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High Activation of γδ T Cells and the γδ2pos T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK.

Pean P, Nouhin J, Ratana M, Madec Y, Borand L, Marcy O, Laureillard D, Fernandez M, Barré-Sinoussi F, Weiss L, Scott-Algara D.

Front Immunol. 2019 Aug 27;10:2018. doi: 10.3389/fimmu.2019.02018. eCollection 2019.


Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae.

Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Lefebvre C, Hocini H, Benjelloun F, Cannou C, Nozza S, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, Menu E.

Front Immunol. 2019 Mar 12;10:430. doi: 10.3389/fimmu.2019.00430. eCollection 2019.


Safety of CD34+ Hematopoietic Stem Cells and CD4+ T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma.

Delville M, Touzot F, Couzin C, Hmitou I, Djerroudi L, Ouedrani A, Lefrère F, Tuchman-Durand C, Mollet C, Fabreguettes JR, Ferry N, Laganier L, Magnani A, Magrin E, Jolaine V, Saez-Cirion A, Wolstein O, Symonds G, Frange P, Moins-Teisserenc H, Chaix-Baudier ML, Toubert A, Larghero J, Parquet N, Brignier AC, Barré-Sinoussi F, Oksenhendler E, Cavazzana M.

Mol Ther Methods Clin Dev. 2019 Feb 26;13:303-309. doi: 10.1016/j.omtm.2019.02.006. eCollection 2019 Jun 14.


[HIV/Aids: the exemplary history of an epidemic which resists].

Barré-Sinoussi F.

Med Sci (Paris). 2018 Jun-Jul;34(6-7):499-500. doi: 10.1051/medsci/20183406001. Epub 2018 Jul 31. French. No abstract available.


Expert consensus statement on the science of HIV in the context of criminal law.

Barré-Sinoussi F, Abdool Karim SS, Albert J, Bekker LG, Beyrer C, Cahn P, Calmy A, Grinsztejn B, Grulich A, Kamarulzaman A, Kumarasamy N, Loutfy MR, El Filali KM, Mboup S, Montaner JS, Munderi P, Pokrovsky V, Vandamme AM, Young B, Godfrey-Faussett P.

J Int AIDS Soc. 2018 Jul;21(7):e25161. doi: 10.1002/jia2.25161.


p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity.

Valle-Casuso JC, Allouch A, David A, Lenzi GM, Studdard L, Barré-Sinoussi F, Müller-Trutwin M, Kim B, Pancino G, Sáez-Cirión A.

J Virol. 2017 Nov 14;91(23). pii: e01324-17. doi: 10.1128/JVI.01324-17. Print 2017 Dec 1.


Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry.

Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Hocini H, Benjelloun F, Cannou C, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, Menu E.

J Immunol. 2017 Sep 1;199(5):1923-1932. doi: 10.4049/jimmunol.1700320. Epub 2017 Jul 31.


Animal models are essential to biological research: issues and perspectives.

Barré-Sinoussi F, Montagutelli X.

Future Sci OA. 2015 Nov 1;1(4):FSO63. doi: 10.4155/fso.15.63. eCollection 2015 Nov. No abstract available.


CD4 T-Cell Responses in Primary HIV Infection: Interrelationship with Immune Activation and Virus Burden.

Chevalier MF, Didier C, Girard PM, Manea ME, Campa P, Barré-Sinoussi F, Scott-Algara D, Weiss L.

Front Immunol. 2016 Sep 29;7:395. eCollection 2016.


Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset.

Ploquin MJ, Madec Y, Casrouge A, Huot N, Passaes C, Lécuroux C, Essat A, Boufassa F, Jacquelin B, Jochems SP, Petitjean G, Angin M, Gärtner K, Garcia-Tellez T, Noël N, Booiman T, Boeser-Nunnink BD, Roques P, Saez-Cirion A, Vaslin B, Dereudre-Bosquet N, Barré-Sinoussi F, Ghislain M, Rouzioux C, Lambotte O, Albert ML, Goujard C, Kootstra N, Meyer L, Müller-Trutwin MC.

PLoS Pathog. 2016 Aug 10;12(8):e1005774. doi: 10.1371/journal.ppat.1005774. eCollection 2016 Aug.


Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles.

Hamimi C, David A, Versmisse P, Weiss L, Bruel T, Zucman D, Appay V, Moris A, Ungeheuer MN, Lascoux-Combe C, Barré-Sinoussi F, Muller-Trutwin M, Boufassa F, Lambotte O, Pancino G, Sáez-Cirión A; ANRS CO21 CODEX cohort.

PLoS One. 2016 Aug 9;11(8):e0160251. doi: 10.1371/journal.pone.0160251. eCollection 2016.


International AIDS Society global scientific strategy: towards an HIV cure 2016.

Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F; International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J.

Nat Med. 2016 Aug;22(8):839-50. doi: 10.1038/nm.4108. Epub 2016 Jul 11.


NK cells control HIV-1 infection of macrophages through soluble factors and cellular contacts in the human decidua.

Quillay H, El Costa H, Duriez M, Marlin R, Cannou C, Madec Y, de Truchis C, Rahmati M, Barré-Sinoussi F, Nugeyre MT, Menu E.

Retrovirology. 2016 Jun 6;13(1):39. doi: 10.1186/s12977-016-0271-z.


Cities central to HIV response for people who use drugs.

Tinasti K, Audoin B, Jomier B, Delfraissy JF, Lévy Y, Barré-Sinoussi F.

Lancet HIV. 2016 May;3(5):e197-9. doi: 10.1016/S2352-3018(16)30017-0. Epub 2016 Apr 11. No abstract available.


S100A9 Tetramers, Which are Ligands of CD85j, Increase the Ability of MVAHIV-Primed NK Cells to Control HIV Infection.

Moreno-Nieves UY, Didier C, Lévy Y, Barré-Sinoussi F, Scott-Algara D; ANRS HIV Vaccine Network (AHVN).

Front Immunol. 2015 Sep 23;6:478. doi: 10.3389/fimmu.2015.00478. eCollection 2015.


Is it time to abandon single intervention cure trials?

Ananworanich J, Barré-Sinoussi F.

Lancet HIV. 2015 Oct;2(10):e410-1. doi: 10.1016/S2352-3018(15)00186-1. Epub 2015 Sep 24. No abstract available.


The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication.

El Costa H, Quillay H, Marlin R, Cannou C, Duriez M, Benjelloun F, de Truchis C, Rahmati M, Ighil J, Barré-Sinoussi F, Nugeyre MT, Menu E.

Mucosal Immunol. 2016 May;9(3):634-46. doi: 10.1038/mi.2015.87. Epub 2015 Sep 9.


The Vancouver Consensus: antiretroviral medicines, medical evidence, and political will.

Beyrer C, Birx DL, Bekker LG, Barré-Sinoussi F, Cahn P, Dybul MR, Eholié SP, Kavanagh MM, Katabira ET, Lundgren JD, Mworeko L, Pala M, Puttanakit T, Ryan O, Sidibé M, Montaner JS; Vancouver Consensus Signatories.

Lancet. 2015 Aug 8;386(9993):505-7. doi: 10.1016/S0140-6736(15)61458-1. No abstract available.


Pre-exposure prophylaxis works--it's time to deliver.

Beyrer C, Bekker LG, Pozniak A, Barré-Sinoussi F.

Lancet. 2015 Apr 18;385(9977):1482-4. doi: 10.1016/S0140-6736(15)60724-3. No abstract available.


Plasmacytoid Dendritic Cell Infection and Sensing Capacity during Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infection.

Jochems SP, Jacquelin B, Chauveau L, Huot N, Petitjean G, Lepelley A, Liovat AS, Ploquin MJ, Cartwright EK, Bosinger SE, Silvestri G, Barré-Sinoussi F, Lebon P, Schwartz O, Müller-Trutwin MC.

J Virol. 2015 Jul;89(13):6918-27. doi: 10.1128/JVI.00332-15. Epub 2015 Apr 22.


Research in action: from AIDS to global health to impact. A symposium in recognition of the scientific contributions of Professor Joep Lange.

Boender TS, Barré-Sinoussi F, Cooper D, Goosby E, Hankins C, Heidenrijk M, de Jong M, Kazatchkine M, Laoye F, Merson M, Reiss P, Rinke de Wit TF, Rogo K, Schellekens O, Schultsz C, Sigaloff KC, Simon J, Zewdie D.

Antivir Ther. 2015;20(1):101-8. doi: 10.3851/IMP2946. Epub 2015 Feb 18. No abstract available.


Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.

Zeisel MB, Lucifora J, Mason WS, Sureau C, Beck J, Levrero M, Kann M, Knolle PA, Benkirane M, Durantel D, Michel ML, Autran B, Cosset FL, Strick-Marchand H, Trépo C, Kao JH, Carrat F, Lacombe K, Schinazi RF, Barré-Sinoussi F, Delfraissy JF, Zoulim F.

Gut. 2015 Aug;64(8):1314-26. doi: 10.1136/gutjnl-2014-308943. Epub 2015 Feb 10. Review.


Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses.

Bruel T, Hamimi C, Dereuddre-Bosquet N, Cosma A, Shin SY, Corneau A, Versmisse P, Karlsson I, Malleret B, Targat B, Barré-Sinoussi F, Le Grand R, Pancino G, Sáez-Cirión A, Vaslin B.

J Virol. 2015 Apr;89(7):3542-56. doi: 10.1128/JVI.03723-14. Epub 2015 Jan 14.


Appeal to global donors to save the Treatment Action Campaign.

Piot P, Barré-Sinoussi F, Karim QA, Karim SS, Beyrer C.

Lancet. 2014 Dec 6;384(9959):e62. doi: 10.1016/S0140-6736(14)62045-6. Epub 2014 Dec 2. No abstract available.


Cell-associated mucosal HIV transmission. Preface.

Barre-Sinoussi F.

J Infect Dis. 2014 Dec 15;210 Suppl 3:S605. doi: 10.1093/infdis/jiu545. No abstract available.


Distinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1.

Quillay H, El Costa H, Marlin R, Duriez M, Cannou C, Chrétien F, Fernandez H, Lebreton A, Ighil J, Schwartz O, Barré-Sinoussi F, Nugeyre MT, Menu E.

J Virol. 2015 Jan 15;89(2):1329-39. doi: 10.1128/JVI.01730-14. Epub 2014 Nov 12.


Modulation of type I interferon-associated viral sensing during acute simian immunodeficiency virus infection in African green monkeys.

Jochems SP, Petitjean G, Kunkel D, Liovat AS, Ploquin MJ, Barré-Sinoussi F, Lebon P, Jacquelin B, Müller-Trutwin MC.

J Virol. 2015 Jan;89(1):751-62. doi: 10.1128/JVI.02430-14. Epub 2014 Oct 29.


Q&A: Françoise Barré-Sinoussi. HIV adversary.

Barré-Sinoussi F, Gomez-Touriño I.

Nature. 2014 Oct 16;514(7522):S8-9. doi: 10.1038/514S8a. No abstract available.


Words matter: Discussing research towards an HIV cure in research and clinical contexts.

Tucker JD, Volberding PA, Margolis DM, Rennie S, Barré-Sinoussi F.

J Acquir Immune Defic Syndr. 2014 Nov 1;67(3):e110-1. doi: 10.1097/QAI.0000000000000305. No abstract available.


Phenotype alterations in regulatory T-cell subsets in primary HIV infection and identification of Tr1-like cells as the main interleukin 10-producing CD4+ T cells.

Chevalier MF, Didier C, Petitjean G, Karmochkine M, Girard PM, Barré-Sinoussi F, Scott-Algara D, Weiss L.

J Infect Dis. 2015 Mar 1;211(5):769-79. doi: 10.1093/infdis/jiu549. Epub 2014 Oct 3.


Natural killer cell responses to dendritic cells infected by the ANRS HIV-1 vaccine candidate, MVAHIV.

Cummings JS, Moreno-Nieves UY, Arnold V, Gilbert A, Yarbrough K, Didier C, Lévy Y, Barré-Sinoussi F, Scott-Algara D; ANRS HIV Vaccine Network (AHVN).

Vaccine. 2014 Sep 29;32(43):5577-84. doi: 10.1016/j.vaccine.2014.07.094. Epub 2014 Aug 13.


Human decidual macrophages and NK cells differentially express Toll-like receptors and display distinct cytokine profiles upon TLR stimulation.

Duriez M, Quillay H, Madec Y, El Costa H, Cannou C, Marlin R, de Truchis C, Rahmati M, Barré-Sinoussi F, Nugeyre MT, Menu E.

Front Microbiol. 2014 Jul 1;5:316. doi: 10.3389/fmicb.2014.00316. eCollection 2014.


An action agenda for HIV and sex workers.

Beyrer C, Crago AL, Bekker LG, Butler J, Shannon K, Kerrigan D, Decker MR, Baral SD, Poteat T, Wirtz AL, Weir BW, Barré-Sinoussi F, Kazatchkine M, Sidibé M, Dehne KL, Boily MC, Strathdee SA.

Lancet. 2015 Jan 17;385(9964):287-301. doi: 10.1016/S0140-6736(14)60933-8. Epub 2014 Jul 22. Review.


Towards a cure for HIV--are we making progress?

Lewin SR, Deeks SG, Barré-Sinoussi F.

Lancet. 2014 Jul 19;384(9939):209-11. doi: 10.1016/S0140-6736(14)61181-8. No abstract available.


Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.

Jacquelin B, Petitjean G, Kunkel D, Liovat AS, Jochems SP, Rogers KA, Ploquin MJ, Madec Y, Barré-Sinoussi F, Dereuddre-Bosquet N, Lebon P, Le Grand R, Villinger F, Müller-Trutwin M.

PLoS Pathog. 2014 Jul 3;10(7):e1004241. doi: 10.1371/journal.ppat.1004241. eCollection 2014 Jul.


Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block.

Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin-Goguet F, Barré-Sinoussi F, Kim B, Sáez-Cirión A, Pancino G.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1325-6. No abstract available.


Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

Saez-Cirion A, Jacquelin B, Barré-Sinoussi F, Müller-Trutwin M.

Philos Trans R Soc Lond B Biol Sci. 2014 May 12;369(1645):20130436. doi: 10.1098/rstb.2013.0436. Print 2014. Review.


NK cells are primed by ANRS MVA(HIV)-infected DCs, via a mechanism involving NKG2D and membrane-bound IL-15, to control HIV-1 infection in CD4+ T cells.

Moreno-Nieves UY, Didier C, Lévy Y, Barré-Sinoussi F, Scott-Algara D; ANRS HIV Vaccine Network (AHVN).

Eur J Immunol. 2014 Aug;44(8):2370-9. doi: 10.1002/eji.201344149. Epub 2014 Jun 24.


Past, present and future: 30 years of HIV research.

Barré-Sinoussi F, Ross AL, Delfraissy JF.

Nat Rev Microbiol. 2013 Dec;11(12):877-83. doi: 10.1038/nrmicro3132. Epub 2013 Oct 28. Review.


Universal health coverage and HIV in resource-constrained countries: a critical juncture for research and action.

Taverne B, Desclaux A, Delaporte E, Ndoye I, Coll Seck AM, Barré-Sinoussi F.

AIDS. 2013 Sep 10;27(14):2173-5. doi: 10.1097/QAD.0b013e3283611a0e. Review. No abstract available.


S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells.

Arnold V, Cummings JS, Moreno-Nieves UY, Didier C, Gilbert A, Barré-Sinoussi F, Scott-Algara D.

Retrovirology. 2013 Oct 24;10:122. doi: 10.1186/1742-4690-10-122.


p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.

Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin-Goguet F, Barré-Sinoussi F, Kim B, Sáez-Cirión A, Pancino G.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E3997-4006. doi: 10.1073/pnas.1306719110. Epub 2013 Sep 30.


The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation.

Chevalier MF, Petitjean G, Dunyach-Rémy C, Didier C, Girard PM, Manea ME, Campa P, Meyer L, Rouzioux C, Lavigne JP, Barré-Sinoussi F, Scott-Algara D, Weiss L.

PLoS Pathog. 2013;9(6):e1003453. doi: 10.1371/journal.ppat.1003453. Epub 2013 Jun 20.


Functional HIV cure is no pipe dream, says codiscoverer of the virus.

Barré-Sinoussi F.

BMJ. 2013 May 13;346:f2947. doi: 10.1136/bmj.f2947. No abstract available.


Who would have thought?

Lederman MM, Barre-Sinoussi F.

Curr Opin HIV AIDS. 2013 May;8(3):163-4. doi: 10.1097/COH.0b013e32835f94ed. No abstract available.


Will it be possible to live without antiretroviral therapy?

Hamimi C, Pancino G, Barré-Sinoussi F, Sáez-Cirión A.

Curr Opin HIV AIDS. 2013 May;8(3):196-203. doi: 10.1097/COH.0b013e32835f94d5. Review.


Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection.

Liovat AS, Rey-Cuillé MA, Lécuroux C, Jacquelin B, Girault I, Petitjean G, Zitoun Y, Venet A, Barré-Sinoussi F, Lebon P, Meyer L, Sinet M, Müller-Trutwin M.

PLoS One. 2012;7(10):e46143. doi: 10.1371/journal.pone.0046143. Epub 2012 Oct 2.


Towards an HIV cure: a global scientific strategy.

International AIDS Society Scientific Working Group on HIV Cure, Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Van Lint C, Verdin E, Woolfrey A, Zaia J, Barré-Sinoussi F.

Nat Rev Immunol. 2012 Jul 20;12(8):607-14. doi: 10.1038/nri3262. Review.


Public health: Towards a cure for HIV.

Deeks SG, Barré-Sinoussi F.

Nature. 2012 Jul 18;487(7407):293-4. doi: 10.1038/487293a. No abstract available.


Innate immunity in the control of HIV/AIDS: recent advances and open questions.

Ploquin MJ, Jacquelin B, Jochems SP, Barré-Sinoussi F, Müller-Trutwin MC.

AIDS. 2012 Jun 19;26(10):1269-79. doi: 10.1097/QAD.0b013e328353e46b. Review.

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