epub 2013 Aug 26.


Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.

Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.

J Immunol. 2013 Apr 15;190(8):3849-53. doi: 10.4049/jimmunol.1202760. Epub 2013 Mar 13.


Resolving multi-molecular protein interactions by photoactivated localization microscopy.

Sherman E, Barr VA, Samelson LE.

Methods. 2013 Mar;59(3):261-9. doi: 10.1016/j.ymeth.2012.12.002. Epub 2012 Dec 22.


Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE.

J Immunol. 2012 Aug 1;189(3):1154-61. doi: 10.4049/jimmunol.1200123. Epub 2012 Jun 25.


15 kDa granulysin causes differentiation of monocytes to dendritic cells but lacks cytotoxic activity.

Clayberger C, Finn MW, Wang T, Saini R, Wilson C, Barr VA, Sabatino M, Castiello L, Stroncek D, Krensky AM.

J Immunol. 2012 Jun 15;188(12):6119-26. doi: 10.4049/jimmunol.1200570. Epub 2012 May 14.


Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.

Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2885-90. doi: 10.1073/pnas.1007098108. Epub 2011 Jan 31.


Imaging techniques for assaying lymphocyte activation in action.

Balagopalan L, Sherman E, Barr VA, Samelson LE.

Nat Rev Immunol. 2011 Jan;11(1):21-33. doi: 10.1038/nri2903. Review.


Interference reflection microscopy.

Barr VA, Bunnell SC.

Curr Protoc Cell Biol. 2009 Dec;Chapter 4:Unit 4.23. doi: 10.1002/0471143030.cb0423s45.


Endocytic events in TCR signaling: focus on adapters in microclusters.

Balagopalan L, Barr VA, Samelson LE.

Immunol Rev. 2009 Nov;232(1):84-98. doi: 10.1111/j.1600-065X.2009.00840.x. Review.


Formation of STIM and Orai complexes: puncta and distal caps.

Barr VA, Bernot KM, Shaffer MH, Burkhardt JK, Samelson LE.

Immunol Rev. 2009 Sep;231(1):148-59. doi: 10.1111/j.1600-065X.2009.00812.x. Review.


Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge.

Kriebel PW, Barr VA, Rericha EC, Zhang G, Parent CA.

J Cell Biol. 2008 Dec 1;183(5):949-61. doi: 10.1083/jcb.200808105.


Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.

Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.

Mol Biol Cell. 2008 Jul;19(7):2802-17. doi: 10.1091/mbc.E08-02-0146. Epub 2008 Apr 30.


Bam32: a novel mediator of Erk activation in T cells.

Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.

Int Immunol. 2008 Jul;20(7):811-8. doi: 10.1093/intimm/dxn039. Epub 2008 Apr 29.


c-Cbl-mediated regulation of LAT-nucleated signaling complexes.

Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.

Mol Cell Biol. 2007 Dec;27(24):8622-36. Epub 2007 Oct 15.


Src-dependent phosphorylation of ASAP1 regulates podosomes.

Bharti S, Inoue H, Bharti K, Hirsch DS, Nie Z, Yoon HY, Artym V, Yamada KM, Mueller SC, Barr VA, Randazzo PA.

Mol Cell Biol. 2007 Dec;27(23):8271-83. Epub 2007 Sep 24.


Persistence of cooperatively stabilized signaling clusters drives T-cell activation.

Bunnell SC, Singer AL, Hong DI, Jacque BH, Jordan MS, Seminario MC, Barr VA, Koretzky GA, Samelson LE.

Mol Cell Biol. 2006 Oct;26(19):7155-66.


T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway.

Barr VA, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell SC, Bernot KM, Toda Y, Nossal R, Samelson LE.

Traffic. 2006 Sep;7(9):1143-62.


Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, Samelson LE.

Nat Immunol. 2005 Jan;6(1):80-9. Epub 2004 Nov 21.


Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth.

Aerbajinai W, Lee YT, Wojda U, Barr VA, Miller JL.

J Biol Chem. 2004 Jan 16;279(3):1916-21. Epub 2003 Oct 30.


High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates.

Bunnell SC, Barr VA, Fuller CL, Samelson LE.

Sci STKE. 2003 Apr 8;2003(177):PL8.


Adenylyl cyclase localization regulates streaming during chemotaxis.

Kriebel PW, Barr VA, Parent CA.

Cell. 2003 Feb 21;112(4):549-60.


T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.

Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE.

J Cell Biol. 2002 Sep 30;158(7):1263-75.


Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

Montagnani M, Chen H, Barr VA, Quon MJ.

J Biol Chem. 2001 Aug 10;276(32):30392-8. Epub 2001 Jun 11.


Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking.

Barr VA, Phillips SA, Taylor SI, Haft CR.

Traffic. 2000 Nov;1(11):904-16.


Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain.

Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF.

J Biol Chem. 2001 Mar 30;276(13):10284-9. Epub 2001 Jan 4.


Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.

Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI.

Mol Biol Cell. 2000 Dec;11(12):4105-16.


Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking.

Phillips SA, Barr VA, Haft DH, Taylor SI, Haft CR.

J Biol Chem. 2001 Feb 16;276(7):5074-84. Epub 2000 Nov 20.


Subcellular localization and internalization of the four human leptin receptor isoforms.

Barr VA, Lane K, Taylor SI.

J Biol Chem. 1999 Jul 23;274(30):21416-24.


Identification of a family of sorting nexin molecules and characterization of their association with receptors.

Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI.

Mol Cell Biol. 1998 Dec;18(12):7278-87.


Insulin stimulates both leptin secretion and production by rat white adipose tissue.

Barr VA, Malide D, Zarnowski MJ, Taylor SI, Cushman SW.

Endocrinology. 1997 Oct;138(10):4463-72.


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