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Items: 1 to 50 of 101

1.

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling.

Alfonso-Pérez T, Hayward D, Holder J, Gruneberg U, Barr FA.

J Cell Biol. 2019 Jan 23. pii: jcb.201808015. doi: 10.1083/jcb.201808015. [Epub ahead of print]

PMID:
30674583
2.

CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization.

Hayward D, Alfonso-Pérez T, Cundell MJ, Hopkins M, Holder J, Bancroft J, Hutter LH, Novak B, Barr FA, Gruneberg U.

J Cell Biol. 2019 Jan 23. pii: jcb.201808014. doi: 10.1083/jcb.201808014. [Epub ahead of print]

PMID:
30674582
3.

Membrane Traffic: Trans-Golgi Tethers Leave a Surprisingly Small GAP.

Barr FA.

Curr Biol. 2017 Nov 20;27(22):R1222-R1225. doi: 10.1016/j.cub.2017.10.003.

4.

Homozygous Mutations in TBC1D23 Lead to a Non-degenerative Form of Pontocerebellar Hypoplasia.

Marin-Valencia I, Gerondopoulos A, Zaki MS, Ben-Omran T, Almureikhi M, Demir E, Guemez-Gamboa A, Gregor A, Issa MY, Appelhof B, Roosing S, Musaev D, Rosti B, Wirth S, Stanley V, Baas F, Barr FA, Gleeson JG.

Am J Hum Genet. 2017 Sep 7;101(3):441-450. doi: 10.1016/j.ajhg.2017.07.015. Epub 2017 Aug 17.

5.

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.

Cundell MJ, Hutter LH, Nunes Bastos R, Poser E, Holder J, Mohammed S, Novak B, Barr FA.

J Cell Biol. 2016 Aug 29;214(5):539-54. doi: 10.1083/jcb.201606033. Epub 2016 Aug 22.

6.

TD-60 links RalA GTPase function to the CPC in mitosis.

Papini D, Langemeyer L, Abad MA, Kerr A, Samejima I, Eyers PA, Jeyaprakash AA, Higgins JM, Barr FA, Earnshaw WC.

Nat Commun. 2015 Jul 9;6:7678. doi: 10.1038/ncomms8678.

7.

GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.

Egerer J, Emmerich D, Fischer-Zirnsak B, Chan WL, Meierhofer D, Tuysuz B, Marschner K, Sauer S, Barr FA, Mundlos S, Kornak U.

J Invest Dermatol. 2015 Oct;135(10):2368-2376. doi: 10.1038/jid.2015.192. Epub 2015 May 22.

8.

KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle.

Bastos RN, Cundell MJ, Barr FA.

J Cell Biol. 2014 Dec 22;207(6):683-93. doi: 10.1083/jcb.201409129. Epub 2014 Dec 15.

9.

Rab18 and a Rab18 GEF complex are required for normal ER structure.

Gerondopoulos A, Bastos RN, Yoshimura S, Anderson R, Carpanini S, Aligianis I, Handley MT, Barr FA.

J Cell Biol. 2014 Jun 9;205(5):707-20. doi: 10.1083/jcb.201403026. Epub 2014 Jun 2.

10.

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation.

Langemeyer L, Nunes Bastos R, Cai Y, Itzen A, Reinisch KM, Barr FA.

Elife. 2014 Feb 11;3:e01623. doi: 10.7554/eLife.01623.

11.

Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.

Liegel RP, Handley MT, Ronchetti A, Brown S, Langemeyer L, Linford A, Chang B, Morris-Rosendahl DJ, Carpanini S, Posmyk R, Harthill V, Sheridan E, Abdel-Salam GM, Terhal PA, Faravelli F, Accorsi P, Giordano L, Pinelli L, Hartmann B, Ebert AD, Barr FA, Aligianis IA, Sidjanin DJ.

Am J Hum Genet. 2013 Dec 5;93(6):1001-14. doi: 10.1016/j.ajhg.2013.10.011. Epub 2013 Nov 14.

12.

The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation.

Cundell MJ, Bastos RN, Zhang T, Holder J, Gruneberg U, Novak B, Barr FA.

Mol Cell. 2013 Nov 7;52(3):393-405. doi: 10.1016/j.molcel.2013.09.005. Epub 2013 Oct 10.

13.

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.

Nunes Bastos R, Gandhi SR, Baron RD, Gruneberg U, Nigg EA, Barr FA.

J Cell Biol. 2013 Aug 19;202(4):605-21. doi: 10.1083/jcb.201301094. Epub 2013 Aug 12.

14.

Review series: Rab GTPases and membrane identity: causal or inconsequential?

Barr FA.

J Cell Biol. 2013 Jul 22;202(2):191-9. doi: 10.1083/jcb.201306010. Review.

15.

Cell organelles.

Voeltz GK, Barr FA.

Curr Opin Cell Biol. 2013 Aug;25(4):403-5. doi: 10.1016/j.ceb.2013.06.001. Epub 2013 Jun 26. No abstract available.

PMID:
23810187
16.

Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.

Hammond D, Zeng K, Espert A, Bastos RN, Baron RD, Gruneberg U, Barr FA.

J Cell Sci. 2013 Aug 1;126(Pt 15):3429-40. doi: 10.1242/jcs.128397. Epub 2013 May 31.

17.

Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II.

Levine TP, Daniels RD, Wong LH, Gatta AT, Gerondopoulos A, Barr FA.

Small GTPases. 2013 Apr-Jun;4(2):62-9. doi: 10.4161/sgtp.24262. Epub 2013 Mar 19. Review.

18.

Analysis of rab GTPases.

Langemeyer L, Barr FA.

Curr Protoc Cell Biol. 2012 Dec;Chapter 15:Unit 15.18. doi: 10.1002/0471143030.cb1518s57.

PMID:
23208545
19.

BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.

Gerondopoulos A, Langemeyer L, Liang JR, Linford A, Barr FA.

Curr Biol. 2012 Nov 20;22(22):2135-9. doi: 10.1016/j.cub.2012.09.020. Epub 2012 Oct 18.

20.

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.

Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, Blundell TL.

Open Biol. 2012 Aug;2(8):120071. doi: 10.1098/rsob.120071.

21.

Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.

Dunsch AK, Hammond D, Lloyd J, Schermelleh L, Gruneberg U, Barr FA.

J Cell Biol. 2012 Sep 17;198(6):1039-54. doi: 10.1083/jcb.201202112. Epub 2012 Sep 10.

22.

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis.

Bastos RN, Penate X, Bates M, Hammond D, Barr FA.

J Cell Biol. 2012 Sep 3;198(5):865-80. doi: 10.1083/jcb.201204107.

23.

RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.

Nottingham RM, Pusapati GV, Ganley IG, Barr FA, Lambright DG, Pfeffer SR.

J Biol Chem. 2012 Jun 29;287(27):22740-8. doi: 10.1074/jbc.M112.362558. Epub 2012 May 25.

24.

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.

Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA.

J Cell Biol. 2012 May 28;197(5):659-75. doi: 10.1083/jcb.201111079. Epub 2012 May 21.

25.

Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells.

Linford A, Yoshimura S, Nunes Bastos R, Langemeyer L, Gerondopoulos A, Rigden DJ, Barr FA.

Dev Cell. 2012 May 15;22(5):952-66. doi: 10.1016/j.devcel.2012.04.010.

26.

The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles.

Lachmann J, Barr FA, Ungermann C.

Mol Biol Cell. 2012 Jul;23(13):2516-26. doi: 10.1091/mbc.E11-12-1030. Epub 2012 May 16.

27.

Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.

Wu X, Bradley MJ, Cai Y, Kümmel D, De La Cruz EM, Barr FA, Reinisch KM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18672-7. doi: 10.1073/pnas.1110415108. Epub 2011 Nov 7.

28.

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.

Nottingham RM, Ganley IG, Barr FA, Lambright DG, Pfeffer SR.

J Biol Chem. 2011 Sep 23;286(38):33213-22. doi: 10.1074/jbc.M111.261115. Epub 2011 Aug 1.

29.

Protein phosphatases and the regulation of mitosis.

Barr FA, Elliott PR, Gruneberg U.

J Cell Sci. 2011 Jul 15;124(Pt 14):2323-34. doi: 10.1242/jcs.087106.

30.

Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment.

Zenner HL, Yoshimura S, Barr FA, Crump CM.

J Virol. 2011 Aug;85(16):8012-21. doi: 10.1128/JVI.00500-11. Epub 2011 Jun 15.

31.

Loss-of-function mutations in RAB18 cause Warburg micro syndrome.

Bem D, Yoshimura S, Nunes-Bastos R, Bond FC, Kurian MA, Rahman F, Handley MT, Hadzhiev Y, Masood I, Straatman-Iwanowska AA, Cullinane AR, McNeill A, Pasha SS, Kirby GA, Foster K, Ahmed Z, Morton JE, Williams D, Graham JM, Dobyns WB, Burglen L, Ainsworth JR, Gissen P, Müller F, Maher ER, Barr FA, Aligianis IA.

Am J Hum Genet. 2011 Apr 8;88(4):499-507. doi: 10.1016/j.ajhg.2011.03.012. Erratum in: Am J Hum Genet. 2011 May 13;88(5):678. Bond, Frances F [corrected to Bond, Frances C].

32.

The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment.

Dunsch AK, Linnane E, Barr FA, Gruneberg U.

J Cell Biol. 2011 Mar 21;192(6):959-68. doi: 10.1083/jcb.201008023. Epub 2011 Mar 14.

33.

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

Zeng K, Bastos RN, Barr FA, Gruneberg U.

J Cell Biol. 2010 Dec 27;191(7):1315-32. doi: 10.1083/jcb.201008106.

34.

Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission.

Bastos RN, Barr FA.

J Cell Biol. 2010 Nov 15;191(4):751-60. doi: 10.1083/jcb.201008108.

35.

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA.

J Cell Biol. 2010 Oct 18;191(2):367-81. doi: 10.1083/jcb.201008051. Epub 2010 Oct 11.

36.

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Grønborg M, Möbius W, Rhee J, Barr FA, Simons M.

J Cell Biol. 2010 Apr 19;189(2):223-32. doi: 10.1083/jcb.200911018.

37.

Rab GTPase function in Golgi trafficking.

Barr FA.

Semin Cell Dev Biol. 2009 Sep;20(7):780-3. doi: 10.1016/j.semcdb.2009.03.007. Review.

PMID:
19508857
38.

Membrane traffic: Golgi stumbles over cilia.

Barr FA.

Curr Biol. 2009 Mar 24;19(6):R253-5. doi: 10.1016/j.cub.2009.01.049.

39.

Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin.

Hennies HC, Kornak U, Zhang H, Egerer J, Zhang X, Seifert W, Kühnisch J, Budde B, Nätebus M, Brancati F, Wilcox WR, Müller D, Kaplan PB, Rajab A, Zampino G, Fodale V, Dallapiccola B, Newman W, Metcalfe K, Clayton-Smith J, Tassabehji M, Steinmann B, Barr FA, Nürnberg P, Wieacker P, Mundlos S.

Nat Genet. 2008 Dec;40(12):1410-2. doi: 10.1038/ng.252. Epub 2008 Nov 9.

40.

Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.

Hayes GL, Brown FC, Haas AK, Nottingham RM, Barr FA, Pfeffer SR.

Mol Biol Cell. 2009 Jan;20(1):209-17. doi: 10.1091/mbc.E08-07-0740. Epub 2008 Oct 22.

41.

Analysis of Rab GTPase and GTPase-activating protein function at primary cilia.

Yoshimura S, Haas AK, Barr FA.

Methods Enzymol. 2008;439:353-64. doi: 10.1016/S0076-6879(07)00426-0.

PMID:
18374177
42.

Cilia--the masterplan.

Barr FA.

J Cell Sci. 2008 Jan 1;121(Pt 1):5-6. No abstract available.

43.

Cytokinesis: placing and making the final cut.

Barr FA, Gruneberg U.

Cell. 2007 Nov 30;131(5):847-60. Review.

44.

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells.

Haas AK, Yoshimura S, Stephens DJ, Preisinger C, Fuchs E, Barr FA.

J Cell Sci. 2007 Sep 1;120(Pt 17):2997-3010. Epub 2007 Aug 7.

45.

Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.

Santamaria A, Neef R, Eberspächer U, Eis K, Husemann M, Mumberg D, Prechtl S, Schulze V, Siemeister G, Wortmann L, Barr FA, Nigg EA.

Mol Biol Cell. 2007 Oct;18(10):4024-36. Epub 2007 Aug 1.

46.

Functional dissection of Rab GTPases involved in primary cilium formation.

Yoshimura S, Egerer J, Fuchs E, Haas AK, Barr FA.

J Cell Biol. 2007 Jul 30;178(3):363-9. Epub 2007 Jul 23.

47.

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.

Fuchs E, Haas AK, Spooner RA, Yoshimura S, Lord JM, Barr FA.

J Cell Biol. 2007 Jun 18;177(6):1133-43. Epub 2007 Jun 11.

48.

Inheritance and biogenesis of organelles in the secretory pathway.

Lowe M, Barr FA.

Nat Rev Mol Cell Biol. 2007 Jun;8(6):429-39. Review.

PMID:
17505521
49.

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1.

Neef R, Gruneberg U, Kopajtich R, Li X, Nigg EA, Sillje H, Barr FA.

Nat Cell Biol. 2007 Apr;9(4):436-44. Epub 2007 Mar 11.

PMID:
17351640
50.

COP sets TRAPP for vesicles.

Haas AK, Barr FA.

Dev Cell. 2007 Mar;12(3):326-7.

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