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Items: 1 to 50 of 59

1.

Tula orthohantavirus nucleocapsid protein is cleaved in infected cells and may sequester activated caspase-3 during persistent infection to suppress apoptosis.

Davies K, Afrough B, Mankouri J, Hewson R, Edwards TA, Barr JN.

J Gen Virol. 2019 Aug;100(8):1208-1221. doi: 10.1099/jgv.0.001291. Epub 2019 Jul 3.

2.

Rescue of Infectious Recombinant Hazara Nairovirus from cDNA Reveals the Nucleocapsid Protein DQVD Caspase Cleavage Motif Performs an Essential Role other than Cleavage.

Fuller J, Surtees RA, Slack GS, Mankouri J, Hewson R, Barr JN.

J Virol. 2019 Jul 17;93(15). pii: e00616-19. doi: 10.1128/JVI.00616-19. Print 2019 Aug 1.

PMID:
31118258
3.

Reply to Rameix-Welti, "No Incongruity in Respiratory Syncytial Virus M2-1 Protein Remaining Bound to Viral mRNAs during Their Entire Life Time".

Edwards TA, Barr JN.

MBio. 2019 May 7;10(3). pii: e00629-19. doi: 10.1128/mBio.00629-19. No abstract available.

4.

Cellular cholesterol abundance regulates potassium accumulation within endosomes and is an important determinant in bunyavirus entry.

Charlton FW, Hover S, Fuller J, Hewson R, Fontana J, Barr JN, Mankouri J.

J Biol Chem. 2019 May 3;294(18):7335-7347. doi: 10.1074/jbc.RA119.007618. Epub 2019 Feb 25.

5.

Correction: Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus.

Punch EK, Hover S, Blest HTW, Fuller J, Hewson R, Fontana J, Mankouri J, Barr JN.

J Biol Chem. 2019 Feb 15;294(7):2579. doi: 10.1074/jbc.AAC119.007718. No abstract available.

6.

Hazara nairovirus elicits differential induction of apoptosis and nucleocapsid protein cleavage in mammalian and tick cells.

Fuller J, Surtees RA, Shaw AB, Álvarez-Rodríguez B, Slack GS, Bell-Sakyi L, Mankouri J, Edwards TA, Hewson R, Barr JN.

J Gen Virol. 2019 Mar;100(3):392-402. doi: 10.1099/jgv.0.001211. Epub 2019 Feb 5.

7.

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.

Selvaraj M, Yegambaram K, Todd EJAA, Richard CA, Dods RL, Pangratiou GM, Trinh CH, Moul SL, Murphy JC, Mankouri J, Éléouët JF, Barr JN, Edwards TA.

MBio. 2018 Nov 13;9(6). pii: e01554-18. doi: 10.1128/mBio.01554-18.

8.

Structure and Function of the Human Respiratory Syncytial Virus M2-1 Protein.

Muniyandi S, Pangratiou G, Edwards TA, Barr JN.

Subcell Biochem. 2018;88:245-260. doi: 10.1007/978-981-10-8456-0_11. Review.

9.

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening.

Easton V, McPhillie M, Garcia-Dorival I, Barr JN, Edwards TA, Foster R, Fishwick C, Harris M.

Antiviral Res. 2018 Aug;156:46-54. doi: 10.1016/j.antiviral.2018.06.003. Epub 2018 Jun 2.

10.

Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus.

Punch EK, Hover S, Blest HTW, Fuller J, Hewson R, Fontana J, Mankouri J, Barr JN.

J Biol Chem. 2018 Jun 29;293(26):9937-9944. doi: 10.1074/jbc.RA118.002494. Epub 2018 Apr 20. Erratum in: J Biol Chem. 2019 Feb 15;294(7):2579.

11.

Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection.

Hover S, Foster B, Fontana J, Kohl A, Goldstein SAN, Barr JN, Mankouri J.

PLoS Pathog. 2018 Jan 19;14(1):e1006845. doi: 10.1371/journal.ppat.1006845. eCollection 2018 Jan.

12.

Viral dependence on cellular ion channels - an emerging anti-viral target?

Hover S, Foster B, Barr JN, Mankouri J.

J Gen Virol. 2017 Mar;98(3):345-351. doi: 10.1099/jgv.0.000712. Epub 2017 Apr 1. Review.

13.

Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets.

García-Dorival I, Wu W, Armstrong SD, Barr JN, Carroll MW, Hewson R, Hiscox JA.

J Proteome Res. 2016 Dec 2;15(12):4290-4303. Epub 2016 Nov 22.

14.

Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle.

Surtees R, Dowall SD, Shaw A, Armstrong S, Hewson R, Carroll MW, Mankouri J, Edwards TA, Hiscox JA, Barr JN.

J Virol. 2016 Sep 29;90(20):9305-16. doi: 10.1128/JVI.00661-16. Print 2016 Oct 15.

15.

The crystal structure of the Hazara virus nucleocapsid protein.

Surtees R, Ariza A, Punch EK, Trinh CH, Dowall SD, Hewson R, Hiscox JA, Barr JN, Edwards TA.

BMC Struct Biol. 2015 Dec 29;15:24. doi: 10.1186/s12900-015-0051-3.

16.

Modulation of Potassium Channels Inhibits Bunyavirus Infection.

Hover S, King B, Hall B, Loundras EA, Taqi H, Daly J, Dallas M, Peers C, Schnettler E, McKimmie C, Kohl A, Barr JN, Mankouri J.

J Biol Chem. 2016 Feb 12;291(7):3411-22. doi: 10.1074/jbc.M115.692673. Epub 2015 Dec 16.

17.

Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach.

Aljabr W, Touzelet O, Pollakis G, Wu W, Munday DC, Hughes M, Hertz-Fowler C, Kenny J, Fearns R, Barr JN, Matthews DA, Hiscox JA.

J Virol. 2016 Apr 29;90(10):4876-4888. doi: 10.1128/JVI.02349-15. Print 2016 May 15.

18.

In memoriam--Richard M. Elliott (1954-2015).

Brennan B, Weber F, Kormelink R, Schnettler E, Bouloy M, Failloux AB, Weaver SC, Fazakerley JK, Fragkoudis R, Harris M, Barr JN, Palese P, García-Sastre A, Dalziel RG, Dutia BM, Lowen AC, Steel J, Randall RE, Paul Duprex W, Rice CM, Tesh RB, Murphy FA, Ebihara H, Vasconcelos PF, Nunes MR, Fooks AR, Smith GL, Goodfellow I, Pappu HR, Lamb RA, Paterson RG, Higgs S, Vanlandingham DL, Dietzgen RG, Stephen Lodmell J, Nichol ST, Daly J, Ullman DE, Plyusnin A, Plyusnina A, Efstathiou S, Hewson R, Tordo N, Cherry S, Boutell C, Hosie MJ, Murcia PR, Neil JC, Palmarini M, Patel AH, Willett BJ, Kohl A, McLauchlan J.

J Gen Virol. 2015 Aug;96(8):1975-8. doi: 10.1099/jgv.0.000241. No abstract available.

19.

Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology.

Munday DC, Howell G, Barr JN, Hiscox JA.

J Pharm Pharmacol. 2015 Mar;67(3):300-18. doi: 10.1111/jphp.12349. Epub 2014 Dec 23.

PMID:
25533920
20.

Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity.

Dowall SD, Matthews DA, Garcia-Dorival I, Taylor I, Kenny J, Hertz-Fowler C, Hall N, Corbin-Lickfett K, Empig C, Schlunegger K, Barr JN, Carroll MW, Hewson R, Hiscox JA.

Genome Biol. 2014;15(11):540.

21.

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis.

Munday DC, Wu W, Smith N, Fix J, Noton SL, Galloux M, Touzelet O, Armstrong SD, Dawson JM, Aljabr W, Easton AJ, Rameix-Welti MA, de Oliveira AP, Simabuco FM, Ventura AM, Hughes DJ, Barr JN, Fearns R, Digard P, Eléouët JF, Hiscox JA.

J Virol. 2015 Jan 15;89(2):917-30. doi: 10.1128/JVI.01783-14. Epub 2014 Oct 29.

22.

Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function.

García-Dorival I, Wu W, Dowall S, Armstrong S, Touzelet O, Wastling J, Barr JN, Matthews D, Carroll M, Hewson R, Hiscox JA.

J Proteome Res. 2014 Nov 7;13(11):5120-35. doi: 10.1021/pr500556d. Epub 2014 Oct 23.

23.

Probing bunyavirus N protein oligomerisation using mass spectrometry.

Shepherd DA, Ariza A, Edwards TA, Barr JN, Stonehouse NJ, Ashcroft AE.

Rapid Commun Mass Spectrom. 2014 Apr 15;28(7):793-800. doi: 10.1002/rcm.6841.

24.

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation.

Tanner SJ, Ariza A, Richard CA, Kyle HF, Dods RL, Blondot ML, Wu W, Trincão J, Trinh CH, Hiscox JA, Carroll MW, Silman NJ, Eléouët JF, Edwards TA, Barr JN.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1580-5. doi: 10.1073/pnas.1317262111. Epub 2014 Jan 13.

25.

The asymmetric structure of an icosahedral virus bound to its receptor suggests a mechanism for genome release.

Dent KC, Thompson R, Barker AM, Hiscox JA, Barr JN, Stockley PG, Ranson NA.

Structure. 2013 Jul 2;21(7):1225-34.

26.

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.

Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA.

Nucleic Acids Res. 2013 Jun;41(11):5912-26. doi: 10.1093/nar/gkt268. Epub 2013 Apr 17.

27.

Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein.

Carter SD, Surtees R, Walter CT, Ariza A, Bergeron É, Nichol ST, Hiscox JA, Edwards TA, Barr JN.

J Virol. 2012 Oct;86(20):10914-23. Epub 2012 Aug 8.

28.

Expression, purification and crystallization of the Crimean-Congo haemorrhagic fever virus nucleocapsid protein.

Carter SD, Barr JN, Edwards TA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 May 1;68(Pt 5):569-73. doi: 10.1107/S1744309112009736. Epub 2012 Apr 21.

29.

The interactome of the human respiratory syncytial virus NS1 protein highlights multiple effects on host cell biology.

Wu W, Tran KC, Teng MN, Heesom KJ, Matthews DA, Barr JN, Hiscox JA.

J Virol. 2012 Aug;86(15):7777-89. doi: 10.1128/JVI.00460-12. Epub 2012 May 16.

30.

A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture.

Dove BK, Surtees R, Bean TJ, Munday D, Wise HM, Digard P, Carroll MW, Ajuh P, Barr JN, Hiscox JA.

Proteomics. 2012 May;12(9):1431-6. doi: 10.1002/pmic.201100470. Epub 2012 May 14.

PMID:
22585751
31.

Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes.

Munday DC, Surtees R, Emmott E, Dove BK, Digard P, Barr JN, Whitehouse A, Matthews D, Hiscox JA.

Proteomics. 2012 Feb;12(4-5):666-72. doi: 10.1002/pmic.201100488. Epub 2012 Jan 19. Review.

PMID:
22246955
32.

Different NF-κB activation characteristics of human respiratory syncytial virus subgroups A and B.

Wu W, Macdonald A, Hiscox JA, Barr JN.

Microb Pathog. 2012 Mar;52(3):184-91. doi: 10.1016/j.micpath.2011.12.006. Epub 2011 Dec 28.

PMID:
22212641
33.

Recent advances in the molecular and cellular biology of bunyaviruses.

Walter CT, Barr JN.

J Gen Virol. 2011 Nov;92(Pt 11):2467-84. doi: 10.1099/vir.0.035105-0. Epub 2011 Aug 24. Review.

PMID:
21865443
34.

Characterization of the interaction between human respiratory syncytial virus and the cell cycle in continuous cell culture and primary human airway epithelial cells.

Wu W, Munday DC, Howell G, Platt G, Barr JN, Hiscox JA.

J Virol. 2011 Oct;85(19):10300-9. doi: 10.1128/JVI.05164-11. Epub 2011 Jul 27.

35.

Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS.

Munday DC, Hiscox JA, Barr JN.

Proteomics. 2010 Dec;10(23):4320-34. doi: 10.1002/pmic.201000228.

PMID:
21110324
36.
37.

Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus.

Munday DC, Emmott E, Surtees R, Lardeau CH, Wu W, Duprex WP, Dove BK, Barr JN, Hiscox JA.

Mol Cell Proteomics. 2010 Nov;9(11):2438-59. doi: 10.1074/mcp.M110.001859. Epub 2010 Jul 20.

38.

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability.

Carter SD, Dent KC, Atkins E, Foster TL, Verow M, Gorny P, Harris M, Hiscox JA, Ranson NA, Griffin S, Barr JN.

FEBS Lett. 2010 Jul 2;584(13):2786-90. doi: 10.1016/j.febslet.2010.05.006. Epub 2010 May 20.

39.

Bunyamwera virus can repair both insertions and deletions during RNA replication.

Walter CT, Barr JN.

RNA. 2010 Jun;16(6):1138-45. doi: 10.1261/rna.1962010. Epub 2010 Apr 29.

40.

How RNA viruses maintain their genome integrity.

Barr JN, Fearns R.

J Gen Virol. 2010 Jun;91(Pt 6):1373-87. doi: 10.1099/vir.0.020818-0. Epub 2010 Mar 24. Review.

PMID:
20335491
41.

Investigating the specificity and stoichiometry of RNA binding by the nucleocapsid protein of Bunyamwera virus.

Mohl BP, Barr JN.

RNA. 2009 Mar;15(3):391-9. doi: 10.1261/rna.1367209. Epub 2009 Jan 23.

42.

Selection for gene junction sequences important for VSV transcription.

Hinzman EE, Barr JN, Wertz GW.

Virology. 2008 Oct 25;380(2):379-87. doi: 10.1016/j.virol.2008.08.001. Epub 2008 Sep 9.

43.
44.
45.

Purification, crystallization and preliminary X-ray crystallographic analysis of the nucleocapsid protein of Bunyamwera virus.

Rodgers JW, Zhou Q, Green TJ, Barr JN, Luo M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):361-4. Epub 2006 Mar 10.

46.

Identification of the Bunyamwera bunyavirus transcription termination signal.

Barr JN, Rodgers JW, Wertz GW.

J Gen Virol. 2006 Jan;87(Pt 1):189-98.

PMID:
16361431
49.

Transcription and replication of nonsegmented negative-strand RNA viruses.

Whelan SP, Barr JN, Wertz GW.

Curr Top Microbiol Immunol. 2004;283:61-119. Review.

PMID:
15298168
50.

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